Archive for the ‘Supplements’ Category

Cancer Metabolism as a Therapeutic Target and Review of Interventions

https://www.mdpi.com/2072-6643/15/19/4245

Cancer Metabolism as a Therapeutic Target and Review of Interventions

by 1,2, 3,4,5 and 6,*
*Author to whom correspondence should be addressed.
Nutrients 2023, 15(19), 4245; https://doi.org/10.3390/nu15194245
Received: 28 August 2023 / Revised: 20 September 2023 / Accepted: 26 September 2023 / Published: 1 October 2023
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Dietary Patterns and Cancer)

Abstract

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to target cancers metabolically by depriving them of glucose. In addition to dietary and lifestyle modifications which work on tumors metabolically, there are a panoply of nutritional supplements and repurposed drugs associated with cancer prevention and better treatment outcomes. These interventions and their evidentiary basis are covered in the latter half of this review to guide future cancer treatment.
nutrients-15-04245  pdf of the study
(See link for article)
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SUMMARY:
  1. Glucose management: low carb, high fat, ketogenic diet
  2. Modified time restricted eating
  3. Exercise: aerobic and resistance training, stress reduction/sleep
  4. 20,000-50,000 IU D3 daily
  5. 1mg and increase to 20-30mg at night extended/slow release
  6. Green tea catechins – 500-100mg daily
  7. Metformin 1,000mg 2X/day
  8. Curcumin 600mg daily
  9. Mebendazole 100-200mg daily
  10. Omega 3 fatty acids 2-4g/day
  11. Berberine 100-1500mg or 500-600mg 2-3X/day
  12. Atorvastatin 40mg 2X/day
  13. Disulfiram 80mg 3Xday or 500mg once a day
  14. Cimetidine 400-800 mg 2X/day
  15. Mistletoe given SubQ by doctor
  16. Ashwaganda 2g/day during chemotherapy
  17. Sildenafil 20mg/day
  18. Itraconazoe 400-600mg/day

There is now a spate of cancer following the rollout of the COVID shots.  Lyme/MSIDS patients are already at a higher cancer risk.  Talk about these interventions with your doctor.

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Activism, Cancer, research, Supplements, Treatment

FREE: Ross Lyme Support Protocol

https://s3.amazonaws.com/hoth.bizango/assets/24360/Ross_Lyme_Support_Protocol.pdf  Protocol Here

The Ross Lyme Support Protocol

By Dr. Marty Ross

The Ross Lyme Support Protocol includes essential steps to begin and continue a chronic Lyme disease treatment. It is designed to:

● boost the immune system

● improve detoxification

● speed recovery

● kill the infection(s)

● protect and repair from the harmful effects of the infection(s) and the herbal or prescription antibiotics.

While the following Lyme disease treatment approach focuses on a limited number of areas, it may correct most of the problems, such as: low energy, pain, insomnia, brain, neurologic, and thinking problems (brain fog), and immune compromise and suppression.

Table of Key Supplements and Herbs in The Core Protocol

What’s New: Ross Protocol 3rd Edition

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Detoxing, Gut Health, Herbs, Inflammation, Lyme, Sleep, Supplements, Treatment

Study: Oral NAD+ & NMN Increases Intracellular NAD+ & Lowers Triglycerides

https://www.townsendletter.com/e-letter-17-nad_plus-supplementation-and-cellular-energy/

Case Study: Oral Supplementation with the NAD+ Precursor Nicotinamide Mononucleotide (NMN)—Effects on Intracellular NAD+ and Triglycerides.

Alan Miller, ND

Abstract

NAD+ is a coenzyme that is essential in numerous metabolic reactions, the most important involving energy production. In the cellular respiration process, NAD+ is required for the production of ATP (adenosine triphosphate), the primary energy currency of cells. NAD+ transfers electrons from molecules including glucose during glycolysis and the citric acid cycle. These electrons are then transferred to the electron transfer chain, where NAD+ acts as an essential mediator in energy production, ensuring the efficient functioning of cells. NAD+ is also critically involved in DNA repair and healthy aging sirtuin enzymes.

Nicotinamide Mononucleotide (NMN) is the most direct biochemical precursor to NAD+ and thus supplementation of this molecule is an efficient method of increasing intracellular NAD+, which can improve cellular energetics and markers of aging. NMN may also lower triglycerides. In a study of intravenous dosing of 300 mg NMN in 10 healthy individuals, researchers discovered a significant reduction in serum triglycerides.

One concern with NMN is that when taken in an oral dose this molecule might be damaged or otherwise metabolized by stomach acid, pancreatic enzymes, or first pass hepatic enzymes. In other studies, we have shown that a liposomal powder preparation can protect other molecules, such as glutathione, from this type of degradation and significantly increase blood levels of the whole molecule.

We performed a small case study in which individuals were given 1000 mg of an oral liposomal NMN preparation (powder in a capsule) once after a baseline blood test. Serial triglyceride tests were performed hourly for five hours. Participants had an average of 15% decrease in triglycerides at hour five, compared to baseline. Another group was tested at baseline for intracellular NAD+ (Jinfinity Labs), then was given 1000 mg of a liposomal powder NMN daily for 15 days. An intracellular NAD+ test was then performed after 15 days. NAD+ levels increased 100 percent over this period.

This is the first case series that has demonstrated a rapid triglyceride-lowering effect of oral liposomal NMN (over 5 hours), along with a 100-percent increase in intracellular NAD+ over a 15-day period.

(See link for full article)

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Heart Issues, research, Supplements, Testing, Treatment

The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

https://www.mdpi.com/2076-2607/11/7/1759

The Use of Natural Bioactive Nutraceuticals in the Management of Tick-Borne Illnesses

By Samuel M. Shor and Sunjya K. Schweig

Microorganisms 2023, 11(7), 1759; https://doi.org/10.3390/microorganisms11071759
Received: 14 May 2023 / Revised: 29 June 2023 / Accepted: 29 June 2023 / Published: 5 July 2023

Abstract

The primary objective of this paper is to provide an evidence-based update of the literature on the use of bioactive phytochemicals, nutraceuticals, and micronutrients (dietary supplements that provide health benefits beyond their nutritional value) in the management of persistent cases of Borrelia burgdorferi infection (Lyme disease) and two other tick-borne pathogens, Babesia and Bartonella species. Recent studies have advanced our understanding of the pathophysiology and mechanisms of persistent infections. These advances have increasingly enabled clinicians and patients to utilize a wider set of options to manage these frequently disabling conditions. This broader toolkit holds the promise of simultaneously improving treatment outcomes and helping to decrease our reliance on the long-term use of pharmaceutical antimicrobials and antibiotics in the treatment of tick-borne pathogens such as Borrelia burgdorferi, Babesia, and Bartonella.  (See link for full article)
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Go here for an excellent article on the above study which breaks it down for the lay person.  The following graph is within the article and will interest you:

For a full list of all 30+ bioactive nutraceuticals, see Appendix A. Summary of Clinical Impact.

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Babesia, Bartonella, Herbs, Lyme, research, Supplements, Treatment

Baseline Protocol for Long-COVID & “Vaccine” Injury Syndromes

https://www.jpands.org/vol28no3/mccullough.pdf  Paper Here

Clinical Rational for SARS-SoV-2 Base Spike Protein Detoxification in Post COVID-19 and Vaccine Injury Syndromes

Publication of Baseline Protocol for Those Suffering from Long-COVID and Post-Acute Sequelae after COVID-19 Vaccination

Peter A. McCullough, M.D., H.P.H., Cade Wynn, Brian C. Procter, M.D.

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Detoxing, Herbs, research, Supplements, Treatment, vaccines, Viruses