Madison Area Lyme Support Group

Might SARS-CoV-2 Have Arisen Via Serial Passage Through an Animal Host or Cell Culture?

https://onlinelibrary.wiley.com/doi/10.1002/bies.202000091

Problems & paradigms  Free Access

Might SARS‐CoV‐2 Have Arisen via Serial Passage through an Animal Host or Cell Culture?

A potential explanation for much of the novel coronavirus’ distinctive genome

Karl SirotkinDan SirotkinFirst published: 12 August 2020 https://doi.org/10.1002/bies.20200009

Abstract

Despite claims from prominent scientists that SARS‐CoV‐2 indubitably emerged naturally, the etiology of this novel coronavirus remains a pressing and open question: Without knowing the true nature of a disease, it is impossible for clinicians to appropriately shape their care, for policy‐makers to correctly gauge the nature and extent of the threat, and for the public to appropriately modify their behavior. Unless the intermediate host necessary for completing a natural zoonotic jump is identified, the dual‐use gain‐of‐function research practice of viral serial passage should be considered a viable route by which the novel coronavirus arose. The practice of serial passage mimics a natural zoonotic jump, and offers explanations for SARS‐CoV‐2’s distinctive spike‐protein region and its unexpectedly high affinity for angiotensin converting enzyme (ACE2), as well as the notable polybasic furin cleavage site within it. Additional molecular clues raise further questions, all of which warrant full investigation into the novel coronavirus’s origins and a re‐examination of the risks and rewards of dual‐use gain‐of‐function research.

______________________

**Comment**

Serial Passage is another way of saying “tinkered with in a lab setting.” 

Excerpt from paper:

The long‐standing practice of serial passage is a form of gain‐of‐function research that forces zoonosis between species, and requires the same molecular adaptations necessary for a natural zoonotic jump to occur within a laboratory, leaving the same genetic signatures behind as a natural jump but occurring in a much shorter period of time.

The paper points out that ‘serial passage’ is often used for vaccine programs.

The paper also admits: 

The dual‐use gain‐of‐function research tool of serial passage was first applied to a strain of H1N1 Swine Flu, a variant of the pandemic influenza virus that was genetically modified before it either leaked out of a Soviet lab or was introduced as part of an attenuated vaccine trial in 1977. Although no one has ever taken responsibility for the introduction of this virus, it would become the first known example of a virus created by serial passage leaving a lab, which was later determined due to its inexplicable genetic distance from any known sister strain.^[8^]

Please refresh your memory on the H1N1 fiasco:  https://madisonarealymesupportgroup.com/2020/08/22/the-2009-swine-flu-scam-murderous-anthony-fauci-betrays-public-trust-again/ (It’s all very similar to COVID-19)

This genetic engineering happened right here in my home state by Dr. Yoshihiro Kawaoka of the Universities of Tokyo and Wisconsin using:

“genetic engineering to combine genes from the H1N1 Swine Flu as well as the H5N1 Bird Flu to create a chimeric virus that was then serially passed through ferrets, creating another airborne virus with potentially pandemic properties.^[12^] Both experiments created a modified genome that appeared to be the result of natural, albeit accelerated, selection since the process of serial passage forces the mutations selected for in natural zoonotic jumps, and masks the direct genetic engineering done on the viruses. These experiments were viewed by many as being sufficiently dangerous that they should not be published,^[13^] however they were both eventually released with certain methodological and sequence details left out.”

This is discussed here by Dr Luc Montagnier:  https://madisonarealymesupportgroup.com/2020/06/11/nobel-prize-winner-on-the-coronavirus/

Excerpt:

He, along with numerous other scientists, states the virus (COVID-19) has been manipulated and that components of HIV have been inserted into the viral sequence, perhaps in pursuit of an AIDS vaccine.

He mentions that the U.S. funded the Wuhan lab in China:  https://madisonarealymesupportgroup.com/2020/04/14/wuhan-lab-got-3-7-million-from-u-s-government/  Dr. Fauci, head of NIAID and part of the coronavirus task force, is the one who sent U.S. tax payer money to China after a moratorium was given to stop this sort of research. That is called breaking the law and he should be in jail.

Lastly,

And whether or not gain‐of‐function research is determined to have played a role in SARS‐CoV‐2’s emergence, the fact that it creates opportunities for pandemic viruses to leak out of labs calls for a re‐examination of the moratorium against this practice, because the emergence of this novel coronavirus has demonstrated that the international public health community is not prepared to handle the leak of a pandemic virus. Furthermore, none of the gain‐of‐function research conducted since 2014 has provided humanity with any tools at all to fight back against the ongoing pandemic caused by this novel coronavirus.

Please considering signing the petition to stop ‘gain of function’ research:  Sign petition here:  https://www.change.org/p/national-institutes-of-health-reinstate-the-global-moratorium-on-gain-of-function-research

A Supercomputer’s COVID-19 Analysis Yields a New Way to Understand the Virus

https://elemental.medium.com/a-supercomputer-analyzed-covid-19-and-an-interesting-new-theory-has-emerged-

A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged

A closer look at the Bradykinin hypothesis

Thomas Smith

Earlier this summer, the Summit supercomputer at Oak Ridge National Lab in Tennessee set about crunching data on more than 40,000 genes from 17,000 genetic samples in an effort to better understand Covid-19. Summit is the second-fastest computer in the world, but the process — which involved analyzing 2.5 billion genetic combinations — still took more than a week.

When Summit was done, researchers analyzed the results. It was, in the words of Dr. Daniel Jacobson, lead researcher and chief scientist for computational systems biology at Oak Ridge, a “eureka moment.” The computer had revealed a new theory about how Covid-19 impacts the body: the bradykinin hypothesis. The hypothesis provides a model that explains many aspects of Covid-19, including some of its most bizarre symptoms. It also suggests 10-plus potential treatments, many of which are already FDA approved. Jacobson’s group published their results in a paper in the journal eLife in early July.

According to the team’s findings, a Covid-19 infection generally begins when the virus enters the body through ACE2 receptors in the nose, (The receptors, which the virus is known to target, are abundant there.) The virus then proceeds through the body, entering cells in other places where ACE2 is also present: the intestines, kidneys, and heart. This likely accounts for at least some of the disease’s cardiac and GI symptoms. (See link for article)

___________________

**Comment**

If true, this would explain the varied and bizarre symptoms many can experience.

Be Aware: Tick Bites Can Cause Lyme Disease, Says Survivor

https://www.connexionfrance.com/index.php/French-news/Health/Be-aware-tick-bites-can-cause-Lyme-disease-says-survivor

Be aware: tick bites can cause Lyme disease, says survivor

Connexion reader Margaret Alderson, 76, says everyone should be aware of tick bites and how they can carry Lyme disease, which is extremely debilitating and often goes undiagnosed – as happened to her.

4 September 2020Margaret Alderson shares her struggle with Lyme disease. By Connexion Journalist

Lyme disease in France: Margaret’s story

After retiring from her job co-ordinating the Erasmus scheme for Middlesex University, she moved to Segonzac in the Dordogne with her husband John, from Ware, Hertfordshire in 2005. She was in excellent health until two years ago when in August 2018, she suddenly fell ill.

“I had dreadful pains in my chest and arm,” she said.

“I thought I was having a heart attack or a stroke. An ECG and blood test at my local A&E revealed that was not the case and I recovered with hefty painkillers. A month later, it happened again but was much worse. My hands would not work and I could hardly walk. Another ECG test showed there were no heart problems. I then saw a neurologist who diagnosed trapped nerves in my elbows and a scoliosis specialist who thought it was a back problem. He wanted to give me a major operation to put rods in my spine.”  (See link for article)

____________________

**Comment**

Sigh…..

40 years and this is where we are still at.

After using this poor woman’s experience, they tout the upcoming Valneva Lyme vaccine.  Please read this article about concerns:  https://madisonarealymesupportgroup.com/2018/12/18/concerns-about-valneva-vla15-lyme-vaccine-trials/

Excerpt:

So there you have it.  Lyme patients have waited patiently for over 40 years for basically ZERO help from mainstream medicine.  You still need to be tested by CLIA certified labs that are outside mainstream testing AND you still need to see specially trained ILADS (Lyme literate) doctors if you want to regain your health.  Both of these endeavors are typically going to cost patients ‘out of pocket.’ There is very little help or hope from mainstream medicine.  BTW: this type of testing and treatment are maligned by ‘authorities’.  

The deck is stacked and appears to remain stacked against the ever-growing number of infected.

Little has changed in Lyme-land.

New Laboratory Test For Lyme Disease Could Be A Game Changer

https://globallymealliance.org/news/new-laboratory-test-for-lyme-disease-could-be-a-game-changer/