Archive for the ‘research’ Category

COVIDGATE: The Corruption of Clinical Trials (Part 1)

https://rightandfree.com/news/2020/11/17/covidgate-the-corruption-of-clinical-trials-part-one

COVIDGATE: The Corruption of Clinical Trials (Part One)

By Michelle Malkin

Shutterstock/Kira_Yan

“Truly striking.” “Tremendous.” “Extraordinary.” “Miraculous.” “A great day for science and humanity.” Those are just a few of the hyperbolic responses from government health officials and Big Pharma cheerleaders to preliminary COVID vaccine trial data released by Pfizer and Moderna this past week.

If it all sounds too good to be true, then congratulations: Your B.S. detector is fully charged and operational.  (See link for article)

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**Comment**

This commentary is spot on.  And it’s never been more important to have your B.S. detector fully charged than now when logic and proper debate has left science.  We’ve entered the “spin zone.”

Malkin points out the issues:

  1. Fauci’s continual flip-flopping on everything from masks to testing
  2. Normalcy can supposedly only return when everyone gets a yet to be proven vaccine 
  3. Various industries are exploring vaccine status verification systems – all of which is based upon press released write-ups from vaccine manufacturers
  4. Despite NOT being peer-reviewed, Fauci states “it’s all good”
  5. No one knows length of protection of the vaccine
  6. No one knows how this affects children as schools prepare to mandate the vaccine to obtain an education
  7. No one knows the synergistic effects of this vaccine with others
  8. No one knows the long-term effects of this vaccine
  9. The Pfizer clinical data is explained here: https://madisonarealymesupportgroup.com/2020/11/14/pfizer-covid-vaccine-frenzy-high-volume-of-adverse-reactions-expected/
  10. The Moderna trial is also being tested on those with a low risk of COVID
  11. The question to ask is how did they define a positive COVID case?
  12. Malkin points to the BMJ which defined this as including those even with only mild symptoms to qualify.  So people with simply a cough and positive lab test qualify.  Please see:  https://madisonarealymesupportgroup.com/2020/07/01/us-scientist-manufactured-pandemic-testing-people-for-any-strain-of-coronavirus-not-specifically-covid-19/  Many of these people don’t have COVID
  13. ZERO trials were designed to detect a reduction in any serious outcomes (hospital admission, intensive care, or death)
  14. ZERO trials are designed to determine if they interrupt viral transmission
  15. Moderna’s trial lacks adequate statistical power to assess severe COVID-19 outcomes.  The reason?  Hospital admissions and deaths are too uncommon in the study population of 30,000 people

Important excerpt:

Vaccinating billions of people to prevent a disease with a 99% survival rate for people under 70 — all based on clinical trial efficacy analysis of less than 200 COVID-19 cases involving patients with coughs and unreliable PCR tests with significant false positive rates — is not the triumph of science. It’s corruption and it’s the tip of the iceberg.

For more:  

There is a full-court press to get everyone to take the experimental DNA vaccine:  https://madisonarealymesupportgroup.com/2020/11/18/who-taps-anti-conspiracy-crusader-to-sway-public-opinion-on-covid-vaccine/

For more on the COVID vaccine:  https://madisonarealymesupportgroup.com/2020/04/21/inovio-covid-19-vaccine-uses-electricity-to-drive-dna-into-body-cells/

https://madisonarealymesupportgroup.com/2020/10/05/covid-19-vaccine-explained/

https://madisonarealymesupportgroup.com/2020/11/11/how-covid-19-vaccine-can-destroy-your-immune-system/

Excerpt:

  • According to a study that examined how informed consent is given to COVID-19 vaccine trial participants, disclosure forms fail to inform volunteers that the vaccine might make them susceptible to more severe disease if they’re exposed to the virus
  • Previous coronavirus vaccine efforts — including those for SARS, MERS and RSV — have revealed a serious concern: The vaccines have a tendency to trigger antibody-dependent enhancement (ADE)
  • ADE means that rather than enhance your immunity against the infection, the vaccine actually enhances the virus’ ability to enter and infect your cells, resulting in more severe disease than had you not been vaccinated

Category:

research, vaccines, Viruses

Yale Scientists Identify Protein That Protects Against Lyme Disease

https://news.yale.edu/2020/11/11/yale-scientists-identify-protein-protects-against-lyme-disease

Yale scientists identify protein that protects against Lyme disease

By Bill Hathaway
November 11, 2020
Lyme tick
(© stock.adobe.com)

Yale researchers have discovered a protein that helps protect hosts from infection with the tick-borne spirochete that causes Lyme Disease, a finding that may help diagnose and treat this infection, they report Nov. 11 in the journal PLOS Pathogens.

Lyme Disease is the most common vector-borne disease in North America and is transmitted by ticks infected with the spirochete Borrelia burgdorferi. The course of the disease varies among individuals, with the majority experiencing mild symptoms easily treated by antibiotics. However, in some cases of untreated Lyme the infection can spread to the heart, joints, nervous system, and other organs.

For the study, the Yale team expressed more than 1,000 human genes in yeast and analyzed their interactions with 36 samples of B. burgdorferi. They found that one protein, Peptidoglycan Recognition Protein 1 (PGLYRP1), acts like an early warning signal to the immune system when exposed to the bacteria. When exposed to the Lyme spirochete, mice lacking PGLYRP1 had much higher levels of B. burgdorferi than mice with the protein and showed signs of immune system dysfunction, the researchers report.

“Stimulating the ability of people to make more of this protein could help fight infection,” said Yale’s Erol Fikrig, the Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and professor of epidemiology (microbial diseases) and of microbial pathogenesis and co-corresponding author of the study.

Fikrig and his colleagues are also investigating whether people with higher levels of PGLYRP1 may be less susceptible to infection by B. burgdorferi, which would help explain why some infected individuals have better outcomes.

Yale’s Noah Palm and Aaron Ring are co-corresponding authors of the paper.  Akash Gupta, Gunjun Arora, and Connor Rosen of Yale are co-lead authors.

The work was primarily funded by the National Institutes of Health and the Steven & Alexandra Cohen Foundation, a nonprofit that supports Lyme and tick-borne disease research.

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**Comment**

A few points:

They state, “The course of the disease varies among individuals, with the majority experiencing mild symptoms easily treated by antibiotics. However, in some cases of untreated Lyme the infection can spread to the heart, joints, nervous system, and other organs.”

OK – this is FALSE.

No, a majority do NOT experience mild symptoms easily treated with antibiotics.
  • Current CDC 2-tiered testing is missing 70-86% of cases.  They have ZERO idea of prevalence due to all the people being misdiagnosed or undiagnosed.  Also, even the people who win the testing lotto and manage to test positive are told they have “false positives” and are sent home empty-handed to worsen.
  • As to being “easily treated with antibiotics,” how do you explain the 40-60% or more who go on with life-long symptoms?  https://madisonarealymesupportgroup.com/2019/02/25/medical-stalemate-what-causes-continuing-symptoms-after-lyme-treatment/ and the fact there has been treatment failure in nearly every antibiotics study ever done?  https://madisonarealymesupportgroup.com/2019/02/22/why-mainstream-lyme-msids-research-remains-in-the-dark-ages/
  • They state that only the “untreated Lyme” patients struggle with infection in the heart, joints, CNS, and other organs when this can happen WITH those who are treated as well.  In fact, in my experience ALL the patients I deal with have these severe symptoms.  ALL!
  • While I don’t want to appear to be a stick in the mud, I’m highly skeptical that lacking a certain protein is the sole reason for having lower levels of Bb.  I can think of numerous reasons for this – including being infected with numerous pathogens – suppressing the immune system.
  • Stay tuned.  These studies promise a lot but often deliver little, especially when the premise behind it all is that this complex illness is due to immune dysregulation NOT the underlying persistent infection. Again, in my experience it’s both that are a problem but by treating the underlying infection, the immune dysregulation is also treated.

Category:

Lyme, research

Immunity to the Coronavirus May Last Years, New Data Hint

https://www.nytimes.com/2020/11/17/health/coronavirus-immunity

Blood samples from recovered patients suggest a powerful, long-lasting immune response, researchers reported.
Credit…Cheney Orr/Reuters

By Apoorva Mandavilli

How long might immunity to the coronavirus last? Years, maybe even decades, according to a new study — the most hopeful answer yet to a question that has shadowed plans for widespread vaccination.

Eight months after infection, most people who have recovered still have enough immune cells to fend off the virus and prevent illness, the new data show. A slow rate of decline in the short term suggests, happily, that these cells may persist in the body for a very, very long time to come.

The research, published online, has not been peer-reviewed nor published in a scientific journal. But it is the most comprehensive and long-ranging study of immune memory to the coronavirus to date.  (See link for article)

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**Comment**

While it’s true this study has not been peer-reviewed or published in a bought-out scientific journal, it completely aligns with other findings and what has occurred historically for viruses.

  • survivors of SARS carry certain important immune cells 17 years after recovering
  • a study at the University of Washington show “memory” cells persist for at least 3 months after infection
  • those recovered from COVID-19 have powerful and protective killer immune cells even when antibodies are not detectable.  Many immunologists have noted that it is completely  natural for antibody levels to drop, as they are just one arm of the immune system.
  • a Yale immunologist is not surprised by the long-lasting response because “that’s what is supposed to happen.”  Akiko Iwasaki
  • another immunologist stated that typically people get infected a second time but that the immune system recognizes it and resolves it so quickly you remain asymptomatic and not infectious, and that “sterilizing immunity” is rare and not the norm
  • the new study by Sette et al., the first to chart the immune response in such detail, looked at antibodies, B cells, and two types of T cells – to better understand the whole immune response over time
  • an author of the study frequently cited suggesting fading immunity admits that reinfections with the coronavirus are rare
  • while immunity duration is difficult to predict studies so far show even small numbers of antibodies or T & B cells may be enough and that study participants have been making “robust amounts”
  • emerging evidence on reinfections with common cold coronaviruses are a result of viral genetic variations and may not be relevant to COVID-19
These results along with successful COVID treatments reveal once again that an experimental, fast-tracked, adverse reaction riddled vaccine isn’t needed.

Category:

research, Viruses

Novel Rickettsia Species Infecting Dogs, United States

https://wwwnc.cdc.gov/eid/article/26/12/20-0272_article

Volume 26, Number 12—December 2020

Novel Rickettsia Species Infecting Dogs, United States

James M. Wilson, Edward B. Breitschwerdt, Nicholas B. Juhasz, Henry S. Marr, Joao Felipe de Brito Galvão, Carmela L. Pratt, and Barbara A. Qurollo

Abstract

In 2018 and 2019, spotted fever was suspected in 3 dogs in 3 US states. The dogs had fever and hematological abnormalities; blood samples were Rickettsia seroreactive. Identical Rickettsia DNA sequences were amplified from the samples. Multilocus phylogenetic analysis showed the dogs were infected with a novel Rickettsia species related to human Rickettsia pathogens.

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Important quote from study:

The cases were geographically distributed among 4 states; the dogs resided in Illinois, Oklahoma, and Tennessee, but the dog from Illinois had traveled to a tick-infested area of Arkansas. The tick species were not identified, but ticks common to these states include Amblyomma americanum, Dermacentor variabilis, and Rhipicephalus sanguineus sensu lato, all of which are known to transmit Rickettsia (3). Haemophysalis longicornis, an invasive tick species recently confirmed in the United States, including in Tennessee and Arkansas, should be considered a potential vector for Rickettsia spp. (9,10).

Based on serologic cross-reactivity, presence of ompA, and phylogenetic tree analysis, the new Rickettsia sp. is an SFG Rickettsia, phylogenetically related to human pathogenic R. heilongjiangensis and R. massiliae, with only 95% identity to each (11,12). Thus, we report a previously unknown and unique Rickettsia sp. with clinical significance for dogs and potentially humans.

Because this novel Rickettsia cross-reacts with R. rickettsia on IFA, it could be underdiagnosed and more geographically widespread. Studies aimed at identifying the tick vector, potential animal reservoirs, and prevalence are ongoing. These 3 canine rickettsioses cases underscore the value of dogs as sentinels for emerging tickborne pathogens (13,14)

For more:

https://madisonarealymesupportgroup.com/2019/11/14/study-shows-ticks-can-transmit-rickettsia-immediately/ ..ticks can transmit infectious Rickettsia virtually as soon as they attach to the host.

https://madisonarealymesupportgroup.com/2020/03/14/dogs-with-proteinuria-found-to-have-exposure-to-rickettsia-ehrlichia-and-lyme-disease/

https://madisonarealymesupportgroup.com/2020/01/11/bartonella-found-in-dogs-after-infection-with-rickettsia/

https://madisonarealymesupportgroup.com/2019/11/24/rickettsia-spp-in-east-texas-with-reduced-tick-density-due-to-controlled-burns/

https://madisonarealymesupportgroup.com/2020/09/30/two-exotic-disease-carrying-ticks-identified-in-rhode-island-first-case-of-parasitic-soft-ticks-reported-in-new-jersey/

Category:

research, Rickettsia

Estimates for Lyme Borreliosis Infections Based on Models Using Sentinel Canine and Human Seroprevalence Data – Far Higher Than ‘Official’ Data

https://www.sciencedirect.com/science/article/pii/S2468042720300580?via%3Dihub

Estimates for Lyme borreliosis infections based on models using sentinel canine and human seroprevalence data

Under a Creative Commons license
open access

Abstract

Two models were developed to estimate Lyme borreliosis (LB) cases. One was based on the seroprevalence of Borrelia infections in human samples. This model used corrections for false negative and false positive results from published test sensitivity and specificity measures. A second model based on Borrelia infections in sentinel dogs was used to quantify the prevalence of Lyme disease Borrelia infections in humans; the reference baseline for this model was human and canine infections in Germany. A comparison of the two models is shown and differences discussed. The relationships between incidence, prevalence and total infection burden for LB were derived from published data and these were used in both models to calculate annual incidence, prevalence and total LB infections. The modelling was conservative and based on medical insurance records coded for erythema migrans. Linear model growth rates were used in place of the commonly adopted exponential growth. The mean of the two models was used to create estimates for various countries and continents. Examples from the analyses for LB estimated for 2018 include:

incidence –

  • USA 473,000/year
  • Germany 471,000/year
  • France 434,000/year
  • UK 132,000/year

prevalence –

  • USA 2.4 million
  • Germany 2.4 million
  • France 2.2 million
  • UK 667,000

total infections –

  • USA 10.1 million
  • Germany 10.0 million
  • France 9.3 million
  • UK 2.8 million

Estimates for the world for 2018 are:

incidence

  • 12.3 million/year

prevalence

  • 62.1 million

total infection burden

  • 262.0 million
These figures are far higher than officially published data and reflect not only the underestimation of diagnosed cases, which is acknowledged by health agencies, but also undiagnosed and misdiagnosed cases.

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For more:

Prevention for pets:  https://madisonarealymesupportgroup.com/2019/04/16/april-lyme-prevention-month-for-dogs-a-pet-owners-guide/

Category:

Lyme, research, Testing