Archive for the ‘Ticks’ Category

TBI’s in Florida

http://doi.org/10.1016/j.ttbdis.2016.09.016

Abstract

Tick-borne diseases are an emerging public health threat in the United States. In Florida, there has been public attention directed towards the possibility of locally acquired Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, in association with the lone star tick. The aim of this study was to determine the prevalence of ticks and the pathogens they carry and potentially transmit, such as B. burgdorferi, in a highly utilized teaching and research forest in North Central Florida.

Ticks were collected by dragging and flagging methods over a four month period in early 2014, identified, and tested by PCR for multiple pathogens including Anaplasma, Borrelia, Rickettsia, and Ehrlichia species. During the study period the following ticks were collected: 2506 (96.5%) Amblyomma americanum L., 64 (2.5%) Ixodes scapularis Say, 19 (0.7%) Dermacentor variabilis Say, and 5 (0.2%) Ixodes affinis Neuman.

Neither Borrelia spp. (0/846) nor Anaplasma spp. (0/69; Ixodes spp. only) were detected by PCR in any of the ticks tested. However, Rickettsia DNA was present in 53.7% (86/160), 62.5% (40/64), 60.0% (3/5) and 31.6% (6/19) of A. americanum, I. scapularis, I. affinis and D. variabilis, respectively. Furthermore, E. chaffeensis and E. ewingii DNA were detected in 1.3% and 4.4% of adult A. americanum specimens tested, respectively.

Although receiving an A. americanum bite is likely in wooded areas in North Central Florida due to the abundance of this tick, the risk of contracting a tick-borne pathogen in this specific area during the spring season appears to be low. The potential for pathogen prevalence to be highly variable exists, even within a single geographical site and longitudinal studies are needed to assess how tick-borne pathogen prevalence is changing over time in North Central Florida.

Of Rabbits and Men

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Tularemia is known as a rabbit disease which is spread to those who handle them including hunters and cooks; however, at the recent Lyme Disease Association 17th Annual Conference on Lyme and Tick-Borne Diseases, Timothy Lepore, MD, FACS, surgeon at Nantucket Cottage Hospital, explained that it is also a disease of those who work with the land such as landscapers and farmers, as well as those who get bit by a tick. There are cases reported in every state but Hawaii, and many other wild and domestic animals can be infected. The highest rates of infection are in Arkansas.

Tularemia first appeared in the United States in Massachusetts in 1937 after importing 30,000 to 40,000 rabbits per year from Europe. Importing came to an end in 1947.

http://columbia-lyme.org/patients/tbd_tularemia.html
Francisella tularensis, a gram negative, aerobic, pleomorphic, highly persistent intracellular pathogen, spread via the lymphatic system can cause fever, chills, headache, myalgia, extreme fatigue, glandular (swollen glands), oropharyngeal (sore throat, nausea, vomiting and diarrhea, abdominal pain and intestinal ulcerations), conjunctivitis, pneumonic (dry cough, respiratory difficulty and chest pain), ulceroglandular (skin ulcer at infection site) and can be septic and lethal. Symptoms typically develop within three or four days of inoculation but can take up to 10 days.

Tests: Tests for Tularemia are not widely available but direct examination of biopsy specimens or secretions by fluorescent antibody or Gram or histochemical stains are often helpful. F. tularensis can also be demonstrated microscopically with fluorescent-labeled antibodies. Antibodies are not typically present in the first ten days after exposure. Patient samples should come from sputum or pharyngeal washings, as the organism is not present in large numbers in blood. Polymerase chain reaction (PCR) tests can also be utilized. It is imperative that lab personnel take strong precautions as it is quite easy to become infected.

Treatment: Antibiotic therapy with Gentamicin (5mg/kg/day, IM or IV) or streptomycin (1 gm twice daily, IM). The recommended treatment period is 10 days. In vitro susceptibility studies indicate that quinolones and fluoroquinolones are also effective against F. tularensis, thus providing an additional option for physicians. Tetracyclines and chloramphenicol can also be used, but a higher rate of relapse is associated with these agents, as they are bacteriostatic rather than bactericidal. Thus, it is recommended that treatment with these medications be extended to 2-3 weeks. If treatment is initiated quickly the mortality rate for tularemia is around 1-2%; however, one-third of untreated patients will die, usually from pneumonia, meningitis or peritonitis.

http://www.idph.state.il.us/public/hb/hbtulare.htm
Transmission: Transmission can occur through the skin or mucous membranes when handling infected animals as well as through tick bite, contact with fluids from infected deer flies, mosquitoes or ticks, handling or eating undercooked rabbit, drinking contaminated water, inhaling dust from contaminated soil, and handling contaminated pelts or paws of animals. It can also be inhaled from infected hay, grain, or soil. Dr. Lepore had patients who contracted it from their pet dog who shook rain water on them after chewing on a dead rabbit, as well as from folks eating road kill, a person who held sick animals, and a gentleman who slept with his pet bunny.
http://www.siumed.edu/medicine/id/tularemia.htm
Tularemia, in aerosol form, is considered a possible bioterrorist agent that if inhaled would cause severe respiratory illness. It was studied in Japan through 1945, the USA through the 60’s, and Russia is believed to have strains resistant to antibiotics and vaccines. An aerosol release in a high population would result in febrile illness in 3-5 days followed by pleuropneumonitis and systemic infection with illness persisting for weeks with relapses. The WHO estimates that an aerosol dispersal of 50 kg of F. tularensis over an area with 5 million people would result in 25,000 incapacitating casualties including 19,000 deaths.

In a mass casualty situation – treat with oral agents for 14 days using Doxycycline (adults 100mg by mouth twice a day, children under 45kg 2.2 mg/kg by mouth twice daily) or Ciprofloxacin (adults 500mg, by mouth twice a day, children 15mg/kg by mouth twice a day).

Those performing autopsies should avoid bone sawing or any procedure likely to cause aerosolization and exposed people should wash with soap and water. In environmental contaminations use a 10% bleach solution for spraying and cleaning using alcohol 10 minutes after using bleach. There have been no reports of human to human transmission.

Hope for Southerners

Up until now, the powers that be have pretty much denied the existence of Lyme Disease in the South. A great example of this happened recently when children from Arkansas were denied treatment because the Director of the Infectious Disease Program stated that although they have ticks that transmit LD, there aren’t any recorded cases.  https://madisonarealymesupportgroup.com/2016/09/24/arkansas-kids-denied-lyme-treatment/

This illogical ideology is about to change thanks to the work of Kerry Clark, PhD, MPH, Professor of Epidemiology & Environmental Health at the University of North Florida. At the recent Lyme Disease Association (LDA) 17th Annual Conference in St. Paul, MN, Clark presented his work showing that Borrelia burgdorferi sensu lato (Bbsl) DNA has been detected in scores of human patients and dogs from the South, who had no travel history to Lyme endemic regions. Bbsl was isolated in culture from patients from both Florida and Georgia – never before described in scientific literature.

https://www.researchgate.net/publication/292984009_A_divergent_strain_isolated_from_a_resident_of_the_southeastern_United_States_was_identified_by_MLST_analysis_as_Borrelia_bissettii

The take home: Clark is finding strains in the South that the current CDC two-tier testing will never pick up in a thousand years.

https://www.researchgate.net/publication/285584725_Isolation_of_live_Borrelia_burgdorferi_sensu_lato_spirochetes_from_patients_with_undefined_disorders_and_symptoms_not_typical_for_Lyme_diseases

The take home: Clark found live Bbsl (bissettii-like strain) in people from the Southeast who had undefined disorders not typical of LD, and were treated for LD even though they were seronegative, proving that B. bissetti is responsible for worldwide human infection.

He also showed DNA of Bbsl in Lone Star ticks which might be a bridge vector of transmission to humans.

To see Dr. Clark’s work, go to: https://www.researchgate.net/profile/Kerry_Clark/publications

Dr. Clark was the first to report finding LD spirochetes in animals and ticks in South Carolina, as well as in wild lizards in South Carolina and Florida. He has documented the presence of LD Borrelia species, Babesia microti, Anaplasma phagocytophilum, Rickettsia species, and other tick-borne pathogens in wild animals, ticks, dogs, and humans in Florida and other southern states.

Willy Speaks From the Grave Rickettsia helvetica

https://www.statnews.com/2016/10/12/swiss-agent-lyme-disease-mystery/

In a riveting article (go to link above) STAT obtained Willy Burgdorfer’s documents found in his garage after his death in 2014.

 Approx. 4 min WBUR interview with Charles Piller, author of the link above.

What makes this crucial for MSIDS patients is his fascination and concern with Rickettsia helvetica, something he coined, “Swiss Agent.” The article poses an idea that doctors might be mistaking this infection for Lyme or that this agent could also be another co-infection complicating and confusing cases.

Rickettsia helvetica is known predominantly in Europe and Asia as relatively rare but linked to sudden deaths from heart disease. Other symptoms include facial palsy, deafness, meningitis, chronic muscle weakness, temporary paralysis, debilitating fatigue, severe headaches, and sarcoidosis.

There is no test in the U.S. for Rickettsia helvetica.

Burgdorfer discovered the pathogen in 1978 in Switzerland. The stacks of papers found in his garage indicate he meant to delve into it further with a prophetic note written in red on top of the stack that stated, “I wondered why somebody didn’t do something, then I realized that I am somebody.”

University of California, Berkeley, medical entomologist and Lyme expert, Robert Lane, states that Rh could cause clinical illness on its own or act with other pathogens worsening cases.

When the discovery of the cause of Lyme was reported in the journal Science in 1982, Burgdorfer identified Rickettsia in Lyme patients’ sera and ticks, but in the final article no mention of it was made.

Currently, the CDC is using molecular techniques on 30,000 sera samples from those with suspected tick-borne illness but will take several more years to finish. It is believed that if Rickettsia helvetica is there, it will be found.

Dr. W. Ian Lipkin, director of the Center for Infection and Immunity at Columbia University, has identified 20 new viruses in ticks, using a process that could result in making tests affordable to patients. He also trying to get funding to include Rickettsia in his research.

We can thank Burgdorfer for contemplating all of this before his death and ultimately contacting Ron Lindorf to retrieve his boxes of research. Willy told him he wanted it available to people on the internet so they could read it for themselves. From there, Lindorf met with Kris Newby, the producer of “Under Our Skin,” the best primer on Lyme Disease out there. http://underourskin.com/#home-underourskin.  If you haven’t seen this film, you need to now. It will explain all the reasons why we find ourselves in a medical quagmire. The sequel, “Emergence,”
http://underourskin.com/sequel/#sequel-home is just as powerful and offers much hope as it follows many patients through treatment to health.

Newby shared the documents with STAT, hoping that an independent report would be made.

 

Did Lyme Create Witches?

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October is historically the season of crunchy leaves, less day light, and a certain fascination with the macabre due to the celebration of Halloween or Allhallowtide, a time of remembering the dead. The stores are filled to the brim with skeletons, spider webs, orange lights, and the witch.

Our fascination with witches is an old one and we have our own history of witchcraft hysteria emanating from the East Coast in the late 1600s when a group of young girls claimed to be possessed by the devil and accused many local women of witchcraft. Hangings ensued, properties possessed, with the fervor finally concluding after 150 men, women, and children were accused.

What in the world happened?

M.M. Drymon in her book, Disguised As The Devil, theorizes the unfortunate history of witches could have been caused by borrelia, a spirochetal infection, more commonly known as Lyme Disease.

Drymon, a historian and Lyme sufferer, makes a convincing case when she describes the details of the cases and symptoms of witches which include: lameness, photophobia, an argumentative, difficult, and anti-social personality, memory problems, confusion/hallucinations, poor word choice and difficulty with speaking, mixing up of words – such as an inability to recite the Lord’s Prayer, as well as numbness, and increased spontaneous abortion rates – all of which are common symptoms for Lyme Disease.

A physician of the time, John Cotta, was bewildered that the seemingly innocent voluntarily confessed to being witches. He believed they had some illness that caused delusions, thereby deceiving themselves. Lyme Disease when it has entered the Central Nervous System and infects the brain, can cause delusions, nightmares, insomnia, memory loss, rage, depression, and many other cognitive issues.

The author also draws a connection that many of the accused had red-hair. Evidently redheads have cells with a dysfunctional MC1R gene, which causes sensitivity to pain – particularly thermal pain, and she feels this made for a better show when witches were burned at the stake. Lyme sufferers have discovered through genetic testing that many have faulty mutations in their genes, particularly an inability to detoxify.

Drymon painstakingly went through ancient records and discovered that the colonists suffered with a disease of the forest edge. A number of things added up to a perfect storm including the practice of pasturing cows and horses in the woods, exposing them to ticks, as well as the practice of bringing into the home straw, eelgrass, and corn husks for bedding. Animal pelts from this time period and preserved in modern museums have been found to be infected with borrelia.

She also notes a connection with human health in the early 1600s, before the witchcraft fiasco, when pigs commonly occupied the area between forest and cleared land. Pigs notoriously dig through the dirt looking for food which would have upset leaf litter exposing tick eggs to freezing temperatures as well as pushing the deer population further away. Archeological work showed 371 bones from pigs reflecting pathologies consistent with Lyme Disease, demonstrating that in the earlier part of colonial settlement, the pigs were the ones who took the brunt of the infection, sparing the colonists, but it wasn’t to last. Gradually, domestic pigs were fenced in the farmyard.

Colonists also burned off the ground, typically in the winter or early spring, which would have helped bring the tick population down; however, for the crucial years (1690-1691) in relation to the witchcraft proceedings, it was probably neglected as it was a male chore and many of the men were off to the Quebec invasion as well as the fact it was a drought year making fires hazardous.

Also, 1690 was a “mast bonanza year,” causing mice, deer, and other acorn eating lovers to come closer to settlers’ homes.  https://daily.jstor.org/can-the-acorn-crop-predictlymedisease/utm_campaign=sep+23+rawlsmd+newsletter%3A+Future+Diagnosis+%26+Treatment+no+rk+%28JsiThf%29&utm_medium=email&_ke=YWNhc2htYW5AY2hhcnRlci5uZXQ%3D&utm_source=All+Restore+Purchasers+  In this link, it is explained that this abundance of acorns attracts deer into oak stands in autumn and white-footed mice and eastern chipmunks the following summer – both top host choices for black-legged ticks.  Adult ticks mate on the deer in the fall and lay eggs on the ground in spring, which turn to larval ticks in summer.  These feed on mice and shipments attracted to the acorns as well as small birds.  The following year, infected nymphs may land on human hosts, transmitting the disease.  The following year, adult ticks can feed on deer and humans.

She claims a drought starting in 1681 until 1692 would also have brought tick carrying animals closer to water sources, where settlers would also frequent. The years of witchcraft hysteria were tough and stressful years due to war.  Salem absorbed refugees from Maine, such as Mercy Lewis and Sarah Churchill.  Stress is an important factor with health, particularly with Lyme Disease, and has been known to activate dormant spirochetes in birds.

By late 1691 an increasing number of afflicted people were recorded, many of them women who all wore long skirts. According to Drymon, these skirts worked much like the current method of tick dragging. These skirts were also commonly pulled over the head for warmth and protection from rain, bringing ticks closer to the head, creating a higher risk for neurological symptoms. They were often made from wool derived from sheep which also attract ticks.

History records marks on the skin.

So called devil’s marks and witches teats, which were circular rashes similar to the bulls-eye rash in LD, were found on the accused. The Goodwin children had red streaks on their bodies. Current science shows Bartonella, a common co-infection, to cause this type of streaking.

A few of the afflicted died while others seemingly recovered; however, some were mentally ill the rest of their lives, and some developed a chronic form of disease and continually suffered. This also happens with Lyme.

Shortly after the 1692 charter, the witchcraft hysteria ended and the colonial government voted to financially compensate victims. Official apologies followed, including the one given by the governor of the Commonwealth of Massachusetts in 1992.

Drymon aptly points out that in one party systems like the theocracy of early Massachusetts, the party represents the interests of the state as a whole with no representation for sub-state level groups, a situation that Lyme patients currently find themselves in due to the CDC’s one-party line preference in regard to the diagnosis and treatment of LD. The structure, Drymon contends, is backed by a firm belief in the “theology” of accepted science, derived predominately from those within the CDC, who ignore the worldwide science. The establishment opposes ANY criticism with demeaning labels such as Lyme cult, Lyme counterculture, Quacks, and imaginary affliction. This closed loop establishment “burns at the stake” doctors who treat people with the chronic form of Lyme by accusing them of medical misconduct, forcing patients to stop treatment until they can find someone else who dares to treat them, which furthers human suffering and offers no platform to speak or for recourse.  These accused doctors have incredible stress placed upon them as well as huge legal fees to prove their innocence against a system that states chronic Lyme Disease doesn’t exist, despite worldwide science proving otherwise.  Lyme patients and their doctors are victims like the accused witches in colonial times.

If ever there was a quagmire in medical history, this is it.

I predict that one day, similarly to in Massachusetts, there will be official apologies. It just may take 300 years.