Supportive Oligonucleotide Therapy (SOT) as a Potential Treatment for Viral Infections and Lyme Disease: Preliminary Results

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Antisense therapy is widely used as an alternative therapeutic option for various diseases. RNA interference might be effective in infections, through the degradation of messenger RNA and, therefore, translation process. Hence, proteins essential for microorganisms and viruses’ proliferation and metabolism are inhibited, leading to their elimination. The present study aimed to evaluate the use of oligonucleotide in patients infected by Epstein-Barr (EBV) or Herpes Simplex Viruses 1/2 or with Lyme Disease caused by Borrelia burgdorferi. Blood samples were collected from 115 patients and the different species were characterized using molecular biology techniques. Then, SOT molecules (Supportive Oligonucleotide Therapy), which are specific small interfering RNA (siRNA), were designed, produced, and evaluated, for each specific strain. Oligonucleotides were administered intravenously to patients and then a quantitative Polymerase Chain Reaction was used to evaluate the effectiveness of SOT. This study revealed that for Lyme Disease, one or two SOT administrations can lead to a statistically significant decrease in DNA copies, while for viruses, two or three administrations are required to achieve a statistically significant reduction in the genetic material. These preliminary results indicate that antisense SOT therapy can be considered a potential treatment for viral as well as Lyme diseases.

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The challenge with Lyme is correctly identifying the patient’s infections as they are typically coinfected with many. Further, it’s all based on using PCR to detect the DNA of various bacteria which is known to find Lyme only 30% of the time.  Further, many of the organisms with Lyme/MSIDS aren’t found in the blood so trying to detect it there is futile (another reason this is so hard to test, diagnose, and treat.)

Using genetic code for a treatment for this is like trying to catch a greased pig.  Lyme in particular changes its outer surface protein which means what goes into you isn’t what comes out of you as the organism mutates to survive.  Yet another reason it’s difficult treating this and why there has never and will never be a Lyme vaccine worth its weight in salt.  You can’t pin something down that changes.

Personally, all this work on treatments using genetics scares the bajeebers out of me.  Hopefully the past three years have caused all of us to pause and consider the implications of using genes and their ability to alter genetic code.  Also, what works in a petri dish often doesn’t work in reality.

Of course, at the end of the day, we are all big boys and girls and have to make our own decisions.  What works for one often doesn’t work for another and if you do your reading, are convinced of its merits, and want to try this, then by all means do it.  If you have success, or if you don’t, please let me know.  Often the best way we move forward is by educating one another on various treatments and health changes.

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