Archive for the ‘Inflammation’ Category

Bartonella: How to Protect Yourself From This Stealthy Intruder

https://www.linkedin.com/pulse/bartonella-how-protect-yourself-from-stealthy-jill-c-carnahan-md/?

Bartonella: How to Protect Yourself From This Stealthy Intruder

Jill C. Carnahan, MD

Founder, Medical Director, Flatiron Functional Medicine
 

A walk through the woods. Playing with your cat. Getting a spider bite. These things might all seem unrelated, but they have one important thing in common – they can all potentially expose you to a sneaky and possibly dangerous bacteria known as Bartonella. 

This stealthy intruder can be dangerous and is notoriously hard to treat. Today we’re going to dive into exactly what Bartonella is. And most importantly we’re going to cover practical and simple ways you can protect yourself from this foreign invader. 

What Is Bartonella?

Bartonella is a type of bacteria that infects your cells – causing a condition known as bartonellosis. It’s estimated that there are over 20 different strains of Bartonella, and that at least 14 of them have the ability to be transmitted to humans.1 Once contracted, Bartonella makes itself at home, particularly in the cells that line your blood vessels and within your red blood cells.

What makes Bartonella unique is its ability to evade your immune system’s defenses. You see, Bartonella has a stealthy infection strategy that goes something like this:2

  1. Adhesion: Once contracted, Bartonella adheres to your red blood cells.
  2. Deformation: After attaching to your red blood cells, Bartonella gets to work on deforming the surface of your cells by creating progressive indentations and invaginations.
  3. Invasion: As the integrity of the surface of your red blood weakens, Bartonella begins its invasion – essentially hijacking your red blood cells.
  4. Persistence: Once your red blood cells are hijacked, Bartonella is able to evade your body’s defenses – allowing this bacteria to thrive and replicate undetected by your immune system.
  5. Suppression: Protected by the camouflage of your red blood cells, Bartonella is able to manipulate your immune system – triggering the secretion of certain chemical messengers that suppress and dampen your immune response.

Bartonella’s deceptive and stealthy infection strategy makes this pathogen particularly skilled at not only persisting and hiding within its host’s body – but it also creates ideal conditions for transmission. Let’s dive into exactly how this deceptive microorganism is transmitted and contracted.

How Do You Contract Bartonella?

Bartonella can be carried by most mammals, including domestic animals like cats, dogs, horses, and cattle. Typically, if you’re exposed to Bartonella, it’s through transmission from an animal. This can occur if you’re scratched by a cat or bitten by a dog. But it’s most often spread through a number of insect vectors such as:3

  • Ticks
  • Fleas
  • Lice
  • Sandflies
  • Red ants
  • Spiders
  • Bed bugs

These blood-sucking insects are the perfect vehicle for Bartonella to spread from host to host. 

What Are the Symptoms of Bartonella?

Bartonella can cause several identifiable conditions such as:4

  • Cat scratch disease
  • Carrion’s disease
  • Trench fever
  • Encephalopathy
  • Pericarditis
  • Chronic bacteremia

But Bartonella can also cause a handful of vague symptoms that are much more difficult to pinpoint, such as:5

Exactly how a Bartonella infection manifests varies substantially depending on the status of your immune system. And what makes this pathogen even trickier, is the fact that it’s often seen as a co-infection with other vector-borne pathogens.

Bartonella as a Co-infection: Its Link to Lyme Disease

The problem with ticks and other insect vectors is that they often harbor multiple infectious organisms. Meaning if you get bitten by a tick or other insect vector, you’re likely to be exposed and potentially infected with more than one organism – such as Bartonella. When multiple pathogens are contracted simultaneously, they’re called co-infections.

In particular, Bartonella has been identified as a co-infection to Lyme disease, the most common tick-borne disease. A co-infection with Bartonella has been found to significantly exacerbate symptoms associated with Lyme disease and can make diagnosis and treatment challenging. 

So let’s take a look at exactly how Bartonella can be addressed and if treatment can eliminate this persistent pathogen.

Is Bartonella Curable?

Because Bartonella is so good at being deceptive and camouflaging itself among your own cells, curing Bartonella requires a multi-faceted approach. So far, our best efforts at eradicating a Bartonella infection involves:6

  • A combination of prescription and herbal antimicrobials that kill off not only actively replicating forms of Bartonella, but also target “persisters” that have set up camp within your cells. These persisters aren’t actively replicating, but are hiding out in your cells and have the potential to replicate later on. 
  • Herbal and/or prescription medications that can break down the protective barrier some bacteria and viruses create, known as a biofilm
  • Supplements to decrease inflammation and support a healthy balance of cytokines and other chemical messengers that modulate your immune response.
  • Steps to boost and support your entire immune system.

Oftentimes treatment can take anywhere from 4-6 months or longer to improve the symptoms of Bartonella. Because Bartonella and other tick-borne illnesses can be difficult and time-consuming to treat, it’s imperative to take steps to protect yourself and your loved ones. 

So, How Can I Protect Myself Against Bartonella and Other Tick-Borne Diseases?

The best way to protect yourself against Bartonella and other tick-borne diseases is to take a two-pronged approach. Firstly, you’ll want to take precautions to prevent and avoid tick and insect bites. And secondly, you’ll want to bolster your natural defenses by ensuring your immune system is firing on all cylinders. Here are the steps I recommend taking: 

Protect Yourself From Tick and Insect Bites

If you’re going somewhere that may put you at risk of insect bites, take steps to protect yourself in the following ways:7

  • Stay on trails and avoid walking in tall grass or through the woods where you’re likely to come into contact with ticks and insects
  • Wear long pants and closed shoes
  • Use insect repellent
  • Wear lightly-colored clothes so you can more easily spot ticks or other insects on you
  • Inspect your clothes and hair and immediately remove any ticks or other insects

But the truth is it’s impossible to entirely avoid the possibility of being bitten by an insect vector that could potentially be carrying Bartonella or other infectious microorganisms. So it’s important to take these precautions in conjunction with the next step – boosting your immune system.

Give Your Immune System a Boost

Your immune system is your most powerful weapon against any and all potentially harmful microorganisms. And the good news is, you have a lot of control over how well your immune system functions. Some of the easiest and most effective ways to support your immune system are:

  • Eat an anti-inflammatory diet: The food you eat either promotes inflammation or fights inflammation. Basing your diet around anti-inflammatory foods minimizes inflammation – that way your immune system can direct all of its energy and resources at any potential threats. The basis of an anti-inflammatory diet is simply building most of your meals around real, whole foods and limiting processed foods. 
  • Take immune-boosting supplements: Supplements are a potent way to get a concentrated dose of immune-boosting nutrients and to fill in any nutritional gaps in your diet. Supplements like Gut Immune, Immune Booster, and Vitamin C help supercharge your immune system. If you want to learn more about how certain supplements boost your immunity, head over, and read my article covering the best immune-boosting supplements.   
  • Decrease your toxic burden: Our never-ending and ever-increasing exposure to environmental toxins can put a serious damper on your immune system. If toxins begin to accumulate in your body, it can overload your body’s detoxification mechanisms and essentially burn out your immune system. To learn exactly how you can begin decreasing your toxic burden and boost your immune system, check out my article How to Boost Your Immune System by Reducing Your Toxic Burden. 
  • Show your gut some love: The health of your gut and the status of your immune system are directly and intricately linked. If your gut is unhealthy, you’re guaranteed to have a weakened immune system. So taking steps to keep your gut healthy and happy is another surefire way to improve your immune system. To learn more about how your gut health impacts your immune system, you can read my article How to Heal Your Gut for a Stronger Immune System.

Your immune system truly is your best defense against any and all potentially harmful pathogens. Prioritizing the health of your immune system is hands-down one of the best things you can do for your overall health.

You Are Your Own Best Advocate

Bartonella is stealthy and deceptive – making it a particularly persistent and challenging infection to address. And the complications from this bacteria can be damaging and life-altering. So protecting yourself from this tricky microbe is crucial. 

And when it comes to protecting yourself from Bartonella, and other pathogens, you are your own best advocate. Following the steps outlined in this article is the best way to keep yourself safe and bolster your defenses. I always say that when it comes to your health, you are in the driver’s seat – and knowledge is your most powerful tool.

That’s why I’m dedicated to delivering the best and most up-to-date research to my patients and readers. If you want to access more empowering information about your health, my blogis chock-full of articles and resources. And if you want to take it even deeper, I encourage you to sign up for my newsletter. You’ll get all my best advice and resources delivered directly to your inbox. All you have to do is enter your name and email in the form below.

References

  1. https://rarediseases.org/rare-diseases/bartonellosis/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255967/
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630881/
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415619/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630881/
  6. https://www.treatlyme.net/guide/kills-bartonella-a-brief-guide
  7. https://kidshealth.org/en/teens/lyme-risk-teen.html
 
 
 
While mainstream entomologists often deny or downplay tick and insect/arachnid transmission of Bartonella:  
 
 
 
 
Considering the severity of Bartonella, I’ve never understood why ‘authorities’ do not err on the side of caution regarding transmission of Bartonella by all insects and arachnids that feed on blood.  In my opinion, anything that feeds on blood should be suspect until proven otherwise.
 
Regarding persistence, Dr. Ericson has shown Bartonella to survive in tissues where a PIC line was removed:  https://madisonarealymesupportgroup.com/2019/02/27/advanced-imaging-found-bartonella-around-pic-line/
 
And mainstream medicine completely ignores the severe psychiatric manifestations that Bartonella can cause:  https://madisonarealymesupportgroup.com/2020/08/30/new-case-report-neuropsychiatric-symptoms-and-bartonella-associated-skin-lesions/
 

Study Shows DSM Works for Lyme – Reduces Inflammatory Markers & Antibody Titers

https://www.mdpi.com/2079-6382/9/9/633

Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo

 
*Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 633; https://doi.org/10.3390/antibiotics9090633
Received: 10 July 2020 / Revised: 17 September 2020 / Accepted: 21 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Drugs Repurposing for the Treatment of Bacterial Infections)

Abstract

Lyme disease caused by the Borrelia burgdorferi (Bb or B. burgdorferi) is the most common vector-borne, multi-systemic disease in the USA. Although most Lyme disease patients can be cured with a course of the first line of antibiotic treatment, some patients are intolerant to currently available antibiotics, necessitating the development of more effective therapeutics. We previously found several drugs, including disulfiram, that exhibited effective activity against B. burgdorferi. In the current study, we evaluated the potential of repurposing the FDA-approved drug, disulfiram for its borreliacidal activity.
 
  • Our results indicate disulfiram has excellent borreliacidal activity against both the log and stationary phase B. burgdorferi sensu stricto B31 MI. Treatment of mice with disulfiram eliminated the B. burgdorferi sensu stricto B31 MI completely from the hearts and urinary bladder by day 28 post infection.
  • Moreover, disulfiram-treated mice showed reduced expressions of inflammatory markers, and thus they were protected from histopathology and cardiac organ damage.
  • Furthermore, disulfiram-treated mice showed significantly lower amounts of total antibody titers (IgM and IgG) at day 21 and total IgG2b at day 28 post infection.
  • FACS analysis of lymph nodes revealed a decrease in the percentage of CD19+ B cells and an increase in total percentage of CD3+ T cells, CD3+ CD4+ T helpers, and naive and effector memory cells in disulfiram-treated mice.

Together, our findings suggest that disulfiram has the potential to be repurposed as an effective antibiotic for treating Lyme disease. View Full-Text

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For more:  https://madisonarealymesupportgroup.com/2019/10/15/disulfiram-psychosis-update/

https://madisonarealymesupportgroup.com/2020/05/26/potential-patient-reported-toxicities-with-disulfiram-treatment-in-late-disseminated-lyme-disease/

https://madisonarealymesupportgroup.com/2020/06/07/disulfiram-for-lyme-disease-profiles-of-two-patients-reporting-good-outcomes/

https://madisonarealymesupportgroup.com/2019/11/19/if-disulfiram-is-the-cure-for-lyme-disease-should-it-be-prescribed-to-all-lyme-disease-patients/

https://madisonarealymesupportgroup.com/2019/06/03/disulfiram-in-the-treatment-of-lyme-babesiosis-3-case-reports/

https://madisonarealymesupportgroup.com/2019/07/14/disulfiram-breakthrough-drug-for-lyme-other-tick-borne-diseases/

 

 

What Lyme & Autism Have in Common Will Surprise You

https://dariningelsnd.com/lyme-and-autism/

July 6, 2020

By Dr. Darin Ingels N.D.

When speaking with children who are chronically ill, it can be difficult to understand what is causing their symptoms.

Children, naturally, might not know how to accurately describe their pains or illness. When there are multiple symptoms, it can be even more challenging as they grow and change so quickly.

For children with autism or other language disorder, they may be limited or unable to communicate why they feel the way they feel. Autism Spectrum Disorder (ASD) and Lyme disease are examples of what seem to be entirely different diseases, but they share an overlap of symptoms.

While autism is usually seen as a developmental disorder and Lyme disease and infectious disease, the two have more in common than you might think. There are interesting connections between the two, especially when diagnosed in children.

Sad boy with symptoms of lyme disease

Symptoms shared by both Autism and Lyme:

  • Neurological symptoms that include difficulty with communication and confusion, disorientation, muscle twitching, sensitivity to light, brain fog, and delayed development.
  • Psychological problems that impact behaviors, obsessive-compulsive disorder, an increased sense of doom, anxiety and outbursts.
  • Physical health issues such as muscle weakness, arthritis, and rashes.
  • Gut health issues including food allergies, bloating, constipation or diarrhea, and abdominal pain.

These symptoms are common features of autism and Lyme disease.

Coincidentally, many of these symptoms are also displayed in auto-immune disorders.

Tests for Lyme can be misleading, as they have a poor accuracy. A specialist is always needed in order to get a better sense of other treatment options because both autism and Lyme can have long-term issues.

However, there are treatments that benefit Lyme and autism alike. Focusing on gut health has been an important part of treatment for both conditions. This is because we are seeing the benefits of specific diets in patients with autism and/or Lyme.

Nutritional support strengthens the integrity of the intestinal membranes, balances the billions of bacteria in our gut and improves digestion and elimination.

All of this help support the immune function of the gut, which ultimately affects brain function.

An effective nutritional protocol would support the immune system, reduce symptoms, calm the nervous system and strengthen the body’s ability to fight infections.

Autoimmune conditions such as autism and Lyme disease benefit greatly from proper diet and lifestyle modifications.

Wheat

Removing casein, dairy, sugar, processed foods and gluten from the diet will allow the body to heal and aid in the detoxification process, naturally.

Reducing environmental factors like external and emotional stressors are extremely important for both Lyme and ASD.

Stress responses increase the load on the immune & nervous system, which can lead to exhaustion and further relapse into symptoms.

Identifying these triggers help you to work around them and eventually train your nervous system to create new patterns and get rid of the old ones. Autoimmune conditions have very unique impacts on the immune system, especially Lyme and autism.

Consider speaking to a specialist about your symptoms, especially if they mimic other autoimmune conditions. And never be afraid to get a second or even third opinion, as it may be necessary in order to get to the root of problem.

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For more:  https://madisonarealymesupportgroup.com/2019/12/22/identification-evaluation-and-management-of-children-with-autism-spectrum-disorder/

https://madisonarealymesupportgroup.com/2018/09/28/toxic-metal-pollution-linked-with-development-of-autism-spectrum-disorder/

https://madisonarealymesupportgroup.com/2018/09/05/pans-autism-the-immune-system-an-interview-with-expert-neurologist-dr-richard-frye/

https://madisonarealymesupportgroup.com/2017/10/26/clinical-trial-shows-most-kids-with-autism-are-not-born-with-it/

Benefits of Berberine Against Chronic Disease

https://www.foundmyfitness.com/topics/berberine?

Benefits of berberine against chronic disease

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By Rhonda Patrick

Background

Berberine is an alkaloid compound present in the roots, stems, rhizomes, and bark of a variety of plants, including Californian poppy, goldenseal, cork tree, Chinese goldthread, Oregon grape, and several plants in the Berberis genus. It is also widely available as a dietary supplement. Berberine has a long history of use in the ancient and traditional medicine systems of India, China, and Persia. Animal and limited human studies demonstrate that berberine may exert pharmacological effects against certain chronic health conditions such as cardiovascular disease, gastrointestinal disorders, neurodegenerative disease, depression, and metabolic dysfunction. Preliminary research in animals also suggests that berberine may exert anti-aging properties and might be beneficial in combating aging-related diseases. However, the bulk of research involving berberine has been conducted in animals, with a paucity of trials in humans. (See link for article)

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**Comment**

Berberine has been a God-send for us.  It has been shown to:

  1. lower lipids
  2. have antioxidant properties
  3. have anti-inflammatory properties
  4. reduce blood glucose levels
  5. protect the liver (in cell-culture studies)
  6. help neurodegenerative disorders
  7. have anti-depressant effects (in mice)
  8. have anti aging effects (in cells, insects, and rodents)
  9. thwarts negative effects of some pharmaceutical drugs
  10. have action against Bartonella:  https://madisonarealymesupportgroup.com/2019/05/05/good-news-for-bartonella-patients-identification-of-fda-approved-drugs-with-higher-activity-than-current-front-line-drugs/

For more:  https://madisonarealymesupportgroup.com/2019/04/05/study-shows-berberine-induces-cell-death-in-leukemia/

Interestingly, Japanese Barberry, a source of Berberine, is a hot-spot for ticks.  https://madisonarealymesupportgroup.com/2015/09/30/barberry-friend-or-foe/

https://madisonarealymesupportgroup.com/2018/06/25/juvenile-tick-attachment-on-mice-significantly-greater-in-japanese-barberry-shrubs/

https://madisonarealymesupportgroup.com/2018/01/20/manage-barberry-lower-ticks/

Yale Researchers Find Explanation for Stress’ Damage in Brown Fat

https://news.yale.edu/2020/06/30/fat-check-researchers-find-explanation-stress-damage-brown-fat

Fat check: Yale researchers find explanation for stress’ damage in brown fat

A man overcome by stress due to work
(© stock.adobe.com)

In their search for what triggers the damaging side-effects caused by acute psychological stress, Yale researchers found an answer by doing a fat check.

In the face of psychological stress, an immune system response that can significantly worsen inflammatory responses originates in brown fat cells, the Yale team reports June 30 in the journal Cell.

Since the hormones associated with stress, cortisol and adrenaline, generally decrease inflammation, it has long puzzled researchers how stress can worsen health problems such as diabetes and autoimmune disease as well as depression and anxiety.

“In the clinic, we have all seen super-stressful events that make inflammatory disease worse, and that never made sense to us,” said Dr. Andrew Wang, assistant professor of internal medicine and immunobiology, and corresponding author of the study.

Cortisol and adrenaline, hormones released in the classic “flight or fight” stress response, generally suppress the immune system, not activate it. These hormones also initiate a massive metabolic mobilization that provides fuel to the body as it addresses threats.

The scientists found that it was an immune system cell — the cytokine interleukin-6 (IL-6) — that triggers inflammation in times of stress. IL-6 has also been shown to play a role in autoimmune diseases, cancer, obesity, diabetes, depression and anxiety.

Wang and colleagues began to study the role of IL-6 in stress after a simple observation: When the researchers drew blood from mice, a very stressful procedure, the blood showed elevated levels of the cytokine.

In a series of experiments in mice, designed by Hua Qing and Reina Desrouleaux in Wang’s lab, the researchers found that IL-6, which is usually secreted in response to infections, was induced by stress alone and worsened inflammatory responses in the stressed animals.

And to their surprise, they found that in times of stress IL-6 was secreted in brown fat cells, which are most known for their roles in regulating metabolism and body temperature. When signals from the brain to brown fat cells are blocked, stressful events no longer worsened inflammatory responses.

“This was a completely unexpected finding,” said Qing, a postdoctoral associate at Yale School of Medicine.

The researchers reasoned that IL-6 must play another role in the “fight or flight” response besides triggering inflammation. They learned it also helps prepare the body to increase production of glucose in anticipation of threats. The brown fat cell response causes IL-6 levels to peak well after the metabolic production of glucose and the release of cortisol and adrenaline. This may explain why stress can trigger inflammation even while immune-suppressing hormones are being released, the researchers said.

Blocking IL-6 production not only protected stressed mice from inflammation, it also made them less agitated when placed in a stressful environment.

Wang and his team also suspect IL-6 may play a role in mental health disorders such as depression and anxiety. Wang observes that many of symptoms of depression, such as loss of appetite and sex drive, mimic those caused by infectious diseases such as the flu — so-called “sickness behaviors” — that can be triggered by IL-6.

Existing drugs designed to treat autoimmune diseases such as rheumatoid arthritis block the activity of IL-6. Preliminary findings suggest these drugs may help alleviate symptoms of depression, the authors note. There is also preliminary evidence that IL-6 may also play a role in diabetes and obesity as well.

 “There is an ever-growing literature on the role of IL-6 outside of immunity. Our work is exciting because it contributes to shortening that gap of knowledge,” said Desrouleaux, a graduate student in biology and biomedical science.