Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19



  • 1.Acute phase SARS-CoV-2-specific T cells display an activated cytotoxic phenotype
  • 2.Broad and polyfunctional SARS-CoV-2-specific T cell responses in convalescent phase
  • 3.Detection of SARS-CoV-2-specific T cell responses also in seronegative individuals


SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19.
  • Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype.
  • Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19.
Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.



While mainstream media keeps peddling its version of truth and that the asymptomatic are demons from hell spreading disease like wildfire, more and more keeps coming out on the body’s amazing innate ability to fight disease.  This work right here shows the body inoculates itself – no need for a vaccine at all if we are allowed to move freely, allowing our bodies to be exposed.

A great example showing lockdowns are counter productive to the healthy population.

I posted about similar work in July:


lymphocytes from 20–50% of unexposed donors display significant reactivity to SARS-CoV-2 antigen peptide pools1,2,3,4.

In conclusion, it is now established that SARS-CoV-2 pre-existing immune reactivity exists to some degree in the general population.





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