Archive for the ‘Treatment’ Category

EM: Course & Outcome in Patients Treated With Rituximab

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634433/

. 2019 Jul; 6(7): ofz292.
Published online 2019 Jun 19. doi: 10.1093/ofid/ofz292
PMCID: PMC6634433
PMID: 31334301

Erythema Migrans: Course and Outcome in Patients Treated With Rituximab

Vera Maraspin,1 Petra Bogovič,1 Tereza Rojko,1 Eva Ružić-Sabljić,2 and Franc Strle1

Abstract

Background

Information on Lyme borreliosis (LB) in patients treated with rituximab is limited to individual case reports.

Methods

We reviewed data on adult patients diagnosed with typical erythema migrans (EM) at the LB outpatient clinic of the University Medical Center Ljubljana, Slovenia, in the 10-year period 2008–2017. For all patients, clinical and laboratory information was acquired prospectively using a standardized questionnaire.

Results

Among 4230 adult patients with a diagnosis of EM, 7 patients (0.17%), 5 women and 2 men with a median age of 65 years (range, 55–66 years), were receiving rituximab for an underlying medical condition. In these 7 patients, signs of disseminated LB (43%) and the isolation rates of borreliae from blood before antibiotic treatment (40%) were unusually high compared with corresponding findings in immunocompetent patients who had EM diagnosed at the same institution (8% vs <2%, respectively). The rates of LB-associated constitutional symptoms and borrelial antibodies in serum were lower than expected (14% and 29%, respectively, in patients receiving rituximab vs 25% and 65% in immunocompetent patients). One of the 7 patients (14%) experienced treatment failure; nevertheless, the outcome of early LB 1 year after antibiotic treatment, as used for immunocompetent patients with EM, was excellent in all 7 patients.

Conclusions

Findings in 7 patients with EM who were receiving rituximab for underlying disease suggest that although early LB in these patients is more often disseminated than in immunocompetent patients, the outcome 1 year after antibiotic treatment, as used for immunocompetent patients, is excellent.

_________________

**Comment**

There should be followed up done on these patients. A one year outcome, if you understand Lyme disease at all, is a short period of time.

Rituximab, a cancer medicine that interferes with the growth and spread of cancer cells, is used alone or in combination with other medicines to treat the following conditions in adults:

Rituximab may cause a serious brain infection that can lead to disability or death, as well as severe skin problems. You are supposed to tell your doctor if you have any of the following before using the drug:

  • liver disease or hepatitis (or if you are a carrier of hepatitis B)
  • kidney disease
  • lung disease or a breathing disorder
  • a weak immune system (caused by disease or by using certain medicines)
  • an active infection, including herpes, shingles, cytomegalovirus, chickenpox, parvovirus, West Nile virus, or hepatitis B or C
  • heart disease, angina (chest pain), or heart rhythm disorder
  • if you have used rituximab in the past
  • pregnancy – it can harm the unborn baby

According to this, Rituximab suppresses the immune system:   https://medivizor.com/blog/SampleLibrary/rheumatoid-arthritis/the-effect-of-rituximab-treatment-on-the-immune-system/

Biological drugs are becoming more popular as a treatment for rheumatoid arthritis (RA). Rituximab is one such drug that works by blocking the activity of immune cells. This then reduces the high level of inflammation seen in the joints of RA patients. Longer courses of treatment are needed for rituximab to be completely effective.

This prolonged treatment can weaken a patient’s immune response and can lead to a condition called hypogammaglobulinemia. This is an immune disorder where the body’s antibody levels are severely reduced, which increases the risk of serious infections.

LLMD’s typically do not recommend immune suppressants for Lyme/MSIDS patients unless they are on antibiotics in tandem. This research study shows why – those in Rituximab had more disseminated Lyme and more borrelia isolated from the blood.  By suppressing the immune system the infection has a greater ability to take over. The fact they had fewer constitutional symptoms and borrelia antibodies in serum means little.  Given time, this could change in a heart-beat. I suspect there were more treatment failures if they followed up on these patients up over years of time.

Patients in the study with solitary EM were prescribed oral antibiotics:

  • doxycycline (100 mg twice daily for 14 days)
  • cefuroxime axetil (500 mg twice daily for 15 days)
  • azithromycin (500 mg twice daily on the first day followed by 500 mg once daily for 4 subsequent days)
  • patients with multiple EM were treated with ceftriaxone (2 g once daily intravenously for 14 days)

For this study, treatment failure was defined as

  1. the occurrence of objective extracutaneous manifestations of LB within 1 year after the start of antibiotic treatment
  2. the appearance/persistence of subjective symptoms or their increased intensity (at the 1-year follow-up visit) that could not be attributed to other causes
  3. persistence of a skin lesion (ie, still visible EM) at a follow-up visit 2–3 months after commencement of treatment
  4. demonstration of borreliae by skin culture at the site of previous EM 2–3 months after the start of treatment (only patients with isolation of borreliae from skin before antibiotic treatment underwent repeated biopsy)

Patients with treatment failure were treated again with an alternative antibiotic.

By looking at the drugs listed, we can see right away that doxy has been shown to throw the spirochete into the non-cell wall form to reemerge later:   https://madisonarealymesupportgroup.com/2019/04/30/the-functional-molecular-effects-of-doxycycline-treatment-on-borrelia-burgdorferi-phenotype/

The emphasis on external lesions is a mistake. Research has shown that antibiotics clear the EM but won’t clear a systemic infection:  https://madisonarealymesupportgroup.com/2017/03/24/one-pill-of-doxy-only-reduces-prevalence-of-rash-not-lyme-disease/

And something must be said about antibiotic levels as well.  In this timely video, Dr. Burrascano explains how some patients need higher drug levels to kill pathogens:  https://madisonarealymesupportgroup.com/2018/12/28/the-history-of-lyme-disease-dr-burrascano/

A one sized approach for Lyme/MSIDS is another mistake.

Sadly, the authors conclude that after one year everyone’s dandy, when nothing could be further from the truth.

 

 

 

 

 

Category:

Lyme, research, Treatment

ILADS Scientific Conference – Registration Now Open

20th Annual ILADS Scientific Conference
Join us in Boston – Registration is Now Open!

We invite you to join us at the 20th Annual International Lyme and Associated Diseases (ILADS) Scientific Conference in Boston from October 31 – November 3, 2019. This year’s conference showcases best practices in the clinical care of patients with Lyme disease and related infections, presents the latest research and trends in treating tick-borne diseases and explores major themes including:

  • How persistent infections and host responses interact to cause chronic disease
  • An introduction to novel antimicrobial strategies in Lyme treatment
  • The role of Big Data in the future of patient care

Conference Highlights:

  • Choose one of two day-long, pre-conference tracks:  Lyme Fundamentals or Exploratory Treatments for Tick-Borne Diseases
  • Daily breakfast chats or networking breakfasts
  • Morning plenary sessions
  • Poster viewing and awards presentation
  • Friday and Saturday afternoon Practical Skills Expansion (PSE) breakout sessions
  • Exhibits by more than 50 vendors showcasing products and services relevant to medical professionals who treat tick-borne diseases

For additional information and a more detailed agenda, please visit ilads.org.

Register before September 7 to receive our early registration discount. We look forward to seeing you at this exciting event!

Register here: https://www.ilads.org/ilads-conference/boston-2019/?

 

 

 

Category:

Activism, Lyme, Treatment

Controversies & Challenges in Treating Lyme & Other Tick-borne Diseases

https://www.ilads.org/research-literature/controversies-challenges/

Controversies & Challenges in Treating Lyme and Other Tick-borne Diseases

By the International Lyme and Associated Diseases Society

Lyme disease is a bacterial infection caused by members of the Borrelia burgdorferi sensu lato complex. Although the disease was initially identified in Europe, it was named after the town where the first group of US cases was described. While historically most cases clustered into certain geographic regions, the infection is increasingly widespread across the globe. Lyme disease is the most common vector-borne disease in the United States, with the Centers for Disease Control (CDC) estimating that more than 300,000 cases of Lyme disease are diagnosed each year.1 Lyme disease is also the most common vector-borne illness in Europe.2

Lyme disease can be very serious. The infection is often multisystemic – involving joints, heart, and the nervous system. Although early recognition and treatment lead to resolution of illness for many patients, there are many who live with persistent, debilitating symptoms, and persistent infection – which ILADS terms chronic Lyme disease.

Lyme disease and other tick-borne illnesses remain poorly understood, and ILADS finds that guidelines that address the illness in surveillance case terms, including those historically promoted by the Centers for Disease Control, do not serve patients well. This document attempts to explain the many challenges faced by patients with tick-borne illnesses, including controversies over terminology and treatment. It seeks to describe ILADS’ position in these controversies and challenges. ILADS Treatment Guidelines, a comprehensive review of the best science on effective treatment for particular aspects of Lyme disease, touch on many of these controversial issues within the context of our evidence-based treatment recommendations.

I. Controversy over Diagnosis

The controversies in Lyme disease exist in a setting of incomplete scientific evidence around tick-borne diseases, including a lack of validated direct testing methods which can be applied across all stages of the disease to accurately distinguish infected from uninfected patients. Serologic testing, often held as a gold standard, has significant performance limitations. Lyme disease is a clinical diagnosis dependent on history, and physical examination, and supported by appropriate laboratory testing. The elements of diagnosis are placed in the context of the activities and experiences of the patient, environmental exposures and risk factors, and consideration of other diagnoses that may explain or impact the patient’s symptoms. At the heart of the controversy is the relative weight given to each element that contributes to the diagnosis. ILADS’ position is that no single data point, including serologic testing, automatically outweighs the contributions from all of the data in the patient’s presentation and evaluation.

ISSUES WITH DIAGNOSIS & DIAGNOSTICS

There is a distinction between diagnosis and diagnostics. A diagnosis encompasses the considered explanation for a patient’s symptoms based on the elements described above, as well as the process by which the diagnosis itself is reached. Diagnosticsrefers to laboratory and other test modalities used to aid in reaching a diagnosis. Challenges exist in both areas when considering Lyme disease.

Diagnosis

Challenges in diagnosis occur in a setting of varied clinical presentations often appearing in the absence of a history of tick bite. Even the erythema migrans rash (EM), a hallmark of the disease, is not always present or remembered, and in its most common form does not resemble the classically described “bull’s eye” rash.3 The sometimes subtle physical findings and diversity of manifestations of Lyme borreliosis require awareness on the part of the examiner in order to discern this infection. Even in the case of Lyme arthritis with effusion, it has been reported that diagnosis in adults often takes longer than in children.4 In addition, since latency is a feature of this infection, some signs and symptoms do not develop for weeks, months or even years after the time of initial infection.5 6 7 All of these features contribute to diagnostic uncertainties and controversy.

Diagnostic Tests

Direct tests (culture, PCR) for Borrelia burgdorferi have performance limitations that must be considered when used in evaluating Lyme disease. These tests are not readily available; the slow growth characteristics of B. burgdorferi in culture and the sparse distribution of the bacteria in blood and tissues result in generally low sensitivities for these tests. The most successful cultures and PCRs have been on specimens from the leading edge of erythema migrans rashes8, a manifestation typically not requiring culture or PCR to clarify the diagnosis. When both culture and PCR have been performed on the same specimens, they have not necessarily given the same result.9 PCR in some studies is shown to perform fairly well in evaluating synovium of Lyme arthritis.10 11 In US studies, blood and CSF generally have very low yield on direct tests for Borrelia burgdorferi.12 Differences in testing methods, tissue and specimens being evaluated contribute to the challenges in direct testing. Emerging direct testing modalities, including a more promising method of culture, present new opportunities for addressing the challenges inherent in direct tests.13 14 As in all testing, interpretation of positives and negatives depends upon the clinical setting.

Serologic tests are the most commonly performed tests for investigating Lyme disease. These tests do not identify the presence or absence of B. burgdorferi, but rather detect the presence of an antibody response that may be attributable to exposure to this pathogen.  Of the dozens of serologic tests available in the US market, none are FDA-approved. Rather, all are FDA-cleared, which means that the test compares favorably with and performs at least as well as other tests already in use, but has not been clinically validated in prospective studies. None has shown clear superiority in performance.

The reliability of diagnostic testing is a function of accuracy and reproducibility. Accuracy is a test’s ability to detect disease when it is present, and not detect disease when it is absent. Reproducibility is the ability of a test to give the same result for a specimen on repeat testing. Highly accurate tests generate few false negatives and few false positives. Unfortunately, Lyme serology produces many false negatives and false positives. Additionally, investigators have repeatedly demonstrated that both ELISA and immunoblot tests for Lyme have poor reproducibility.15 16 17 18

Test Performance

When antibody testing is done too early or too late in infection, false negatives may result. Further, it has been shown that after an antibody response develops, it can wane or persist regardless of disease status.19 20 21 In Embers’ study of Bb-infected primates, some untreated animals had antibodies develop and then disappear over time, despite persistence of infection. Finally, some patients fail to develop antibody responses to this infection.22 23 Interpreting test results within the context of the patient’s clinical history is important in assessing the likelihood that a positive test represents the presence of the disease and that a negative test represents its absence.24 The occurrence of false negatives and false positives greatly contributes to the controversy over diagnosis.

Performance characteristics are not only affected by timing of testing but also by the particular disease manifestation being evaluated. Western blot testing, for example, has been found to perform very well in cases of arthritis (96% sensitivity) but less well in neurologic presentations (72% sensitivity).25 26 Note that even when the tests perform well, some cases will be missed if we rely solely on test results. In the vaccine trials, it may be noted that reliance on serology alone for the diagnosis of Lyme disease would have missed one third of cases.27

ELISA

The ELISA quantitatively measures IgM, IgG or a combination of IgM and IgG antibodies in an automated format. ELISA sensitivities have been shown to vary by disease stage and manifestation.28 In early Lyme, sensitivities of ~40% have been reported, rising to as high as 82% in disseminated or late/convalescent samples. In a clinical setting consistent with Lyme disease, the likelihood that a positive ELISA is a true positive is high. However, in the same setting, the likelihood that a negative ELISA is a true negative is less certain.

Western Blot Interpretation

Western blots, either IgM or IgG, qualitatively measure antibody reactions across a range of more than 2 dozen B. burgdorferiantigens. The determination of which antibody reactions to include in establishing criteria for a positive Western blot has been the subject of much controversy. Dressler et al. developed criteria based on the frequency with which particular antibodies appeared in clinically well-characterized patients. They then applied statistical parameters to determine which particular antigens to include and the minimum number of antibody responses needed to achieve a test specificity of 99%.29 Of interest is the absence of 31 and 34 kDa proteins (ospA and ospB) which may occur infrequently but are significant for Bb, especially when occurring together.30, 31 Other investigators have proposed different criteria for Western Blot interpretation. Engstrom et al.’s proposed criteria for interpretation of IgM Western blot, and Dressler, et al.’s proposed criteria for IgG Western blot were adopted for standardization.32

Two-Tier Testing

The commonly recommended testing scheme for evaluating a person suspected of having Lyme disease calls for a first step using a highly sensitive ELISA, only followed by a Western Blot if the first step result is positive or equivocal.33 Negative samples by ELISA are not investigated further. Tests used in this strategy are subject to the confounders of testing described above, and because they are linked sequentially in the stated manner, those confounders are magnified, making the possibility of false negatives much greater.

This test strategy, like the interpretation parameters of the tests involved, was adopted for standardization of testing practices,34 35 which were deemed unreliable at the time. Primarily designed and intended to enhance testing specificity, the overall sensitivity of a sequence of this sort necessarily falls. Nevertheless, it was adopted by the CDC and the Association of State and Territorial Public Health Laboratory Directors “as a temporary measure,” despite objections, at the Second National Conference on Serologic Diagnosis of Lyme Disease held in Dearborn, Michigan in 1994.36 This test strategy has not been replaced.

Clinical practice necessarily places emphasis on identifying every infected patient in order to identify, treat, and prevent adverse consequences. Therefore, ILADS concludes that the two-tiered test strategy does not adequately serve clinician or patient.

THE ILADS POSITION ON DIAGNOSIS AND TESTING

Lyme disease is a clinical diagnosis based on the history and physical findings, and supported by appropriate laboratory tests when they are indicated. These elements must be considered in the context of the individual patient’s full story and with consideration of other diagnoses that may explain or confound the patient’s diagnosis. No single element of the diagnostic process outweighs the full and complete evaluation. The strengths and limitations of laboratory testing must be understood by the clinician in order to use testing modalities effectively and avoid some of the pitfalls of diagnosis that can result from over-reliance on laboratory testing to rule in or rule out an illness.

II. Controversy over Treatment

Lyme disease is a complex illness with many variables. The severity of the infection and a person’s response to treatment may depend on 1) which species or strains of the bacteria the person has, 2) how long they have been ill, 3) which body systems are involved, 4) whether other tick-borne diseases are present, and 5) the person’s underlying health status. Commonly prescribed antibiotic regimens generally follow a one-size-fits-all approach using 30 or fewer days of antibiotic therapy, but several investigators37 38 39 have found that many people remain ill after receiving such care. ILADS maintains that in light of all of the potential variables, antibiotic treatment must be individualized.

ILADS members have treated tens of thousands of patients with Lyme and associated tick-borne diseases in the US and across the globe. Based on the collective work of its members, ILADS has a wealth of clinical expertise in treating complex and advanced cases of Lyme disease.

To determine the best possible course of action given the available data, ILADS convened a working group to conduct a thorough review of the literature with regards to managing blacklegged tick bites, treatment of EM rashes, and persistent (chronic) manifestations of Lyme disease. The team used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system to evaluate and rate the quality of the evidence and the strength of ensuing recommendations. In reviewing the literature and making recommendations, ILADS placed a high value on preventing chronic infection, on not causing the abrogation of the immune response, and on the ability of the clinician to exercise clinical judgment.40

As of February 2018, ILADS’ treatment guidelines are the only Lyme disease guidelines available at the National Guideline Clearinghouse, an initiative of the Agency for Healthcare Research and Quality (AHRQ), under the umbrella of the US Department of Health and Human Services. These guidelines were developed with careful attention to the peer-reviewed scientific evidence presented in the Lyme research using a rigorous GRADE41 assessment of the pertinent trial evidence.

SUMMARY OF ILADS’ RECOMMENDATIONS

Generally speaking, treatment decisions hinge on the duration of the illness, the types of symptoms and signs the person has, and whether they were previously treated for this specific infection in the past.

  • ILADS recommends that prophylaxis be discussed with all who have had a blacklegged tick bite. This is to prevent the onset of infection; technically speaking, antibiotic prophylaxis of a known bite is not treatment because the person is not yet ill.
  • When the decision is made to use antibiotic prophylaxis, ILADS recommends 20 days of doxycycline (provided there are no contraindications). Additionally, ILADS recommends against single-dose doxycycline.
  • ILADS recommends that most patients with erythema migrans receive an initial 4-6 weeks course of antibiotic therapy. Subsequent management decisions are based on whether the signs and symptoms remain or relapse.
  • ILADS recommends that patients with persistent (chronic) signs and symptoms of Lyme disease receive individualized care that tailors antibiotic treatment to their specific situation. The duration of treatment and the choice of antibiotic or antibiotic combinations are clinical decisions to be made with several factors in mind. Long-term antibiotic therapy is not without risks, and should only proceed under close supervision.

Read the ILADS Treatment Guidelines for more detailed discussion of our treatment recommendations.

III. Controversy over Chronic Lyme Disease

Chronic Lyme disease, which ILADS defines as an ongoing infection with any of the pathogenic bacteria in the Borrelia burgdorferi sensu lato group, is poorly understood and often mischaracterized. Although the infection was often described as “chronic” early in the history of Lyme disease, that terminology was abandoned by the Infectious Disease Society of America (IDSA) and many IDSA-affiliated researchers and clinicians in the late 1990s.42 The rationale for that switch is unclear, as the bacteria’s ability to cause a chronic and sometimes post-antibiotic persistent infection was already well documented in the scientific literature.43 44 The CDC generally maintains that Lyme disease is an acute infection and it does not readily acknowledge that the infection can persist following antibiotic treatment. Instead, the CDC recognizes other potential causes for ongoing symptoms. The CDC endorses the use of the term “Post-Treatment Lyme Disease Syndrome”(PTLDS) when symptoms persist for more than six months following antibiotic.45

ILADS agrees that for many patients, Lyme disease is strictly an acute infection. However, for many other individuals, the infection is chronic. Common symptoms include:

  • Fatigue
  • Cognitive dysfunction
  • Headaches
  • Sleep disturbances
  • Migratory myalgia and arthralgia
  • Numbness and tingling
  • Neuropathic pain
  • Depression and anxiety
  • Musculoskeletal problems.46

The diagnostic controversies discussed above also apply to patients with chronic Lyme disease, causing many medical providers to miss a Lyme diagnosis. As a result, patients can exhibit significant symptoms of Lyme disease for years and even decades that are misattributed to other entities — fibromyalgia, chronic fatigue syndrome, and depression are common misdiagnoses. Although Lyme symptoms overlap with the symptoms of these illnesses, a well-conducted meta-analysis demonstrated that persistent Lyme disease symptoms were a distinct set of symptoms that differed from those of other chronic, difficult-to-manage diseases.47 Additionally, in comparing the cerebrospinal fluid of patients with chronic, post-treatment manifestations of Lyme disease to that of patients with chronic fatigue syndrome, researchers found that the two groups could be distinguished from each other on the basis of proteins that were unique to a particular group.48

Patients with chronic Lyme disease may require prolonged treatment — i.e., additional courses of antibiotics. An unknown percentage of patients, with data ranging from 10 to more than 30%, report prolonged symptoms despite prior antibiotic treatment for Lyme disease.49 50 51 Given B. burgdorferi’s wide array of survival mechanisms, this statistic is not surprising. B. burgdorferi is notoriously adaptable, which enhances its survival. As noted in the ILADS guidelines, and by others, the bacteria can alter its morphology, engage in antigenic variation, invoke periods of dormancy, inhabit protective niches, and form biofilms that protect the bacteria from the immune system and the effects of antibiotics.52 53 These survival mechanisms allow for B. burgdorferi persistence following short-term antibiotic therapy. Repeated courses of antibiotics that do not address these bacterial protections are also likely to fail.

THE ILADS POSITION ON TREATING CHRONIC LYME DISEASE

Based on the extensive collective experience of ILADS members and a rigorous review of the broader scientific literature, ILADS maintains it is in the best interest of chronic Lyme disease patients for clinicians to offer additional treatment.54 Taking into account the strength of the evidence addressing the effectiveness of antibiotic retreatment, the burden of disease in this patient population, and the risks associated with various antibiotic options, ILADS concludes that the very real consequences of an untreated chronic Lyme infection far outweigh the potential consequences of long-term antibiotic therapy. Further, we assert that although it is too early to standardize restrictive protocols, effective treatment options are available for these patients.

IV. Controversy over Time of Attachment Before Transmission

Many professionals mistakenly believe that Lyme disease cannot be transmitted when a blacklegged tick has been attached for 24 to 48 hours. This is incorrect. Several animal studies have documented that although the risk of Lyme disease is quite low for attachment times under 24 hours, the risk is not zero.55 The length of attachment for transmission of other members of the Bb sensu lato complex pathogens to occur may differ from that of B. burgdorferi.56 ILADS recommends that patients with a known blacklegged tick bite of any duration should discuss the possibility of Lyme disease with their providers.

V. Other Challenges in Treating Lyme Disease

Other Tick-Borne Infections

Blacklegged ticks can transmit at least four other infections.57 The frequency of tick-borne co-infections in Lyme disease patients from endemic areas ranges from 4-45%.58 Not all providers appreciate the risks of acquiring co-infections nor the clinical significance of these pathogens. If co-infections are unidentified and unaddressed, a provider may treat Lyme disease effectively, yet have patients who remain ill.

Pressures on Clinicians

Medical providers face the challenge of these often complicated patients in practice settings that may impose time constraints and other limitations to their choices in diagnosis and treatment. The diagnostic possibilities are themselves complex and the requirements for follow-up and careful observation of progress and further decision-making significant. Placed in the context of a “controversial illness” and personal concerns about experience and expertise in this area of medicine, the pressure on individual clinicians can be substantial.

Misuse of Treatment Guidelines

Treatment guidelines were called for by the Institute of Medicine to assist clinicians by assembling the best available evidence from the medical literature as well as assessments of risks and benefits of treatments and alternatives in order to inform patient care. The IOM standards for guidelines development recommend that patients and others affected by a guideline be included in the development process as this would help assure that guidelines address and prioritize the issues most important to patients. Guidelines are not intended to supplant the judgment of a clinician in the care of individual patients. When insurers, employers, medical boards, or other entities treat guidelines as if they are laws, misusing them to determine payment, as performance measures, or for disciplinary purposes, it can undermine the utility of these works for clinicians.

Insurance Issues

Health insurance companies create policies for payment of benefits to guide in claims decisions. When these policies are narrowly determined, as they are when based on surveillance case definitions of Lyme disease, they may impede a patient’s recovery of benefits, and importantly, may prevent receipt of care. When cost assessments are performed, ILADS holds that they need to include the costs of non-treatment, the costs of other kinds of management that will be required if the underlying cause of illness is not treated, and the cost of disability as a result of the illness.

The Marginalization of Patients with Lyme Disease

While any patient, particularly one with a chronic illness, is at risk of marginalization,59 60 61 Lyme disease patients face a particularly intense set of challenges: the stigma associated with this controversial diagnosis; the polarization of medical providers concerning diagnosis and treatment; the challenges of obtaining insurance coverage for treatment beyond the acute phase of the disease; the potential to experience isolation because of the illness.

All of these factors and the controversies we have explored above contribute to the experiences of patients who struggle with the very real effects of Lyme disease. The medical uncertainties surrounding tick-borne diseases may lead some clinicians to take a hands-off approach to these illnesses, or to fail to coordinate with a Lyme-treating colleague. Patients experience mis- and missed diagnoses and, at times, their symptoms may be erroneously attributed to a psychiatric diagnosis or malingering. The cumulative effect is that many patients become marginalized.

The evidence regarding Lyme and other tickborne diseases continues to evolve. ILADS and ILADEF recognize that many in the greater medical community may not be sufficiently versed in the scientific evidence of Lyme disease and other tick-borne illnesses, giving rise to misconceptions about the disease. Evidence-based medicine is the integration of clinical research, clinical expertise and patient values and preferences. Given that the clinical evidence is limited and of low quality, clinical expertise and patient values take on increased importance. To assure the decisions about treatment and outcomes remain patient-centered and individualized, ILADS and ILADEF strongly encourage patients to be actively involved in decisions affecting their medical care.

ADDITIONAL RESOURCES

1 The Centers for Disease Control website, https://www.cdc.gov/lyme/faq/index.html. Last visited 11/1/17.
2 Vector-borne diseases. European Environment Agency. Last visited 1/31/18.
3 Smith RP, Schoen RT, Rahn DW, et al. Clinical characteristics and treatment outcome of early lyme disease in patients with microbiologically confirmed erythema migrans. Annals of Internal Medicine. 2002;136(6):421–428. [PubMed]
4 Daikh, B. E., Emerson, F. E., Smith, R. P., Lucas, F. L. and McCarthy, C. A. (2013), Lyme Arthritis: A Comparison of Presentation, Synovial Fluid Analysis, and Treatment Course in Children and Adults. Arthritis & Rheumatism, 65: 1986–1990. doi:10.1002/acr.22086
5 Logigian EL, Kaplan RF, Steere AC. Chronic neurologic manifestations of Lyme disease. New Engl J of Med. 1990;323:1438-44.
6 Logigian EL, Steere AC. Clinical and electrophysiologic findings in chronic neuropathy of Lyme disease Neurology Feb 1992, 42 (2) 303; DOI: 10.1212/WNL.42.2.303
7 Steere AC, Levin RE, Molloy PJ, Kalish RA, Abraham JH 3rd, Liu NY, Schmid CH.Treatment of Lyme arthritis.Arthritis Rheum. 1994 Jun;37(6):878-88.
8 Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP. Diagnosis of lyme borreliosis. Clin Microbiol Rev. 2005 Jul;18(3):484-509. Review.
9 Smith, supra note 3
10 Nocton JJ, Dressler F, Rutledge BJ, Rys PN, Persing DH, Steere AC. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis.N Engl J Med. 1994 Jan 27;330(4):229-34.
11 Priem S, Burmester GR, Kamradt T, Wolbart K, Rittig MG, Krause A. Detection of Borrelia burgdorferi by polymerase chain reaction in synovial membrane, but not in synovial fluid from patients with persisting Lyme arthritis after antibiotic therapy. Ann Rheum Dis. 1998 Feb;57(2):118-21.
12 Augero-Rosenfeld, supra note 6.
13 Sapi E, Pabbati N, Datar A, Davies EM, Rattelle A, Kuo BA. Improved culture conditions for the growth and detection of Borrelia from human serum. Int J Med Sci. 2013;10(4):362-76. doi: 10.7150/ijms.5698. Epub 2013 Feb 18.
14 Magni R, Espina BH, Shah K, et al. Application of Nanotrap technology for high sensitivity measurement of urinary outer surface protein A carboxyl-terminus domain in early stage Lyme borreliosis. Journal of Translational Medicine. 2015;13:346. doi:10.1186/s12967-015-0701-z.
15 Bakken LL, Callister SM, Wand PJ, Schell RF. Interlaboratory comparison of test results for detection of Lyme disease by 516 participants in the Wisconsin State Laboratory of Hygiene/College of American Pathologists Proficiency Testing Program. Journal of Clinical Microbiology. 1997;35(3):537-543.
16 Ang CW, Notermans DW, Hommes M, Simoons-Smit AM, Herremans T. Large differences between test strategies for the detection of anti-Borrelia antibodies are revealed by comparing eight ELISAs and five immunoblots. European Journal of Clinical Microbiology & Infectious Diseases. 2011;30(8):1027-1032. doi:10.1007/s10096-011-1157-6.
17 Cook MJ, Puri BK. Commercial test kits for detection of Lyme borreliosis: a meta-analysis of test accuracy. International Journal of General Medicine. 2016;9:427-440. doi:10.2147/IJGM.S122313.
18 Leeflang MM, Ang CW, Berkhout J, Bijlmer HA, Van Bortel W, Brandenburg AH, et al.The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis. BMC Infect Dis. 2016 Mar 25;16:140. doi: 10.1186/s12879-016-1468-4. Review.
19 Embers ME1, Hasenkampf NR1, Jacobs MB1, Tardo AC1, Doyle-Meyers LA2, Philipp MT1, Hodzic E3. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.PLoS One. 2017 Dec 13;12(12):e0189071. doi: 10.1371/journal.pone.0189071. eCollection 2017.
20 Kalish RA, McHugh G, Granquist J, Shea B, Ruthazer R, Steere AC.Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10-20 years after active Lyme disease. Clin Infect Dis. 2001 Sep 15;33(6):780-5. Epub 2001 Aug 10.
21 Craft JE, Fischer DK, Shimamoto GT, Steere AC.Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness..J Clin Invest1986;78(4):934-939.
22 Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, Golightly MG. Seronegative Lyme disease. Dissociation of specific T- and B-lymphocyte responses to Borrelia burgdorferi.N Engl J Med. 1988 Dec 1;319(22):1441-6.
23 Dressler F, Whalen J, Reinhardt BN, Steere AC. Western blotting in the serodiagnosis of Lyme disease.. J Infect Dis. 1993;167:392-400.
24 Maloney EL The need for clinical judgment in the diagnosis and treatment of Lyme disease. J of Amer Phys and Surg. 2009;14(3):82-9.
25 Dressler, supra note 23
26 Maloney, supra note 24
7 Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig E, Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS.Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med. 1998 Jul 23;339(4):209-15.
28 Dressler, supra note 23
29 Dressler, supra note 23
30 Engstrom SM, Shoop E, Johnson RC.Immunoblot interpretation criteria for serodiagnosis of early Lyme disease. J Clin Microbiol 1995; 33:419-27.
31 Ma B, Christen B, Leung D, Vigo-Pelfrey C. Serodiagnosis of Lyme borreliosis by western immunoblot: reactivity of various significant antibodies against Borrelia burgdorferi. J Clin Microbiol. 1992; 30(2):370-6.
32 Centers for Disease Control and Prevention and Association of State and Territorial Public Health Laboratory Directors (ASTPHLD).1994. Proceedings of the 2nd National Conference on Serologic Diagnosis of Lyme Disease (Dearborn, MI). ASTPHLD, Washington, D.C.
33 See, e.g., Two-Step Laboratory Testing Process. Centers for Disease Control. Last visited 1/31/18.
34 Dressler, supra note 23
35 Centers for Disease Control and Prevention, supra note 32
36 Centers for Disease Control and Prevention, supra note 32
37 Logigian EL, Kaplan RF, Steere AC Successful treatment of Lyme encephalopathy with intravenous ceftriaxone.J Infect Dis. 1999 Aug;180(2):377-83.
38 Aucott JN, Rebman AW, Crowder LA, Kortte KB. Post-treatment Lyme disease syndrome symptomatology and the impact on life functioning: is there something here? Qual Life Res (2013) 22:75–84
39 Shadick NA, Phillips CB, Logigian EL, Steere AC, Kaplan RF, Berardi VP, Duray PH, Larson MG, Wright EA, Ginsburg KS, Katz JN, Liang MH The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study.Ann Intern Med. 1994 Oct 15;121(8):560-7.
40 Cameron DJ, Johnson LB, Maloney EL.. Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease.Expert Rev Anti Infect Ther. 2014 Sep;12(9):1103-35. doi: 10.1586/14787210.2014.940900. Epub 2014 Jul 30.Review.
41 The Grading of Recommendations Assessment, Development and Evaluation (GRADE) system is a basis for evidence assessment and the development of recommendations to ensure a transparent and trustworthy guideline process.
42 Maloney, Elizabeth L. Controversies in Persistent (Chronic) Lyme Disease. Journal of Infusion Nursing 39.6 (2016): 369–375. PMC. Web. 22 Jan. 2018.
43 Cameron, supra note 40
44 Embers, supra note 19
45 CDC Website https://www.cdc.gov/lyme/faq/index.html. Last visited 9/20/17.
46 Cameron, supra note 40
47 Cairns V, Godwin J., Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms. Int J Epidemiol 2005;34(6):1340-5[Crossref], [PubMed], [Web of Science].
48 Schutzer SE, Angel TE, Liu T, Schepmoes AA, Clauss TR, Adkins JN, Camp DG, Holland BK, Bergquist J, Coyle PK, Smith RD, Fallon BA, Natelson BH. Distinct cerebrospinal fluid proteomes differentiate post-treatment lyme disease from chronic fatigue syndrome. PLoS One. 2011 Feb 23;6(2):e17287. doi: 10.1371/journal.pone.0017287.
49 Maloney, supra note 42
50 Shadick, supra note 39
51 Aucott, supra note 38
52 Cameron, supra note 40
53 Berndtson K. Review of evidence for immune evasion and persistent infection in Lyme disease. Int J Gen Med. 2013 Apr 23;6:291-306. doi: 10.2147/IJGM.S44114. Print 2013.
54 Cameron, supra note 40
55 Michael J. Cook, Lyme borreliosis: a review of data on transmission time after tick attachment. Int J Gen Med. 2015; 8: 1–8.
56 Dolan MC, Breuner NE, Hojgaard A, Boegler KA, Hoxmeier JC, Replogle AJ, Eisen L.Transmission of the Lyme Disease Spirochete Borrelia mayonii in Relation to Duration of Attachment by Nymphal Ixodes scapularis (Acari: Ixodidae).J Med Entomol. 2017 Sep 1;54(5):1360-1364. doi: 10.1093/jme/tjx089.
57 Tick-Borne Diseases. Columbia University Medical Center. Available at http://www.columbia-lyme.org/patients/tick_borne.html. Last visited 1/28/18.
58 Swanson SJ, Neitzel D, Reed KD, Belongia EA. Coinfections Acquired from Ixodes ticks. Clin Microbiol Rev. 2006 Oct; 19(4): 708–727.
doi:10.1128/CMR.00011-06.
59 Ali A1, Vitulano L, Lee R, Weiss TR, Colson ER. Experiences of patients identifying with chronic Lyme disease in the healthcare system: a qualitative study.BMC Fam Pract. 2014 May 1;15:79. doi: 10.1186/1471-2296-15-79.
60 Johnson L1, Aylward A, Stricker RB. Healthcare access and burden of care for patients with Lyme disease: a large United States survey.Health Policy. 2011 Sep;102(1):64-71. doi: 10.1016/j.healthpol.2011.05.007. Epub 2011 Jun 14.
61 Institute of Medicine (US) Committee on Lyme Disease and Other Tick-Borne Diseases: The State of the Science. Critical Needs and Gaps in Understanding Prevention, Amelioration, and Resolution of Lyme and Other Tick-Borne Diseases: The Short-Term and Long-Term Outcomes: Workshop Report. Washington (DC): National Academies Press (US); 2011

Category:

Lyme, Treatment

About Rife Machines For Lyme Disease – Dr. Ross

About Rife Machines for Lyme Disease

In this video, Marty Ross MD discusses

  • how Rife machines could work to kill Lyme
  • effectiveness of Rife for Lyme disease based on research and clinical experience, and
  • books about how to Rife.

For video go to:   https://www.treatlyme.net/guide/rife-machine-lyme-disease

__________________

More on Rife:  https://madisonarealymesupportgroup.com/2018/11/30/the-quantum-world-rife-machines-lyme-disease/

For more on treatments:

https://madisonarealymesupportgroup.com/2016/02/13/lyme-disease-treatment/

https://madisonarealymesupportgroup.com/2016/01/16/babesia-treatment/

https://madisonarealymesupportgroup.com/2016/01/03/bartonella-treatment/

https://madisonarealymesupportgroup.com/2016/02/07/mycoplasma-treatment/

https://madisonarealymesupportgroup.com/2017/10/03/removing-parasites-to-fix-lyme-chronic-illnesses-dr-jay-davidson/

https://madisonarealymesupportgroup.com/2016/03/28/combating-viruses/

https://madisonarealymesupportgroup.com/2018/06/23/the-role-of-retroviruses-in-chronic-illness-a-clinicians-perspective/

Category:

Lyme, Treatment

How 5 Remedies Help Reduce Inflammation – Greg Lee

https://www.linkedin.com/pulse/how-five-remedies-treatments-help-reduce-inflammation-greg-lee/

How These Five Remedies and Treatments Help Reduce Inflammation Symptoms from Lyme Disease, Parasites, and Mold

For people who suspect they have multiple infections including Lyme disease, co-infections, parasites, and mold

by Greg Lee

Fireworks have gotten more spectacular since I was a kid. At a recent Independence Day celebration, my kids and I were dazzled by an amazing display that burst forth from a single white firework shooting up into the night. Then, several yellow streamers of light slowly fell like an umbrella which whistled. Suddenly, blue, red, green, and white sparkles blossomed forth. We kept saying, “Ooooh and aaaah!” with each new spray of color.

How is a complex fireworks show similar to recurring inflammatory symptoms from unknown infections?

Just like a fireworks display shooting across the night, multiple infections can trigger bursts of unexpected symptoms

Some patients with stealthy infections like Lyme disease, mold, or parasites can have relapsing symptoms that can randomly appear and disappear. Unfortunately, these infections may not show up on blood1, saliva, or stool2 tests. Carlotta felt run down ever since she got sick with mononucleosis as a teenager. She would have occasional bouts of migrating pain, memory recall issues, and vision problems. Lab tests couldn’t identify the underlying reason for her symptoms. Multiple medical providers suggested that she go see a counselor or psychiatrist. Her symptoms would flare up during phases of her menstrual cycle, during a full moon, and in response to eating carbohydrates. Not only food but also medications made her symptoms worse.

Her flu-like symptoms would flare up when she took antibiotics

Carlotta’s symptoms increased when she took antibiotics for sinus problems. The toxic die off from drug treatment dramatically increased her flu-like symptoms of fatigue, brain fog, and misspeaking words. She felt that her immune system was producing too much inflammation in response to some unknown infection. Unfortunately, over the counter medications did little to relieve her symptoms.

Anti-inflammatory medications didn’t help much

Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin, Advil, and Aleve took the edge off some of her flu-like symptoms. Dietary changes helped reduce symptoms however they would flare up for unknown reasons and when she ate food with wheat or sugar.

What else can help to reduce fatigue, brain fog, and flu-like symptoms from hidden infections?

Here are five multi-microbial treatments that can help with reducing symptoms from multiple types of infections

Carlotta received an electrodermal scan which detected the electrical frequencies of Lyme disease and parasitic worms in her intestines and liver. The scan also detected frequencies of mold in her sinuses. She received a combination of microparticle, aka liposomal essential oils, liposomal herbs, and treatments to help with reduce recurring symptoms from her multiple infections. These remedies have also reduced toxins and inflammatory compounds in multiple lab studies.

Multi-microbial Treatment #1: Clove bud

This herb has acrid and warm properties. In lab and animal studies, clove bud has an inhibitory effect against Vibrio cholerae, Bacillus anthracis, Salmonella typhi, Corynebacterium diptheriae, Bacillus dysenteriae, E. coli, Bacillus subtilis, Staphlococcus aureus3, Methicillin-resistant Staphylococcus aureus (MRSA)4, Enterococcus faecalis5, Staphylococcus epidermidis, Streptococcus pyogenes, and Pseudomonas aeruginosa6. Biflorin, a compound in clove buds, protected against bacterial endotoxins, and inflammatory compounds tumor necrosis factor-α (TNF-α) and interleukin (IL-6) in a mouse study7. This herb has also been recommended for the treatment of worms and parasites in humans8.

In Chinese medicine, it is used to warm the abdomen and relieve pain. Clove is also used to treat hiccups, nausea, morning sickness, vomiting, and diarrhea. This herb is also used to treat impotence, and coldness in the body and extremities. It also promotes digestion by increasing bile and gastric acid secretions. Clove is also used topically to treat toothache. The essential oil has anti-asthmatic properties.

Essential oil of clove contains these compounds: eugenol, caryophyllene, acetyleugenol, α- caryophyllene, and chavicol. In lab research, clove essential oil completely dissolves the borrelia biofilm and kills the drug persistent spirochete form of the Lyme9. In another study, clove essential oil inhibits Candida, Aspergillus, and some dematophytes including fluconazole resistant strains10. In another study, the compound eugenol was effective at inhibiting different fungi including Fusarium moniliforme, Fusarium oxysporum, Aspergillus species, Mucor species, Trichophyton rubrum and Microsporum gypseum11. In a third study, clove essential oil increased the effectiveness of fluconazole and voriconazole against multiple Candida species12. In another study, this essential oil was effective at inhibiting drug resistant Candida biofilms13. Low internal doses of clove essential oil have been used safely and effectively for years with patients diagnosed with Lyme disease, parasites, and mold toxicity. This herb is contraindicated in cases of fever and excess internal heat accompanied with symptoms of dryness. Side effects of this herb include dizziness, palpitations, chest oppression, headache, perspiration, decreased blood pressure, and skin rash. In addition to clove, cinnamon can be effective against many different microbes and parasites.

Multi-microbial Treatment#2: Cinnamon bark

The properties of this herb are acrid, sweet, and hot. Cinnamon has an inhibitory effect on dermatophytes, pathogenic fungi, and many gram positive bacteria14. In a lab study, cinnamon compounds inhibited the malaria parasite15. These compounds are succinic acid, glutathione, L-aspartic acid, beta-alanine, and 2-methylbutyryl glycine. Given the similarity between malaria and Babesia, this herb may be effective against this co-infection. Another compound, cinnamaldehyde, has inhibits parasitic worms in a lab study16. Cinnamon was also effective at reducing parasitic cysts of Giardia in a rat study.17

This herb also contains the following active compounds: cinnamic aldehyde, cinnamic acid, cinnamyl acetate, phenylpropyl acetate, cinncassiol-A, -B, -C1, -C2, -C3, cinnzelanine, and cinnzeylanol.

This herb is used in Chinese medicine to treat a wide variety of disorders including intolerance to cold, cold extremities, weakness, soreness and coldness of the low back and knees, impotence, lack of libido, excess urine production, and loose stools. It is also used to treat wheezing, asthma, labored breathing, swelling, and profuse phlegm. Cinnamon is also used for dizziness, flushed face, sore throat, and coldness in the lower extremities. This herb also treats epigastric and abdominal pain, vomiting, diarrhea, gas, bloating, slow digestion, hernia pain, and spasmodic pain in the stomach and intestines. It is also used to treat hypercoagulation, irregular menstruation, amenorrhea, dysmenorrhea, postpartum pain, external injuries, trauma, deep rooted sores, psoriasis, and feelings of oppression in the abdomen.

Cinnamon is contraindicated during pregnancy and in patients with signs of excess heat, excess dryness, and excess bleeding. Excess amount of cinnamon can result in symptoms of flushed face, red eyes, dry mouth and tongue, bleeding, nausea, vomiting, abdominal pain, excess urination, anuria, burning sensations upon urination, excess serum proteins in the urine, dizziness, blurred vision, and numbness of the tongue.

Intravenous cinnamon reduced blood pressure, decreased heart rate, peripheral vasodilation, and decreased vessel resistance within 3-5 minutes. Subcutaneous injection of cinnamon in dogs increased the white blood cell count by 150 – 200%. In a rat study, essential oil of cinnamon has an analgesic and sedative effect.

In lab research, cinnamon bark essential oil completely eradicates the Lyme disease biofilm and the drug persistent spirochete form18. Cinnamon bark essential oil was effective at inhibiting Aspergillus and Penicillium mold species19. This essential oil inhibits Aspergillus species and aflatoxin, aflatoxin-B1, and aflatoxin-G1 production. These toxins are inhibited because the essential oil binds to the DNA of aflatoxins. Also, this essential oil reacts with reactive oxygen species produced by aflatoxins, which has a protective effect on cells20. In another study, cinnamon bark essential oil was the most effective against oral isolates of Candida albicans21. Another study demonstrated that cinnamon bark essential oil was effective against fluconazole susceptible Candida species22. Liposomal cinnamon oil was effective at inhibiting MRSA and it’s biofilms in a lab study23. Low dilutions of liposomal cinnamon essential oil have been taken internally by people diagnosed with multiple infections safely without reported side-effects. In addition to cinnamon, artemisia has antimicrobial effects against many pathogens.

Multi-microbial Treatment#3: Artemisia

Artemisia and its derivative compounds, artemisinin, liposomal artemisinin, and artesenuate, are being used by physicians to fight Babesia24 infections. Artemisinin has been used effectively with other anti-protozoa medications to cure relapsing Babesia. Artemisinin has also been effective in multiple studies against cytomegalovirus, Toxoplasma gondii (protozoa), Schistosoma species and Fasciola hepatica (worms) and Cryptococcus neoformans (fungi)25.

Artemisia is recommended for treating leptospirosis and Lyme disease in Chinese medicine26. Artemisia annua is also effective in inhibiting Staphylococcus aureus (staph), Bacillus anthracis (anthrax), Corynebacterium diphtheriae (diphtheria), Pseudomonas aeruginosa, Bacillus dysenteriae (dysentery), and Mycobacterium tuberculosis (tuberculosis)27. Using the whole herb instead of a derivative compound increases the benefits by including other active compounds. Multiple sesquiterpene and flavonoid compounds from Artemisia annua neutralized the effects of bacterial toxins in a lab study28. Artemisia annua contains rosmarinic acid which demonstrated a synergistic interaction with artemisinin against the malaria protozoa in a lab study29. This herb and it’s compound artemisinin inhibited the production of bacterial endotoxins and the inflammatory cytokine TNF-α in a rat study30.

Artemisia annua has the properties of clears heat, treats malaria, cools the blood, clears liver heat, and brightens the eyes. It is also used to treat “steaming bone disorder” or the feeling that one’s bones are being cooked, tidal fever, unremitting low-grade fever, thirst, soreness and weakness of the low back and knees, irritability, and heat in the palms, soles, and the middle of the chest. Other symptoms this herb is used to treat are warmth at night and chills in the morning, absence of perspiration, heavy limbs, stifling sensation in the chest, and a flushed face. This herb also treats red eyes, dizziness, photophobia, arrhythmia, and jaundice.

This herb is cautioned in patients with diarrhea and coldness in the stomach. Azole antifungals and calcium channel blockers may present significant herb-drug interactions with this herb. In long term studies, this herb had no adverse effects on vital organs31. In addition to artemisia, silver nanoparticles have multiple anti-microbial properties.

Multi-microbial Treatment#4: Silver Nanoparticles

Silver nanoparticles have been used safely and effectively to inhibit many drug resistant and biofilm forming bacteria and fungi including Streptococcus mutans32, Streptococcus pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa33, Escherichia coli34, and Enterococcus faecalis35 in lab studies. Silver particles are also effective at inhibiting multiple species of pathogenic fungi and their toxins in lab studies36. This form of silver has also been effective against multiple protozoa including Entamoeba histolytica, Cryptosporidium parvum, and Plasmodium falciparum (malaria)37. In water studies, silver has also been effective at reducing the amount of helminth (worm) eggs in waste water38.

When in combination with cinnamon bark, silver inhibits H7N3 influenza A virus a lab experiment39. When combined with tea tree essential oil in a microparticle liposome, silver greatly enhances the antimicrobial and anti-toxin properties against Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans40. In addition to silver, Microcurrent offers a highly flexible and targeted treatment for inhibiting pathogens, toxins, and resulting inflammation.

Multi-microbial Treatment#5: Frequency Specific Microcurrent

Frequency Specific Microcurrent (FSM) is amazingly targeted and customizable form of electrical frequency treatment for chronic infections. Carlotta received anti-microbial, anti-toxin, anti-inflammatory frequencies directed into her sinuses, liver, intestines, and memory regions of the brain. Frequencies were also applied to neutralize mold toxins, inhibit spirochetes, fungi, protozoa, bacteria, parasites, and reduce brain and intestinal inflammation. She also received frequencies for increasing adrenal energy, disrupting biofilms in her sinuses, and zapping intracellular infections. With each microcurrent treatment, she felt less toxic and less inflamed, more energetic, and was able to find and speak words with greater clarity. Multiple remedies and treatment may be effective at reducing symptoms from Lyme, parasites and mold, toxins, and resulting inflammation.

Using multiple treatments, patients report faster improvements in their chronic inflammation symptoms

Similar to a dazzling multi-stage fireworks display, the proper combination of treatments and liposomal remedies may give your immune system a burst of support to fight multiple types of infections including Lyme disease, parasites and mold. These treatments may also help to neutralize toxins and lower inflammation. For the first time in years, Carlotta looked forward to going to her kid’s sporting events with an abundance of energy. She remembered her family’s activity schedule without having to look at a calendar. She restarted movement classes since her migrating pains had ceased. Since liposomal remedies require specific training on their formulation and come with cautions on their use, work with a Lyme literate natural practitioner to develop a safe and effective strategy for addressing symptoms from multiple infections.

– Greg

P.S. Do you have experiences where treatment or remedies helped you reduce symptoms from multiple infections? Tell us about it in a comment below.

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Activism, Herbs, Inflammation, Lyme, Treatment