Berberine induces cell death in leukemia cells – study
03/21/2019 / By Michelle Simmons
A study published in The American Journal of Chinese Medicine revealed that a compound called berberine induces cell death in leukemia cells. In this study, the subcellular localization and the apoptotic mechanisms of berberine were investigated.
- Berberine is an isoquinoline alkaloid found in medicinal plants used in traditional and folk medicines.
- In the study, researchers at Nagasaki International University in Japan first treated human promyelocytic leukemia cells with berberine, then examined its antiproliferative activity.
- Five to 15 minutes after treatment, berberine exhibited powerful antiproliferative activity in the cells.
- Then, the researchers investigated the effect of berberine on inducing cell death and found that the compound induced cell death in leukemia cells.
In conclusion, these findings suggest that berberine can induce cell death in leukemia cells immediately after administration.
Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y. BERBERINE INDUCES APOPTOTIC CELL DEATH VIA ACTIVATION OF CASPASE-3 AND -8 IN HL-60 HUMAN LEUKEMIA CELLS: NUCLEAR LOCALIZATION AND STRUCTURE–ACTIVITY RELATIONSHIPS. The American Journal of Chinese Medicine. 6 October 2017; 45(7): 1497-1511. DOI: 10.1142/S0192415X17500811
Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric. It might cause stronger heartbeats which might help heart conditions. It also helps regulate how the body uses sugar in the blood which may help with diabetes. It also might also be able to kill bacteria and reduce swelling. https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine
https://draxe.com/berberine/ According to Dr. Axe, research on berberine shows benefit for the following conditions: