Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease).
Shortly after adopting a 6-week-old cat, a veterinarian was bitten on the left index finger. Within 3 weeks, he developed headache, fever, and left axillary lymphadenopathy. Initial blood cultures from the cat and veterinarian were sterile. Repeat cultures from the cat grew Bartonella-like organisms with lophotrichous flagella. Sera from the veterinarian were not reactive against Bartonella henselae, B. quintana, or B. elizabethae antigens but were seroreactive (reciprocal titer, 1,024) against the feline isolate. Sequential serum samples from the cat were reactive against antigens of B. henselae (titer, 1,024), B. quintana (titer, 128), and the feline isolate (titer, 2,048). Phenotypic and genotypic characterization of this and six additional feline isolates, including microscopic evaluation, biochemical analysis, 16S rRNA gene sequencing, DNA-DNA hybridization, and PCR-restriction fragment length polymorphism of the 16S gene, 16S-23S intergenic spacer region, and citrate synthase gene identified the isolates as B. clarridgeiae.
This is the first report of cat scratch disease associated with B. clarridgeiae.
More and more strains of Bart are going to be found to be problematic to humans.
To this day, mainstream research and medicine is NOT factoring Bartonella into Lyme/MSIDS, yet nearly everyone I work with has it. Research is scant and typically pushing the idea that only immunocompromised people around cats get it. While this case certainly had cat exposure, many do not: https://madisonarealymesupportgroup.com/2019/01/23/chest-imaging-of-cat-scratch-disease-in-2-year-old-immunocompetent-baby-with-no-history-of-cat-contact/
To my knowledge there is little to no research showing the combined effect of Lyme and Bartonella. This is desperately needed as well as the combined effect with Babesia, Mycoplasma, Tularemia, various viruses, and other coinfections.
Current research has shown the polymicrobial nature of this, yet mainstream medicine blindly continues on treating this is a singular pathogen disease when nothing could be further from the truth: https://madisonarealymesupportgroup.com/2018/10/30/study-shows-lyme-msids-patients-infected-with-many-pathogens-and-explains-why-we-are-so-sick/
Key Quote: “Our findings recognize that microbial infections in patients suffering from TBDs do not follow the one microbe, one disease Germ Theory as 65% of the TBD patients produce immune responses to various microbes.”
Please see microscopy on Bartonella. Slides in link: https://madisonarealymesupportgroup.com/2019/02/27/advanced-imaging-found-bartonella-around-pic-line/ Dr. Ericson has a vested interest in getting down to the bottom of things as her own son is struggling with persistent Bartonellosis. She is now looking at Bartonella in skin cancer and Gulf War Illness as well as the role of biofilms in chronic Bartonellosis. Please consider helping her research project.