Curcio Sabino R., Tria Laurel P., and Gucwa Azad L.. Vector-Borne and Zoonotic Diseases. October 2016, ahead of print. doi:10.1089/vbz.2016.2020.
Online Ahead of Print: October 24, 2016
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Sabino R. Curcio1, Laurel P. Tria,2 and Azad L. Gucwa1
1Department of Biomedical Sciences, Long Island University, Post Campus, Brookville, New York.
2Northwell Health Laboratories, Lake Success, New York.
Address correspondence to:
Azad L. Gucwa
Department of Biomedical Sciences
720 Northern Boulevard
Brookville, NY 11548
Introduction: Babesiosis is an emerging tick-borne disease (TBD) caused by Babesia microti, an intracellular parasite of red blood cells. Currently, it is the highest ranked pathogen transmitted by blood transfusion. Most healthy individuals infected with B. microti are asymptomatic, but may be at risk for chronic infection. Similar to Lyme disease transmitted by Borrelia burgdorferi, B. microti is spread by Ixodes scapularis ticks. The rate of coinfection with these TBDs in humans is unclear as most studies have focused their prevalence in ticks or rodent reservoirs.
Materials and Methods: In this study, we aimed to determine the seroprevalence of B. microti infection in individuals who tested positive for Lyme disease. Serum samples obtained from 130 subjects in New York were tested by immunofluorescence assay (IFA) for the presence of IgM and IgG antibodies against B. microti.
Results: Overall, 26.9% of the serum samples tested were positive for IgM and IgG antibodies against B. microti, suggesting exposure to TBD (tick borne disease). Individuals who tested positive for Lyme disease as determined by two-tiered serological testing and the presence of both IgM and IgG antibodies directed against B. burgdorferi, were significantly increased for antibodies directed against B. microti (28.6%; p < 0.05), suggesting the possibility of coinfection with both TBDs. In contrast, the Lyme disease-negative control group had only 6.7% of samples seropositive for B. microti.
Conclusions: These findings suggest the need for more extensive studies investigating infection rates with multiple TBDs in areas where they are endemic and further support for the need to implement an FDA-approved screening test for blood products to help prevent transfusion-transmitted babesiosis.
This study further shows evidence that when a person contracts LD, they are at risk for other co-infections as the LD lowers their immune function making them sitting ducks for other pathogens. This is a real and present problem as most general practitioners haven’t a clue about co-infections. The testing for all the TBI’s are poor and experience with symptomology is crucial in treating folks with TBI’s. I truly believe that the addition of co-infections make TBI cases exponentially more difficult to treat.
If you type the various coinfections (Bartonella, Babesia, Mycoplasma, etc.) into the search bar on this website you can read about them and various treatment options. Feel free to copy these and take them to your health care provider for discussion.