Archive for the ‘Ticks’ Category

Bb Can Cause Infectious Myelopathy

https://www.ncbi.nlm.nih.gov/pubmed/29613895
Continuum (Minneap Minn). 2018 Apr;24(2, Spinal Cord Disorders):441-473. doi: 10.1212/CON.0000000000000597.

Infectious Myelopathies.

Grill MF.

Abstract
PURPOSE OF REVIEW:
This article reviews bacterial, viral, fungal, and parasitic pathogens associated with myelopathy. Infectious myelopathies may be due to direct infection or parainfectious autoimmune-mediated mechanisms; this article focuses primarily on the former.
RECENT FINDINGS:
Some microorganisms exhibit neurotropism for the spinal cord (eg, enteroviruses such as poliovirus and flaviviruses such as West Nile virus), while others are more protean in neurologic manifestations (eg, herpesviruses such as varicella-zoster virus), and others are only rarely reported to cause myelopathy (eg, certain fungal and parasitic infections). Individuals who are immunocompromised are at increased risk of disseminated infection to the central nervous system. Within the last few years, an enterovirus D68 outbreak has been associated with cases of acute flaccid paralysis in children, and emerging Zika virus infection has been concurrent with cases of acute flaccid paralysis due to Guillain-Barré syndrome, although cases of myelitis have also been reported. Associated pathogens differ by geographic distribution, with myelopathies related to Borrelia burgdorferi (Lyme disease) and West Nile virus more commonly seen in the United States and parasitic infections encountered more often in Latin America, Southeast Asia, and Africa. Characteristic CSF and MRI patterns have been identified with many of these infections.
SUMMARY:
A myriad of pathogens are associated with infectious myelopathies. Host factors, geographic distribution, clinical features, CSF profiles, and MRI findings can assist in formulating the differential diagnosis and ultimately guide management.

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**Comment**

Myelopathy is a neurologic deficit related to the spinal cord which can be caused by trauma (spinal cord injury) or inflammation (myelitis).  Inflammation can be caused by numerous things including pathogens such as Borrelia burgdorferi (Bb), the causative agent of Lyme Disease, as well as numerous viruses that can also be a part of the Lyme/MSIDS symptom picture which can be transmitted directly from ticks or activated due to the reaction of the body to the tick bite.  Much research is needed in this particular area.

Myelopathy is typically a clinical diagnosis with patients complaining of weakness, clumsiness, muscle atrophy, sensory deficits, bowel/bladder symptoms, sexual dysfunction, altered tons, spasticity, and hyperreflexia among other symptoms.  https://en.wikipedia.org/wiki/Myelopathy  Treatment depends upon the underlying cause.  If infectious, pathogen specific antibiotics, and/or things to reduce inflammation are in order.

Personal response:  While I was not diagnosed with myelopathy specifically, one of my hallmark symptoms was spinal and occipital pain.  After ruling out Chiari:  https://madisonarealymesupportgroup.com/2016/04/02/chiari/ and regularly seeing an upper cervical chiropractor for structural malalignment, MSM helped me tremendously.  Please read about MSM here:  https://madisonarealymesupportgroup.com/2018/03/02/dmso-msm-for-lyme-msids/

Make sure to discuss all treatment options with your health care provider.

 

 

BBA57 Found to Help Bb Evade Immune System

https://www.ncbi.nlm.nih.gov/pubmed/29610317

Proc Natl Acad Sci U S A. 2018 Apr 2. pii: 201718595. doi: 10.1073/pnas.1718595115. [Epub ahead of print]

Plasticity in early immune evasion strategies of a bacterial pathogen.

Bernard Q, Smith AA, Yang X, Koci J, Foor SD, Cramer SD, Zhuang X, Dwyer JE, Lin YP, Mongodin EF, Marques A, Leong JM, Anguita J, Pal U.

Abstract

Borrelia burgdorferi is one of the few extracellular pathogens capable of establishing persistent infection in mammals. The mechanisms that sustain long-term survival of this bacterium are largely unknown. Here we report a unique innate immune evasion strategy of B. burgdorferi, orchestrated by a surface protein annotated as BBA57, through its modulation of multiple spirochete virulent determinants. BBA57 function is critical for early infection but largely redundant for later stages of spirochetal persistence, either in mammals or in ticks. The protein influences host IFN responses as well as suppresses multiple host microbicidal activities involving serum complement, neutrophils, and antimicrobial peptides. We also discovered a remarkable plasticity in BBA57-mediated spirochete immune evasion strategy because its loss, although resulting in near clearance of pathogens at the inoculum site, triggers nonheritable adaptive changes that exclude detectable nucleotide alterations in the genome but incorporate transcriptional reprograming events. Understanding the malleability in spirochetal immune evasion mechanisms that ensures their host persistence is critical for the development of novel therapeutic and preventive approaches to combat long-term infections like Lyme borreliosis.

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**Comment**

So it’s recognized that Borrelia Burgdorferi is capable of causing persistent infection in “mammals,” but evidently, according to the CDC/IDSA/NIH, not humans.  

This would be humorous if it didn’t kill people.

 

 

Canadian Citizen Scientists Helping With Tick Surveillance

PMCID: PMC5872229
PMID: 29498648

Citizen Science and Community Engagement in Tick Surveillance—A Canadian Case Study

Abstract

Lyme disease is the most common tick-borne disease in North America and Europe, and on-going surveillance is required to monitor the spread of the tick vectors as their populations expand under the influence of climate change. Active surveillance involves teams of researchers collecting ticks from field locations with the potential to be sites of establishing tick populations. This process is labor- and time-intensive, limiting the number of sites monitored and the frequency of monitoring. Citizen science initiatives are ideally suited to address this logistical problem and generate high-density and complex data from sites of community importance. In 2014, the same region was monitored by academic researchers, public health workers, and citizen scientists, allowing a comparison of the strengths and weaknesses of each type of surveillance effort. Four community members persisted with tick collections over several years, collectively recovering several hundred ticks. Although deviations from standard surveillance protocols and the choice of tick surveillance sites makes the incorporation of community-generated data into conventional surveillance analyses more complex, this citizen science data remains useful in providing high-density longitudinal tick surveillance of a small area in which detailed ecological observations can be made. Most importantly, partnership between community members and researchers has proven a powerful tool in educating communities about of the risk of tick-vectored diseases and in encouraging tick bite prevention.

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**Comment*

Please know that according to an independent Canadian tick expert John Scott, climate change has nothing to do with the spread of ticks and the pathogens they carry:  

https://madisonarealymesupportgroup.com/2017/08/14/canadian-tick-expert-climate-change-is-not-behind-lyme-disease/  “The climate change range expansion model is what the authorities have been using to rationalize how they have done nothing for more than thirty years. It’s a huge cover-up scheme that goes back to the 1980’s. The grandiose scheme was a nefarious plot to let doctors off the hook from having to deal with this debilitating disease. I caught onto it very quickly. Most people have been victims of it ever since.”
“This climate change ‘theory’ is all part of a well-planned scheme. Even the ticks are smarter than the people who’ve concocted this thing,” he says.
“Climate change has nothing to do with tick movement. Blacklegged ticks are ecoadaptive, and tolerate wide temperature fluctuations. On hot summer days, these ticks descend into the cool, moist leaf litter and rehydrate. In winter, they descend into the leaf litter, and are comfortable under an insulating blanket of snow.Ticks have antifreeze-like compounds in their bodies, and can tolerate a wide range of temperatures. For instance, at Kenora, Ontario, the air temperature peaks at 36°C and dips to –44°C, and blacklegged ticks survive successfully.
“Ticks are marvellous eco-adaptors. They will be the last species on the planet. Do you see how silly this theory of climate change is as a way to rationalize what’s happening. It’s all a red herring to divert your attention,” he explains. “In simple terms, the feds have diverted our attention by saying ‘let’s worry about ticks and climate change, put all our funding there and we will solve the problem of Lyme disease’.”

Similarly to the latest fashion trends from Paris driving fashion across the world, the phrase “climate change,” is the latest angle in Science to obtain grants that is driving research.  

This research is not helping patients in the least.  

https://madisonarealymesupportgroup.com/2017/01/28/sit-down-science/  How research is being manipulated to fit industry agendas.

https://madisonarealymesupportgroup.com/2017/01/02/fake-science/ Exactly how this manipulation occurs.

https://madisonarealymesupportgroup.com/2017/07/08/global-warming-numbers-fudged/

https://madisonarealymesupportgroup.com/2017/01/13/lyme-science-owned-by-good-ol-boys/

https://madisonarealymesupportgroup.com/2017/08/04/science-for-sale/

https://madisonarealymesupportgroup.com/2017/12/05/bought-documentary-on-pharma-vaccines-gmos/

 

 

 

 

Novel Viruses Found in Lone Star, American Dog, & Black Legged Ticks

http://msphere.asm.org/content/3/2/e00614-17

Identification of Novel Viruses in Amblyomma americanumDermacentor variabilis, and Ixodes scapularis Ticks

Rafal TokarzStephen SameroffTeresa TagliafierroKomal JainSimon H. WilliamsD. Moses CucuraIlia RochlinJavier MonzonGiovanna CarpiDanielle TuftsMaria Diuk-WasserJory BrinkerhoffW. Ian Lipkin
James M. Pipas, Editor
DOI: 10.1128/mSphere.00614-17
ABSTRACT

Ticks carry a wide range of known human and animal pathogens and are postulated to carry others with the potential to cause disease. Here we report a discovery effort wherein unbiased high-throughput sequencing was used to characterize the virome of 2,021 ticks, including Ixodes scapularis (n = 1,138), Amblyomma americanum (n = 720), and Dermacentor variabilis (n = 163), collected in New York, Connecticut, and Virginia in 2015 and 2016. We identified 33 viruses, including 24 putative novel viral species. The most frequently detected viruses were phylogenetically related to members of the Bunyaviridae and Rhabdoviridae families, as well as the recently proposed Chuviridae. Our work expands our understanding of tick viromes and underscores the high viral diversity that is present in ticks.

IMPORTANCE The incidence of tick-borne disease is increasing, driven by rapid geographical expansion of ticks and the discovery of new tick-associated pathogens. The examination of the tick microbiome is essential in order to understand the relationship between microbes and their tick hosts and to facilitate the identification of new tick-borne pathogens. Genomic analyses using unbiased high-throughput sequencing platforms have proven valuable for investigations of tick bacterial diversity, but the examination of tick viromes has historically not been well explored. By performing a comprehensive virome analysis of the three primary tick species associated with human disease in the United States, we gained substantial insight into tick virome diversity and can begin to assess a potential role of these viruses in the tick life cycle.

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**Comment**

The article states the high diversity of viruses was not unexpected and that some of these viruses have not been found in vertebrates and are not likely horizontally transmitted but that they are phylogenetically related to human & animal pathogens.  They also state some of the viruses do not replicate within the tick but rather parasitize hosts within the tick such as fungus or nematode.

 

Interestingly, the black legged tick, normally considered the biggest player in transmitting Lyme Disease, also had three times more viruses than the Lone Star Tick.

 

Pathogens From Ticks in UK Cats

https://www.ncbi.nlm.nih.gov/pubmed/29558992

Parasit Vectors. 2018 Mar 20;11(1):201. doi: 10.1186/s13071-018-2789-5.

Anaplasma phagocytophilum, Bartonella spp., haemoplasma species and Hepatozoon spp. in ticks infesting cats: a large-scale survey.

Abstract

BACKGROUND:

Ticks derived from cats have rarely been evaluated for the presence of pathogens. The aim of this study was to determine the prevalence of Anaplasma phagocytophilum, Bartonella spp., haemoplasma species and Hepatozoon spp. in ticks collected from cats in the UK.

METHODS:

Five hundred and forty DNA samples extracted from 540 ticks collected from cats presenting to veterinarians in UK practices were used. Samples underwent a conventional generic PCR assay for detection of Hepatozoon spp. and real-time quantitative PCR assays for detection of Anaplasma phagocytophilum and three feline haemoplasma species and a generic qPCR for detection of Bartonella spp. Feline 28S rDNA served as an endogenous internal PCR control and was assessed within the haemoplasma qPCR assays. Samples positive on the conventional and quantitative generic PCRs were submitted for DNA sequencing for species identification.

RESULTS:

Feline 28S rDNA was amplified from 475 of the 540 (88.0%) ticks. No evidence of PCR inhibition was found using an internal amplification control. Of 540 ticks, 19 (3.5%) contained DNA from one of the tick-borne pathogens evaluated. Pathogens detected were: A. phagocytophilum (n = 5; 0.9%), Bartonella spp. (n = 7; 1.3%) [including Bartonella henselae (n = 3; 0.6%) and Bartonella clarridgeiae (n = 1; 0.2%)], haemoplasma species (n = 5; 0.9%), “Candidatus Mycoplasma haemominutum” (n = 3; 0.6%), Mycoplasma haemofelis (n = 1; 0.2%), “Candidatus Mycoplasma turicensis” (n = 1; 0.2%), Hepatozoon spp. (n = 2; 0.4%), Hepatozoon felis (n = 1; 0.2%) and Hepatozoon silvestris (n = 1; 0.2%).

CONCLUSION:

These data provide important information on the prevalence of tick-borne pathogens in ticks infesting cats, with the identification of haemoplasma species, A. phagocytophilum, H. felis and Bartonella spp. (including B. henselae and B. clarridgeiae). This study also documents the first report of H. silvestris in ticks collected from domestic cats.

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**Comment**

More and more is coming out about these same pathogens causing disease in humans.

Bartonella clarridgeiae has caused Cat Scratch Disease in humans:  http://jcm.asm.org/content/38/8/2943.full

Haemoplasma species (Mycoplasma) can be chronic in cats and cause anemia:  http://journals.sagepub.com/doi/abs/10.1177/1098612X15573562?journalCode=jfma

Humans can be infected with Myco:  https://madisonarealymesupportgroup.com/2017/07/16/mycoplasma-and-other-intracellular-bacterial-infections-in-rheumatic-diseases-comorbid-condition-or-cause/

As to Hepatozoon spp. (felis & silvestris):  http://www.troccap.com/canine-guidelines/vector-borne-parasites/hepatozoon/Public health considerations
Hepatozoon infection in humans has not been described except for a single case in which the species was not identified.  So it’s been found in at least one human.  The thing is they aren’t regularly looking for it.

Transmission route:  ingestion of tick vectors (but how’d the ONE human get it?  I doubt they were eating ticks!)

Clinical signs
H.canis infects the hemolymphatic tissues and causes anemia and lethargy. Infection varies from being subclinical to severe with lethargy, fever, cachexia and pale mucous membranes due to anemia.
Diagnosis
It’s diagnosed by microscopic detection of intracellular H. canis gamonts in neutrophils and monocytes in stained capillary blood smears. The degree of parasitaemia is directly proportional to the severity of clinical signs. PCR of whole blood for H. canis detection is sensitive and specific.
Treatment
It is treated with imidocarb dipropionate at 5-6 mg/kg IM or SC every 14 days until gamonts are no longer present in blood smears. The decrease of parasitemia is slow and usually requires several repeated imidocarb treatments.

More in ticks:  https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/  (The actual number is 16 and counting)