Archive for the ‘Heart Issues’ Category

Borrelia Antibodies Found in Patients With Coronary Heart Disease & Case Report on Lyme Presenting as Complete Heart Block

https://danielcameronmd.com/borrelia-antibodies-found-in-patients-with-coronary-heart-disease/

BORRELIA ANTIBODIES FOUND IN PATIENTS WITH CORONARY HEART DISEASE

borrelia-antibodies-coronary-heart-disease

Borrelia burgdorferi, the causative agent of Lyme disease, can be associated with cardiovascular complications. This is known as Lyme carditis, and occurs when the spirochete bacteria penetrate the heart tissue. The infection can lead to heart block and other complications, as it disrupts the heart’s electrical signals.

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How many patients who underwent surgery for coronary heart disease (CHD) had evidence of a prior infection with Borrelia burgdorferi (the bacterium which causes Lyme disease)?

A study by Pietruszka and colleagues, “Serologic Status of Borrelia burgdorferi sensu lato in Patients with Cardiovascular Changes,” sought to answer that question.¹ The authors examined the level of anti-Borrelia burgdorferi IgG antibodies in the blood serum of patients with advanced coronary heart disease.

The study participants included 70 patients – 22 women and 48 men – between the ages 50-82, who required surgery for coronary artery disease. An ELISA test for Lyme disease was positive in 34% of these patients and ‘borderline’ in 17% of patients.

The study found, “more than a third of the patients had elevated IgG levels against Borrelia as detected by a screening test, indicating previous contact with spirochetes,” the authors wrote.

These individuals were asked whether they had noticed a tick bite during their lifetime and if they ever exhibited typical Lyme disease symptoms.

Borrelia burgdorferi, the causative agent of Lyme disease, can be associated with cardiovascular complications.

More than half (57%) had recalled a tick bite but had not been diagnosed or treated for Lyme disease. The majority (85%) did not notice an erythema migrans rash.

“We found a link between antibody levels and tick bites but not with other risk factors for the development of CHD,” the authors wrote.

“These findings support the idea that, as one of many factors, the contact with spirochetal antigens may indicate a potential positive correlation with the formation of cardiovascular changes,” they added.

“… infectious agents such as Borrelia burgdorferi sensu lato spirochetes, which cause Lyme disease, may also play a role in the development of cardiovascular disease.”

Cardiac complications due to Lyme disease typically occur a few weeks to a few months after infection, the authors point out. Symptoms include loss of consciousness, dizziness, palpitations, chest pain, and shortness of breath.

“The most common symptoms are conduction disorders (which manifest as various degrees of heart block), atrial fibrillation (AFib), and tachycardia,” the authors wrote.

Additionally, an infection with B. burgdorferi may “lead to changes in arteries, and CAD as a result,” the authors point out. Astherosclerosis, an inflammatory condition, is associated with a build-up of plaque in the arteries.

Plaques have been found to include a variety of bacteria. One study concluded “that exposure to infectious pathogens such as spirochetes increases the risk of atherosclerosis in tick-endemic areas.”

References:
  1. Pietruszka K, Reagan F, Stążka J, Kozioł MM. Serologic Status of Borrelia burgdorferi sensu lato in Patients with Cardiovascular Changes. International Journal of Environmental Research and Public Health. 2023; 20(3):2239. https://doi.org/10.3390/ijerph20032239

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https://www.sciencedirect.com/science/article/pii/S2214250923001233?via%3Dihub

Lyme disease presenting as complete heart block in a young man: Case report and review of pathogenesis

https://doi.org/10.1016/j.idcr.2023.e01799Get rights and content
Under a Creative Commons license
open access

Abstract

Lyme carditis is a serious complication of Lyme disease, the most common vector-borne infection in both the United States and Northern Europe. It is a rare manifestation of Lyme disease that primarily affects young adults with a marked 3:1 male-to-female predominance. The presentation of Lyme carditis is heterogenous and often non-specific, although the most common clinical manifestation is AV block, which can be acute in onset and can rapidly progress to complete heart block. We discuss the case of a young adult male with complete heart block as a complication of Lyme infection, presenting with two episodes of syncope without prodromal symptoms months after tick bites. There are several pathogen, host and environmental factors that can play an important role in the epidemiology and pathogenesis of this serious condition that is reversible if treated in a timely manner. It is important for clinicians to be familiar with the presentation and treatment of this infection that is now being observed in a wider geographic distribution so as to avoid serious long-term complications and unnecessary permanent pacemaking implantation.

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**Comment**

The ‘powers that be’ continue to state that these manifestations are ‘rare’ when testing, which has a sordid history, misses over 70% of all cases, leaving a majority of patients undiagnosed and untreated.

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Category:

Heart Issues, Lyme, research, Testing, Ticks

Study: Oral NAD+ & NMN Increases Intracellular NAD+ & Lowers Triglycerides

https://www.townsendletter.com/e-letter-17-nad_plus-supplementation-and-cellular-energy/

Case Study: Oral Supplementation with the NAD+ Precursor Nicotinamide Mononucleotide (NMN)—Effects on Intracellular NAD+ and Triglycerides.

Alan Miller, ND

Abstract

NAD+ is a coenzyme that is essential in numerous metabolic reactions, the most important involving energy production. In the cellular respiration process, NAD+ is required for the production of ATP (adenosine triphosphate), the primary energy currency of cells. NAD+ transfers electrons from molecules including glucose during glycolysis and the citric acid cycle. These electrons are then transferred to the electron transfer chain, where NAD+ acts as an essential mediator in energy production, ensuring the efficient functioning of cells. NAD+ is also critically involved in DNA repair and healthy aging sirtuin enzymes.

Nicotinamide Mononucleotide (NMN) is the most direct biochemical precursor to NAD+ and thus supplementation of this molecule is an efficient method of increasing intracellular NAD+, which can improve cellular energetics and markers of aging. NMN may also lower triglycerides. In a study of intravenous dosing of 300 mg NMN in 10 healthy individuals, researchers discovered a significant reduction in serum triglycerides.

One concern with NMN is that when taken in an oral dose this molecule might be damaged or otherwise metabolized by stomach acid, pancreatic enzymes, or first pass hepatic enzymes. In other studies, we have shown that a liposomal powder preparation can protect other molecules, such as glutathione, from this type of degradation and significantly increase blood levels of the whole molecule.

We performed a small case study in which individuals were given 1000 mg of an oral liposomal NMN preparation (powder in a capsule) once after a baseline blood test. Serial triglyceride tests were performed hourly for five hours. Participants had an average of 15% decrease in triglycerides at hour five, compared to baseline. Another group was tested at baseline for intracellular NAD+ (Jinfinity Labs), then was given 1000 mg of a liposomal powder NMN daily for 15 days. An intracellular NAD+ test was then performed after 15 days. NAD+ levels increased 100 percent over this period.

This is the first case series that has demonstrated a rapid triglyceride-lowering effect of oral liposomal NMN (over 5 hours), along with a 100-percent increase in intracellular NAD+ over a 15-day period.

(See link for full article)

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Category:

Heart Issues, research, Supplements, Testing, Treatment

The Real Shot in the Dark: New Strain COVID Shot is Already DOA

https://www.ukcolumn.org/video/what-did-pfizer-know-a-shot-in-the-dark  Video Interview Here (Approx. 1 Hour)

What did Pfizer know? A shot in the dark

Thursday, 6th July 2023

Joining Debi Evans is an old friend of UK Column, Cheryl Grainger, a self-employed training consultant to the pharmaceutical industry. Grainger observed from very early on during the pandemic that everything she had been trained to teach others within the industry was now apparently non-applicable. Inspired by the success of a team in the USA that obtained withheld documents on the Pfizer/BioNTech Covid–19 injection, Grainger set out on a one-woman mission to follow the same model in order to obtain the AstraZeneca primary data. Her efforts haven’t stopped there.

Finding herself on the spot to ask a question at a board meeting of the British medicines regulator, the MHRA, in March 2023, she asked the Board about the agency’s Yellow Card serious adverse reaction reports. She was sharply shut down. This led her to wonder: has anyone criticised the MHRA or challenged its funding stream? How independent is the MHRA? Grainger has written two articles for UK Column: Taking on the MHRA—Part 1 and Taking on the MHRA—Part 2. In this interview, Cheryl Grainger walks us through what Pfizer knew before its Covid injection was authorised.

Debi Evans was recently joined by Dr Naomi Wolf to discuss the Pfizer papers. Dr Wolf is co-founder and CEO of the Daily Clout. Her team has published the bestseller The Pfizer Documents Analysis Volunteers’ Reports—Find out what Pfizer, FDA tried to conceal.

What did Pfizer know? In January 2023, with the help of Steve Bannon at the War Room, the Daily Clout and a team of expert volunteers from all around the world began analysing the hundreds of thousands of pages of primary Pfizer documents that had been earmarked to be hidden from public view for 75 years but that were released through successful legal action taken by US lawyer Aaron Siri.

The Pfizer papers can be found here. With 74 reports now in from experts around the world, Cheryl Grainger explains in this interview what their findings mean. What did Pfizer know about the effects on children, pregnant mothers and fertility? What did they know about the dangers to babies? Is shedding real, and if so, how does it happen? The interview covers the meaning of P1 and P2, how the clinical trials were conducted, and why the Pfizer Covid injection has been called a bait-and-switch in the USA.  (See link for article and video)

https://petermcculloughmd.substack.com/p/fda-vrbpac-hopelessly-chasing-outgoing?

FDA VRBPAC Hopelessly Chasing Outgoing XBB.1.5 as Fall Target

Strain is 27% and Shrinking Fast–New Vaccine will be Obsolete on Arrival

PETER MCCULLOUGH, MD
JUL 14, 2023

By Peter A. McCullough, MD, MPH

From Rita Rubin, Science Reporter for JAMA: “On June 15, members of the US Food and Drug Administration’s (FDA) Vaccine and Related Biological Products Advisory Committee (VRBPAC) voted unanimously to recommend updating the COVID-19 vaccine composition to a monovalent XBB lineage.

On June 16, the FDA announced that it had advised manufacturers planning to update their COVID-19 vaccines that they should specifically target XBB.1.5. Scientists from Moderna, Novavax, and Pfizer had told the FDA and its advisory committee that their XBB.1.5 monovalent vaccines could be ready to inject into arms by late July or early fall.

Although the FDA decides what antigens the COVID-19 vaccines should include, the US Centers for Disease Control and Prevention (CDC) is responsible for deciding who should get them and when. As soon as the FDA greenlights an XBB.1.5 vaccine, “I’m sure the ACIP will have a specially called meeting” to decide how it should be used, William Schaffner, MD, chair of the department of preventive medicine at the Vanderbilt University School of Medicine, said in an interview.

ACIP stands for the CDC’s Advisory Committee on Immunization Practices, on which Schaffner serves as the liaison representing the National Foundation for Infectious Diseases, where he is medical director. At the ACIP meeting on an XBB.1.5 vaccine, “I think there will be a rather elaborate discussion on who will receive this vaccine,” Schaffner predicted.”  (See link for article)

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Category:

Activism, Heart Issues, vaccines, Viruses

Young Adults Most At-Risk for Lyme Carditis

https://danielcameronmd.com/young-adults-most-at-risk-for-lyme-carditis/

YOUNG ADULTS MOST AT-RISK FOR LYME CARDITIS

young-adult-lyme-carditis

Cardiac involvement is a rare complication of Lyme disease. But it is estimated that up to 10% of patients in the U.S. with untreated Lyme disease go on to develop Lyme carditis, according to the authors of a recent study. And, young adults are most at-risk.

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Lyme carditis often presents with non-specific symptoms, such as lightheadedness, syncope, dyspnea, palpitations, and chest pain, the authors explain. While an estimated 30% of patients exhibit no symptoms.

The most common clinical manifestation “is AV block, which can be acute in onset and can rapidly progress to complete heart block,” writes Carnazzo.

In their article, “Lyme disease presenting as complete heart block in a young man: Case report and review of pathogenesis,” Carnazzo et al. discuss the case of a young man with complete heart block as a complication of Lyme disease, who presented with symptoms months after several tick bites.¹

Interestingly, young adults, particularly males, are most at-risk for developing Lyme carditis, the authors point out.

“Clinical suspicion for Lyme carditis should be high for young patients with unexplained high grade heart block, particularly in Lyme disease endemic areas.”

Their case report describes a 37-year-old man who lived in northwestern Wisconsin. He presented to the emergency department with two episodes of syncope without prodromal symptoms which had occurred over a 5-day period.

“During these days, he had increasingly frequent episodes of dizziness and near-syncope,” writes Carnazzo.

“He also reported fever, chills, muscle aches, and bilateral lower extremity erythematous rash that had developed 3 weeks earlier that had resolved by the time of presentation.”

Two months before his symptoms began, the patient had removed several ticks from his left thigh and groin.

“Lyme carditis can be difficult to recognize in cases where classic signs of Lyme disease are not obvious upon patient presentation and EM rash or tick bite difficult to recall.”

An electrocardiogram (ECG) revealed complete heart block, so a temporary pacemaker was inserted.

The man was diagnosed with Lyme carditis after he tested positive for B. burgdorferi on Western blot and treated successfully with IV ceftriaxone.

After 9 days, the heart block had completely resolved.

The authors conclude:

  • “It is important for clinicians to be familiar with the presentation and treatment of this infection that is now being observed in a wider geographic distribution so as to avoid serious long-term complications…”
  • “Timely diagnosis and treatment of heart block due to Lyme carditis can lead to immediate and life-saving temporary pacing during initiation of antibiotic therapy, while avoiding unnecessary permanent pacemaker placement.”
  • “Patients presenting with AV block should be asked about possible tick exposure, history of erythema migrans rash, recent travel to a high incidence Lyme disease area and other constitutional symptoms of Lyme disease like fever, fatigue, malaise, chills, muscle and joint pain.”
Related Articles:

Lyme carditis presents without typical Lyme disease symptoms

Successful removal of pacemakers for Lyme carditis

Lyme carditis causes complete heart block in 26-year-old man

References:
  1. Carnazzo MC, Scholin C, Shweta F, Calvin AD. Lyme disease presenting as complete heart block in a young man: Case report and review of pathogenesis. IDCases. 2023 May 12;32:e01799. doi: 10.1016/j.idcr.2023.e01799. PMID: 37234726; PMCID: PMC10205533.

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**Comment**

Take all percentages regarding Lyme/MSIDS with a grain of salt.  In fact, they should just stop giving them.  Since testing misses a vast majority of cases (studies have shown anywhere between 50-85% are missed), throwing percentages out is mere conjecture.  Most patients are initially mis or undiagnosed and that is a fact.  Therefore, there are probably far more cases of Lyme carditis that are not even attributed to tick-borne illness.

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And now that more than 70% have been “fully vaccinated” for COVID, the plot thickens as the clot-shots are known to cause a multitude of heart and other organ problems.

Category:

Heart Issues, Lyme, research, vaccines

Unraveling Bartonella: Dr. Mozayeni

https://www.betterhealthguy.com/episode185

Episode #185: Unraveling Bartonella with Dr. B. Robert Mozayeni, MD

 
 
About My Guest

My guest for this episode is Dr. B. Robert Mozayeni.  B. Robert Mozayeni, MD is an expert in Translational Medicine, the science and art of advancing medical science safely and efficiently.  He is the Chief Medical Officer of Galaxy Diagnostics, LLC.  He is a co-founder of the Foundation for the Study of Inflammatory Diseases.  He serves as an advisor to pharmaceutical and nutraceutical companies and serves on an Institutional Review Board specializing in nutraceutical products for pain management.  He is the immediate past President of ILADS, the International Lyme and Associated Diseases Society where his goal was to advance the science of translational medicine.  In late 2019, Dr. Mozayeni launched T Lab Inc., a research and clinical laboratory engaged in research using advanced microscopy to understand better the pathogenesis of disease in inflammatory conditions associated with persistent infections.  He has research and clinical expertise with regard to autoimmune diseases and the effects of chronic infection and inflammation on vascular physiology and neurovascular conditions seen commonly with autoimmune and neurovascular diseases.  With a strong foundation in the basic sciences and evidence-based medicine, he analyzes complex medical cases using a combination of basic scientific principles and clinical experience along with the balance of the evidence base.  Dr. Mozayeni has published numerous papers on immunology and cerebrovascular blood flow hemodynamics.  He has been actively researching and publishing his work on chronic rheumatic diseases and their relationship to persistent human Bartonella spp. infection.  Of note, chronic persistent Bartonella spp. infections are strongly associated with neurovascular diseases.  Thus, Dr. Mozayeni is uniquely qualified in the combined areas of chronic persistent endovascular infections and related rheumatological and neurovascular diseases.   He has also published papers providing new insights as to a potential infectious  (Bartonella spp.) cause of osteoarthritis and also, a case of arthritis associated with hypermobility that was likely caused by Bartonella spp.

Key Takeaways
  • What advances have been observed in recent years in the realm of Bartonella?
  • What are common symptoms of Bartonella?
  • How is Bartonella transmitted?- Might Bartonella lead to autoimmunity?
  • Can Bartonella be a trigger for PANS?
  • Might Bartonella be a contributor to osteoarthritis?
  • Is there a connection between Bartonella and hypermobility or EDS?
  • Does Bartonella contribute to MS?
  • What is the connection between Bartonella and SIBO?
  • Can Bartonella act as a trigger for MCAS?
  • Is Bartonella activation observed in those with COVID?
  • What is the state of the art in Bartonella testing?
  • What is Babesia odocoilei?
  • What agents are most helpful in the treatment of Bartonella?
  • Is there a place for herbs and other natural interventions in Bartonella treatment?
  • Should pets be considered as a potential source of exposure to Bartonella?
Connect With My Guest

http://TMGMD.com

Related Resources

Article: Unraveling the Mystery of Bartonellosis

Transcript

Go to top link for transcript, video, and audio

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Category:

Bartonella, Cancer, Eye Issues, Heart Issues, Inflammation, Psychological Aspects