Archive for the ‘research’ Category

Two Plants in Plaintain Family Show Antioxidant and Bb Inhibiting Properties

https://www.mdpi.com/1422-0067/25/13/7112

Plantago major and Plantago lanceolata Exhibit Antioxidant and Borrelia burgdorferi Inhibiting Activities

by Pille-Riin Laanet, Olga Bragina, Piia Jõul and Merike Vahe*
Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
*Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2024, 25(13), 7112; https://doi.org/10.3390/ijms25137112
Submission received: 18 May 2024 / Revised: 15 June 2024 / Accepted: 20 June 2024 / Published: 28 June 2024
(This article belongs to the Special Issue Antioxidant, Anti-inflammatory, and Antimicrobial Activities of Phytochemicals: Bridging Traditional Knowledge and Molecular Insights)

Abstract

Lyme disease, caused by Borrelia burgdorferi sensu lato infection, is the most widespread vector-borne illness in the Northern Hemisphere. Unfortunately, using targeted antibiotic therapy is often an ineffective cure. The antibiotic resistance and recurring symptoms of Lyme disease are associated with the formation of biofilm-like aggregates of B. burgdorferi. Plant extracts could provide an effective alternative solution as many of them exhibit antibacterial or biofilm inhibiting activities. This study demonstrates the therapeutic potential of Plantago major and Plantago lanceolata as B. burgdorferi inhibitors. Hydroalcoholic extracts from three different samples of each plant were first characterised based on their total concentrations of polyphenolics, flavonoids, iridoids, and antioxidant capacity. Both plants contained substantial amounts of named phytochemicals and showed considerable antioxidant properties. The major non-volatile constituents were then quantified using HPLC-DAD-MS analyses, and volatile constituents were quantified using HS-SPME-GC-MS. The most prevalent non-volatiles were found to be plantamajoside and acteoside, and the most prevalent volatiles were β-caryophyllene, D-limonene, and α-caryophyllene. The B. burgdorferi inhibiting activity of the extracts was tested on stationary-phase B. burgdorferi culture and its biofilm fraction. All extracts showed antibacterial activity, with the most effective lowering the residual bacterial viability down to 15%. Moreover, the extracts prepared from the leaves of each plant additionally demonstrated biofilm inhibiting properties, reducing its formation by 30%.
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**Comment**
Both plants are in the plantain family, which is a diverse family of flowering plants and herbs and includes snapdragons, foxglove, particularly the broadleaf or greater plaintain (Plantago major) which is considered an herb, and narrowleaf plantain or ribwort (Plantago lanceolata).  You will find the former to be a common weed that is often found along the edge of the road.  This is handy because if you react to bee/wasp stings you can chew these leaves which are highly anti-inflammatory and them put it directly on the sting until you get home.  I’ve had to do this.  The tea is also excellent for bronchitis.  While narrowleaf plantain is has supposedly been introduced in WI, I don’t believe I’ve ever seen it and I consider myself a plant freak.
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Word of warning: many think herbs are always safe.  I know of patients who messed themselves up pretty badly with herbs.  Herbs are strong medicine.  Never forget that.  For some they make all the difference.  For others, not so much.  Make sure you learn all you can about these powerful plants and as always – use with caution – as with any treatment.  I’m certainly not trying to dissuade you, just remind you to take heed, do your homework, and preferably work with experienced herbalists.  Nothing beats experience.

Category:

Biofilm, Herbs, Inflammation, Lyme, research, Treatment

Aussie, German, Korean, Japanese, & Scandinavian Studies on COVID Shots: Excess Deaths, Organ Damage, Auto-Immunity, Myocarditis & Pericarditis, & Deadly Batches

https://childrenshealthdefense.org/defender/covid-vaccine-excess-deaths-australia/

Australian Researcher Finds Link Between COVID Vaccines and Excess Deaths

The number of excess deaths in Australia was positively correlated with the number of COVID-19 booster vaccinations, according to a new peer-reviewed study. However, critics cautioned that the study’s methods were too simplistic and that its results could be misleading.

by Suzanne Burdick, Ph.D.
AUGUST 15, 2024

Article excerpts:

Denis Rancourt, Ph.D., lead author of a recent study examining excess mortality in 125 countries, cautioned against drawing conclusions from Allen’s analysis. He told The Defender:

“This type of correlation analysis between bulk measures of excess mortality and vaccine doses administered has many caveats, pitfalls and known confounding factors.

“It should never be used as a stand-alone result, as was done here. On its own, it has a high likelihood of being misleading, and it does not imply any meaningful relation.”

Rancourt said that even if a relationship exists between COVID-19 vaccination and excess death, there are better ways of statistically showing it.

“Scientists should avoid being right for the wrong reasons,” Rancourt said. “A better approach is to look for temporal associations, which has been done in some detail for Australia.”  (See link for article)

Also, please see:  https://madisonarealymesupportgroup.com/2024/08/15/study-of-125-countries-meta-analysis-on-covid-shots/  The shots are worthless but dangerous.

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https://slaynews.com/news/top-study-links-covid-shots-surge-organ-damage-among-children/

Top Study Links Covid Shots to Surge in Organ Damage among Children

Frank Bergman

A team of leading scientific researchers in Germany has just issued a warning to the public after finding direct links between Covid mRNA shots and vital organ damage among children.

Specifically, the researchers found that Pfizer’s mRNA injection is responsible for skyrocketing cases of Immunoglobulin G4-related disease (IgG4-RD) in children aged 5 to 11 years old.

IgG4-RD is a condition that causes inflammation inside the body and damages internal organs, according to Oxford University.

It can affect many different organs, meaning people can have wide-ranging symptoms.

The pancreas is most commonly affected, followed by the bile ducts in the liver, the salivary glands, and the kidneys.  (See link for article)

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https://petermcculloughmd.substack.com/p/large-korean-study-recommends-monitoring

Large Korean Study Recommends Monitoring mRNA Vaccinated Patients for Auto-immunity

Modest Risks Identified, but Cumulative Effects with Repeated Boosters are Concerning

 
JUL 27, 2024

By Peter A. McCullough, MD, MPH

Article excerpts:

There is great concern that with continued dosing of mRNA COVID-19 vaccines, the human body is forced to produce not only the foreign and potentially lethal Wuhan Spike protein, but probably about a dozen additional frameshifted proteins as shown by Boros and colleagues. Invariably these peptides induce an immune attack against the human body as they are expressed on cell surfaces and in some cases like Spike protein, trimerize and are circulatory in blood for months after injection.

Now a large study from Korea by Jung et al, suggests there are increased risks for some autoimmune illnesses after at least two mRNA shots, but not nearly as high as the established dangers of vaccine myo-pericarditis or Guillain-Barre Syndrome.  (See link for article)

https://www.jiac-j.com/article/S1341-321X(24)00209-5/abstract

Japanese Study: COVID mRNA Shots “Significantly Associated” With Myocarditis & Pericarditis

Abstract

Background

The association between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines and myocarditis/pericarditis in the Japanese population has not been systematically investigated. This study was aimed at clarifying the association between SARS-CoV-2 mRNA vaccines (BNT162b2 and mRNA-1273) and myocarditis/pericarditis as well as influencing factors by using the Japanese Adverse Drug Event Report database.

Methods

Reporting odds ratios (RORs) and 95 % confidence intervals (95 % CIs) for the association between the vaccines and myocarditis/pericarditis were calculated using data from the database (April 2004–December 2023). Age, sex, onset time, and outcomes in symptomatic patients were evaluated.

Results

The total number of reports was 880,999 (myocarditis: 1846; pericarditis: 761). The adverse events associated with the vaccines included myocarditis (919 cases) and pericarditis (321 cases), with the ROR [95 % CIs] being significant for both (myocarditis: 30.51 [27.82–33.45], pericarditis: 21.99 [19.03–25.40]). Furthermore, the ROR [95 % CIs] of BNT162b2 and mRNA-1273 were 15.64 [14.15–17.28] and 54.23 [48.13–61.10], respectively, for myocarditis, and 15.78 [13.52–18.42] and 27.03 [21.58–33.87], respectively, for pericarditis. Furthermore, most cases were ≤30 years or male. The period from vaccination to onset was ≤8 days, corresponding to early failure type based on analysis using the Weibull distribution. Outcomes were recovery or remission for most cases; however, they were severe or caused death in some cases.

Conclusion

In the Japanese population, SARS-CoV-2 mRNA vaccination was significantly associated with the onset of myocarditis/pericarditis. The influencing factors included age of ≤30 years and male. Furthermore, although most adverse events occurred early after vaccination, overall outcomes were good.
 

Scandinavian Study Confirms Pfizer Pushed ‘BAD BATCHES’ of Covid Shots onto Public

by Vibeke Manniche1, Max Schmeling2, Jonathan D. Gilthorpe3 and Peter Riis Hansen4,5,*
 
Medicina 2024, 60(8), 1343; https://doi.org/10.3390/medicina60081343
Submission received: 17 July 2024 / Revised: 13 August 2024 / Accepted: 14 August 2024 / Published: 19 August 2024

Abstract

Background and Objective: An unexpected batch-dependent safety signal for the BNT162b2 mRNA COVID-19 vaccine was recently identified in a nationwide study from Denmark, but the generalizability of this finding is unknown. Therefore, we compared batch-dependent rates of suspected adverse events (SAEs) reported to national authorities in Denmark and Sweden. 
 
Materials and Methods: SAE and vaccine batch data were received from national authorities in Denmark and Sweden, and analyses of heterogeneity in the relationship between numbers of vaccine doses and SAEs per batch were performed, along with comparison of SAE rates and severities for batches that were shared between the two countries. 
 
Results: Significant batch-dependent heterogeneity was found in the number of SAEs per 1000 doses for both countries, with batches associated with high SAE rates detected in the early phase of the vaccination campaign and positive correlations observed between the two countries for the severity of SAEs from vaccine batches that they shared. Mild SAEs predominated in the batches used in the early part of the vaccination roll-out, where markedly higher SAE rates per 1000 doses in Denmark for the batches that were shared between the two countries suggested that a large proportion of these SAEs were under-reported in Sweden. 
 
Conclusions: The batch-dependent safety signal observed in Denmark and now confirmed in Sweden suggests that early commercial batches of BNT162b2 may have differed from those used later on, and these preliminary and hypothesis-generating results warrant further study.
 
They simply couldn’t allow too many people to be maimed and killed early on.  People would have noticed.
 
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Category:

Activism, research, vaccines, Viruses

Elucidating Host-Microbe Interactions to Address Vector-Borne Diseases

https://medicine.yale.edu/internal-medicine/infdis/news-article/elucidating-host-microbe-interactions-to-address-vector-borne-diseases/

Elucidating Host-microbe Interactions to Address Vector-borne Diseases

July 08, 2024
by Serena Crawford
Article Excerpts:
In a new study, Yale researchers identified the targets in the human body to which pathogens transmitted by mosquitoes, ticks, and other vectors bind. Their findings, they say, could help address the rising threat of vector-borne diseases, a leading cause of death worldwide.

The study was published in Cell.

“We wanted to better understand the precise mechanisms by which pathogens interact with humans to infect the host and cause disease,” said first author Thomas Hart, PhD, postdoctoral associate at Yale School of Medicine (YSM). “To do so, we tested for interactions between thousands of human proteins and dozens of microbial pathogens, then examined the importance of those identified,” he said.

Pathogens must interact with host molecules, namely host proteins, to infect a host, evade the immune system, and cause symptoms, Hart explained.

One surprising finding was that Borrelia burgdorferi, which causes Lyme disease, appears to interact with epidermal growth factor (EGF), said corresponding author Erol Fikrig, MD, Waldemar Von Zedtwitz Professor of Medicine (Infectious Diseases) and professor of microbial pathogenesis at YSM; and professor of epidemiology (microbial diseases) at the Yale School of Public Health. “Why Borrelia interacts with EGF and what that does for Borrelia pathogenesis is not yet known, and that could have implications for Lyme disease,” he said.
Many of the host-microbe interactions uncovered were unpredictable and unexpected, revealing a suite of novel host-pathogen interactions that can potentially be leveraged to create new classes of anti-infectives that target unique and previously unknown host-microbe interaction nodes, Palm added.  (See link for article)

Category:

Lyme, research

TMJ Arthritis Triggered By Lyme Disease

https://danielcameronmd.com/tmj-arthritis-triggered-by-lyme-disease/

TMJ ARTHRITIS TRIGGERED BY LYME DISEASE

woman with TMJ from Lyme disease holding her jaw

A case report by Weise and colleagues demonstrates that Lyme disease can induce temporomandibular joint (TMJ) pain and may be misdiagnosed as a common temporomandibular disorder (TMD).

By 

In the article, “Acute arthritis of the right temporomandibular joint due to Lyme disease: a case report and literature review,” the authors describe a 25-year-old patient who presented to a medical center with acute pain in the right temporomandibular joint and mouth opening disorders.¹

Over a 5-year period, the woman’s distal bite was treated with removable and fixed orthodontic appliances. Three months after the first symptoms, “the patient developed increasing pain in the right TMJ, increasing active mouth opening restriction to 20 mm and a habitual deviation of the lower jaw to the left.”

The patient was initially diagnosed with a total ventral deviation of the discus on the right side without reduction. Treatment with anti-inflammatory medications, a bite splint and a corticosteroid injection, however, were not effective and the woman’s symptoms continued.

Although the patient did not recall a tick bite or EM rash, testing for Lyme disease was positive and she was diagnosed with Lyme arthritis affecting the right temporomandibular joint.

“Early interdisciplinary diagnosis of Lyme disease and early antibiotic therapy are essential to avoid misdiagnosis and unnecessary, sometimes invasive, therapies.”

The patient was prescribed a 3-week course of Cefuroxime. After one week of antibiotic treatment, her symptoms improved.

“It can be assumed that there must have been an infection with Borrelia in the right temporomandibular joint for a longer period of time before the symptoms occurred.”

Lyme disease presenting with TMJ “very often is misinterpreted as a temporomandibular disorder,” the authors state.

“In the case of unclear TMJ problems and when the TMD treatment is not successful,” the authors stress, “the possibility of a [Lyme disease] infection should definitely be considered as a differential diagnosis.”

References:
  1. Weise, C., Schulz, M.C., Frank, K. et al. Acute arthritis of the right temporomandibular joint due to Lyme disease: a case report and literature review. BMC Oral Health 21, 400 (2021). https://doi.org/10.1186/s12903-021-01744-4

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**Comment**

Been there, done that.

Sadly, what isn’t mentioned is the fact most people don’t test positive – sometimes ever.

What happens to these sorry-sacks?  Well, they simply go on to suffer and are gaslit by mainstream medicine who will then tell them it’s all in their head.

One other little factoid is that this person could very well relapse in the future.  What happens then?  Well, it’s quite simple.  If she stays in the mainstream medical paradigm, and doesn’t get to an independent doctor, she will simply suffer because this paradigm doesn’t recognize chronic/persistent Lyme/MSIDS.

Category:

Lyme, research

Flubendazole With Herxheimer Reactions Followed by a Cure in a Patient With Symptoms Suggestive of Chronic Lyme

https://www.fortunejournals.com/articles/effect-of-flubendazole-with-jarishherxheimer-reactions-followed-by-cure-in-a-patient-with-a-polymorphic-persistent-syndrome-sugges.

Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease?

Article Information

Alexis Lacout1, Christian Perronne2

1Centre de diagnostic ELSAN, Centre médico-chirurgical 83 avenue Charles de Gaulle 15000 Aurillac, France

2Infectious Diseases, Paris

*Corresponding author: Alexis Lacout. Centre de diagnostic ELSAN, Centre médico-chirurgical 83 avenue Charles de Gaulle 15000 Aurillac, France

Received: 02 February 2023; Accepted: 09 February 2023; Published: 13 March 2024

Citation: Alexis Lacout, Christian Perronne. Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease. Archives of Microbiology and Immunology. 8 (2024): 96-100.

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Abstract

This paper discusses the case of a 40-year-old male patient presenting with a “polymorphic persistent syndrome after a possible tick bite” (SPPT), a syndrome officially recognized by the French High Authority for Health (HAS). Anti-infection protocols were implemented, gradually improving the patient’s clinical condition until complete remission was achieved. Each time flubendazole was taken, it was accompanied by severe symptoms – not suggestive of adverse reactions but of a Jarisch-Herxheimer reaction. Each administration of flubendazole was followed by a period of remission of symptoms.  ________________

**Comment**

Please note study author Dr. Christian Perronne, a long outspoken critic of how Lyme has been handled as well as COVID.  He’s yet another doctor who has been persecuted for this departure from ‘consensus’ based medicine where doctors are expected to check their brains at the door and simply follow illogical and unscientific government dictates.

Flubendazole is a antiparasitic (anthelmintic) agent and a fluorine analogue of mebendazole which is better absorbed when taken with or after a meal.  Used as a dewormer in humans and animals for 40 years, recent studies suggest its potential use as an anticancer agent.  The same can be said of Fenbendazole (Fedben).

I highly recommend viewing Dr. Lee Merrit’s 50 Min video: The Parasite Paradigm.  Parasite egg sacks and cancer look identical under a microscope and German scientists have been saying for decades that cancer is caused by parasites.  Her protocols are found here.

Flubendazole is also available in a slow-release parenteral preparation given subcutaneously or intramuscularly, which allows sustained release over 5 days. The usual dosage is 750 mg/wk for onchocerciasis. It is used to treat hookworm, T. trichiura, and A. lumbricoides. Side effects are vague and mostly abdominal, such as nausea, abdominal pain and rumbling, soft/loose stools, and dyspepsia.  Breathlessness and fatigue have also been reported.

For more on Perronne’s work:

Category:

Activism, Cancer, Lyme, Parasites, research, Treatment