TOUCHED BY LYME: Treating psychiatric Lyme symptoms with disulfiram
Kristina Bauer, a Lyme advocate, patient and mother of four children with congenital Lyme disease, is the founder of the Texas Lyme Alliance.
After she became interested in the use of disulfiram for treating Lyme disease, she started a Facebook support group called Disulfiram Experience for Lyme and a website called Disulfiram for Lyme.
The website features several video interviews with doctors and researchers about treating Lyme with disulfiram. In her latest one, she interviews psychiatrist Robert Bransfield MD, a leading expert on how Lyme disease affects the brain–and how he has found that disulfiram can help.
(Disulfiram, also known as Antabuse, was used for decades to help treat alcoholism. It has recently been repurposed to treat Lyme disease. Read more about the drug here.)
Dr. Bransfield is an expert on Lyme-related suicide. While no formal statistics are kept on what contributes to the 45,000 suicides per year in the United States, he estimates that some 1200 are likely attributable to depression and other brain manifestations that can result from chronic Lyme disease.
For over 30 years, he has treated Lyme patients who have psychiatric symptoms. Since 2018, he has put more than 60 of them on disulfiram, with good results.
Watch the interview here:
TOUCHED BY LYME is written by Dorothy Kupcha Leland, LymeDisease.org’s Vice-president and Director of Communications. She is co-author of When Your Child Has Lyme Disease: A Parent’s Survival Guide. Contact her at dleland@lymedisease.org.
I’m so thankful many patients are improving on disulfiram. Make sure you discuss side-effects with your doctor; however, as some like myself went into psychosis: https://madisonarealymesupportgroup.com/2019/10/15/disulfiram-psychosis-update/ Being at risk doesn’t mean necessarily that it isn’t for you. There are numerous steps you can take to mitigate this side-effect.
Also, reports are coming in that patients can experience depression after stopping disulfiram treatment. Please discuss this as well with your doctor and consider titrating slowly off it just as you titrated up to a full dose.
Can You Really Sweat Out Toxins? The Truth About Exercise and Detoxing
By Beth Janes Posted 06-01-2020
Exercise is one of those things that’s so good for you and has so much science backing up its advertised health benefits, it’s not hard to believe one more proclaimed benefit: That a good, sweaty workout would help expel toxins. After all, your body only has a few ways to get rid of waste, and it makes sense it would do so through the pores of its largest organ — skin — if given the chance.
In reality, the link between exercise and detoxification isn’t quite so simple. Exercise does play a huge role in the process, but it doesn’t have much to do with sweat. While researchhas found traces of heavy metals like lead, mercury, and cadmium in the sweat of those with high blood levels of the toxins, for example, whatever toxins are released through perspiration (if any) are likely an overall drop in the bucket compared to what’s eliminated via urine and stool.
“Sweat is certainly an area of interest, and there’s the possibility that some things do come out in sweat,” says Dr. Bill Rawls, M.D., medical director of Vital Plan. “But sweat’s primary function is thermoregulation, not detoxing. The main way your body removes toxins is through the liver and kidneys, which process them and turn them water soluble so they can be expelled through urine and stool.”
Even so, being active does play an integral role in the detoxification process. Keep reading to learn more — plus natural ways to maximize the cleansing power of exercise.
Movement Matters for Detox
For all of you who hear the word exercise and automatically think it means you must hit the gym, break into a jog, or otherwise go hard, relax — literally. While there’s certainly benefits to intense physical activity, low-to-moderate intensity activities are also extremely good for you, especially when it comes to detoxing.
“What we all really need is to just be active and move more throughout the day, and that can mean anything, really,” Dr. Rawls says. For example, everyday leisure activities like walking, biking and kayaking count.
So does housework, gardening, and other “work” you might otherwise have a machine do, which might mean raking leaves versus blowing them, or washing dishes by hand instead of loading them into the dishwasher. “Our bodies were designed to move, and up until about 100 years ago, when we started processing and using petroleum, that’s what we did,” Dr. Rawls says.
Unfortunately, the modern world has dealt most people a one-two punch when it comes to toxins: Not only are we moving much less than our ancestors thanks to machines, appliances, cars, and industrial processes, we’re also exposed to many, many more toxins because of those exact things. We’re also exposed to toxins from cleaning and other household items, self-care products, as well as in food in drinks in the form of herbicide and pesticide residue, plus chemicals from plastic packaging.
“All those toxins are not compatible with human life; they damage cells and DNA, they inhibit normal functioning of cells, and they interfere with cellular messaging systems,” Dr. Rawls explains. Many also are free radicals that directly attack cells.
All combined, toxins put an enormous amount of stress on cells, causing them to burn out faster, which ultimately accelerates aging. In other words, detoxing is not only key for your health and healthy functioning of your systems now, it’s an investment in longevity, he says. And that’s why exercise, especially, which is already a multifaceted, well-known age decelerator, is the perfect detox tool.
3 Ways Exercise Supports Your Body’s Detoxification Processes
1. It Improves Circulation.
All cells are water-based and bathed in what’s called extracellular fluid, which helps encourage cells to release toxins and carry them away to the liver and kidneys for disposal, Dr. Rawls says. However the less you move, the more that fluid stagnates and the more toxins build up in your system and can do damage.
“You don’t have to do triathlons or run 10 miles a day,” says Dr. Rawls. “Just make it your goal to move more throughout the day, which is enough to flush out toxins from cells and the fluid around cells and keep it flowing.”
2. Exercise Lowers Inflammation.
Physical activity has also been proven time and again to help control inflammation, which reduces your body’s overall toxic load. Because while there are plenty of toxins we take in from the external world — from air pollution or pesticides, for example — chronic inflammation is itself toxic to our cells and produces an overabundance of natural “toxins.”
Here’s what’s happening: Under normal, healthy conditions, the body uses free radicals to break down cellular waste — the byproducts produced by cells as they make energy as well as other debris like bacteria or neutralized viruses. That waste is then carried away through the lymphatic system and filtered out in lymph nodes. The process is typically tightly controlled because free radicals also break down healthy tissue.
However, when cells are stressed due to environmental toxins, as well as psychological stress, a poor diet, lack of sleep, and other factors, cells produce more waste and burn out more quickly. That leads to a flood of excess free radicals, which also begin breaking down more and more healthy tissue, leading to more waste. It’s a vicious cycle that contributes to chronic illness and accelerates the general aging process.
“In short, chronic inflammation is a reaction to the whole plumbing system of the body becoming overwhelmed and getting clogged and backing up,” Dr. Rawls says. “Your cells are so polluted that your system is collecting waste at a faster pace than the normal flow can get rid of.” Physical activity is effective because it helps both reduce inflammation and help clear lymphatic congestion.
3. It Helps Reduce Places For Toxins to Hide.
Fat tissue seems to be one place certain toxins like to hide once they get inside your body. And research suggests those who are overweight or obese tend to have higher body burdens of common environmental toxins. Exercise, along with a healthy diet, helps reduce fat tissue and keep your weight and, potentially, the amount of toxins in your system in check.
Herbs That Support Your Detox Efforts
Increasing your daily activity will go a long way toward more effective detoxification. Add supportive herbs into the mix, and the results are likely to be even better. Here are a few areas and specific herbs to focus on, according to Dr. Rawls:
Multitasking Adaptogenic Herbs
Adaptogens are very beneficial overall because they help balance and support a number of different functions and systems. One of their most important jobs, however, is supporting the immune system, which controls your body’s inflammatory response. So while they’re well-known for their anti-inflammatory powers, they also help protect the vascular system and liver.
Plants known to help protect cardiac function and your vascular system help ensure good circulation and blood flow for the carrying away of toxins. They also contribute to the cardio-protective effects of exercise, Dr. Rawls says.
Most herbs have anti-inflammatory (as well as antioxidant) powers. However certain plants and other substances are known to help system-wide inflammation, as well as the inflammation that can contribute to the painful joints that otherwise may make exercise uncomfortable.
“We’re exposed to so many toxins these days that we’re burning out our liver cells quickly,” Dr. Rawls says. Herbs that help protect liver cells do so by increasing their natural antioxidant protection. And the healthier your liver, the better the detoxification process.
No matter what you do when you start to think about optimizing your body’s detoxification powers, be wary of products that claim too-good-to-be-true cleansing powers. Most of them simply pump you full of natural laxatives without actually addressing the bigger, underlying issues, Dr. Rawls says.
The truth is, you already have the best detox tool available — the ability to move. Look at products, then, that help support healthy functioning of your cells and body so you feel motivated, energized, and ready to get up and go.
References
1. Sears, Margaret E., Kathleen J. Kerr and Riina I. Bray. 2012. “Arsenic, Cadmium, Lead, and Mercury in Sweat: A Systematic Review.” J Environ Public Health. 184745.
2. University of Arkansas Medical School. “Can you sweat toxins out of your body?” UAMC Health. March 8, 2019. https://uamshealth.com/medical-myths/can-you-sweat-toxins-out-of-your-body/
3. Hammer, Mark, Sabia Severine, G. David Batty, et al. 2012. “Physical Activity and Inflammatory Markers Over 10 Years: Follow-Up in Men and Women From the Whitehall II Cohort Study.” Circulation. 126(8):928–933
4. Ertek, Sibel and Arrigo Cicero. 2012. “Impact of Physical Activity on Inflammation: Effects on Cardiovascular Disease Risk and Other Inflammatory Conditions.” Arch Med Sci. 8(5):794-804.
5. Dimitrov, Stoyan, Elaine Hulteng and Suzi Hong. 2017. “Inflammation and exercise: Inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation.” Brain, Behavior and Immunity. 61:60-68.
6. La Merril, Michele, Claude Emond, Min Ji Kim, et al. 2013. “Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants.” Environ Health Perspect. 2013 Feb; 121(2): 162–169.
7. Kim, Min-Ji, Philippe Marchand, Corneliu Henegar, et al. 2011. “Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects Before and After Drastic Weight Loss.” Environ Health Perspect Mar;119(3):377-83.
Evidence Exposes FRAUDULENT Lancet HCQ COVID-19 Study
Published on
Written by J.C McCallum
New article in the UK Guardian newspaper exposes the company behind a Lancet-published study from late May that claimed people with COVID-19 had a higher risk of death from taking hydroxychloroquine.
A search of publicly available material suggests several of Surgisphere’s employees have little or no data or scientific background. An employee listed as a science editor appears to be a science fiction author and fantasy artist. Another employee listed as a marketing executive is an adult model and events hostess.
The company’s LinkedIn page has fewer than 100 followers and last week listed just six employees. This was changed to three employees as of Wednesday.
While Surgisphere claims to run one of the largest and fastest hospital databases in the world, it has almost no online presence. Its Twitter handle has fewer than 170 followers, with no posts between October 2017 and March 2020.
Until Monday, the “get in touch” link on Surgisphere’s homepage redirected to a WordPress template for a cryptocurrency website, raising questions about how hospitals could easily contact the company to join its database.
Desai has been named in three medical malpractice suits, unrelated to the Surgisphere database. In an interview with the Scientist, Desai previously described the allegations as “unfounded”.
In 2008, Desai launched a crowdfunding campaign on the website Indiegogo promoting a wearable “next generation human augmentation device that can help you achieve what you never thought was possible”. The device never came to fruition.
Desai’s Wikipedia page has been deleted following questions about Surgisphere and his history.
Lancet, the journal who published the study, and another has now issued an “expression of concern” about the study:
Two of the world’s leading medical journals – the Lancet and the New England Journal of Medicine – published studies based on Surgisphere data. The studies were co-authored by the firm’s chief executive, Sapan Desai.
Late on Tuesday, after being approached by the Guardian, the Lancet released an “expression of concern” about its published study. The New England Journal of Medicine has also issued a similar notice.
One of the biggest issues with the study is there have been errors found in the data, and hospitals the study claimed were participants say they’ve never even heard of Surgisphere:
The Lancet study, which listed Desai as one of the co-authors, claimed to have analysed Surgisphere data collected from nearly 15,000 patients with Covid-19, admitted to 1,200 hospitals around the world, who received hydroxychloroquine alone or in combination with antibiotics.
The negative findings made global news and prompted the WHO to halt the hydroxychloroquine arm of its global trials.
But only days later Guardian Australia revealed glaring errors in the Australian data included in the study. The study said researchers gained access to data through Surgisphere from five hospitals, recording 600 Australian Covid-19 patients and 73 Australian deaths as of 21 April.
But data from Johns Hopkins University shows only 67 deaths from Covid-19 had been recorded in Australia by 21 April. The number did not rise to 73 until 23 April. Desai said one Asian hospital had accidentally been included in the Australian data, leading to an overestimate of cases there. The Lancet published a small retraction related to the Australian findings after the Guardian’s story, its only amendment to the study so far.
The Guardian has since contacted five hospitals in Melbourne and two in Sydney, whose cooperation would have been essential for the Australian patient numbers in the database to be reached. All denied any role in such a database, and said they had never heard of Surgisphere. Desai did not respond to requests to comment on their statements.
Also with such a large collection of data that needed to be anonymized, it would normally take a huge company to take on such an effort:
One of the questions that has most baffled the scientific community is how Surgisphere, established by Desai in 2008 as a medical education company that published textbooks, became the owner of a powerful international database. That database, despite only being announced by Surgisphere recently, boasts access to data from 96,000 patients in 1,200 hospitals around the world.
When contacted by the Guardian, Desai said his company employed just 11 people. The employees listed on LinkedIn were recorded on the site as having joined Surgisphere only two months ago. Several did not appear to have a scientific or statistical background, but mention expertise in strategy, copywriting, leadership and acquisition.
Dr James Todaro, who runs MedicineUncensored, a website that publishes the results of hydroxychloroquine studies, said: “Surgisphere came out of nowhere to conduct perhaps the most influential global study in this pandemic in the matter of a few weeks.
“It doesn’t make sense,” he said. “It would require many more researchers than it claims to have for this expedient and [size] of multinational study to be possible.”
Desai told the Guardian: “Surgisphere has been in business since 2008. Our healthcare data analytics services started about the same time and have continued to grow since that time. We use a great deal of artificial intelligence and machine learning to automate this process as much as possible, which is the only way a task like this is even possible.”
It is not clear from the methodology in the studies that used Surgisphere data, or from the Surgisphere website itself, how the company was able to put in place data-sharing agreements from so many hospitals worldwide, including those with limited technology, and to reconcile different languages and coding systems, all while staying within the regulatory, data-protection and ethical rules of each country.
Peter Ellis, the chief data scientist of Nous Group, an international management consultancy that does data integration projects for government departments, expressed concern that Surgisphere database was “almost certainly a scam”.
“It is not something that any hospital could realistically do,” he said. “De-identifying is not just a matter of knocking off the patients’ names, it is a big and difficult process. I doubt hospitals even have capability to do it appropriately. It is the sort of thing national statistics agencies have whole teams working on, for years.”
“There’s no evidence online of [Surgisphere] having any analytical software earlier than a year ago. It takes months to get people to even look into joining these databases, it involves network review boards, security people, and management. It just doesn’t happen with a sign-up form and a conversation.”
It sounds like this company essentially ‘punked’ the medical world with a bogus study and now these medical journals like Lancet are having to conduct their own investigation into the data. It’s sad because this has certainly had major consequences in how people view HCQ.
You know the old saying, “A lie can travel halfway around the world while the truth is still puttin on its shoes”. And our garbage media is perfect for such a lie.
Thursday’s retraction doesn’t mean that the drug is helpful — or harmful — with respect to the coronavirus. Rather, the study authors were unable to confirm that the data set was accurate.
This is quite telling and shows how the media is complicit. Everything is set up to make you doubt and worry over HCQ. Meanwhile, any good information on Remdesivir and they sell it like a drug-pusher on the street corner.
Compare the above statement with the following:
The medical community learned Wednesday about the results of three different trials testing Gilead Sciences’ experimental drug remdesivir as a COVID-19 treatment. Based on the results from ONE of those trials from the National Institute of Allergy and Infectious Diseases (NIAID), Anthony Fauci, MD, director of the agency, called the drug the new “standard of care.” https://www.medscape.com/viewarticle/929688
What I want to point out is that HCQ, a drug used safely for decades and is on the World Health Organization’s Model List of Essential Medicines, the safest and most effective drugs needed in a health system, all of a sudden is held a dim, shadowy light while Remdesivir, a far more expensive drug which failed for Ebola and is questionable for COVID-19, is always held in a positive light. Please remember that half of the members on the COVID-19 treatment panel have financial interests in Gilead Sciences: https://www.covid19treatmentguidelines.nih.gov/panel-financial-disclosure/
Elizabeth L. Maloney, MD Publishes on Reducing the Burden of Lyme Disease
Elizabeth L. Maloney, MD, President, Partnership for Tick-Borne Diseases Education Family Medicine Physician, Wyoming, MN
Elizabeth L. Maloney, MD, President of the Partnership for Tick-Borne Diseases Education and Family Medicine Physician in Wyoming, MN published a paper titled “Reducing the Burden of Lyme Disease” in Minnesota Family Physician. It includes discussion of tick bite management, early treatment, and shared decision-making.
In the article, Dr. Maloney highlights the expensive cost of Lyme disease, stating that, “Nationwide, the annual direct medical costs could reach 1.3 billion dollars” and calls attention to the disadvantages in research the illness has suffered, as well as clinical trial evidence that is “generally scant and/or of low quality”.
The author advises that, “Blacklegged tick bites acquired in Minnesota carry a significant risk of Lyme disease,” and offers guidance for making decisions regarding antibiotic prophylaxis of asymptomatic bites.
Maloney stresses the importance of early treatment and writes,
“Early Lyme disease, when promptly diagnosed and appropriately treated with antibiotics, is curable.” Above all, she states, “the risks and benefits of all options should be discussed with patients in the setting of shared decision-making in order to arrive at a therapeutic plan that fits both the clinical circumstances and the patient’s goals and values.”
(See top link for full article)
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**Comment**
Early treatment is imperative; however, doctors still take a “wait and see” approach after patients get bitten by a tick. This approach is maiming thousands of people and needs to change. ILADS recommends 20 days of doxycycline for an acute tick bite, but it’s important to keep track of any symptoms as many coinfections will not be covered under that particular mono-therapy. Also, remember that testing is wrong half the time.
Version 1 : Received: 30 May 2020 / Approved: 31 May 2020 / Online: 31 May 2020 (17:51:52 CEST)
How to cite: Guérin, V.; Lévy, P.; Thomas, J.; Lardenois, T.; Lacrosse, P.; Sarrazin, E.; Regensberg de Andreis, N.; Wonner, M. Azithromycin and Hydroxychloroquine Accelerate Recovery of Outpatients with Mild/Moderate COVID-19. Preprints2020, 2020050486 (doi: 10.20944/preprints202005.0486.v1). Guérin, V.; Lévy, P.; Thomas, J.; Lardenois, T.; Lacrosse, P.; Sarrazin, E.; Regensberg de Andreis, N.; Wonner, M. Azithromycin and Hydroxychloroquine Accelerate Recovery of Outpatients with Mild/Moderate COVID-19. Preprints 2020, 2020050486 (doi: 10.20944/preprints202005.0486.v1).
Abstract
The challenge regarding COVID-19 is to prevent complications and fatal evolution. Azithromycin (AZM) and hydroxychloroquine (HCQ) have proven their antiviral effect in vitro. We aimed to assess the efficacy and safety of AZM alone or combined to HCQ, prescribed, at an early stage, in patients with Covid-19, in a primary care setting.
Eighty-eight patients received either no or a symptomatic treatment (NST) (n=34) or AZM alone (n=34) or AZM+HCQ (n=20). The efficacy end point was the time to clinical recovery and the safety end point was the occurrence of cardiovascular events.
The mean (SD) times to achieve clinical recovery were respectively 25.8 days (11.1), 12.9 days (13.4) and 9.2 days (9.3), showing a statistically significant difference between NST and AZM alone (p<0.0001) or AZM+HCQ (p<0.0001).
To improve the evidence level, a case-control analysis was performed on a sample of 57 patients (19/group) matched for age, sex and BMI. The statistical difference between NST and AZM was confirmed (p=0.0149) as well as the difference with AZM+HCQ (p=0.0002). No cardiac toxicity was recorded in any patient. No statistical difference was shown between AZM and AZM+HCQ groups, although the dual therapy tended to be more effective in patients over 50 years, based on an analysis using the cox model.
In conclusion, AZM and AZM+HCQ favourably impacted the course of the disease. We need trials, ideally prospective/double blind, to show if a statistical difference can be evidenced with a broader group, and clarify the indications of each treatment depending on initial clinical presentation.