Ross Lyme & Tick-borne Diseases Protocol Version 4
https://www.treatlyme.net/lyme-disease-treatment-guidelines
About The Ross Lyme & Tick-borne Diseases Protocol—Version 4
New in Version 4
The Ross Lyme & Tick-borne Diseases Protocol–Version 4 update, released 6/17/24, has a number of significant changes.
Name change. In Version 4, I have updated our name to include “tick-borne”. This recognizes that people can have Bartonella, Babesia, or other tick-borne diseases, separate from having Lyme (Borrelia) infection.
But there are more significant updates than our name change. Version 4
- Emphasizes plant-based foods recommendations in Part 2. Diet;
- Promotes healthy intestinal microbiome—even on antibiotics with a new Part 3. Healthy Intestinal Microbiome; and
- Includes an herbal antibiotic only option to treat the three Bs (Borrelia, Bartonella, and Babesia) simultaneously in Part 12. Lyme Infection and Part 13. Bartonella & Babesia Infections.
- Moves lifestyle, and related areas, of sleep, diet, healthy intestinal microbiome, and exercise to the front of the protocol to emphasize the key role these areas have in recovery.
Introduction
These are support and treatment guidelines to treat chronic Lyme or tick-borne infections. This protocol addresses most problems that keep a person from getting well. It is more comprehensive than the antibiotic focused Infectious Disease Society of America (IDSA), International Lyme and Associated Disease Society (ILADS), and United States Centers for Disease Control and Prevention guidelines. While herbal and prescription antibiotics may decrease the germ load in chronic Lyme and tick-borne infections, they often do not correct the underlying problems that cause ongoing symptoms.
The Ross Lyme Support Protocol includes essential steps for the beginning and throughout a chronic Lyme disease or tick-borne infection treatment. It is designed to:
- boost the immune system,
- improve detoxification,
- speed recovery,
- kill the infections, and
- protect and repair from the harmful effects of the infections and the herbal or prescription antibiotics.
While the following Lyme disease and tick-borne infection treatment approach focuses on a limited number of areas, it may correct most of the problems like:
- low energy,
- pain,
- insomnia,
- brain, neurologic, and thinking problems (brain fog), and
- immune compromise and suppression.
Herxheimer Reactions. When a person starts a Lyme disease or tick-borne infection treatment or changes herbal and prescription antibiotics, it is common to experience some worsening in symptoms. See Herxheimer Die-off Reaction: Inflammation Run Amok for more information about this and the steps you can take to treat it.
Treatment Length and Persistence. Generally, it takes a minimum of six months to see if these supports and treatments will help. Supplements can speed recovery, but treating Lyme still takes time. Once you have marked improvement, then you can likely stop many of these nutritional supports except for probiotics, curcumin, ashwagandha, and a good multivitamin. See Getting Healthy: Will I? When? How Do I? for more information about Lyme disease and tick-borne infection treatment length and persistence.
About Supplements. Throughout this protocol I include supplements as nutritional supports based on their known functions. Basic research and my clinical experience show they may help the various symptoms and problems in Lyme disease and tick-borne infections. (See link for article)
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**Comment**
Lots of great info here.
For more:
- https://madisonarealymesupportgroup.com/2016/02/13/lyme-disease-treatment/
- https://madisonarealymesupportgroup.com/2022/10/25/why-chronic-lyme-treatment-fails-a-review-with-strategies/
- https://madisonarealymesupportgroup.com/2022/12/02/why-the-nih-cdc-will-never-dismantle-barriers-for-lyme-treatment/
- https://madisonarealymesupportgroup.com/2021/09/21/the-evidence-for-persistent-lyme-promising-new-treatments/
- https://madisonarealymesupportgroup.com/2020/03/02/why-is-lyme-disease-so-hard-to-treat/
- https://madisonarealymesupportgroup.com/2023/10/02/novel-treatment-for-relapsing-lyme-babesia-and-bartonella/
- https://madisonarealymesupportgroup.com/2024/01/12/combination-antibiotic-therapy-for-treatment-of-lyme-disease/
- https://madisonarealymesupportgroup.com/2024/03/12/superior-efficacy-of-combination-antibiotics-therapy-versus-monotherapy-for-lyme-disease-in-mouse-model/
Histamine is one of the primary pro-inflammatory mediators released when mast cells degranulate. So, getting your histamine levels under control is a top priority. One way to do this is by following a “low-histamine diet” – an elimination diet that aims to minimize the amount of histamine you ingest from foods and beverages.
While DAO supplements are excellent for reducing the amount of histamine absorbed from the food you ingest, these mighty supplements are unable to enter your bloodstream to reduce the amount of histamine produced within your body. This means that excess histamine produced by your own cells needs to be addressed by other methods. Which is where natural antihistamines and mast cell stabilizers can be useful:
There is no single factor that has been shown as the definitive cause of MCAS. However, various microbes can disrupt the immune system and cause mast cells to go haywire. Two major environmental triggers of MCAS include mold and an elevated overall toxic burden.

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