Archive for the ‘research’ Category

Lyme Disease: A Persistent Infection

https://danielcameronmd.com/lyme-disease-persistent-infection/

LYME DISEASE: A PERSISTENT INFECTION

woman with lyme disease infection holding her head
Chronic manifestations of Lyme disease have been described for more than three decades. In 1970, Logigian and Steere described 27 patients with chronic neurologic Lyme disease, who had been ill for up to 14 years. Some improved, some relapsed and others remained ill. [1]
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There are multiple studies indicating that Lyme disease can result in a persistent infection, causing chronic symptoms that may require treatment with extended courses of antibiotics. The National Institute of Health (NIH) conducted three Lyme disease trials, which validated the existence and severity of chronic manifestations of Lyme disease.2-4  The study’s patients were ill for years, an average of 9 years in one trial. Three of the four trials confirmed that treatment with antibiotics can fail. These patients reported severe fatigue, impaired cognitive function, pain and poor function despite antibiotic treatment.5

Some doctors have dismissed the possibility that a persistent tick-borne infection might underlie a patient’s illness,6 while other doctors believe that Lyme disease may cause a persistent infection and be an underlying cause of illness.7

Dr. Shor and colleagues summarized potential mechanisms for a persistent infection.

“Potential survival mechanisms of Lyme disease persistence include:

  • immune evasion
  • immune modulation
  • presence of subpopulations of persister cells
  • physical seclusion—within cells, collagen-rich tissues, and immunologically protected sites (CNS, joints, and eyes), is one method of immune evasion
  • biofilm generation is another recognized form of physical seclusion. Published reports document that Borrelia burgdorferi can produce biofilm in vitro and examination of infected human tissues demonstrated B. afzelii and B. burgdorferi embedded in biofilm.” [7]
Editor’s perspective: Patients are finding it increasingly difficult to locate a doctor who is willing to at least consider the presence of a persistent infection.
Related Articles:

Chronic neurological Lyme disease or co-morbid conditions?

What is chronic Lyme disease?

Long-term problems for some Lyme neuroborreliosis patients

References:
  1. Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. N Engl J Med. Nov 22 1990;323(21):1438-44. doi:10.1056/NEJM199011223232102
  2. Klempner MS, Hu LT, Evans J, et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med. Jul 12 2001;345(2):85-92. doi:10.1056/NEJM200107123450202
  3. Krupp LB, Hyman LG, Grimson R, et al. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology. Jun 24 2003;60(12):1923-30. doi:10.1212/01.wnl.0000071227.23769.9e
  4. Fallon BA, Keilp JG, Corbera KM, et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology. Mar 25 2008;70(13):992-1003. doi:10.1212/01.WNL.0000284604.61160.2d
  5. Rebman AW, Aucott JN, Weinstein ER, Bechtold KT, Smith KC, Leonard L. Living in Limbo: Contested Narratives of Patients With Chronic Symptoms Following Lyme Disease. Qual Health Res. Mar 2017;27(4):534-546. doi:10.1177/1049732315619380
  6. Wormser GP, McKenna D, Karmen CL, et al. Prospective Evaluation of the Frequency and Severity of Symptoms in Lyme Disease Patients With Erythema Migrans Compared With Matched Controls at Baseline, 6 Months, and 12 Months. Clin Infect Dis. Jan 23 2020;doi:10.1093/cid/ciz1215
  7. Shor S, Green C, Szantyr B, et al. Chronic Lyme Disease: An Evidence-Based Definition by the ILADS Working Group. Antibiotics (Basel). Dec 16 2019;8(4)doi:10.3390/antibiotics8040269

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For more:

If you haven’t signed Lyme Advocate Carl Tuttle’s petition, please do:  https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/29506824?  The petition is calling for a congressional investigation of the CDC, IDSA, and ALDF for their mismanagement of Lyme/MSIDS – for their long denial of chronic Lyme and the damage it causes.  This denial has played out in patients not getting diagnosed and treated properly with long-term antimicrobials due to abysmal serology tests which are wrong 86% or more of the time.  It also plays out in the fact doctors who dare to treat outside the unscientific and antiquated CDC Lyme guidelines are hunted down and persecuted, making doctors afraid to treat patients.

The same government funded institutions behind the Lyme debacle are currently also behind the COVID debacle and need to be held accountable.  They have done many of the same things which has resulted in patients not getting the care they need.  These corrupt public health ‘authorities’ are the problem.

Category:

Lyme, research

85% of Turkish MS Patients Have Lyme – Study Shows

https://storage.googleapis.com/journal-uploads/ejbps/article_issue/volume_6_april_issue_4/1553939970.pdf

FREQUENCY OF BORRELIA BURGDORFERI WESTERN BLOT AND LTT POSITIVITY AMONG MULTIPLE SCLEROSIS PATIENTS FROM TURKEY

Barbaros Çetin* Dokuz Eylul University, Faculty of Science, Department of Biology, Izmir, Turkey.

Article Received on 29/01/2019 Article Revised on 19/02/2019 Article Accepted on 12/03/2019

ABSTRACT

In Turkey, Borrelia burgdorferi infections are not well known among physicians and almost completely overlooked. On the other hand, a small number of seropositivity studies (%3.3-%73) show that Borrelia burgdorferi is common in Turkey. There is no diagnostic biological marker in multiple sclerosis (MS). Only several clinical criteria used for diagnosis. These criteria are also compatible with other diseases. Lyme disease is currently among them. In the chronic phase of Lyme, demyelination can form and this can be confused with MS.

In this study 126 patients, between ages 17 and 66, with a definite diagnosis of multiple sclerosis was evaluated, and were found according to be found positive Borrelia burgdorferi western blot and LTT test results 108 (%85.72). Only 18 (%14.28) patients have negative test results.

The results show that LYME disease is very common in Turkey and LYME patients with neurological symptoms are misdiagnosed with multiple sclerosis.

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Important excerpts:

Multiple sclerosis affects at least 2.8 million people worldwide.

Worldwide, MS prevalence parallels the distribution of the Lyme disease pathogen Borrelia burgdorferi, and in America and Europe, the birth excesses of those individuals, who later in life develop MS exactly mirror the seasonal distributions of Borrelia transmitting Ixodes ticks.

According to the one of the most effective scientific papers, written by 4 Norwegian scientists, 10 of 10 MS patients were found to have a cyst form of the Borrelia spirochete bacteria. No bacteria were found in a control group. The cysts turned into spirochetal bacteria when cultured. The studies conclude that all ten MS patients have been infected with a spirochete. Concludes that MS could very well be a chronic infection.[8]

Since 1911, more than the past one hundred years, several older but also recent autopsy findings linked to in many articles found that all deceased MS patients’ brains harbored living lyme spirochetes. Even when tests, notorious for their large percentage of false negatives were used on living MS patients, staggeringly many tested positive for active Lyme borreliosis.[9]

“Spirochetes in MS” (Buzzard, E.F.), Published in the famous Lancet magazine in 1911, revealed the presence of Lyme spirochetes in the brains of MS patients. Over a period of more than a century, more than 50 international scientific papers proving the MS-Lyme relationship have been published in prestigious medical journals.[16-111] If you follow the European Medical Literature concerning Multiple Sclerosis from 1911 to 1939, you may find that in France, Germany and England, there were independent researchers all observing similar things and coming to similar conclusions:

  1. Spirochetes are often found in conjunction with the lesions in the brains of patients who have died with MS.
  2. These spirochetes can be isolated and can infect many mammalian animal models; including: mice, rats, hamsters, guinea pigs, rabbits, dogs, and primates.
  3. The spirochetes could be re-isolated from the brains of the infected animals and be inoculated into more un-infected animals and re-isolated from their brains.
  4. Multiple sclerosis may often be associated with Borrelia infection.
  5. Points out that a considerable body of clinical evidence supports the concept that cystic L-forms of Borrelia burgdorferi may cause MS. 

For more:

Category:

Lyme, research

PTSD, COVID-19 & Lyme Disease: A Perspective

https://danielcameronmd.com/ptsd-covid-19-and-lyme-disease-a-perspective/

PTSD, COVID-19 AND LYME DISEASE: A PERSPECTIVE

man with PTSD and COVID-19 getting console in therapy

“Post-traumatic stress disorder (PTSD) is a severe mental health condition caused by a terrifying event outside the normal range of usual human experience.”[1] While it is often associated with events such as an assault or disaster, post-traumatic stress disorder can occur in people with severe health problems.

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Patients with chronic Lyme disease have reported symptoms of PTSD. Now, an article entitled “PTSD as the second tsunami of the SARS-Cov-2 pandemic,” by Dutheil et al. indicates that some COVID-19 patients are experiencing post-traumatic stress disorder, as well.¹

The authors highlight several observations on the SARS-Cov-2 pandemic and PTSD that would also apply to Lyme disease patients that I have seen in my practice.

PTSD in COVID-19 pandemic

  • “With a poor understanding of viruses and spreading mechanisms, the evocation of SARS is generating a great anxiety contributing to promote PTSD.”
  • “In the families of cases, the brutal death of family members involved a spread of fear and a loss of certainty, promoting PTSD.”
  • “PTSD symptoms involve chronic severe anxiety with re-experiencing the traumatic event, flashbacks, nightmares, increased arousal, and reduced social life.”
  • “People suffering from PTSD are prone to not seek care, because of barriers such as lack of information and cost of mental health care, being afraid of stigmatization, or beliefs that symptoms may increase with time.”
  • “PTSD individuals are more at-risk of suicidal ideation, suicide attempt, and deaths by suicide, in huge proportions.”

PTSD in chronic Lyme disease

  • The poor understanding of Lyme disease and associated tick-borne illnesses has generated a great deal of anxiety.
  • The severity of chronic illness following Lyme disease involves a spread of fear and a loss of certainty.
“People suffering from PTSD are prone to not seek care, because of barriers such as lack of information and cost of mental health care, being afraid of stigmatization, or beliefs that symptoms may increase with time.”
  • I have Lyme disease patients who re-experience the traumatic event, flashbacks, nightmares, increased arousal, and reduced social life, as described by the authors.
  • I have seen Lyme disease patients who “are prone to not seek care, because of barriers such as lack of information and cost of mental health care, being afraid of stigmatization, or beliefs that symptoms may increase with time.”
  • I have seen suicidal ideation in patients I have treated. Dr. Robert Bransfield, a psychiatrist specializing in tick-borne illnesses, has described suicidal ideation, suicide attempt, and deaths by suicide in patients in his practice.²

Author’s perspective: I hope that a better understanding of post-traumatic stress disorder in COVID-19 patients will lead to a better understanding of PTSD in Lyme disease.

Related Articles:

Lyme carditis diagnosis during a COVID-19 quarantine

COVID-19 delays diagnosis of Lyme disease

9 ways COVID-19 and Lyme disease can look alike

References:
  1. Dutheil F, Mondillon L, Navel V. PTSD as the second tsunami of the SARS-Cov-2 pandemic. Psychol Med. Apr 24 2020:1-2. doi:10.1017/S0033291720001336
  2. Bransfield RC. Aggressiveness, violence, homicidality, homicide, and Lyme disease. Neuropsychiatr Dis Treat. 2018;14:693-713. doi:10.2147/NDT.S155143

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**Comment**

PTSD is very, very real.  I’ve had it myself.  My husband had it. People don’t typically understand that Lyme/MSIDS IS a brain disease and can affect you psychologically in many ways.  You can hear voices, hallucinate, have PTSD or OCD, depression, de-personalization, and so many other mental issues.

It’s important to get to the root of the issue – and that’s treating the infections; however, you may also need to address the mental health aspects as well with a trained professional.  A word of warning; however, I would highly recommend a Lyme literate professional as many patients have been abused at the hands of uneducated professionals who blindly follow the CDC/IDSA ideology.  These people can cause more harm than good.  I would also seek to get a referral from either a knowledgable patient or health professional you know and trust.

For more:

Category:

Lyme, Psychological Aspects, research, Viruses

Study Shows ADE in Those Getting COVID JABS

https://www.journalofinfection.com/article/S0163-4453(21)00392-3/fulltext

Infection-enhancing anti-SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and Delta variants. A potential risk for mass vaccination?

Published: August 09, 2021DOI:https://doi.org/10.1016/j.jinf.2021.08.010

Abstract

Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :4203–4219, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants.
Using molecular modeling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity.
Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.
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Important points:
  • Antibodies developed from the current COVID injections cause the body to overreact to mutations like Delta, proving ADE.
  • While the author recommends scrapping current jabs with newer ones, can we just admit they are all unnecessary, ineffective, and unsafe?
  • Mutations/variations are a normal, mundane aspect of viral evolution, but experts are stating that mass vaccination campaigns are causing them as they push the virus to mutate to survive.
  • Logic would indicate these vaccination campaigns should be stopped for this very reason, along with the fact these jabs have caused more reports of adverse reactions and death than any other jabs in the history of VAERS, and VAERS typically only captures 1% of reports, so it’s actually far, far worse in reality.
  • Dr. Lee Merrit explains that ALL animals in previous mRNA biologic studies DIED from ADE (antibody dependent enhancement).  Key word:  ALL
  • Natural immunity should be accepted and embraced, as historically it is the only thing that confers lasting immunity.

Category:

research, vaccines, Viruses

New Study Finds Evidence of Lyme Bacteria in Brain Tissue

https://www.newscentermaine.com/article/news/health/new-study-finds-evidence-of-lyme-bacteria-in-brain-tissue-news-center-maine-tick-week-deer-dog-cdc-tulane-university-borrelia-burgdorferi-lab-disease/97-

New study finds evidence of Lyme bacteria in brain tissue

The research shows how pathogens that cause Lyme can linger in the body despite early treatment.
 

MAINE, Maine — According to the U.S, Centers for Disease Control & Prevention, Lyme disease can cause long-term health effects including fatigue, chronic pain, heart issues, and neurological problems.

The CDC says most symptoms caused by the tick-borne illness can be treated successfully with antibiotics if caught early.

A new study by Tulane University shows that Lyme bacteria can persist in a patient’s brain. Researchers found Lyme bacteria in the brain tissue of an elderly woman even after she had received 10 days of antibiotics following a tick bite.

Dr. Monica Embers, Ph.D., is an associate professor of microbiology and immunology at Tulane University School of Medicine in New Orleans. She and other researchers at the Tulane National Primate Research Center conducted the study in collaboration with the Lyme and Tick-Borne Diseases Research Center at Columbia University Irving Medical Center. 

The study was recently published in “Frontiers in Neurology,” the leading peer-reviewed journal for neurologists. It’s a breakthrough that could lead to changes in recommendations for treatment, including longer courses of antibiotics to address a growing public health crisis. (See link for article)

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**Comment**

Excerpt:

“This is not a pathogen you want in your brain,” she said.

But that’s exactly what researchers found in a 69-year-old woman who donated her brain to Columbia University for research before she died from dementia-related complications.

The woman received 10 days of antibiotics.  She went on to develop late-stage Lyme.

Despite years of IV treatment, the woman suffered from sleep disorders, personality changes, and dementia. Lyme pathogens were also found in her spinal cord. 

Embers states that Borrelia evades the immune system by changing its proteins and burying into the body.  It can also evade antibiotics.

Lyme bacteria is persistent and evasive in the human body.

A doctor goes onto state that blood testing is often negative.

 

Another woman was mentioned in the article who had to hunt to find practitioners willing to treat her.  After finding two, she finally got relief after going on a regimen of antibiotics, anti-viral medications, and supplements; however she still suffers from numbness & leg pain.

Her Lyme journey is featured in the book, “The Waiting Room: Invisible Voices of Lyme.”  

Watch Dr. Embers’ full interview below.

For more:

None of this is new, and everything experienced by these patients has been experienced by thousands of others for 40 years.  Spirochetes were found in Vicky Logan decades ago.

Vicky’s doctor, Dr. Kenneth Liegner wrote a lengthy book chronicling Vicky’s story and his unrelenting efforts to get her IV treatment which kept her alive.  

He also gave details about a 2001 International Lyme Conference in New York where attendees were censored by having their microphones shut off whenever they brought up the issue of chronic Lyme disease. Wormser denied to Liegner that the event was CDC sponsored, which is an important detail as it possibly could have been opened up by legislators; however, distributed materials showed the event was in fact CDC-sponsored.

But the real zinger occurred when Liegner requested an autopsy on Vicki and the pathologist not only refused, he refused to even let an outside pathologist use the facilities to perform it.  

The reason?  Wait for it…..

……danger of infection to himself and his staff.

But, I thought Lyme disease was benign and similar to the common cold – easily cured with 21 days of doxy?

Liegner wasn’t about to let the ball drop and found a way to get Vicki to the Chief of Neuropathology at Columbia Presbyterian where her autopsy results are now available to all.  Without this critical step, propelled by Liegner, the pathologist at Hudson Valley Hospital would have successfully prevented medical knowledge of chronic and neurologic Lyme disease as well as the cause of her hypotension, a missed diagnosis of myocardial infarction.

Under “Microscopic Description” it states, “The autopsy shows histopathologic findings consistent with the neurological manifestations of chronic Lyme disease.”

In the 1800’s, Texans had the battle cry, “Remember the Alamo.”

For Lyme patients, advocates, and the doctors who dare to treat them, we have a battle cry too:

“Remember Vicki Logan.”

Call me crazy, but the continued denial of Borrelia persistence despite a plethora of research demonstrating it in both animals and humans is akin to the current COVID madness despite effective treatments, and denial of COVID injection adverse reactions and deaths.  Our corrupt public health ‘authorities’ and conflict-riddled researchers have already determined what fits in their accepted narrative and a persistent infection just doesn’t fit, as it would render the need for lucrative Lyme vaccines null and void and we certainly can’t take away that lucrative cash cow.

Category:

Lyme, research, Treatment