Archive for the ‘Psychological Aspects’ Category

Hydration May Affect Cognitive Function in Some Older Adults

https://neurosciencenews.com/hydration-cognition-15313/?

Hydration may affect cognitive function in some older adults

Summary: Among older women, lower levels of hydration were associated with lower scores on tests designed to measure attention, working memory, and motor speed. Researchers also found over-hydration may have a detrimental effect on cognitive function.Source: Penn State

Not getting enough water is enough to make you feel sluggish and give you a headache, but a new Penn State study suggests it may also relate to cognitive performance.

The researchers investigated whether hydration levels and water intake among older adults was related with their scores on several tests designed to measure cognitive function. They found that among women, lower hydration levels were associated with lower scores on a task designed to measure motor speed, sustained attention, and working memory. They did not find the same result for men.

The findings were recently published in the European Journal of Nutrition.

“The study gives us clues about how hydration and related drinking habits relate to cognition in older adults,” said Hilary Bethancourt, a postdoctoral scholar in biobehavioral health and first author on the study. “This is important because older adults already face an increased risk of cognitive decline with advancing age and are often less likely than younger adults to meet daily recommendations on water intake.”

Asher Rosinger, Ann Atherton Hertzler Early Career Professor in Global Health, said the researchers found similar results when the participants were overhydrated.

“We found a trend suggesting overhydration may be just as detrimental to cognitive performance as dehydration for older adults,” said Rosinger, who also directs the Water, Health, and Nutrition Laboratory and was senior author on the study. “Because of this, being in the ‘sweet spot’ of hydration seems to be best for cognitive function, especially for tasks requiring sustained attention.”

According to the researchers, scientists have long suspected that dehydration may have an effect on cognitive performance. However, previous studies have largely focused on young, healthy people who are dehydrated after exercise and/or being in the heat.

Bethancourt said that because exercise and elevated ambient and body temperatures can have their own, independent effects on cognition, she and the other researchers were interested in the effects of day-to-day hydration status in the absence of exercise or heat stress, especially among older adults.

As we age, our water reserves decline due to reductions in muscle mass, our kidneys become less effective at retaining water, and hormonal signals that trigger thirst and motivate water intake become blunted,” Bethancourt said.

“Therefore, we felt like it was particularly important to look at cognitive performance in relation to hydration status and water intake among older adults, who may be underhydrated on a regular basis.”

For the study, the researchers used data from a nationally representative sample of 1271 women and 1235 men who were 60 years of age or older. Data were collected by the Nutrition and Health Examination Survey. Participants gave blood samples and were asked about all foods and drinks consumed the previous day. The researchers calculated hydration status based on concentrations of sodium, potassium, glucose, and urea nitrogen in participants’ blood. Total water intake was measured as the combined liquid and moisture from all beverages and foods.

Participants also completed three tasks designed to measure different aspects of cognition, with the first two measuring verbal recall and verbal fluency, respectively.

A final task measured processing speed, sustained attention, and working memory. Participants were given a list of symbols, each matched with a number between one and nine. They were then given a list of numbers one through nine in random order and asked to draw the corresponding symbol for as many numbers as possible within two minutes.

Bethancourt said that when they first plotted the average test scores across different levels of hydration status and water intake, there appeared to be a distinct trend toward higher test scores in relation to adequate hydration and/or meeting recommended water intake. However, much of that was explained by other factors.

“Once we accounted for age, education, hours of sleep, physical activity level, and diabetes status and analyzed the data separately for men and women, the associations with hydration status and water intake were diminished,” Bethancourt said. “A trend toward lower scores on the number-symbol test among women who were categorized as either underhydrated or overhydrated was the most prominent finding that remained after we accounted for other influential factors.”

Bethancourt said that because the data was cross-sectional, they can’t be sure whether suboptimal hydration levels are causing cognitive impairment or if people with impaired cognition are just more likely to be under- or overhydrated. The researchers were also unsure why they failed to see the same associations among men. Still, she said the results raise interesting questions.

This shows a glass of water

“It was interesting that even though the test of attention, processing speed, and working memory took only a few minutes, it was the one most strongly associated with lower hydration levels,” Bethancourt said. “Other research has similarly suggested that attention may be one of the cognitive domains most affected by hydration status. This left us wondering what the effects of inadequate hydration might be on more difficult tasks requiring longer periods of concentration and focus.”

Rosinger said the findings suggest older adults may want to pay close attention to their hydration status, by both consuming enough liquids to avoid dehydration as well as ensuring adequate electrolyte balance to avoid overhydration.

“Because older adults may not necessarily feel thirsty when their body is reaching a state of underhydration and may be taking diuretics that can increase salt excretion, it is important for older adults and their physicians to better understand the symptoms of being both under- and overhydrated,” said Rosinger.

W. Larry Kenney, Marie Underhill Noll Chair in Human Performance, and David M. Almeida, professor of human development and family studies, also participated in this work.

ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE

Source:
Penn State
Media Contacts:
Katie Bohn – Penn State
Image Source:
The image is in the public domain.

Original Research: Closed access
“Cognitive performance in relation to hydration status and water intake among older adults, NHANES 2011–2014”. Hilary J. Bethancourt, W. Larry Kenney, David M. Almeida, Asher Y. Rosinger.
European Journal of Nutrition doi:10.1007/s00394-019-02152-9.

Abstract

Cognitive performance in relation to hydration status and water intake among older adults, NHANES 2011–2014

Purpose

Risks of dehydration and cognitive decline increase with advancing age, yet the relation between dehydration, water intake, and cognitive performance among older adults remains understudied.

Methods
Using data from the 2011–2014 cycles of the Nutrition and Health Examination Survey (NHANES), we tested if calculated serum osmolarity (Sosm) and adequate intake (AI) of water among women (n = 1271) and men (n = 1235) ≥ 60 years old were associated with scores of immediate and delayed recall, verbal fluency, and attention/processing speed. Sosm was categorized as < 285 (hyperhydrated), 285–289, 290–294, 295–300, or > 300 (dehydrated) mmol/L. AI of water was defined as ≥ 2 L/day for women and ≥ 2.5 L/day for men.

Results
Women with Sosm between 285 and 289 mmol/L scored 3.2–5.1 points higher on the Digit Symbol Substitution test (DSST) of attention/processing speed than women in other Sosm categories (P values < 0.05). There was evidence of a curvilinear relationship between DSST scores and Sosm among women and men (P values for quadratic terms < 0.02). Meeting an alternative AI on water intake of ≥ 1 mL/kcal and ≥ 1500 mL, but not the sex-specific AI, was associated with scoring one point higher on a verbal fluency test (P = 0.02) and two points higher on the DSST (P = 0.03) among women. Significant negative associations between dehydration or inadequate water intake and test scores were not observed among men.

Conclusion
Hydration status and water intake were moderately associated with attention/processing speed among females. Future work should consider the effects of both dehydration and overhydration on cognitive function and investigate potential sex differences in cognitive responses to hydration status.

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For more:  https://madisonarealymesupportgroup.com/2019/12/28/what-is-brain-fog-what-can-a-patient-do-to-get-rid-of-it/

 

 

What is Brain Fog & What Can a Patient Do to Get Rid of It?

https://globallymealliance.org/dealing-with-brain-fog/

by Jennifer Crystal

WHAT IS BRAIN FOG, EXACTLY? WHAT DOES IT FEEL LIKE? WHAT CAN A PATIENT DO TO GET RID OF IT?

Writing a weekly blog post is a thrilling and rewarding process. I love connecting with readers like me over various aspects of living with tick-borne illness, and I’m grateful to be able to share my story. I’m also thankful to have the physical ability to write on a tight deadline, which I haven’t always been able to do. In my worst days of fighting Lyme disease and two of its co-infections babesia and Ehrlichia, I couldn’t write at all. This was in part due to the achiness of my joints, but mostly, it was due to brain fog.

So what is brain fog, exactly? What does it feel like? What can a patient do to get rid of it? Now that I have greater neurological clarity, I can offer some information and tips on what I’ve learned about this frustrating symptom.

What is brain fog?

Lyme is an inflammatory disease. When Lyme pathogens in the form of spirochetes cross the blood-brain barrier, inflammation occurs in the central nervous system. “Common neurocognitive problems include poor memory, slower speed of thinking, difficulty with retrieval of words, and impaired fine motor control,” writes Brian A. Fallon, MD and Jennifer Sotsky, MD, in their book Conquering Lyme Disease: Science Bridges the Great Divide. “The slower mental processing speed contributes to the patient’s experience of ‘brain fog,’”[i]

A Johns Hopkins study published in the Journal of Neuroinflammation showed that scans done on 12 patients with Post-Treatment Lyme Disease Syndrome (PTLDS) all showed a chemical marker for brain inflammation, compared with 19 healthy controls. In an article published by Hopkins Medicine, Dr. John Aucott, Director of the Johns Hopkins Lyme Disease Research Center said: “What this study does is provide evidence that the brain fog in patients with [PTLDS] has a physiological basis and [that it] isn’t just psychosomatic or related to depression or anxiety.”[ii]

A patient with brain fog can experience delayed response times, making it difficult for them to write clearly or comprehend text or conversation. As Drs. Fallon and Sotsky explain, “Patients may have difficulty reading and find that when they move on to the next paragraph, they have forgotten what they [just]read before….Patients may have spatial disorientation such that familiar routes become suddenly difficult to navigate or appear unfamiliar… [Or] patients may have new on-set dyslexic changes, reversing numbers or letters when writing or words and phrases when speaking. They may confuse left and right and may find themselves making verbal errors that are uncharacteristic of them.…Other examples of cognitive errors might include placing the cereal box in the refrigerator or asking one’s spouse to please put the milk back in the radiator.”i

What does brain fog feel like?

During a relapse of my tick-borne illnesses, I had a brain scan done that showed this precise type of inflammation, which made for a lack of oxygen to the left side of my brain. What did those symptoms actually feel like inside my head? In my post, Living With Lyme Brain, I likened brain fog to thick molasses that slowly pours into all the crevices of your brain, until it feels so full that it might explode out of your skull. When I was at my sickest, I felt this fog all the time and wished I could open a spigot to relieve the pressure.

As I got better, my brain fog dissipated, but it still returns from time to time. It can come on slowly, like mist settling over a valley, and can then build into an impenetrable cloud. I get it when I’m neurologically over stimulated: after watching a fast-paced TV show, while hearing loud music, or after reading for too long. “Too long” is defined differently for every patient; at my lowest points, one sentence was hard to comprehend. Eventually, I could read a short article in a light entertainment magazine. Now I can read a whole book, but I still need to pace it out, chapter by chapter.

If I read for too long, I feel pressure start to build, beginning at the base of my cranium and then spreading up over my eyes. Once my head gets full, I struggle to find the right vocabulary, and sometimes I invert my word order. When the brain fog builds to this intense point, it causes me to be very tired. A graduate school professor once joked, “Sometimes, without warning, Jen runs out of steam.” He was right. Suddenly, my eyes would glaze over and I’d zone out.

Sometimes brain fog comes on not from neurological overstimulation but from physical fatigue. When I exercise for too long, or push myself too hard before an afternoon nap, I feel brain fog come on even if I haven’t been doing anything intellectual.

Once I hit this level of fatigue, it becomes hard for me to think clearly. This doesn’t just mean losing the ability to read a book or grade a student’s essay. I get recurring thoughts and feel sensitive and sad. I ask myself, am I actually feeling upset about a situation, or am I just experiencing brain fog?

What I do about brain fog

Once I’ve determined I’m experiencing brain fog, here’s what has helped the most to alleviate it:

  • Antibiotics: To alleviate the symptom of brain fog, you have to eliminate the cause: spirochetes. Lyme is a bacterial infection that needs to be treated with antibiotic therapy. My brain fog did not get better until I’d been on enough antibiotic therapy to really get at the spirochetes in my brain. Due to Herxheimer reactions, the brain fog actually got worse before it got better, but long-term antibiotic therapy eventually cleared up my infection enough to check the inflammation in my brain. The appropriate antibiotic protocol, and length of treatment, is different for every patient. What worked for me might not work for you, so it would not help you to learn about my specific protocol. Please discuss your symptoms and treatment with a Lyme Literate Medical Doctor (LLMD).
  • Anti-inflammatory medication: My LLMD put me on an anti-inflammatory medication that worked in conjunction with my antibiotic to get across the blood-brain barrier. This was a prescription medication, different than over-the-counter anti-inflammatory pills.
  • Herbal/nutritional supplements: Certain supplements such as essential fatty acids can help reduce inflammation in the brain. Talk with your LLMD about which supplements would be best for you.
  • Anti-inflammatory diet: For me, it helped to eliminate sugar and gluten from my diet. For others, it also helps to eliminate dairy. Some foods like certain green vegetables, nuts, lemon, ginger, and blueberries are known to have anti-inflammatory properties.
  • Water: The more you can flush your system, the faster you will eliminate live and dead Lyme bacteria (just be sure to keep your electrolytes balanced; I do so with electrolyte-infused water).
  • Time limits: To stop my brain fog before it starts, I impose time limits on my screen and reading time. Even if I’m feeling okay after an hour of watching TV, I make myself take a break, so that the fog doesn’t suddenly come rolling in.
  • Rest: These days, the very best thing I can do when my brain fog flares is rest, rest, rest. This means sleep, but it also means just having some quiet down time lying on the couch or going for a short walk. Many people think of reading or watching TV as resting, but for a patient with neurological Lyme disease, that is not the case. We need quiet, calm activities like coloring, baths, or soft instrumental music. The idea is to shut your brain off—to get away from screens, noises, and other stimuli.

Brain fog can be overwhelming. When you’re experiencing it, you might feel like the pressure in your head will never go away. With time, rest, and proper treatment, though, the fog eventually lifts so you can enjoy clearer skies.

[i] Fallon, Brian A. and Sotsky, Jennifer. Conquering Lyme Disease: Science Bridges the Great Divide. New York: Columbia University Press, 2018 (52, 314).

[ii] https://www.hopkinsmedicine.org/news/publications/hopkins_medicine_magazine/medical_rounds/spring-summer-2019/visualizing-brain-fog-in-post-treatment-lyme-disease

Opinions expressed by contributors are their own.

Jennifer Crystal is a writer and educator in Boston. Her memoir about her medical journey is forthcoming. Contact her at lymewarriorjennifercrystal@gmail.com.

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For more:  https://madisonarealymesupportgroup.com/2019/12/28/hydration-may-affect-cognitive-function-in-some-older-adults/

Trauma is Not Your Fault, But Healing Is Your Responsibility

https://thoughtcatalog.com/brianna-wiest/2019/10/trauma-is-not-your-fault-but-healing-is-your-responsibility/

Trauma Is Not Your Fault, But Healing Is Your Responsibility

What happened to you was not your fault.

It was not something you asked for, it was not something you deserved.

What happened to you was not fair.

You were merely collateral damage on someone else’s warpath, an innocent bystander who got wrecked out of proximity...(See link for full article)

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**Comment**

Due to Lyme/MSIDS affecting the brain, it’s imperative to address the mind.  This illness will sift you like wheat.  It will often isolate you as family, friends, and co-workers don’t understand it, along with the fact that mainstream medicine hasn’t accepted the relapsing/chronic nature of it.  It often seems as if the world is against you.  It causes needless divorces and breaks families apart.

Dealing with all of this while you feel like death warmed over is the challenge of a life time but deal with it you must.

For more:  https://madisonarealymesupportgroup.com/2015/10/18/psychiatric-lymemsids/

https://madisonarealymesupportgroup.com/2019/11/22/differentiating-psychosomatic-somatopsychic-multisystem-illnesses-and-medical-uncertainty/

https://madisonarealymesupportgroup.com/2019/11/29/its-all-in-your-head-medicines-silent-epidemic/

Hormones & Emotional Health

https://www.womensinternational.com/blog/hormones-and-emotional-health/

Hormones and Emotional Health

Adapted from Moods & Emotions a Connections e-Book
A publication of Women’s International Pharmacy

hormones and emotional healthEmotional health is inseparably linked to our hormones. Hormones are powerful substances, with even small quantities able to produce profound effects on health. Moods may be affected by many factors, including:

  • Social and physical environment
  • Diet
  • Exercise
  • Sleep patterns

These factors are also connected to hormones, which regulate the brain’s response system and thereby determine moods. When hormonal conditions are unbalanced, emotions may become “out of whack.”

Sex Hormones, Mood Fluctuations, and Women’s Mental Health

Sex hormones play an important regulatory role in the sense of well-being. From puberty through menopause, women experience a continuous cycle of hormonal fluctuations that affect brain chemistry and, by extension, their moods. This physiological fact of life may partially explain why “depression and anxiety disorders are 2-3 more times more common in women than men,” according to Dr. Elizabeth Lee Vliet.

There is a “previously unrecognized connection between declining hormone levels in perimenopausal women and the high incidence of depression and anxiety disorders,” Dr. Vliet states. She reported on research conducted at Rockefeller University, which indicated that sex hormones are the most potent chemical signals affecting the brain. Changes in the levels of these hormones influence neurotransmitters (such as dopamine and serotonin), which in turn affect moods.

Dr. Vliet also reported on a Yale study, which concluded that hormone therapy over a six-month period appeared to result in an improvement in all categories of perimenopausal symptoms, including:

  • Depression
  • Anxiety attacks
  • Sleep disturbances
  • Short-term memory problems

Mood Changes and Estrogen Imbalance

Estrogen levels have a domino effect on brain chemistry and moods. Aside from estrogen’s many roles in sexual and developmental health, it is also known to be a neuro-stimulant with anti-depressive effects. Dr. Phyllis Bronson states that

“high levels of estrogen produce an imbalance in the system that aggravates or causes symptoms of tension and anxiety.”

Most women tend toward either estrogen dominance or estrogen deficiency, yet a woman will often experience both high and low levels due to hormonal fluctuations relative to her “normal” estrogen level. For instance, normal fluctuations occur during premenstrual syndrome (PMS), while perimenopause causes irregular fluctuations. During these fluctuations, women may experience mixed symptoms as their hormonal balance shifts.

Some women with high estrogen levels may be predisposed to anxiety and panic attacks. On the other hand, low levels of estrogen can lead to episodes of depression. Mood changes associated with a woman’s declining estrogen levels tend to respond well to estrogen therapy; upon receiving treatment, women often report feeling more alert and energetic.

Anxiety and Progesterone Deficiency

The estrogen-progesterone ratio may be the key to properly treating mood disorders. A study by Dr. Bronson found that “a deficiency of progesterone is clearly implicated as a primary factor in mid-life anxiety patterns.” She observed that when estrogen levels were high and progesterone levels low, patients “would exhibit extreme rage, followed by [a] conciliatory, self-defeating demeanor.”

The largest concentration of progesterone receptors is in the limbic area of the brain. This is the center of emotion and is also called the “area of rage and violence” by animal physiologists. Progesterone has a calming effect on the brain, suggesting that its deficiency may lead to anxiety.

Progesterone for PMS, Postnatal Depression, and Menopausal Mood Swings

Premenstrual syndrome and postnatal depression both may occur with a sudden drop in progesterone and may include considerable anxiety. Dr. Katharina Dalton found that these conditions may be effectively treated with progesterone, especially if administered before symptoms develop. For PMS, she suggested supplementing with progesterone from ovulation until menstruation; for preventing postnatal depression, she recommended beginning progesterone therapy immediately after delivery, tapering off until menstruation returns.

Dr. Bronson agrees that progesterone may be an effective treatment for anxiety in perimenopausal women. However, she found higher doses (specifically, 400-600mg daily administered on the skin) to be more effective, with most of her patients reporting significant improvements in emotional health. To achieve the best results in progesterone therapy, both Dr. Bronson and Dr. Dalton’s findings emphasize the importance of using bioidentical progesterone instead of synthetic progestins.

Stress and Thyroid Hormones

The thyroid gland produces several different hormones that have powerful and far-reaching consequences to health. The primary thyroid hormones are thyroxine (T4) and triiodothyronine (T3). These respond to pituitary thyroid-stimulating hormone (TSH) as part of the body’s complex system that regulates endocrine gland secretions.

Thyroid hormones affect every cell in the body in one way or another, including the parts of the body that regulate emotions. Thyroid deficiency inhibits the brain’s neurotransmitters, potentially leading to depression. Thyroid hormones also influence blood glucose levels and the release of stress hormones, two contributors to mood fluctuation.

Insulin, Glucose, and Dietary Factors in Mood Fluctuations

Dr. Dalton noticed a correlation between aggressive, emotional outbursts and blood sugar levels while treating women suffering from PMS. When asked about the time of day or circumstances immediately preceding such outbursts, her patients frequently reported that they occurred later in the morning after missing breakfast, or the evening while preparing a meal (especially if that was occurring later than usual). Many women also reported confusion or forgetfulness during the time surrounding these outbursts.

Paying careful attention to what and when you eat is important to emotional health. In Depression-Free for Life, Dr. Gabriel Cousens identifies foods according to a glycemic index, comparing their impact on blood sugar and mood. For example, eating foods that are high on the glycemic index (such as white flour products, refined and sweetened cereals, and candy bars) should be avoided, as they tend to cause “wild swings in blood sugar, a high followed by a low.”

Other Substances Affecting Mood

Many other hormones, amino acids, and nutrients also affect moods, making difficult to diagnose mood disorders because each individual’s biochemistry has unique needs. We are still learning about how these substances work together to influence emotions. For example:

  • Either too little or too much of the hormone melatonin can lead to depression,
  • People with depression also often have elevated cortisol levels
  • Amino acids (such as glutamine) can affect the neurotransmitters
  • Nutrients such as vitamin B6 and other trace minerals also play an important role in regulating our moods

Conclusion

Because moods are complex, with a wide variety of possible causes or combinations of factors, symptoms of mood disorders may vary significantly from one person to the next and from one day to the next. The common approach of prescribing mind-altering medications may not be the best answer for everyone, particularly if any possible underlying hormonal imbalances are not addressed. However, emotional as well as physical health is a vital contributor to our quality of life, so it’s important to continue exploring how hormones affect mental and emotional well-being to help develop effective treatments for each patient’s needs.

High Level of Psychiatric Disorders Found in Individuals With Chronic Pain

https://www.practicalpainmanagement.com/resources/news-and-research/high-level-psychiatric-disorders-found-individuals-chronic-pain

High Level of Psychiatric Disorders Found in Individuals with Chronic Pain

December 16, 2019
Depression, anxiety, and other emotional distress are common in this population.

A PPM Brief

Psychiatric problems significantly affect somatic (body) disorders, which can make treatment difficult and affect prognosis negatively. In some studies, rates of psychiatric disorders in patients with chronic pain have been shown to be higher than the general population.1 One recent study2 evaluated comorbid psychiatric disorders in patients with chronic pain to examine the effects of sociodemographic details and the level of somatic sense perception on disease severity…..(See link for article)

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**Comment**

Important quote:

“Although the mechanisms of the relationship between chronic pain and psychiatric disorders are not fully understood, effective management of both pain intensity and comorbid psychiatric conditions is necessary for the quality of life of patients,” they concluded.

This makes complete sense.  As a patient, I found depression coincided with how I felt physically.  They worked in tandem.  The worse I felt physically, the worse I felt mentally.  I highly doubt I’m alone.  Also, due to the fact mainstream medicine is still in a coma regarding all things tick-borne, family and friends often take the side of the CDC/IDSA that we are all making it up and are nuts.  Isolation, disbelief, and abuse does not help one’s mental outlook!

The medical profession is part of the problem.

For more:  https://madisonarealymesupportgroup.com/2019/04/18/ketamine-reduces-depression-related-behaviors-in-mice-limits-bb-in-vivo-relieves-chronic-pain/

https://madisonarealymesupportgroup.com/2018/11/06/acupuncture-beats-injected-morphine-for-pain-groundbreaking-study/

More on pain management:  https://madisonarealymesupportgroup.com/2018/10/08/thc-vs-cbd-for-pain-the-differences-interactions/

https://madisonarealymesupportgroup.com/2018/01/24/medical-marijuana-for-lyme-a-doctors-perspective/