Archive for the ‘Inflammation’ Category

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

https://www.frontiersin.org/articles/10.3389/fnagi.2022.903455/full

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

Yuanjie Sun1, Yoshihisa Koyama1,2* and Shoichi Shimada1,2
  • 1Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, Osaka, Japan
  • 2Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan

As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied. The causes of neuroinflammation can be roughly divided into the following domains: viral infection, autoimmune disease, inflammation from peripheral organs, mental stress, metabolic disorders, and lifestyle. In particular, the effects of neuroinflammation caused by inflammation of peripheral organs have yet unclear mechanisms. Many diseases, such as gastrointestinal inflammation, chronic obstructive pulmonary disease, rheumatoid arthritis, dermatitis, chronic fatigue syndrome, or myalgic encephalomyelitis (CFS/ME), trigger neuroinflammation through several pathways. The mechanisms of action for peripheral inflammation-induced neuroinflammation include disruption of the blood-brain barrier, activation of glial cells associated with systemic immune activation, and effects on autonomic nerves via the organ-brain axis. In this review, we consider previous studies on the relationship between systemic inflammation and neuroinflammation, focusing on the brain regions susceptible to inflammation.

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**Comment**

Lyme/MSIDS also causes peripheral nervous system inflammation.  Once borrelia enter the cerebrospinal fluid (CSF), they elicit an inflammatory response.   This study states about 15% of patients with Lyme disease develop peripheral and central nervous system involvement, although I suspect it’s much, much higher.  It also states inflammation plays a causal role in the array of neurologic changes associated with Lyme disease.

Category:

Inflammation, research

Case Report: Severe Back Pain in Child Caused by Lyme Disease

https://www.sciencedirect.com/science/article/abs/pii/S0735675722002297?via%3Dihub

Radiculoneuritis due to Lyme disease in a North American child

Alexandra H.BakerMDab
https://doi.org/10.1016/j.ajem.2022.03.063Get rights and content

Highlights

  • Peripheral nerve pain can be a presentation of early disseminated Lyme disease
  • Isolated neuroradiculits from Lyme is rare but important to recognize and treat
  • Patients with painful radiculitis should be tested for Borrelia infection

Abstract

Lyme disease is the most frequently reported vector-borne illness in the United States. It is caused by infection with Borrelia burgdorferi via the bite of an infected blacklegged tick (Ixodes spp.) Lyme disease has three stages: early localized, early disseminated, and late. Early disseminated Lyme disease may include neurologic manifestations such as cranial nerve palsy, meningitis, and radicular pain (also called radiculoneuritis). Isolated radiculoneuritis is a rare presentation of early disseminated Lyme disease and is likely underrecognized. We report a case of isolated Lyme radiculoneuritis in a child in Massachusetts characterized by fever and allodynia of the upper back that was treated in the emergency department. Laboratory investigation demonstrated elevated inflammatory markers and positive Lyme testing. Magnetic resonance imaging with gadolinium contrast revealed nerve root enhancement in C5-C6 and C6-C7. The symptoms resolved with oral doxycycline. Neuropathic pain should raise suspicion for neurologic manifestations of Lyme disease in North America even in the absence of meningitis and cranial nerve palsy. We report how timely recognition of this rare syndrome in North America is important and may prevent progression to late disease.

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**Comment**

Again, this is not a “rare” syndrome, but is just “rarely” reported.  Big diff.  The authors even state that this syndrome is “likely underrecognized.”

Category:

Inflammation, Lyme, Pain Management, research, Treatment

3 Case Reports on Baker’s Cysts & Lyme Diagnosis

https://journals.lww.com/jbjscc/Abstract/2022/03000/Pediatric_Lyme_Disease_Presenting_as_a_Ruptured.61.aspx

Pediatric Lyme Disease Presenting as a Ruptured Popliteal Cyst

A Report of 3 Cases

Sager, Alora F. MS1; Carolan, Patrick L. MD2; Georgiadis, Andrew G. MD3,4,a; Laine, Jennifer C. MD3,4 Author Information

JBJS Case Connector: January-March 2022 – Volume 12 – Issue 1 – e21.00813

doi: 10.2106/JBJS.CC.21.00813

Abstract
Cases: 

This case report describes 3 pediatric patients presenting with acute calf or knee pain, calf swelling, and a ruptured popliteal cyst diagnosed by magnetic resonance imaging. Lyme disease was serologically confirmed in each case. In all instances, treatment was delayed because of atypical presentation. All patients responded favorably after antibiotic therapy.

Conclusion: 

The differential diagnosis of Lyme disease should be considered in the context of children presenting with atraumatic unilateral calf pain and a ruptured popliteal cyst. Otherwise, this unusual presentation could delay diagnosis or result in unnecessary surgical intervention, particularly in pediatric patients.

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**Comment**

Again, I’m not sure just how “unusual” this presentation is. Remember that “rarely reported” is quite different that rarely occurs. I’ve had a Baker’s Cyst for a year and it’s not fun.

I have found the following to help tremendously:

  • https://madisonarealymesupportgroup.com/2022/05/04/why-do-some-people-develop-severe-lyme-arthritis-others-dont/  See comment section.  For me, getting rid of gluten was huge, as is drinking plenty of water, taking MSM, systemic enzymes, LDN, niacinamide & vitamin C daily.  All of these are anti-inflammatories.  While I do not have Lyme/MSIDS symptoms, I believe this Baker’s Cyst is damage done by the infections.  I also believe you can have an active infection cause a Baker’s Cyst directly.  While anti-inflammatories will help both, it’s imperative you treat the underlying infections as well if you are symptomatic.

This current research also shows CoQ10 to be a relevant antioxidant for preventing mitochondrial dysfunction in Lyme.

Category:

Inflammation, Lyme, research

US Data Shows “Vaccine” Injuries Skyrocketed; Strategies to Recover

https://www.theepochtimes.com/vaers-autophagy_4497753

Latest US Data Shows Vaccine Injuries Skyrocketed; How Will We Recover?

BY Dr. Yuhong Dong and Health 1+1 May 28, 2022

At present, the adverse events brought about by the COVID-19 vaccines are getting more and more attention from the public. If vaccination causes injury or damage, how can the body heal itself?

Juliana Mastrantonio of New York is an 18-year-old full-time college student and part-time pharmacy technician. Prior to the vaccination, she was in good health and exercised daily. Juliana was infected with COVID-19 in December 2020 and recovered without long COVID symptoms.

Juliana received her first dose of Pfizer vaccine on December 10, 2021 and her second dose on January 2, 2022. Within one week after the second dose, Juliana developed pelvic pain that gradually worsened, and she became hospitalized.

Four days after being discharged from the hospital, she developed other severe symptoms, headaches, and tremors. When she woke up the next morning, she found herself immobile from the waist down, and was paralyzed. And she is currently undergoing rehabilitation.  (See link for article)

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SUMMARY:

  • Since Juliana was previously healthy and only developed these severe symptoms after ‘vaccination,’ it is highly likely there is a link.
  • The EMA has updated AstraZeneca’s shot product information to include rare spinal disorders as a side effect of the vaccine.
  • The shots can cause mitochondrial damage and induce cytokine storms that impair the immune system which leads to autoimmune diseases.
  • ALL the COVID shots have been hastily used without adequate testing andmay cause autoimmune diseases in organs if they contain the spike proteins and components of the virus.
  • As of May 13, 2022 VAERS has received more than 1.2 million adverse events reports; however, AHRQ states this only captures less than 1% of the true number.  Events include:

    • more than 28,000 deaths
    • over 157,000 hospitalizations
    • over 129,000 cases requiring urgent care
    • more than 190,000 cases requiring doctor office visits
    • all of which meet the definition of a serious adverse event
    • the vast majority of events occurred within 3 days of ‘vaccination’
    • 65% of deaths were related to the Pfizer shot, the most used injection
    • 26% were related to Moderna
    • 9% were related to J&J
    • the rest are unknown
    • The most common COVID-19 vaccine related adverse events reported by VAERS:
      • Permanent disability: nerve injury
      • Myocarditis, Pericarditis: cardiac injury
      • Heart attacks: cardiovascular injury
      • Bell’s palsy: facial nerve injury (with unknown etiology)
      • Shingles: dormant virus activated
  • Three strategies to detoxify the “vaccines” are:
    • prevent attachment of spike protein to ACE2 receptors by using ivermectin, suramin, catechin, curcumin, prunella vulgaris extract.
    • neutralize the downstream toxicity by using NAC, Vitamin C, other antioxidants.
    • enhancing self repair mechanism (autophagy) of cells through intermittent fasting as well as consuming polyphenols such as EGCG, Oleuopein, punicalagin, apigenin, resveratrol, pterostilbene, curcumin

For more:  https://madisonarealymesupportgroup.com/2020/12/21/warning-3150-injuries-in-1st-week-of-covid-vaccines-among-american-healthcare-workers-pregnant-women-included/

Category:

Activism, Detoxing, diet and nutrition, Gut Health, Herbs, Inflammation, Supplements, Treatment, vaccines, Viruses

FREE Webinar: Impact of Gut Microbiome on Immunity & Inflammation

https://info.allergyresearchgroup.com/impact-of-the-gut-microbiome-on-immunity-and-inflammation-webinar

Impact of the Gut Microbiome on Immunity and Inflammation

Description 

The gut microbiome consists of a complex set of microbial communities that shape human physiology in multiple ways, both subtle and profound. Two-thirds of the body’s lymphocytes reside in gut-associated lymphoid tissue (GALT) or traverse GALT and return home to other organs. Interaction between gut microbes and GALT creates a basal state of immune activation that starts at the mucosal surface and impacts the entire body. The composition and metabolic activity of intestinal microbes yields effects that promote inflammation and that help resolve inflammation. These effects result from the impact of structural components of microbial cells (e.g., lipopolysaccharides) and metabolites of microbial enzyme activity (e.g., butyrate, hydrogen sulfide).

Recent studies have shown that T-lymphocyte function is especially sensitive to the bacterial composition of the microbiome. The structure and function of the gut microbiome is molded by personal genetics, diet, co-habitation, environmental toxins, hygiene, personal care products, psychosocial stress, intercurrent infections, vitamin D, tryptophan metabolites, nutritional status, medications, herbs, probiotics, and prebiotics. Disturbances in the ecology of the microbiome/host relationship create a condition called dysbiosis, which influences the development and the outcome of many different diseases. The ability to recognize and correct dysbiosis is a skill that can help clinicians improve the outcomes of infectious, allergic, and autoimmune disorders and may aid the immunotherapy of malignancy.

We hope you can join us live on May 18th at 4 PM MT. If not, don’t worry, signing up will still grant you access to the webinar recording.

Time 

2022-05-18 16:00:00 MT
Speaker:
Leo Galland, M.D., is recognized as a world leader in functional and integrative medicine and a pioneer in the study of intestinal permeability and the gut microbiome as they impact immune function and systemic health. Educated at Harvard University and the NYU School of Medicine, he completed a residency in internal medicine at the N.Y.U.-Bellevue Medical Center and held faculty positions at the Albert Einstein College of Medicine, Stony Brook University and the University of Connecticut, where he also completed a fellowship in Behavioral Medicine. He subsequently served as Director of Clinical Research at the Gesell Institute of Human Development in New Haven, Connecticut. Since 1985, he has maintained a private consulting practice in New York City where he evaluates and treats patients with complex medical disorders, who visit him from all over the world. Board certified in internal medicine, he is a Fellow of the American College of Physicians and the American College of Nutrition. Dr. Galland has received the Albert Norris Marquis Lifetime Achievement Award from Marquis Who’s Who for his contributions to medical innovation and the Linus Pauling Award from the Institute of Functional Medicine for developing basic principles of functional medicine. He is recognized in The Leading Physicians of the Worldand America’s Top Doctors. Dr. Galland has contributed to world medical literature with several dozen articles in scientific journals and chapters in medical textbooks. He created the section on Functional Foods for the Encyclopedia of Human Nutrition. An international best-selling author, Dr. Galland has appeared in The New York Times, The Washington Post, The Wall Street Journal, on the Dr. Oz Show, The Today Show, and Good Morning America, PBS, CNN, MSNBC, and Fox. His PBS Special, The Allergy Solution, aired over a thousand times. Since January 2020, he has studied the COVID-19 pandemic in depth, compiling his findings in an online, extensively referenced and free Coronavirus Guidebook, and has created educational videos on the long COVID syndrome.
For more:

Category:

diet and nutrition, Gut Health, Herbs, Inflammation, Lyme, Supplements, Treatment