Archive for the ‘Ticks’ Category

Hope for Southerners

Up until now, the powers that be have pretty much denied the existence of Lyme Disease in the South. A great example of this happened recently when children from Arkansas were denied treatment because the Director of the Infectious Disease Program stated that although they have ticks that transmit LD, there aren’t any recorded cases.  https://madisonarealymesupportgroup.com/2016/09/24/arkansas-kids-denied-lyme-treatment/

This illogical ideology is about to change thanks to the work of Kerry Clark, PhD, MPH, Professor of Epidemiology & Environmental Health at the University of North Florida. At the recent Lyme Disease Association (LDA) 17th Annual Conference in St. Paul, MN, Clark presented his work showing that Borrelia burgdorferi sensu lato (Bbsl) DNA has been detected in scores of human patients and dogs from the South, who had no travel history to Lyme endemic regions. Bbsl was isolated in culture from patients from both Florida and Georgia – never before described in scientific literature.

https://www.researchgate.net/publication/292984009_A_divergent_strain_isolated_from_a_resident_of_the_southeastern_United_States_was_identified_by_MLST_analysis_as_Borrelia_bissettii

The take home: Clark is finding strains in the South that the current CDC two-tier testing will never pick up in a thousand years.

https://www.researchgate.net/publication/285584725_Isolation_of_live_Borrelia_burgdorferi_sensu_lato_spirochetes_from_patients_with_undefined_disorders_and_symptoms_not_typical_for_Lyme_diseases

The take home: Clark found live Bbsl (bissettii-like strain) in people from the Southeast who had undefined disorders not typical of LD, and were treated for LD even though they were seronegative, proving that B. bissetti is responsible for worldwide human infection.

He also showed DNA of Bbsl in Lone Star ticks which might be a bridge vector of transmission to humans.

To see Dr. Clark’s work, go to: https://www.researchgate.net/profile/Kerry_Clark/publications

Dr. Clark was the first to report finding LD spirochetes in animals and ticks in South Carolina, as well as in wild lizards in South Carolina and Florida. He has documented the presence of LD Borrelia species, Babesia microti, Anaplasma phagocytophilum, Rickettsia species, and other tick-borne pathogens in wild animals, ticks, dogs, and humans in Florida and other southern states.

Willy Speaks From the Grave Rickettsia helvetica

https://www.statnews.com/2016/10/12/swiss-agent-lyme-disease-mystery/

In a riveting article (go to link above) STAT obtained Willy Burgdorfer’s documents found in his garage after his death in 2014.

 Approx. 4 min WBUR interview with Charles Piller, author of the link above.

What makes this crucial for MSIDS patients is his fascination and concern with Rickettsia helvetica, something he coined, “Swiss Agent.” The article poses an idea that doctors might be mistaking this infection for Lyme or that this agent could also be another co-infection complicating and confusing cases.

Rickettsia helvetica is known predominantly in Europe and Asia as relatively rare but linked to sudden deaths from heart disease. Other symptoms include facial palsy, deafness, meningitis, chronic muscle weakness, temporary paralysis, debilitating fatigue, severe headaches, and sarcoidosis.

There is no test in the U.S. for Rickettsia helvetica.

Burgdorfer discovered the pathogen in 1978 in Switzerland. The stacks of papers found in his garage indicate he meant to delve into it further with a prophetic note written in red on top of the stack that stated, “I wondered why somebody didn’t do something, then I realized that I am somebody.”

University of California, Berkeley, medical entomologist and Lyme expert, Robert Lane, states that Rh could cause clinical illness on its own or act with other pathogens worsening cases.

When the discovery of the cause of Lyme was reported in the journal Science in 1982, Burgdorfer identified Rickettsia in Lyme patients’ sera and ticks, but in the final article no mention of it was made.

Currently, the CDC is using molecular techniques on 30,000 sera samples from those with suspected tick-borne illness but will take several more years to finish. It is believed that if Rickettsia helvetica is there, it will be found.

Dr. W. Ian Lipkin, director of the Center for Infection and Immunity at Columbia University, has identified 20 new viruses in ticks, using a process that could result in making tests affordable to patients. He also trying to get funding to include Rickettsia in his research.

We can thank Burgdorfer for contemplating all of this before his death and ultimately contacting Ron Lindorf to retrieve his boxes of research. Willy told him he wanted it available to people on the internet so they could read it for themselves. From there, Lindorf met with Kris Newby, the producer of “Under Our Skin,” the best primer on Lyme Disease out there. http://underourskin.com/#home-underourskin.  If you haven’t seen this film, you need to now. It will explain all the reasons why we find ourselves in a medical quagmire. The sequel, “Emergence,”
http://underourskin.com/sequel/#sequel-home is just as powerful and offers much hope as it follows many patients through treatment to health.

Newby shared the documents with STAT, hoping that an independent report would be made.

 

Did Lyme Create Witches?

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October is historically the season of crunchy leaves, less day light, and a certain fascination with the macabre due to the celebration of Halloween or Allhallowtide, a time of remembering the dead. The stores are filled to the brim with skeletons, spider webs, orange lights, and the witch.

Our fascination with witches is an old one and we have our own history of witchcraft hysteria emanating from the East Coast in the late 1600s when a group of young girls claimed to be possessed by the devil and accused many local women of witchcraft. Hangings ensued, properties possessed, with the fervor finally concluding after 150 men, women, and children were accused.

What in the world happened?

M.M. Drymon in her book, Disguised As The Devil, theorizes the unfortunate history of witches could have been caused by borrelia, a spirochetal infection, more commonly known as Lyme Disease.

Drymon, a historian and Lyme sufferer, makes a convincing case when she describes the details of the cases and symptoms of witches which include: lameness, photophobia, an argumentative, difficult, and anti-social personality, memory problems, confusion/hallucinations, poor word choice and difficulty with speaking, mixing up of words – such as an inability to recite the Lord’s Prayer, as well as numbness, and increased spontaneous abortion rates – all of which are common symptoms for Lyme Disease.

A physician of the time, John Cotta, was bewildered that the seemingly innocent voluntarily confessed to being witches. He believed they had some illness that caused delusions, thereby deceiving themselves. Lyme Disease when it has entered the Central Nervous System and infects the brain, can cause delusions, nightmares, insomnia, memory loss, rage, depression, and many other cognitive issues.

The author also draws a connection that many of the accused had red-hair. Evidently redheads have cells with a dysfunctional MC1R gene, which causes sensitivity to pain – particularly thermal pain, and she feels this made for a better show when witches were burned at the stake. Lyme sufferers have discovered through genetic testing that many have faulty mutations in their genes, particularly an inability to detoxify.

Drymon painstakingly went through ancient records and discovered that the colonists suffered with a disease of the forest edge. A number of things added up to a perfect storm including the practice of pasturing cows and horses in the woods, exposing them to ticks, as well as the practice of bringing into the home straw, eelgrass, and corn husks for bedding. Animal pelts from this time period and preserved in modern museums have been found to be infected with borrelia.

She also notes a connection with human health in the early 1600s, before the witchcraft fiasco, when pigs commonly occupied the area between forest and cleared land. Pigs notoriously dig through the dirt looking for food which would have upset leaf litter exposing tick eggs to freezing temperatures as well as pushing the deer population further away. Archeological work showed 371 bones from pigs reflecting pathologies consistent with Lyme Disease, demonstrating that in the earlier part of colonial settlement, the pigs were the ones who took the brunt of the infection, sparing the colonists, but it wasn’t to last. Gradually, domestic pigs were fenced in the farmyard.

Colonists also burned off the ground, typically in the winter or early spring, which would have helped bring the tick population down; however, for the crucial years (1690-1691) in relation to the witchcraft proceedings, it was probably neglected as it was a male chore and many of the men were off to the Quebec invasion as well as the fact it was a drought year making fires hazardous.

Also, 1690 was a “mast bonanza year,” causing mice, deer, and other acorn eating lovers to come closer to settlers’ homes.  https://daily.jstor.org/can-the-acorn-crop-predictlymedisease/utm_campaign=sep+23+rawlsmd+newsletter%3A+Future+Diagnosis+%26+Treatment+no+rk+%28JsiThf%29&utm_medium=email&_ke=YWNhc2htYW5AY2hhcnRlci5uZXQ%3D&utm_source=All+Restore+Purchasers+  In this link, it is explained that this abundance of acorns attracts deer into oak stands in autumn and white-footed mice and eastern chipmunks the following summer – both top host choices for black-legged ticks.  Adult ticks mate on the deer in the fall and lay eggs on the ground in spring, which turn to larval ticks in summer.  These feed on mice and shipments attracted to the acorns as well as small birds.  The following year, infected nymphs may land on human hosts, transmitting the disease.  The following year, adult ticks can feed on deer and humans.

She claims a drought starting in 1681 until 1692 would also have brought tick carrying animals closer to water sources, where settlers would also frequent. The years of witchcraft hysteria were tough and stressful years due to war.  Salem absorbed refugees from Maine, such as Mercy Lewis and Sarah Churchill.  Stress is an important factor with health, particularly with Lyme Disease, and has been known to activate dormant spirochetes in birds.

By late 1691 an increasing number of afflicted people were recorded, many of them women who all wore long skirts. According to Drymon, these skirts worked much like the current method of tick dragging. These skirts were also commonly pulled over the head for warmth and protection from rain, bringing ticks closer to the head, creating a higher risk for neurological symptoms. They were often made from wool derived from sheep which also attract ticks.

History records marks on the skin.

So called devil’s marks and witches teats, which were circular rashes similar to the bulls-eye rash in LD, were found on the accused. The Goodwin children had red streaks on their bodies. Current science shows Bartonella, a common co-infection, to cause this type of streaking.

A few of the afflicted died while others seemingly recovered; however, some were mentally ill the rest of their lives, and some developed a chronic form of disease and continually suffered. This also happens with Lyme.

Shortly after the 1692 charter, the witchcraft hysteria ended and the colonial government voted to financially compensate victims. Official apologies followed, including the one given by the governor of the Commonwealth of Massachusetts in 1992.

Drymon aptly points out that in one party systems like the theocracy of early Massachusetts, the party represents the interests of the state as a whole with no representation for sub-state level groups, a situation that Lyme patients currently find themselves in due to the CDC’s one-party line preference in regard to the diagnosis and treatment of LD. The structure, Drymon contends, is backed by a firm belief in the “theology” of accepted science, derived predominately from those within the CDC, who ignore the worldwide science. The establishment opposes ANY criticism with demeaning labels such as Lyme cult, Lyme counterculture, Quacks, and imaginary affliction. This closed loop establishment “burns at the stake” doctors who treat people with the chronic form of Lyme by accusing them of medical misconduct, forcing patients to stop treatment until they can find someone else who dares to treat them, which furthers human suffering and offers no platform to speak or for recourse.  These accused doctors have incredible stress placed upon them as well as huge legal fees to prove their innocence against a system that states chronic Lyme Disease doesn’t exist, despite worldwide science proving otherwise.  Lyme patients and their doctors are victims like the accused witches in colonial times.

If ever there was a quagmire in medical history, this is it.

I predict that one day, similarly to in Massachusetts, there will be official apologies. It just may take 300 years.

 

Chlamydia-Like Organisms Found in Ticks

http://www.mdpi.com/2076-2607/4/3/28/pdf

There are currently nine families in the order Chlamydiales. Most are familiar with the family that includes trachomatis (the most commonly reported STD) and C. pneumonia (spreads by air). The other eight families are Chlamydia-Like Organisma (CLO’s). Many of these CLO’s are found in environmental samples such as water, soil, and various animals including mammals, reptiles, fish and our common enemy, the tick, along with other arthropods.

Scientists do not yet understand how this affects human health; however, associations have been made between CLO’s and tubal factor infertility, adverse pregnancy outcome, lower respiratory tract infections, and pneumonia.

The following abstract shows that ticks can carry CLO’s as well as borrelia (the causative agent of Lyme Disease), Babesia, Bartonella, Anaplasma, B. miyamotoi, tick-borne encephalitis, Mycoplasma, and more.
http://doi.org/10.3390/microorganisms4030028

Abstract
Ticks carry several human pathogenic microbes including Borreliae and Flavivirus causing tick-born encephalitis. Ticks can also carry DNA of Chlamydia-like organisms (CLOs). The purpose of this study was to investigate the occurrence of CLOs in ticks and skin biopsies taken from individuals with suspected tick bite.

DNA from CLOs was detected by pan-Chlamydiales-PCR in 40% of adult ticks from southwestern Finland. The estimated minimal infection rate for nymphs and larvae (studied in pools) was 6% and 2%, respectively. For the first time, we show CLO DNA also in human skin as 68% of all skin biopsies studied contained CLO DNA as determined through pan-Chlamydiales-PCR.

Sequence analyses based on the 16S rRNA gene fragment indicated that the sequences detected in ticks were heterogeneous, representing various CLO families; whereas the majority of the sequences from human skin remained “unclassified Chlamydiales” and might represent a new family-level lineage. CLO sequences detected in four skin biopsies were most closely related to “uncultured Chlamydial bacterium clones from Ixodes ricinus ticks” and two of them were very similar to CLO sequences from Finnish ticks.

These results suggest that CLO DNA is present in human skin; ticks carry CLOs and could potentially transmit CLOs to humans.

Two other studies have come to the same conclusion: that there exists a high prevalence and diversity of Chlamydiales DNA in ticks and the very real possibility of human infection.  https://www.ncbi.nlm.nih.gov/pubmed/24698831 and https://www.ncbi.nlm.nih.gov/pubmed/26386066

All of this continues to demonstrate why Lyme Disease isn’t typically just Lyme Disease but MSIDS, multi systemic infectious disease syndrome, a literal menagerie of pathogens invading the human host making our cases extremely complex and difficult.

Worth mentioning again is the fact spirochetes have been detected in semen and vaginal secretions demonstrating that MSIDS is an STD and can be passed congenitally.

http://afmr.org/Western/
These narratives substantiate a study presented at the annual Western Regional Meeting of the American Federation for Medical Research, with an abstract published in the January issue of the Journal of Investigative Medicine, in which researchers tested semen samples and vaginal secretions from three groups: controls without evidence of Lyme, random subjects who tested positive for Lyme, and married heterosexual couples engaging in unprotected sex who tested positive for Lyme. The results were clear: all of the controls tested negative in semen and vaginal secretions. All women with Lyme tested positive in vaginal secretions, while about half of the men tested positive in semen. One of the heterosexual couples showed identical strains. Internist Raphael Stricker stated, “There is always some risk of getting Lyme Disease from a tickbite in the woods, but there may be a bigger risk of getting Lyme Disease in the bedroom.” Reference: The Journal of Investigative Medicine 2014;62:280-281.

http://www.scientificamerican.com/article/mothers-may-pass-lyme-disease-to-children-in-the-womb/
“Scientists have long suspected, however, that the spiral-shaped Lyme bacteria, Borrelia burgoferi, can be passed gestationally, since other “spirochetes” – most notably the syphilis bacteria – are known to be transmitted in the womb, causing a range of birth defects.”

The Role of Birds in Tickborne Illness

http://link.springer.com/article/10.1007%2Fs00442-016-3731-1

Abstract
Birds play a central role in the ecology of tick-borne pathogens. They expand tick populations and pathogens across vast distances and serve as reservoirs that maintain and amplify transmission locally. Research into the role of birds for supporting ticks and tick-borne pathogens has largely been descriptive and focused in small areas. To expand inference beyond these studies, we conducted a quantitative review at the scale of North America to identify avian life history correlates of tick infestation and pathogen prevalence, calculate species-level indices of importance for carrying ticks, and identify research gaps limiting understanding of tick-borne pathogen transmission. Across studies, 78 of 162 bird species harbored ticks, yielding an infestation prevalence of 1981 of 38,929 birds (5.1 %). Avian foraging and migratory strategies interacted to influence infestation. Ground-foraging species, especially non-migratory ground foragers, were disproportionately likely to have high prevalence and intensity of tick infestation. Studies largely focused on Borrelia burgdorferi, the agent of Lyme disease, and non-migratory ground foragers were especially likely to carry B. burgdorferi-infected ticks, a finding that highlights the potential importance of resident birds in local pathogen transmission. Based on infestation indices, all “super-carrier” bird species were passerines. Vast interior areas of North America, many bird and tick species, and most tick-borne pathogens, remain understudied, and research is needed to address these gaps. More studies are needed that quantify tick host preferences, host competence, and spatiotemporal variation in pathogen prevalence and vector and host abundance. This information is crucial for predicting pathogen transmission dynamics under future global change.

A 2015 study in Northern California showed 57 of 100 birds that carried ticks were infected with borrelia, the causative agent of Lyme Disease.

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