A Clinical Diagnostic System for Late-Stage Neuropsychiatric Lyme Borreliosis Based upon an Analysis of 100 Patients

Healthcare 2020, 8(1), 13; (registering DOI)
Received: 8 December 2019 / Revised: 23 December 2019 / Accepted: 3 January 2020 / Published: 6 January 2020
Many late-stage chronic Lyme disease clinical findings are neuropsychiatric. A total clinical assessment is critical in diagnosis, especially since controversy surrounds the reliability of laboratory testing. The clinical findings of one hundred Lyme disease patients with chronic neuropsychiatric symptoms were entered into a database. The prevalence of each clinical finding pre-infection and post-infection was compared and calculated within the 95% confidence interval. Patients had minimal symptoms pre-infection, but a high post-infection prevalence of a broad spectrum of acquired multisystem symptoms. These findings included:
  • impairments of attention span
  • memory
  • processing
  • executive functioning
  • emotional functioning
  • behavior
  • psychiatric syndromes
  • vegetative functioning
  • neurological
  • musculoskeletal
  • cardiovascular
  • upper respiratory
  • dental
  • pulmonary
  • gastrointestinal
  • genitourinary
  • other symptoms

The most prevalent symptoms included:

  • sustained attention impairments
  • brain fog
  • unfocused concentration
  • joint symptoms
  • distraction by frustration
  • depression
  • working memory impairments
  • decreased school/job performance
  • recent memory impairments
  • difficulty prioritizing multiple tasks
  • fatigue
  • non-restorative sleep
  • multitasking difficulties
  • sudden mood swings
  • hypersomnia
  • mental apathy
  • decreased social functioning
  • insomnia
  • tingling
  • word finding difficulties
  • name retrieval
  • headaches
  • sound hypersensitivity
  • paresis
  • anhedonia
  • depersonalization
  • cold intolerance
  • body temperature fluctuations
  • light sensitivity
  • dysfluent speech

The average patient had five symptoms pre-infection and 82 post-infection. Pattern recognition is critical in making a diagnosis. This study was used to develop three clinical assessment forms.



A simple perusal of these symptoms reveals how insidious this complex disease is. This is not what authorities have been telling us Lyme causes. Lyme/MSIDS is a systemic illness that can affect every single organ of the human body – and often collectively.  The idea that 21 days of an antibiotic are going to take care of this is pure comedy if you study it for any length of time at all. It is not uncommon for patients to see numerous specialists for the wide array of issues they must contend with.

Time for mainstream medicine to awaken from its coma.

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