Archive for the ‘Inflammation’ Category

What Does Lyme Disease Do To Your Body?

 Approx. 5 Min.

What Does Lyme Disease Do To Your Body?

Published on Apr 23, 2019
What exactly is the connection between a tick bite and lyme disease? While we’re not sure exactly where and when the disease originated, we do know a lot about how it works, its signs, its symptoms in humans and dogs, how it’s spread and its treatment.
SICK is a new series that looks at how diseases actually work inside our body. We’ll be visiting medical centers and talking to top researchers and doctors to uncover the mysteries of viruses, bacteria, fungi and our own immune system. Come back every Tuesday for a new episode and let us know in the comments which diseases you think we should cover next.
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What this video didn’t touch upon is the very real probability that Lyme/MSIDS is spread by more than the sole perp of the deer tick:  https://madisonarealymesupportgroup.com/2019/04/02/transmission-of-lyme-disease-lida-mattman-phd/  From 2005, Dr. Lida Mattman isolated Lyme (borrelia) from:

mosquitoes, fleas, mites, semen, urine, blood, plasma and Cerebral Spinal Fluid. She discovered that this bacteria is dangerous because it can survive and spread without cell wall (L shape). Because L-forms do not possess cell wall, they are resistant to antibiotics that act upon the cell wall.

Others have found other various ways Bb is transmitted as well:

Nobody seems to want to talk about this, yet it’s important.

 

 

 

 

Category:

Heart Issues, Inflammation, Lyme, Ticks

Three-Antibiotic Cocktail Clears “Persister” Lyme Bacteria in Mouse Study

https://yubanet.com/scitech/three-antibiotic-cocktail-clears-persister-lyme-bacteria-in-mouse-study/

Three-Antibiotic Cocktail Clears “Persister” Lyme Bacteria in Mouse Study

Scientists isolate slow-growing variant Lyme bacteria forms that caused severe symptoms, resisted standard single-antibiotic Lyme treatment in the mouse model

By Johns Hopkins University
April 23, 2019 – A new study from researchers at the Johns Hopkins Bloomberg School of Public Health found that a slow-growing variant form of Lyme bacteria caused severe symptoms in a mouse model. The slow-growing variant form of Lyme bacteria, according to the researchers, may account for the persistent symptoms seen in ten to twenty percent of Lyme patients that are not cured by the current Lyme antibiotic treatment.

The study, published March 28 in Discovery Medicine, also found that these “persister” Lyme bacteria were resistant to standard single-antibiotic Lyme treatments currently used to treat Lyme patients, while a three-antibiotic cocktail eradicated the Lyme bacteria in the mouse model.

For their study, the scientists isolated slow-growth forms of the Lyme bacterium, Borrelia burgdorferi. They found that, compared to normal fast-growth forms, the slow-growing forms caused more severe arthritis-like symptoms and resisted standard antibiotic treatment in test tube as well as in a mouse model. The scientists found that a combination of three antibiotics—daptomycin, doxycycline and ceftriaxone—cleared the Lyme infection in the study mice. The scientists now hope to test the combination in people with persistent Lyme disease.

“There is a lot of excitement in the field, because we now have not only a plausible explanation but also a potential solution for patients who suffer from persistent Lyme disease symptoms despite standard single-antibiotic treatment,” says study senior author Ying Zhang, MD, PhD, professor in the Department of Molecular Microbiology and Immunology at the Bloomberg School.

Lyme disease afflicts about 300,000 people in the United States every year. It is caused by Borrelia bacteria that live inside common species of ticks and are transmitted to humans by tick bites. Treatment with a single antibiotic—either doxycycline, amoxicillin or cefuroxime—for two to four weeks clears infection and resolves symptoms in most patients. However, some 10 to 20 percent of Lyme patients who are treated continue to suffer persistent symptoms including fatigue, muscle and joint aches, and brain fog that can six months or longer.

This post-treatment Lyme disease syndrome has been controversial among many doctors, in part because studies of these patients usually have failed to show that Borrelia bacteria can be cultured from their blood, especially after treatment—a standard method for revealing the presence of an infection or relapse. However, Borrelia, like many bacteria, can switch under low-nutrient conditions or other stresses from their normal fast-growth mode to variant forms as in “stationary phase” with little or no growth.

Studies also have hinted that these stationary-phase variants can be killed with the right drugs. Research by Zhang and colleagues has shown that a combination of daptomycin, doxycycline and cefoperazone reliably kills cultures of B. burgdorferi that include stationary-phase variant forms.

In this new study, Zhang and colleagues grew stationary-phase B. burgdorferi and isolated two distinct no-growth forms, called microcolony and planktonic forms. They confirmed that these forms are resistant to standard antibiotics such as doxycycline and even two-drug combinations used for treating Lyme disease. They also showed that these stationary-phase forms, compared to normal-growing spiral forms of B. burgdorferi, cause worse Lyme disease-like symptoms in mice—chiefly inflammation and joint-swelling. However, treating these mice with the combination of daptomycin, doxycycline and ceftriaxone effectively eradicated the infection.

“A lot of physicians have been wanting to do clinical trials of antibiotic combinations in post- treatment Lyme disease syndrome patients, and now we have results in animals that support the idea of such trials,” Zhang says.

He and his colleagues are making plans for their own trial of the persister drug combination against post-treatment Lyme disease syndrome. They note that the idea of persister bacteria causing severe and persistent infections with varying susceptibilities to different drugs might apply to other infectious diseases in which symptoms sometimes persist, despite standard treatment.

“Stationary Phase Persister/Biofilm Microcolony of Borrelia burgdorferi Causes More Severe Disease in a Mouse Model of Lyme Arthritis: Implications for Understanding Persistence, Post-Treatment Lyme Disease Syndrome (PTLDS), and Treatment Failure” was written by Jie Feng, Tingting Li, Rebecca Yee, Yuting Yuan, Chunxiang Bai, Menghua Cai, Wanliang Shi, Monica Embers, Cory Brayton, Harumi Saeki, Kathleen Gabrielson, and Ying Zhang.

Funding for the research was provided by the Steven and Alexandra Cohen Foundation, Global Lyme Alliance, LivLyme Foundation, NatCapLyme, and the Einstein-Sim Family Charitable Fund.

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**Comment**

The 10-20% being used to identify those with remaining symptoms is inaccurate and NEEDS to change. For a great read explaining this:  https://madisonarealymesupportgroup.com/2019/02/25/medical-stalemate-what-causes-continuing-symptoms-after-lyme-treatment/

In short, Microbiologist Holly Ahern recently wrote that the arbitrary label “Post Treatment Lyme Disease Syndrome,” or PTLDS, which the CDC estimates to be 10-20% of patients only truly represents a subgroup of patients who have been diagnosed early, treated with standard short-term antibiotics, and whom remained symptomatic or developed new symptoms. It does not and should not include a third group who were misdiagnosed or undiagnosed beyond the first few weeks of infection. She states estimates based on existing research show this unaccounted for group makes up 30-40% of Lyme disease patients. By combining the PTLDS group with the third group, there are 60% of patients ending up with chronic symptoms, a number that more closely matches my experience as a patient advocate (9)  https://madisonarealymesupportgroup.com/2019/02/22/why-mainstream-lyme-msids-research-remains-in-the-dark-ages/

This is important because 60% is much bigger than 10-20% and reveals the vast suffering and the dire need for research on this neglected subgroup of patients.

Recently, this came out regarding treatment:  https://madisonarealymesupportgroup.com/2019/04/17/global-lyme-alliance-doing-kick-butt-research/

Dr. Kim Lewis and his team at Northeastern University, independently, discovered that Disulfiram, used for treating alcoholism, was extremely effective in culture and in mice in to killing burgdorferi in all forms.

This is promising as it won’t destroy the gut like antibiotics.

 

 

 

Category:

Inflammation, Lyme, research, Treatment

When Lyme Disease & Ehlers-Danlos Syndrome Overlap

https://www.lymedisease.org/lyme-ehlers-danlos/

When Lyme disease and Ehlers-Danlos syndrome overlap

ella steinbeck, ehlers-danlos and Lyme disease

by Ella Steinbeck

I have been absent. Not just absent from my regular activities or a couple of dinner parties but I have been absent from life.

I have something called Ehlers-Danlos Syndrome. It’s painful and horrible and since it affects collagen there is no part of my body that is off limits. If you have time to Google it, I suggest it.

It’s all very medical and interesting if you’re into that kind of thing. Very Dr. House-y. You’ll learn about connective tissue, mast cell activation disorder and POTS or dysautonomia. That will all sum up EDS in a very confusing package with a not-so-pretty bow.

I have written about it in the past in a column titled “Dealing with Ehlers-Danlos…or why hyper-mobility isn’t a cool cell phone plan and doing the splits is bad” in The Rockland County Times.

Lyme disease enters the picture

Two weeks ago, I found out that I have Lyme disease. Late Lyme. Chronic Lyme. This means it’s gone untreated and has settled into my body for many years. Another illness. How can this be?

I’m not exactly sure when I contracted Lyme or if I had multiple exposures. But I can safely say I either got it when I was 29 years old or when I was 6. I wish I was kidding. How is this possible?

Where should I start? This story is not exactly what I would call “linear.” Bear with me. I was (and am) having a ton of cognitive issues, depression, anxiety, and physical pain.

My memory had been getting progressively worse. I was having a hard time with word retrieval and getting appointments right. Brain fog is part of Ehlers-Danlos because we often times have autonomic dysfunction. (Depression, anxiety, and autonomic dysfunction are part of Lyme as well, but I didn’t know that yet.)

I’d look at the computer and not be able to recall names of who I needed to email. I would start with A’s and scroll through all of them, then the B’s and so on until I’d see something that jogged my memory.

Or, I’d put in a word and hope some old emails would pop up that connected to the person and email address that I was hoping to recall. I had a general feeling of confusion, like I was doing something wrong all the time.

Disorientation

It was very disorienting and hard to tell people about. I couldn’t think of the words to tell them even if I really wanted to. Every time I told a story, it was filled with “never mind “or “uhh, shoot, I can’t remember.”

I would fill in sentences with acceptable words but not the words I wanted to use. It was affecting me socially. I’d opt to keep my mouth shut and do a lot of smiling and nodding. I tried to limit my speech to simple interactions.

Why was I getting worse? Could it be Alzheimer’s? It’s possible. I was in a severe car accident when I was 22 years old. I had multiple serious injuries and a traumatic brain injury. I also had several other concussions in the past.

I knew I should probably have this looked into. I tried to get into a brain study for TBI and Alzheimer’s, but was not accepted. I couldn’t take it anymore. I felt like I was going crazy. I had to do something.

I decided to make an appointment at the Psychoneuroplasticity Center outside of Dallas TX in November of 2018. Why there? They take into account the whole person. They look at nutrition, do brain mapping, investigate the adrenal system and assess hormones. I felt this was my best shot at understanding whatever was going on inside my brain and body.

Lo and behold, I found out I qualified for Mensa and didn’t have Alzheimer’s disease. Yay!

Brain inflammation

I do have brain inflammation and some malabsorption issues. I have a bit of a learning disability or ophthalmological disturbance called convergence insufficiency. It’s addressed with behavioral optometry and can be rehabbed. I’ve been pretty successful with that actually. As an aside, I’m not sure you should qualify for Mensa if you didn’t even know your IQ was being tested.

My brain also has enough Delta waves. This is why marijuana doesn’t work for me and makes me depressed and paranoid. I’ve never smoked pot successfully. When I say “never,” I mean never. I can’t use medical marijuana and it won’t work even if you have “really-good-stuff-man.”

Right before I got my diagnostics back from the PNP Center, a doctor I saw for a pain treatment had a hunch. He said his wife (who was also a doctor) had Lyme.

Something about my story made him think I had Lyme. I immediately went for a test, assuming he was wrong. I mean, I was “classic EDS.” Ask anyone or anyone who knows about EDS–cognitive issues, joint pain, POTS and mast cell issues are all present in Ehlers-Danlos Syndrome. Turns out they also show up in Lyme. My weird allergies, interstitial cystitis, and migraines can all be EDS…or Lyme.

Five CDC-positive bands

My Western Blot test showed five CDC-positive bands. So, Ehlers-Danlos may not be the reason for all of my orthostatic and mast cell problems. It may not even be the reason for all of my pain.

Does this mean that if I had been treated for Lyme 13 years ago, I might have lived a normal life? Maybe. I have been in pain since I was a kid. I managed it somewhat successfully until 13 years ago.

Was it Ehlers-Danlos and residual pain from that car accident causing some of my problems while the pain from Lyme is responsible for stopping my life? I’m hoping to find the answers.

I started Lyme disease treatment two weeks ago. The first step is three months of doxycycline. I’ll keep you posted. Hopefully, I’ll be able to do that in a more linear and conclusive fashion.

I try to keep a positive upbeat façade about everything. Nobody likes a Debbie Downer. I hate looking like I need sympathy. But I’d love some empathy. I guess that’s why I wrote this. You never know what a person is going through by looking at them.

Less take, more give

This world could use some compassion and empathy. A little less take and a lot more give. Be kind and ask questions.

If you see a person get on a full bus and ask, “Would anyone mind giving me a seat? I know I look fine but I am sick,” offer them your seat. I once asked that on three different buses. Not one person gave me their seat.

It’s hard when you don’t look sick. I have had people shove me on purpose when I am using a cane for the muscle treatments that I get. I had two different bus drivers close their doors on the cane as I was using it to get onto the bus.

I am tall, thin, somewhat put together (depending on the day) and “able” looking, but I am not able. I need help. I am fighting every day I get out of bed.

Some days are filled with aggressive rest. When I do venture out, every step seems like a miracle. Carrying a bag means I may have spasms and pain later that will need treatment or medication.

So, what’s it like to have an invisible disability? It’s really hard. What is it like to have two invisible illnesses? Really, really hard. Could it be worse? Absolutely. I know that.

Ella Steinbeck writes a column for New York’s Rockland County Times, where this article was first published. You can follow her on Instagram @lifewithlymeandehlersdanlos.

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**Comment**

Lyme/MSIDS can look like 1,000 different diseases, and many are being misdiagnosed with a plethora of things that could be fixed with simple antimicrobials. The stories are endless:

https://madisonarealymesupportgroup.com/2019/03/24/cat-scratch-disease-caused-teens-schizophrenia-like-symptoms-report-says/

https://madisonarealymesupportgroup.com/2019/01/23/never-had-a-single-ms-als-or-parkinsons-patient-in-past-5-years-who-didnt-test-positive-for-lyme-dr-klinghardt/

https://madisonarealymesupportgroup.com/2019/03/07/blast-from-the-past-10-year-old-video-shows-state-of-lyme-hasnt-changed-misdiagnosed-with-ms-told-it-cant-be-lyme/

https://madisonarealymesupportgroup.com/2019/04/07/missing-links-connect-the-dots-between-lyme-mental-health/

https://madisonarealymesupportgroup.com/2018/10/03/lyme-patient-misdiagnosed-with-anxiety-depression/

https://madisonarealymesupportgroup.com/2019/03/26/lyme-its-known-involvement-in-mental-health/

https://madisonarealymesupportgroup.com/2019/03/09/researchers-identify-herpes-1-chlamydia-pneumoniae-several-types-of-spirochaete-as-major-causes-of-alzheimers/

I literally could go onto infinity…..

 

 

 

Category:

Activism, Inflammation, Lyme, Psychological Aspects

Six Benefits of Massage Therapy

https://fitness.mercola.com/sites/fitness/archive/2019/04/19/benefits-of-massage-therapy.aspx?

Six Benefits of Massage Therapy

Written by Dr. Joseph Mercola

April 19, 2019

benefits of massage therapy

STORY AT-A-GLANCE

  • Six areas where massage has been shown to produce beneficial results include pain, mental health, inflammation, immune function, muscle spasms and flexibility
  • Specialized receptors in your dermis, the second layer of skin, react to external stimuli such as pressure by sending messages through your nervous system to your brain to stimulate the release of endorphins
  • In the treatment of pain, including muscle and bone pain, headaches, deep internal pain, fibromyalgia and spinal cord pain, massage therapy relieves pain better than getting no treatment at all, and when compared to other pain treatments such as acupuncture and physical therapy, massage therapy still proved beneficial
  • Massage therapy can be helpful for relieving side effects associated with conventional cancer treatment, including pain, fatigue, nausea, anxiety and depression
  • If you try massage therapy and find you’re not getting relief, you may want to try increasing the dose and frequency. There are other variables that impact massage effectiveness as well, such as the technique used and the skill level of the massage therapist

Massage is one of the oldest and simplest forms of medical care used to promote general well-being and ease pain and anxiety. Your skin is your largest sensory organ and specialized receptors in the dermis, the second layer of skin, react to external stimuli such as heat, cold and pressure by sending messages through your nervous system to your brain that stimulate the release of endorphins.

Endorphins promote relaxation and a sense of well-being, relieve pain and reduce levels of stress chemicals such as cortisol and noradrenaline, thereby slowing your heart rate, respiration and metabolism, and lowering your blood pressure.

Deeper, more vigorous massage stimulates blood circulation to improve the supply of oxygen and nutrients to body tissues and helps your lymphatic system flush away waste products. It eases tense and knotted muscles and stiff joints, improving mobility and flexibility.

Massage is also said to increase activity of the vagus nerve, one of 10 cranial nerves that affects the secretion of food absorption hormones, heart rate and respiration.

It has proven to be an effective therapy for a variety of health conditions — particularly stress-related tension, which can play a significant role in the development of both psychological and physical health problems. Here, I review six areas where massage has been shown to produce beneficial results: pain, mental health, inflammation, immune function, muscle spasms and flexibility.

Massage Therapy for Pain Relief

Pain is an extremely common problem — so much so, deaths from opioid addiction are at an all-time high, killing an estimated 47,600 Americans in 2017 alone.1 As of June 2017, opioids became the leading cause of death among Americans under the age of 50. Massage is just one of many alternative pain treatments that can be helpful.

A systematic review and meta-analysis2 published in 2016 included 60 high-quality and seven low-quality studies that looked into the use of massage for various types of pain, including muscle and bone pain, headaches, deep internal pain, fibromyalgia and spinal cord pain.

The review revealed massage therapy relieves pain better than getting no treatment at all, and when compared to other pain treatments such as acupuncture and physical therapy, massage therapy still proved beneficial.

More specifically, studies have shown massage therapy can relieve pain associated with:

• Tension headaches and migraines3,4 — In one study,5 participants who received two 30-minute traditional massages for five weeks reported a decrease in the frequency of migraine attacks compared to controls who did not receive massage therapy. They also had fewer sleep disturbances and testing revealed an increase in serotonin.

In another,6 the effect of Thai massage — which focuses on compression, stretching, pulling and rocking motions7 — was assessed on patients with either chronic tension headaches or migraines.

Participants received either ultrasound treatment or three Thai massage sessions per week for three weeks. Those receiving Thai massage reported an increase in pain pressure threshold, while those in the ultrasound group experienced a decrease. Both groups had a significant reduction in migraine intensity.

• Labor pain — According to Rebecca Dekker, who has a Ph.D. in nursing and founded Evidence Based Birth, one hypothesis for how massage works to reduce pain is the gate control theory.8“Gentle, or nonpainful massage, can act on the Gate Control Method by flooding the body with pleasant sensations so that the brain does not perceive the painful sensations as much,” she says.

Intense, deep massage, on the other hand, is thought to act via diffuse noxious inhibitory control. “The idea is that the stimulation from painful massage is so intense that it stimulates the brain to release its own natural pain-relieving hormones called endorphins.

Your body is then flooded with endorphins that help you perceive less pain from contractions,” Dekker says, adding, “Researchers also think that massage might work by decreasing cortisol, or stress hormones and increasing levels of serotonin and dopamine in your brain.”

• Fibromyalgia — The National Fibromyalgia and Chronic Pain Association recommends massage for fibromyalgia pain, noting it can ease symptoms.9

A systematic review and meta-analysis10 of nine randomized controlled trials involving 404 patients looking at the effects of massage therapy for fibromyalgia concluded “Massage therapy with duration ≥5 weeks had beneficial immediate effects on improving pain, anxiety and depression in patients with FM [fibromyalgia]. Massage therapy should be one of the viable complementary and alternative treatments for FM.”

• Cancer pain — According to the Australian Cancer Council,11 massage therapy can be helpful for relieving side effects associated with conventional cancer treatment, citing evidence showing massage can reduce pain, fatigue, nausea, anxiety and depression in cancer patients.

The Council notes that while some worry cancer may spread through massage, such fears are unfounded, and light massage “can safely be given to people at all stages of cancer,” as “the circulation of lymph — from massage or other movement — does not cause cancer to spread.”

A scientific paper12 discussing massage therapy for cancer patients published in Current Oncology in 2007 also noted that massage is “very safe” and that “complications are rare … Adverse effects were associated mainly with massage delivered by laypeople and with techniques other than Swedish massage.”

One of the largest observational studies13 on massage and cancer was done at the Memorial Sloan-Kettering Cancer Center in New York City, which evaluated symptom scores for pain, fatigue, stress and anxiety, nausea and depression among 1,290 cancer patients. Patients had the option of three styles of massage: Swedish, light touch and foot massage. Findings revealed “Symptom scores declined in severity by approximately 50%. Swedish and light touch massage were found to be superior to foot massage.”

• Back pain — A number of studies also support the use of massage for back pain. Among them:

◦ A 2017 study reported that 49.4% of patients with persistent lower back pain who received 10 massage sessions over a 12-week period were clinically improved at 12 weeks, and of those, 75% were still clinically improved at 24 weeks.14

◦ A 2011 study15 concluded massage therapy (one hour of weekly sessions for 10 weeks) “may be effective for treatment of chronic back pain, with benefits lasting at least six months.” Both relaxation and structural massage were helpful, providing about the same amount of benefit.

◦ A 2016 study16 evaluating the effect of Thai massage on patients with upper back pain lasting at least three months found the treatment significantly decreased muscle tension and pain intensity at the end of the treatment session.

◦ A 2016 meta-analysis by the Cochrane Library looking at 25 trials, a majority of which were funded by nonprofit organizations, concluded massage was better than inactive controls for acute, sub-acute and chronic low back pain. When it came to function, massage was effective for sub-acute and chronic pain but not acute cases.

◦ A 2007 study17 found patients who had low back pain for at least six months who received 30-minute massages twice a week for five weeks reported less pain, depression, anxiety and sleep disturbance than controls who received relaxation therapy instead.

Frequency and Dosage Matter for Certain Types of Pain

Some people experience immense relief from massage, anecdotally speaking, while others do not. The difference might come down to the dose. Researchers from the Group Health Research Institute in Seattle looked into the optimal massage dose for people with chronic neck pain.18

Study participants received 30-minute massages two or three times a week, or 60-minute massages one, two or three times weekly. A control group received no massages.

Compared with the no-massage group, those who got massages three times a week were nearly five times more likely to report a significant improvement in function and more than twice as likely to report a significant decrease in pain.

The best pain-relief results were obtained by those who received 60-minute massages two or three times a week. It appears that longer massages worked best for neck pain, as did multiple treatments a week, especially during the first four weeks.

If you try massage therapy and find you’re not getting relief, you may want to try increasing the dose and frequency. There are other variables that impact massage effectiveness as well, such as the technique used and the skill level of the massage therapist.

When choosing a massage therapist, ask your holistic health care provider to recommend a certified massage therapist who is experienced in the type of pain relief you’re seeking.

Massage Therapy for Mental Health

Another area where massage therapy can be helpful is in the treatment of stress, anxiety and depression, including stress experienced by dementia patients. As mentioned, massage affects your nervous system through the nerve endings in your skin, which stimulates the release of “feel good” endorphins that help induce a sense of relaxation and well-being.

A 2015 study19 found Thai massage significantly reduces a stress marker called salivary alpha-amylase (sAA), suggesting it “may have a modest effect on stress reduction.” The American Massage Therapy Association also cites a number of studies20 showing massage helps ease stress, lowering heart rate, blood pressure21 and cortisol levels.

Studies22,23 looking at psychological states specifically have also demonstrated massage results in lower scores on the perceived stress scale, the POMS depression scale and the anxiety state scale.

A meta-analysis24 looking at massage therapy in depressed patients concluded “Massage therapy is significantly associated with alleviated depressive symptoms.” Similarly, a proof-of-concept randomized controlled study25 assessing the effects of Swedish massage on patients with generalized anxiety disorder found two weekly sessions for six weeks to be an effective treatment.

Massage May Help Quell Inflammation

The benefits of massage therapy for pain relief are established enough that it’s commonly used during physical therapy and rehabilitation from injury.

In one study,26 researchers took muscle biopsies from study participants who had received massage therapy or no treatment for exercise-induced muscle damage. According to the authors, massage therapy reduced inflammation and promoted mitochondrial biogenesis in the skeletal muscle.

The study is not without detractors,27 however, who have pointed out its flaws. Still, there’s reason to suspect that massage does have a beneficial impact on inflammation, as pain and inflammation tend to go hand in hand.28 By lowering one, you lower the other, and as discussed above, there’s plenty of evidence supporting the claim that massage can ease pain.

Other research29 from Cedars-Sinai Medical Center in Los Angeles, which I’ll discuss again further below, has also found Swedish massage decreased levels of several interleukins, which play a role in inflammation. According to the authors:

“Preliminary data suggest that a single session of Swedish Massage Therapy produces measurable biologic effects. If replicated, these findings may have implications for managing inflammatory and autoimmune conditions.”

Timing of Massage Therapy May Affect Pain Relief and Inflammation

Timing of treatment may be of the essence here. As noted by licensed massage therapist Amy Bradley Radford in an article in Massage Magazine:30

“If pain is a signal for inflammation to start, then you must limit how much pain you give someone in higher levels of inflammation, or you just feed the fire … There are two ways massage therapists can approach inflammation: directly and indirectly, and which way we choose depends on each client’s ability to heal …

Some clients’ bodies … can heal from pain well through deeper work, stretching or trigger-point therapy.Then there are others … in which that same treatment completely backfires, with the person having to go through days of pain and recovery after the treatment. What is the difference? … The answer is that Client B has more pain and inflammation …

This can present a difficult paradox for the therapist, as the client in more pain typically wants you to ‘work out those knots’ so that he can feel better … If a client has to recover from bodywork instead of feeling immediately better from that appointment, then whatever work was applied put her body into more pain and inflammation, and she did not have the energy to meet the new, additional demand created by the massage …

If your client comes in at a pain level of eight and after the session he is at a three, what does that tell you? That whatever treatment you offered actually gave energy back to the body by reducing pain and therefore inflammation. The energy to heal was offered and received.

This process has a basis in Chinese medicine, which seeks to balance the body by shifting energy, or chi. The important part is that pain decreased and energy demand went down, creating a surplus of energy to fight inflammation or to be given to the area in greatest need of healing.”

This appears to be sensible advice worth keeping in mind by patients and massage therapists alike. If your pain is worse immediately after your session, you may need either a lighter form of massage, or you may need to wait a bit before you get another treatment. As a general rule, the effects of massage therapy tend to be rather rapid, so if you feel pain relief at the end of the session, chances are your inflammation level has been positively impacted.

Massage Therapy Boosts Immune Function

Lymphatic massage31 is characterized by long, gentle, rhythmic strokes performed with light pressure to increase the flow of lymph through your body, thereby aiding the removal of toxins.

By increasing circulating lymphocytes, a form of white blood cells that are especially prevalent in the lymphatic system and fight off infections and disease, lymphatic massage also helps boost your immune function.

Research32 confirming this was published by scientists at Cedars-Sinai Medical Center in Los Angeles. According to the authors:

“Compared to light touch, Swedish Massage Therapy caused a large effect size decrease in AVP [arginine-vasopressin], and a small effect size decrease in CORT [cortisol] … Massage increased the number of circulating lymphocytes … Swedish Massage Therapy decreased IL-4, IL-5, IL-10, and IL-13 levels relative to baseline measures.”

As mentioned earlier, this study concluded that, if findings are able to be replicated, Swedish massage may turn out to be a valuable adjunct in the management of inflammatory and autoimmune conditions.

Two Additional Areas Where Massage Therapy Is Useful

Last but not least, two other areas where massage therapy is useful is in the treatment of spasms or cramps, and to improve flexibility. Injured and overworked muscles have a tendency to spasm and cramp, causing pain and discomfort.

Massage therapy, in this case neuromuscular massage, which involves deeper pressure, can help relax and soften these muscles to prevent spasms and cramping.33

Similarly, by easing stiff muscles and joints, massage therapy can help improve flexibility and range of motion.34 This may be especially beneficial for those who suffer from arthritis or muscle injuries. As noted in one systematic review and meta-analysis35 on the effectiveness of massage on the range of motion of the shoulder:

“Massage therapy is one of the complementary and alternative intervention for improving the functional status for patients who had impaired shoulder function in physical therapy clinics.

It relieves the muscle hardness by applying mechanical pressure on the affected area using the hands, and improves the range of motion of the joints.

In addition, it improves the excitability of the nerves in the muscle fiber and inhibits muscle pain. Massage therapy is also known to improve edema by promoting blood circulation within the muscle, and helps remove fatigue substances.”

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**Comment**

Lyme/MSIDS patients would stick a needle in their eye if they thought it would help relieve their pain.  Please consider massage therapy.

Besides having to determine what kind of patient you are (one that does better after intense deep tissue massage or one that needs light touch due to high inflammation & pain), you also need to make sure the massage lotions & creams being used are toxin-free:  http://www.greenmedinfo.com/blog/your-massage-harming-you?

Category:

Inflammation, Pain Management, Transmission, Treatment

The Powerful Aspirin Alternative Your Doctor Never Told You About

http://www.greenmedinfo.com/blog/powerful-aspirin-alternative-grows-trees-1?

The Powerful Aspirin Alternative Your Doctor Never Told You About

Friday, April 12th 2019 at 4:15 am
Written By: Sayer Ji, Founder
“© [Originally published: 2017-07-23, Article updated: 2019-04-11] GreenMedInfo LLC. This work is reproduced and distributed with the permission of GreenMedInfo LLC. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.”
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Given the newly released cardiovascular disease prevention guidelines recommending against daily low-dose aspirin use, natural, safe and effective alternatives are needed now more than ever. Thankfully, one particularly therapeutic alternative has been known about by the biomedical research community for decades…

In a previous article titled “The Evidence Against Aspirin and For Natural Alternatives,” we discussed the clear and present danger linked with the use of aspirin as well as several clinically proven alternatives that feature significant side benefits as opposed to aspirin’s many known side effects.

Since writing this article, even more evidence has accumulated indicating that aspirin’s risks outweigh its benefits. Most notably, a 15-year Dutch study published in the journal Heart found that among 27,939 healthy female health professionals (average age 54) randomized to receive either 100 mg of aspirin every day or a placebo the risk of gastrointestinal bleeding outweighed the benefit of the intervention for colorectal cancer and cardiovascular disease prevention in those under 65 years of age. Most recently, last month, new cardiovascular disease prevention guidelines submitted jointly by the American College of Cardiology and the American Heart Associated and published in the Journal of the American College of Cardiology, earlier this year, contradict decades of routine medical advice by explicitly advising against the daily use of low-dose or baby aspirin (75-100 mg) as a preventive health strategy against stroke or heart attack, in most cases.

Of course, aspirin is not alone as far as dangerous side effects are concerned. The entire non-steroidal anti-inflammatory (NSAID) category of prescription and over-the-counter drugs is fraught with serious danger. Ibuprofen, for instance, is known to kill thousands each year, and is believed no less dangerous than Merck’s COX-2 inhibitor NSAID drug Vioxx which caused between 88,000-140,000 cases of serious heart disease in the five years it was on the market (1999-2004). Tylenol is so profoundly toxic to the liver that contributing writer Dr. Michael Murray recently asked in his Op-Ed piece, “Is it Time for the FDA to Remove Tylenol From the Market?” Just as serious are tylenol’s empathy destroying properties that were only identified four years ago.

Given the dire state of affairs associated with pharmaceutical intervention for chronic pain issues, what can folks do who don’t want to kill themselves along with their pain?

Pine Bark Extract (Pycnogenol) Puts Aspirin To Shame

When it comes to aspirin alternatives, one promising contender is pycnogenol, a powerful antioxidant extracted from French maritime pine bark, backed by over 40 years of research, the most compelling of which we have aggregated on GreenMedInfo.com here: Pycnogenol Research. Amazingly, you will find research indexed there showing it may have value for over 80 health conditions.

In 1999, a remarkable study published in the journal Thrombotic Research found that pycnogenol was superior (i.e. effective at a lower dosage) to aspirin at inhibiting smoking-induced clotting, without the significant (and potentially life-threatening) increase in bleeding time associated with aspirin use. The abstract is well worth reading in its entirety:

“The effects of a bioflavonoid mixture, Pycnogenol, were assessed on platelet function in humans. Cigarette smoking increased heart rate and blood pressure. These increases were not influenced by oral consumption of Pycnogenol or Aspirin just before smoking. However, increased platelet reactivity yielding aggregation 2 hours after smoking was prevented by 500 mg Aspirin or 100 mg Pycnogenol in 22 German heavy smokers. In a group of 16 American smokers, blood pressure increased after smoking. It was unchanged after intake of 500 mg Aspirin or 125 mg Pycnogenol. In another group of 19 American smokers, increased platelet aggregation was more significantly reduced by 200 than either 150 mg or 100 mg Pycnogenol supplementation. This study showed that a single, high dose, 200 mg Pycnogenol, remained effective for over 6 days against smoking-induced platelet aggregation. Smoking increased platelet aggregation that was prevented after administration of 500 mg Aspirin and 125 mg Pycnogenol. Thus, smoking-induced enhanced platelet aggregation was inhibited by 500 mg Aspirin as well as by a lower range of 100-125 mg Pycnogenol. Aspirin significantly (p<0.001) increased bleeding time from 167 to 236 seconds while Pycnogenol did not. These observations suggest an advantageous risk-benefit ratio for Pycnogenol.” [emphasis added]

As emphasized in bold above, pycnogenol unlike aspirin did not significantly increase bleeding time. This has profound implications, as aspirin’s potent anti-platelet/’blood thinning’ properties can also cause life-threatening hemorrhagic events. If this study is accurate and pycnogenol is more effective at decreasing pathologic platelet aggregation at a lower dose without causing the increased bleeding linked to aspirin, then it is clearly a superior natural alternative worthy of far more attention by the conventional medical establishment and research community than it presently receives.

Not Just A Drug Alternative

Pycnogenol, like so many other natural interventions, has a wide range of side benefits that may confer significant advantage when it comes to reducing cardiovascular disease risk. For instance, pycnogenol is also:

  • Blood Pressure Reducing/Endothelial Function Enhancer: A number of clinical studies indicate that pycnogenol is therapeutic for those suffering with hypertension. Pycnogenol actually addresses a root cause of hypertension and cardiovascular disease in general, namely, endothelial dysfunction (the inability of the inner lining of the blood vessels to function correctly, e.g. fully dilate).[1] It has been shown to prevent damage in microcirculation in hypertensive patients, as well as reducing the dose of blood pressure drugs in hypertensive patients,[2] including hypertensive diabetic patients.[3] It has even been found to reduce intraocular hypertension found in glaucoma patients.[4]
  • Anti-Inflammatory Effects: There is a growing appreciation among the medical community that inflammation contributes to cardiovascular disease. Several markers, including C-reactive protein are now being fore grounded as being at least as important in determining cardiovascular disease risk as various blood lipids and/or their ratios, such as low-density lipoprotein (LDL). Pycnogenol has been found to reduce C-reactive protein in hypertensive patients.[5] Pycnogenol has been found to rapidly modulate downward (inhibit) both Cox-1 and Cox-2 enzyme activity in human subjects, resulting in reduced expression of these inflammation-promoting enzymes within 30 minutes post-ingestion.[6]Another observed anti-inflammatory effect of pycnogenol is its ability to down-regulate the class of inflammatory enzymes known as matrix metalloproteinases (MMPs).[7]Pycnogenol has also been found to significantly inhibit NF-kappaB activation, a key body-wide regulator of inflammation levels whose overexpression and/or dysregulation may result in pathologic cardiovascular manifestations.[8] Finally, pycnogenol has been found to reduce fibrinogen levels, a glycoprotein that contributes to the formation of blood clots; fibrinogen has been identified as an independent risk factor for cardiovascular disease.[9]
  • The Ideal Air Travel Companion: In a previous article entitled, “How Pine Bark Extract Could Save Air Travelers Lives,” we delve into a compelling body of research that indicates pycnogenol may be the perfect preventive remedy for preventing flight-associated thrombosis, edema, and concerns related to radiotoxicity and immune suppression.

Given the evidence for pycnogenol’s pleotrophic cardioprotective properties, we hope that pycnogenol will become more commonly recommended by health care practitioners as the medical paradigm continues to evolve past its reliance on synthetic chemicals, eventually (we hope) returning to natural, increasingly evidence-based interventions. However, it is important that we don’t fall prey to the one-disease-one-pill model, convincing ourselves to focus on popping pills – this time natural ones – as simply countermeasures or ‘insurance’ against the well-known harms associated with the standard American diet, lack of exercise and uncontrolled stress. The ultimate goal is to remove the need for pills altogether, focusing on preventing cardiovascular disease from the ground up and inside out, e.g. letting high quality food, clean water and air, and a healthy attitude nourish and sustain your health and well-being.

References

[1] Ximing Liu, Junping Wei, Fengsen Tan, Shengming Zhou, Gudrun Würthwein, Peter Rohdewald. Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients. Life Sci. 2004 Jan 2;74(7):855-62. PMID: 14659974

[2] Gianni Belcaro, Maria Rosaria Cesarone, Andrea Ricci, Umberto Cornelli, Peter Rodhewald, Andrea Ledda, Andrea Di Renzo, Stefano Stuard, Marisa Cacchio, Giulia Vinciguerra, Giuseppe Gizzi, Luciano Pellegrini, Mark Dugall, Filiberto Fano. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost. 2006 Oct;12(4):440-4. PMID: 17000888

[3] Sherma Zibadi, Peter J Rohdewald, Danna Park, Ronald Ross Watson. Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008 May;28(5):315-20. PMID: 19083426

[4] Robert D Steigerwalt, Belcaro Gianni, Morazzoni Paolo, Ezio Bombardelli, Carolina Burki, Frank Schönlau. Effects of Mirtogenol on ocular blood flow and intraocular hypertension in asymptomatic subjects. Mol Vis. 2008;14:1288-92. Epub 2008 Jul 10. PMID: 18618008

[5] Maria Rosaria Cesarone, Gianni Belcaro, Stefano Stuard, Frank Schönlau, Andrea Di Renzo, Maria Giovanna Grossi, Mark Dugall, Umberto Cornelli, Marisa Cacchio, Giuseppe Gizzi, Luciano Pellegrini. Kidney flow and function in hypertension: protective effects of pycnogenol in hypertensive participants–a controlled study. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):41-6. Epub 2010 Jan 22. PMID: 20097689

[6] Angelika Schäfer, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol). Biomed Pharmacother. 2006 Jan;60(1):5-9. Epub 2005 Oct 26. PMID: 16330178

[7] Tanja Grimm, Angelika Schäfer, Petra Högger. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Wei Sheng Yan Jiu. 2011 Jan;40(1):103-6. PMID: 14990359

[8] Tanja Grimm, Zuzana Chovanová, Jana Muchová, Katarína Sumegová, Anna Liptáková, Zdenka Duracková, Petra Högger. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006;3:1. Epub 2006 Jan 27. PMID: 16441890

[9] G Belcaro, M R Cesarone, S Errichi, C Zulli, B M Errichi, G Vinciguerra, A Ledda, A Di Renzo, S Stuard, M Dugall, L Pellegrini, G Gizzi, E Ippolito, A Ricci, M Cacchio, G Cipollone, I Ruffini, F Fano, M Hosoi, P Rohdewald. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol. Redox Rep. 2008;13(6):271-6. PMID: 19017467

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For more:  https://madisonarealymesupportgroup.com/2019/04/08/three-alternative-strategies-that-can-address-severe-chronic-pain/

https://madisonarealymesupportgroup.com/2018/12/09/live-webinar-the-pain-solution-with-dr-bill-rawls/

https://madisonarealymesupportgroup.com/2019/01/10/fatigue-joint-pain-and-low-testosterone-had-lyme-podcast/

 

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Inflammation, Pain Management, research, Supplements, Treatment