Archive for the ‘Lyme’ Category

Lyme Can’t Kill You? – Yeah Right

 Approx. 4 Min.

Dr. Alan Macdonald held the presentation”Human Borrelia Deaths, Autopsy studies, and Chronic Morbidities” at the NorVect conference 2014.

He did autopsies on 123 patients with borrelia infections as the cause of death.

 

 

Line Immunoblot Assay for Tick-Borne Relapsing Fever and Findings in Patient Sera From Australia, Ukraine, & the USA

https://www.mdpi.com/2227-9032/7/4/121

Line Immunoblot Assay for Tick-Borne Relapsing Fever and Findings in Patient Sera from Australia, Ukraine and the USA

Healthcare 2019, 7(4), 121; https://doi.org/10.3390/healthcare7040121
Received: 11 July 2019 / Revised: 25 September 2019 / Accepted: 16 October 2019 / Published: 21 October 2019
(This article belongs to the Special Issue Lyme Disease and Related Tickborne Infections)
Tick-borne relapsing fever (TBRF) is caused by spirochete bacteria of the genus Borrelia termed relapsing fever Borreliae (RFB). TBRF shares symptoms with Lyme disease (LD) caused by related Lyme disease Borreliae (LDB). TBRF and LD are transmitted by ticks and occur in overlapping localities worldwide. Serological detection of antibodies used for laboratory confirmation of LD is not established for TBRF. A line immunoblot assay using recombinant proteins from different RFB species, termed TBRF IB, was developed and its diagnostic utility investigated. The TBRF IBs were able to differentiate between antibodies to RFB and LDB and had estimated sensitivity, specificity, and positive and negative predictive values of 70.5%, 99.5%, 97.3%, and 93.4%, respectively, based on results with reference sera from patients known to be positive and negative for TBRF. The use of TBRF IBs and analogous immunoblots for LD to test sera of patients from Australia, Ukraine, and the USA with LD symptoms revealed infection with TBRF alone, LD alone, and both TBRF and LD. Diagnosis by clinical criteria alone can, therefore, underestimate the incidence of TBRF. TBRF IBs will be useful for laboratory confirmation of TBRF and understanding its epidemiology worldwide. View Full-Text
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Parenting When Children Have Lyme Disease: Fear, Frustration, Advocacy

https://www.mdpi.com/2227-9032/7/3/95

Parenting When Children Have Lyme Disease: Fear, Frustration, Advocacy

Received: 30 June 2019 / Revised: 1 August 2019 / Accepted: 3 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue Lyme Disease and Related Tickborne Infections)
Increasing numbers of Canadians, including children and adolescents, are being infected with Borrelia burgdorferi and contracting Lyme disease. In the present study, we provided a qualitative analysis of written correspondence produced by 23 parents of children and adolescents with Lyme disease. The goal of this study was to investigate how medical and psychological issues were highlighted by parents describing their family’s Lyme disease experiences. The results suggest a series of four stages in these families where satisfactory treatment had not been obtained over months or years.
The experiences of parents evolved from feelings of worry for the child to frustration with the lack of a helpful treatment, to mistrust of physicians’ actions, and, in some case, to a rejection of the conventional health care system as a whole. Improved diagnostic testing and treatment guidelines, as well as family-centered practices of medical care were proposed as important features for improving the experiences of families living with Lyme disease. View Full-Text
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Disulfiram Psychosis Update #2

For those of you reading my posts I’ve thought of a few other things for practitioners and patients to be aware of.

  1. The Purell Sanitizer, located in each and every hospital room was a trigger for psychosis.  Hand sanitizers are up to 60% alcohol – a no, no for those using Disulfiram/Antabuse. I could smell the nurses a mile away. I also learned from a nurse that Purell is killing nurses due to liver toxicity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954566/“Based upon an average of 30 hand rubbings per healthcare professional per day, it can be assumed that a healthcare worker may be exposed to a maximum 5,500 mg/m3 per work shift, five times above the recommended occupational time weighted average limit. Thus, in order to answer the question posed in the title, studies on spatial and temporal variability of alcohol emission from ABHRs in real world situations and studies on certain high risk individuals are needed.”
    According to the FDA says hand sanitizers are contributing to superbugs such as MRSA. Also, Triclosan degrades to dioxins in the body which are also toxic. A 2014 study  found that triclosans spurred the growth of breast cancer cells, and another study found they can kill brain cells. Other studies have found it interferes with hormones.  https://www.newsmax.com/health/Headline/illness-washing-hands-sanitizers/2014/12/23/id/614647/  This entire issue was ameliorated by having a sign placed outside my room so those coming in would either use soap and water or gloves when entering.
  2. Certain flowers also set me off.  I’m afraid I can’t tell you which ones but if anyone else suffers from a toxic reaction to disulfiram, keep all plants out of the room.

When I say “set me off,” these items would cause me to have a psychotic episode – even when I was nearly being discharged. All it took was a flower delivery person who had used Purell and I about had to stay longer in the hospital.

For more: https://madisonarealymesupportgroup.com/2019/10/14/november-2019-lyme-support-meeting-oct-meeting-canceled-due-to-reaction-to-disulfiram/

https://madisonarealymesupportgroup.com/2019/10/15/disulfiram-psychosis-update/

 

 

Researchers Conclude Asian Longhorned Tick Contributes Minimally to Lyme Disease in the U.S.

https://www.sciencedirect.com/science/article/pii/S1877959X19303498

Original article

Failure of the Asian longhorned tick, Haemaphysalis longicornis, to serve as an experimental vector of the Lyme disease spirochete, Borrelia burgdorferi sensu stricto

Under a Creative Commons licenseopen access

Abstract

The invasive, human-biting Asian longhorned tick, Haemaphysalis longicornis, was detected in New Jersey in the eastern United States in August of 2017 and by November of 2018 this tick had been recorded from 45 counties across 9 states, primarily along the Eastern Seaboard. The establishment of H. longicornis in the United States has raised the questions of how commonly it will bite humans and which native pathogens may naturally infect this tick. There also is a need for experimental vector competence studies with native pathogens to determine if H. longicornis can acquire a given pathogen while feeding, pass it transstadially, and then transmit the pathogen in the next life stage.

In this experimental study, we evaluated the vector competence of a population of H. longicornis originating from the United States (New York) for a native isolate (B31) of the Lyme disease spirochete, Borrelia burgdorferi sensu stricto (s.s.).

In agreement with a previous experimental study on the vector competence of H. longicornis for Borrelia garinii, we found that uninfected H. longicornis larvae could acquire B. burgdorferi s.s. while feeding on infected Mus musculus mice (infection prevalence >50% in freshly fed larvae) but that the infection was lost during the molt to the nymphal stage. None of 520 tested molted nymphs were found to be infected, indicating that transstadial passage of B. burgdorferi s.s. is absent or rare in H. longicornis; and based on the potential error associated with the number of nymphs testing negative in this study, we estimate that the upper 95% limit for infection prevalence was 0.73%.

An Ixodes scapularis process control showed both effective acquisition of B. burgdorferi s.s. from infected mice by uninfected larvae and transstadial passage to the nymphal stage (infection prevalence of 80–82% for both freshly fed larvae and molted nymphs). We also observed that although H. longicornis larvae could be compelled to feed on mice by placing the ticks within feeding capsules, attachment and feeding success was minimal (<0.5%) when larvae were placed freely on the fur of the mice.

We conclude that H. longicornis is unlikely to contribute more than minimally, if at all, to transmission of Lyme disease spirochetes in the United States.

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**Comment**

Transmission can still happen and if you are the sorry sucker it happens to – it makes all the difference in the world.  Here’s the deal – ticks are not your friends. Take each and every tick bite as seriously as a heart attack.  Little is known about the Asian Longhorned tick but in Asia it’s bite KILLS 15% of those whom contract it. Don’t take this lightly.

https://madisonarealymesupportgroup.com/2019/06/09/first-us-human-bite-from-worrying-longhorned-tick-noted-but-its-actually-the-second-human-bite/

Excerpt:

Several other human pathogens have been detected in the ticks, but it’s not clear the Asian longhorned species are able to transmit them to humans. They include Anaplasma, Ehrlichia, Rickettsia, and Borreliaspecies. Lyme disease is caused by Borrelia burgdorferi bacteria.

She warned that the organisms are present in states where longhorned ticks have been found and that it’s possible that the tick—known to be an aggressive biter—might be able to transmit Heartland virus, given its close relationship to SFTS virus.

Pritt said it’s clear that the invasive species is here to stay for the foreseeable future, and next steps should include public awareness campaigns that incorporate the new information, easy-to-use resources for labs to identify the tick, and more research to understand the implications of the new findings.

For a great read on this aggressive biter which can clone itself and is found in sunny open locations:   https://madisonarealymesupportgroup.com/2018/09/12/three-surprising-things-i-learned-about-asian-longhorned-ticks-the-tick-guy-tom-mather/.  This picture demonstrates how if you brush against a blade of grass a literal cluster bomb of ticks explodes onto you.  To downplay this is really short sighted.three_surprising_4.png-2