GBS as an Initial Manifestation of Lyme Disease: Diagnostic Challenges

April 3, 2026

https://www.cureus.com/articles/467640-guillain-barr-syndrome-as-the-initial-manifestation-of-lyme-disease-diagnostic-challenges

Guillain-Barré Syndrome as the Initial Manifestation of Lyme Disease: Diagnostic Challenges

Ahmed Elnour • Naveed Sultan • Abdul Monem • Khalid Ghalib

Published: March 20, 2026

DOI: 10.7759/cureus.105552

Open Access
Peer-Reviewed

Cite this article as: Elnour A, Sultan N, Monem A, et al. (March 20, 2026) Guillain-Barré Syndrome as the Initial Manifestation of Lyme Disease: Diagnostic Challenges. Cureus 18(3): e105552. doi:10.7759/cureus.105552

Abstract

Lyme disease is a common tick-borne infection in the United States and Europe that may involve the nervous system during the disseminated stage. Guillain-Barré syndrome (GBS) is an acute immune-mediated polyneuropathy usually triggered by infection; however, its association with Borrelia burgdorferi is uncommon and can pose diagnostic challenges.

We report the case of a previously healthy 61-year-old female patient who presented with progressive ascending weakness and areflexia suggestive of GBS. During hospitalisation, she developed bilateral facial nerve palsy, prompting further evaluation. Cerebrospinal fluid (CSF) findings and electrophysiological studies supported acute inflammatory demyelinating polyneuropathy, while serologic testing confirmed Lyme disease. The patient received intravenous immunoglobulin (IVIG) followed by intravenous ceftriaxone and achieved complete neurological recovery.

This case emphasizes the need to consider Lyme disease in patients presenting with acute inflammatory neuropathy, particularly in endemic regions, as early diagnosis and targeted therapy can significantly improve outcomes.

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**Comment**

The researchers state that the association between GBS with Lyme is uncommon, yet nobody is counting cases!  How can they know?

Answer: they don’t.  They shouldn’t state things that are pure conjecture.

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Lyme, research, vaccines, Viruses

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A Bacterial Toxin Facilitating Chronic Infection

https://www.biozentrum.unibas.ch/news/detail/a-bacterial-toxin-facilitating-chronic-infection

A bacterial toxin facilitating chronic infection

Some pathogens persist in the body causing chronic infections. Researchers led by Prof. Christoph Dehio and Prof. Tilman Schirmer at the Biozentrum, University of Basel, have now discovered a mechanism of highly selective targeting of host proteins by a bacterial toxin that is critical for the bacteria to establish chronic infection. The study recently published in “PNAS” provides new insights into the activity and function of bacterial toxins.

The bacterial pathogen Bartonella (purple) in interaction with human host cells (green).

When pathogens invade our body the immune system is put on alert. The body’s immune cells are recruited to the site of infection and an inflammatory reaction is initiated to rapidly eliminate the invaders. Some pathogens, however, have developed clever strategies to evade this line of defense. Bartonella is one of them. Manipulating the body’s cells to its advantage enables the pathogen to persist in the host.

Researchers led by Prof. Christoph Dehio and Prof. Tilman Schirmer at the Biozentrum, University of Basel, have now elucidated an important mechanism how Bartonella  ensures long-term survival in the body. It injects a bacterial toxin into the body’s cells, which deactivates a specific group of proteins important for the immune response. This mechanism is vital for the pathogen’s capacity to cause chronic infection.

Bacterial toxins modulate signaling pathways in host cells

In mammalian cells, so-called Rho GTPases serve as molecular ON-OFF switches controlling a wide range of signaling pathways and thus pivotal cellular activities, such as cell movement, cytoskeletal dynamics and also the innate immune response. Due to their central regulatory role, this protein family is a target of choice for bacterial toxins. These thwart cellular signaling and facilitate the pathogen to survive in the host. However, many bacterial toxins targeting multiple GTPases cause massive collateral damage to the cells and typically limits pathogen survival to the acute infection phase.

Bartonella subtly colonizes the host

In contrast, Bartonella hijacks the host in a “gentle” way. The pathogen employs toxins that very selectively target host cell functions. In doing so, Bartonella reduces the efficacy of the immune system without causing collateral damage, enabling the pathogen to persist in the host. “We have now been able to elucidate the mechanism of highly selective recognition of specific host proteins by the Bartonella toxin Bep 1,” says Dehio. “Bep 1 exclusively targets proteins of the Rac-subfamily but not the other members of the large Rho GTPase family that are typically inactivated all together by toxins with primary acute infection patterns.”

Elucidating bacterial toxin selectivity

Employing a combination of structural analysis, modeling and biochemical methods, the researchers have now been able to elucidate the mechanism underlying this unique target selectivity. “The spectrum of target proteins is determined by large on shape complementarity and the electrostatic interactions of a short structural element in Bep1 with two protein segments unique to the Rac-subfamily,” explains Dehio. This simple, yet elegant, evolutionary treat equips Bartonella with a precise molecular tool to selectively interfere with host signaling.

Original publication:
Nikolaus Dietz, Markus Huber, Isabel Sorg, Arnaud Goepfert, Alexander Harms, Tilman Schirmer and Christoph Dehio. Structural basis for selective AMPylation of Rac-subfamily GTPases by Bartonella effector protein 1 (Bep1). Proceedings of the National Academy of Sciences (PNAS) 2021

Contact: Communications, Katrin Bühler

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**Comment**

This right here, is why patients remain sick.  We are typically filled with multiple stealth pathogens with the capability to quietly impede the normal mechanisms the body uses to clear infections.  Sadly, Bartonella is not the only organism capable of this guerrilla warfare – Borrelia, the causative agent of Lyme disease also changes its outer surface protein to remain cloaked and accepted by the immune system.  If antimicrobials are used, it also has the ability to shape shift and go into a dormant state only to reemerge when conditions are conducive for growth.

When will mainstream medicine get the memo?

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Category:

Bartonella, research

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RFK Jr. Stirs Controversy Amid Pledge to Fight Lyme Disease Despite Prior Attacks on Vaccine Perception

https://www.msn.com/en-us/politics/government/rfk-jr-stirs-controversy-amid-pledge-to-fight-lyme-disease-despite-prior-attacks-on-vaccine-perception

RFK Jr. stirs controversy amid pledge to fight Lyme disease despite prior attacks on vaccine perception

Story by Kim LaCapria

April 2, 2026

As the prospect of a viable vaccine for Lyme disease approaches, experts feared that Health Secretary Robert F. Kennedy, Jr.’s previous claim that no one would “fight harder” for a treatment than he might not bear out, CNN reported.

During the January 2025 Senate confirmation hearings before Kennedy’s appointment as Secretary of the Department of Health and Human Services, an exchange pertaining to Lyme disease stood out to many who had long contended with the illness.

Kennedy’s sometimes dissonant positions on public health aside, he asserted that he and two of his children had endured the “devastating effects of Lyme disease” firsthand.

“There is nobody who will fight harder to find a vaccine or a treatment for Lyme disease than me,” Kennedy promised. He convened a roundtable HHS discussion on the illness in December, reiterating his stated commitment to improving treatment for affected Americans.

“We’ve got to figure out a way to make it safe for children to go back in the woods again,” he said at the sit-down.

On the other hand, Kennedy’s unconventional views on vaccines routinely run contrary to scientific consensus, and medical experts have warned that his positions undermine trust in preventive medicine and pose a risk to public health.

On March 23, Pfizer and French vaccine company Valneva announced that they would formally seek approval for the first new Lyme disease vaccine in over 20 years, a four-dose regimen that demonstrated efficacy of over 70% in clinical trials.  (See link for article)

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**Comment**

Strap yourself in…..

  1. The only ‘experts’ referred to in this article are adherents to the ‘vaccine’ religion where supposedly ‘vaccines’ are the answer to all of life’s problems.
  2. Only an adherent of the ‘vaccine’ religion would state that a person who would ‘fight hard’ for a treatment, but happens to have questions about ‘vaccines’ as dissonant. The two things are not exclusive!  Have we truly lost all ability to reason?
  3. The author tips her hand completely by stating that RFK’s views on ‘vaccines’ are contrary to scientific consensus, demonstrating perfectly what is wrong with medicine today. Silly old me still believes that medical decisions should be between patient and doctor and that medical history, genetics, and all manner of issues should be taken into account – not a ‘one size fits all’ dictate where the only real winner is Big Pharma and its stake-holders making a mint off of sick people. Further, there are plenty of experts who hold a contrary view about vaccines, but they were conveniently left out of the article to further the illusion of scientific consensus.
  4. Regarding undermining trust in preventative medicine and posing a risk to public health, that’s already been accomplished thanks to the handling of COVID by the very people entrusted with public health on down to the doctors and nurses who blindly followed orders.  Every single thing our public health ‘experts’ said was patently false and killed thousands of people and maimed thousands more.  In fact, many experts are stating the true down wind effects will be felt for decades.   
  5. Pfizer and Valneva should be out of business after the COVID clot shot.  The results are in: they failed miserably on every point with these injections that don’t stop transmission or prevent illness, but have caused more adverse reactions than any other vaccine in history.  What an utter farce, and yet……they are still pushing out their products – including a Lyme vaccine if you are foolish enough to ever trust them again and take it.
  6. The author obviously neglected to study the bioweaponization issue for herself when she uses Dr. Richard Ostfeld (a scientist at the Cary Institute of Ecosystem Studies who is completely dependent and beholden to government grants to pay his bills and complete his research) to debunk that Lyme was an intentionally created bioweapon.   He is not a bioweaponization expert.  It is now officially on record via declassified documents that our government purposely force-fed ticks pathogens, made them radioactive so they could track them when they dropped them from airplanes and via other forms of release, and has a vested interest in covering this all up via denial.
  7. Ostfeld also tips is hand entirely when he states that Lyme can be cleared from your system with antibiotics within a couple of weeks. Talk about a ostrich with his head in the sand. There are thousands upon thousands suffering because the standard treatment failed to work.  He also obviously believes our government is logical and sane and would never do something so mad.
Remember Tuskagee, Dr. Ostfeld?

How about Operation Sea Spray, the NYC Subway experiment, Operation LAC, the AEC experiments, the Vanderbilt ‘Nutrition Study‘ on pregnant women, the radioactive ‘nutrition’ experiments on retarded children, Project Artichoke to study torture (interrogation) and MK-Ultra (mind control) and at least four sub-projects exposing children to radiation for mind control.

Oh – lest we forget a more recent NIH Clinical Trial scandal, which has yet to be rectified where hundreds of New York City orphans were used by government agencies and pharmaceutical companies in deadly AIDS drug trials, where over 200 of them died and others had organ failure, deformities, and brain damage.

So yeah, our government is totally capable of creating and dispersing a bioweapon via ticks.

 

Category:

Lyme, Transmission, vaccines

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Study Identifies 86 Serious Neuropsychiatric Safety Signals Linked to COVID-19 Shots

April 1, 2026

https://www.thefocalpoints.com/p/breaking-study-identifies-86-serious

BREAKING: Study Identifies 86 Serious Neuropsychiatric Safety Signals Linked to COVID-19 Vaccination

CDC/FDA safety thresholds breached for 86 adverse events including dementia, schizophrenia, suicidal and homicidal thoughts, stroke, psychosis, depression, cognitive impairment, delusions, and more.
Apr 14, 2025

By Nicolas Hulscher, MPH

The study by Thorp et al titled, Association between COVID-19 Vaccination and Neuropsychiatric Conditions, was just uploaded to the Preprints.org preprint server. They analyzed VAERS data from January 1990 through December 2024 and identified alarming increases in 86 adverse events related to brain function, behavior, and cognition following COVID-19 mRNA injection:

Introduction: COVID-19 mRNA vaccines are known to penetrate the blood-brain barrier and could potentially cause a myriad of unintended adverse effects. The purpose of this study is to explore potential associations between vaccination and neuropsychiatric conditions.

Methods: Data were collected from the U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Food and Drug Administration (FDA). The CDC/FDA Vaccine Adverse Event Reporting System (VAERS) was queried from January 1, 1990, to December 27, 2024, for adverse events (AEs) involving neuropsychiatric complications following COVID-19 vaccination. The timeframe included 420 months for all vaccines except COVID-19 vaccines which have been available to the public for only 48 of the 420 months (from January 1, 2021, to December 27, 2024). Proportional reporting ratios (PRRs) were calculated by time comparing AEs after COVID-19 vaccination to those after influenza vaccination and to those after all other vaccines. The CDC/FDA stipulates a safety concern if a PRR is ≥ 2.

Results: Comparing COVID-19 vaccination to influenza vaccinations, the CDC/FDA’s safety signals (PRR, 95% confidence interval, p-value, Z-score) were breached for the following combinations: 47 AEs associated with cognitive impairment (PRR: 118, 95% CI: 87.2-160, p < 0.0001, Z-score: 30.9); 28 AEs associated with general psychiatric illness (PRR: 115, 95% CI: 85.1-156, p < 0.0001, Z-score: 30.8); and 11 AEs associated with suicide/homicide (PRR: 80.1, 95% CI: 57.3-112, p < 0.0001, Z-score: 25.7). Likewise, when comparing COVID-19 vaccination to all other vaccines except COVID-19, the safety signals were also breached for the following: 47 AEs associated with cognitive impairment (PRR: 26.8, 95% CI: 19.8-36.1, p < 0.0001, Z-score: 21.5); 28 AEs associated with general psychiatric illness (PRR: 28.6, 95% CI: 21.2-38.6, p < 0.0001, Z-score: 21.9); and 11 AEs associated with suicide/homicide (PRR: 14.0, 95% CI: 10.3-19.0, p < 0.0001, Z-score: 16.8).

Conclusions: There are alarming safety signals regarding neuropsychiatric conditions following COVID-19 vaccination, compared to the influenza vaccinations alone and to all other vaccinations combined. These data raise concerns about long-term consequences, including continued cognitive decline, dementia, and neuropsychiatric morbidity and mortality. An immediate global moratorium on COVID-19 vaccination is warranted.  (See link for article)

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**Comment**

Psychosis, schizophrenia, delusion, delirium, and brain injury, along with Alzheimer’s depression, sleep disorders, and hemorrhagic stroke all listed…..

Why these kill shots are still on the market defies ALL logic and sanity.

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Activism, Psychological Aspects, research, vaccines, Viruses

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Best Herbal Antibiotic Plans for Lyme, Bartonella, and Babesia

March 31, 2026

https://treatlyme.com/guide/best-herbal-antibiotics-for-lyme-bartonella-babesia/

Best Herbal Antibiotic Plans for Lyme, Bartonella, and Babesia

By Dr. Marty Ross

best-herbal-antibiotics-for-lyme-bartonella-babesia
Updated: January 24, 2025

Science Meets Buhner for Best Herbal Antibiotic Options

History Speaks

Historically, most herbal antibiotic regimens for used tick-borne infections are based on the writings and experience of master herbalist Stephen Buhner. His work is science related. However, most of the herbal antibiotics he recommends do not have actual studies showing they work in the lab or in humans for killing specific tick-borne infections. For instance, he recommends Andrographis to kill Borrelia based on science showing it kills another spirochete called Leptospirosis. And Buhner recommends Sida Acuta to address Babesia because it is used as an antimalarial, even though there is no research showing it works for Babesia.

Buhner’s writings occurred before the discovery of persister Borrelia (Lyme) and Bartonella which I describe below. So, his writings did not specifically address how to deal with these hibernation forms of germs.

Enter Science

Over the last few years, researchers are rushing to find new ways to kill the terrible Bs (Borrelia, Bartonella, and Babesia). Some of the interest in looking at herbal medicine options is the discovery of hibernating persister growth states of Borrelia and Bartonella that do not respond to classic herbal medicines or prescription regimens that target growing states of these germs. Out of this laboratory work, we now know that Buhner’s Andrographis does not work against Borrelia, but many other agents do.

In 2023 Shor and Schweig published their review of newer laboratory studies showing which herbal medicines work in the lab to kill the growing, persister, and biofilm states of Borrelia and Bartonella. This work also reveals numerous agents that can kill Babesia. Table 1. below is drawn from the Shor-Schwieg article. My table is more limited than the one published in their paper but focuses on what I have found clinically to be the most relevant herbal antibiotics.

Table 1. Herbal Antibiotic Actions

How to Interpret Table 1
  • About G P B. Borrelia and Bartonella exist in growing states, hibernation states, and biofilm communities. The growing states are also called active states. The hibernators are also called persisters or stationary states. Biofilms are mostly known as biofilms. I prefer to use the terms growing (G), persister (P) and biofilms (B) while Shor and Schweig refer to active, stationary, and biofilm states. Keep this in mind if you review their article and more extensive table.
  • About Blank. In some instances, a blank space in the table means the research did not look to see if an herbal agent actually addresses the identified problem. For instance, Zhang and colleagues showed that cinnamon, clove, and oregano oils kill Borrelia biofilms, but their research did not look at whether these herbal oils help Bartonella biofilm. Given the similarity of biofilm structures, cinnamon, clove and oregano oils may actually be good agents against Bartonella biofilms.
  • About Sida Acuta and Houttuynia. Buhner recommends Sida Acuta and Houttuynia to address Bartonella. He also recommends Sida Acuta for Babesia. These key herbal antibiotics are not included in my table or the work of Shor-Schweig because there was no research conducted looking at these agents. This does not mean they do not work, but based on science, we do not know.  (See link for article)

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**Comment**

The article gives numerous treatment options for each pathogen.  We can be extremely thankful to have all of this information in an easy to find and use format which is supported by science.

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Babesia, Bartonella, Herbs, Lyme, research, Treatment

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