Archive for the ‘Inflammation’ Category

The Power Trio: NAD+, Glutathione, & Methylcobalamin in Lyme Treatment

https://www.lymedisease.org/power-trio-nad-glutathione-b12/

The power trio: NAD+, glutathione, and methylcobalamin in Lyme treatment

California’s Board of Pharmacy may soon restrict access to a variety of compounds that many Lyme patients find essential to getting well. This doctor explains why she thinks that’s a bad idea–and how you can take action to stop it. Sign the petition here.

By Pamela M. Davis, MD

If you’re dealing with Lyme disease or know someone who is, you’ve probably heard about NAD+, glutathione, and methylcobalamin. These compounds are generating significant buzz in the Lyme treatment community, and for good reason.

Let’s dive into what makes these treatments so promising and why they might be game-changers for Lyme patients.

Living with Lyme disease is like fighting a battle on multiple fronts. From crushing fatigue to brain fog, from joint pain to neurological symptoms, Lyme can feel overwhelming.

What makes it particularly challenging is how the bacteria affects multiple body systems simultaneously, creating a complex web of symptoms that can be difficult to address.

Enter the power trio

This is where our three heroes come in: NAD+, glutathione, and methylcobalamin. When properly compounded in sterile conditions (this part is crucial!), these substances work together to support your body’s natural healing processes. Let’s break down how each one helps.

Your cellular battery charger: NAD+

Think of nicotinamide adenine dinucleotide (NAD+) as your cells’ rechargeable battery. In Lyme disease, these batteries often run dangerously low. Here’s what NAD+ does:

  • Boosts energy production at the cellular level
  • Helps clear the mental fog that many Lyme patients struggle with
  • Supports your body’s repair systems
  • Helps regulate sleep cycles (which are often disrupted in Lyme patients)

Real talk: Many Lyme patients report feeling a noticeable uptick in energy and mental clarity within days of starting NAD+ treatment. Especially when it is given intravenously. While individual results vary, the energy boost can be significant enough to help patients return to daily activities they’d previously given up.

Your body’s master detoxifier: glutathione

If NAD+ is your battery charger, glutathione is your body’s cleanup crew. During Lyme treatment, your body deals with a lot of toxins, both from the bacteria themselves and from their die-off during treatment.

Here’s where glutathione shines:

  • Neutralizes harmful free radicals that cause inflammation
  • Supports your liver in processing and eliminating toxins
  • Helps reduce the severity of herxheimer reactions
  • Strengthens your immune response

Pro tip: Many Lyme patients find that glutathione helps them tolerate their primary treatments better by reducing side effects and detox symptoms.

Your nerve repair expert: methylcobalamin

This active form of vitamin B12 is particularly crucial for Lyme patients dealing with neurological symptoms.

Here’s what makes it special:

  • Directly supports nerve repair and protection
  • Helps improve brain fog and cognitive function
  • Supports energy production
  • Aids in mood regulation

The best part? Methylcobalamin’s benefits often become noticeable within weeks, particularly in areas of cognitive function and energy levels.

Better together: the synergy effect

While each of these compounds is powerful on its own, the magic really happens when they work together. Think of it as a well-coordinated team: NAD+ provides the energy; glutathione handles the cleanup; methylcobalamin repairs the damage. Together, they create a comprehensive support system for your body during Lyme treatment.

What makes this approach different? The key lies in proper compounding and administration. When these substances are prepared in sterile conditions and administered properly (usually through IV or injection), they can:

  • Reach therapeutic levels more effectively
  • Work more quickly than oral supplements
  • Provide more consistent results
  • Support your primary Lyme treatment protocol

Real-world implementation

If you’re considering these treatments, here’s what you should know:

  • They work best as part of a comprehensive treatment plan
  • Proper administration via IV or injection is crucial for effectiveness
  • Response can vary from person to person
  • Regular monitoring helps optimize results

Looking Forward: The use of these compounds in Lyme disease treatment continues to evolve, with new protocols and applications being developed. While they’re not a magic bullet, they represent a powerful tool in the Lyme treatment toolkit.

The bottom line

For many Lyme patients, the combination of NAD+, glutathione, and methylcobalamin provides valuable support during treatment. While they shouldn’t replace your primary Lyme protocol, they can significantly enhance your body’s ability to heal and manage symptoms.

Remember: Always work with a qualified healthcare provider who understands both Lyme disease and these compounds. They can help you determine the right protocol for your specific situation and ensure you’re getting the highest quality, properly compounded versions of these supplements.

Alarming developments in California

Recently the California Board of Pharmacy (BOP) has proposed limiting and/or completely blocking access to these life changing compounds. They are also looking to further reduce the number of credentialed compounding pharmacies operating in the state of California.

Because of the need to control costs and to keep these compounds fresh and protected from excessive heat in order for them to be effective, local pharmacies are key.

Firefighters in particular are making statements about their need to have easy access to glutathione to help their lungs recover after battling fires.

Please consider signing the petition to stop the pharmacy board from closing the very necessary compounding pharmacies and blocking access to these very effective treatments.

Dozens of vitamins, antioxidants, enzymes, peptides, hormones and herbs that are legal, effective and needed by so many suffering with chronic diseases are also at risk of being banned by the California board of Pharmacy. Even if you are from another state, your opinion matters because where California goes many other states might follow.

You can give a public comment at the Board of Pharmacy meeting on November 7. You can either do this in person in San Diego, or online via WebEx. Go to StopTheBOP to learn more about this issue and how you can make your opinion known.

*Disclaimer: This post is for informational purposes only and should not be considered medical advice. Always consult with your healthcare provider before starting any new treatment protocol.*

Pamela Davis, MD, is in private practice in Los Angeles. She sees patients in person and via telemedicine, and can be reached through her website.

IBD Masquerading as Lyme Disease

https://pubmed.ncbi.nlm.nih.gov/37392196/

Borrelia Burgdorferi, a Root Cause of Inflammatory Bowel Disease: A Case Report of Successful Treatment and Remission

PMID: 37392196

Abstract

Background: The Borrelia species is recognized to cause a myriad of non-specific symptoms among Lyme patients. It has also been documented in the literature to have the ability to incite autoimmune responses. Despite this, very few clinical cases have ever put together the autoimmune connection to such infections, including in Crohn’s disease.

Case presentation: A 14-year-old adolescent male with a previous diagnosis of Crohn’s disease was discovered to have underlying Lyme disease caused by Borrelia burgdorferi infection. Identifying this as a potential cause of his autoimmune condition, an integrative medical approach was initiated, resulting in successful treatment and complete remission.

Conclusions: Lyme disease should be recognized as a potential trigger of autoimmune conditions, especially Crohn’s disease. This underlying cause is novel to the literature and may help many patients obtain the proper diagnosis so that curative treatment may be received.

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**Comment**

Inflammatory bowel disease (IBD) is a term that describes disorders involving long-standing (chronic) inflammation of tissues in your digestive tract. Types of IBD include:

  • Ulcerative colitis. This condition involves inflammation and sores (ulcers) along the lining of your large intestine (colon) and rectum.
  • Crohn’s disease. This type of IBD is characterized by inflammation of the lining of your digestive tract, which often can involve the deeper layers of the digestive tract. Crohn’s disease most commonly affects the small intestine. However, it can also affect the large intestine and uncommonly, the upper gastrointestinal tract.

Both ulcerative colitis and Crohn’s disease usually are characterized by diarrhea, rectal bleeding, abdominal pain, fatigue and weight loss.  Source

First Swedish Studies Expose 5G Symptoms

https://drtesslawrie.substack.com/p/the-first-5g-studies-have-emerged?

The first 5G studies have emerged from Sweden exposing symptoms linked to 5G radiation

What will control this rampant industry?

Dr. Tess Lawrie

A recent scientific article published in Reviews on Environmental Health reviews seven small-scale studies on microwave syndrome associated with the rollout of 5G.

Despite many scientists raising concerns about the potential negative impacts of fifth generation (5G) technology on health, governments and industry have ignored calls for a moratorium on 5G deployment.

Prior to the accelerated rollout of 5G technology in 2020 (under cover of the Covid lockdowns) very little research had been conducted on the biological effects of exposure to 5G radiofrequency (RF) radiation and no long-term health studies were available. A few animal studies, however, revealed negative effects on the liver, kidneys, brain, muscles, bones and plasma after exposure to 5G frequencies around 3.5 GHz.

Mobile phone carrier waves operate within the microwave frequency range. Since the 1960s, we have known that microwave radiation is harmful to health, with symptoms of ‘microwave syndrome’ including difficulties sleeping, headaches, fatigue, irritability, concentration problems, loss of short-term memory, emotional distress, depression, anxiety, unusual touch-based sensations including burning skin, cardiovascular symptoms, shortness of breath, and muscle- and joint pain.

In Sweden, since the rollout of 5G, seven small case studies were conducted that tracked the health impacts of high RF radiation on 16 people living or working close to 5G base stations or towers (within 3 to 538 metres). These individuals, who ranged in age from four to 83 years, started experiencing symptoms characteristic of microwave syndrome shortly after the activation of 5G. In most cases, their symptoms waned or disappeared after they moved away from the source. In the studies, each person rated, on a scale of zero to ten, their experience of 41 different health issues associated with microwave syndrome.

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**Comment**

In a recent post ‘Vaccines’ & Harmful Intent it was stated that the COVID ‘plandemic’ was the excuse used to inject billions with a mysterious cocktail of untested and unproven  nanotechnology.  I would argue the same can be said for 5G, AI, Wifi, 3D, digital ID, and smart meter rollout, all of which have not been proven to be safe, and in fact have been connected to a wide range of disease in all biological life forms.

For more:

5 Things You Can Do to Support Your Lyme Diagnosis With Nutrition

https://www.globallymealliance.org/blog/5-things-you-can-do-to-support-your-lyme-diagnosis-with-nutrition

Part 2 of the Lyme and Nutrition Series, sponsored by RxSugar®
Learn how to manage Lyme disease by improving gut health, reducing inflammation, and incorporating specific dietary changes, as well as the five actionable diet tips for a healthier Lyme journey.

Lyme disease might be the diagnosis, but it’s not always the name of the game. It is an addition to a trifecta between immune function, inflammation and gut health. These three pieces have a direct influence on each other, but now, Lyme disease makes it into a “quadrifecta”.

There is an interdependent link between the health of our gut, where the majority of our immune system lives, and inflammation; this is amplified by Lyme disease. Treatment can also play a role in this as well if antibiotics are used, which also affect the health of our gut. This diagram shows the interconnected relationship between the four pieces, the “Lyme Quadrifecta:”

Lyme "quadrafecta" graphic

A disruption of our gut’s bacterial balance, known as gut dysbiosis, intensifies inflammation, weakening our immune system and complicating recovery from Lyme disease. Since a significant portion of our immune system resides in our gut, maintaining its health becomes paramount when combating Lyme disease.

I promised to share five diet tips to help with your Lyme diagnosis, but it’s not just about the list itself. Making sure you understand why I’m suggesting things is just as important. I want you to grasp why these tips are helpful. When we know the “why”, we can take charge of our own health better. Knowing the reasons behind these suggestions gives you the power to make smart decisions about what you eat and how you take care of yourself. It will help you follow through on the changes you’re looking to make.

My Lyme journey began in April 2014, following a tick bite. It all started with exhaustion, a sore throat, and knee pain. Within a few months, it spread to my joints and tendons. Despite seeing a rheumatologist for several months, my symptoms didn’t fit neatly into any diagnosis.

By spring 2015, the joint and muscle pain, along with swelling, were overwhelming. With no answers from doctors, I decided to take matters into my own hands. I switched gears, putting on my dietitian hat and becoming my own patient zero. After days of researching science journals, I presented my findings to my family doctor. It wasn’t about the supplements or the lack of diagnosis; it boiled down to focusing on my gut health. This was something I could do. And something I had full decision power over. It was empowering to take control back.

I embarked on a strict elimination diet, fine-tuning it over time to be able to share a more practical approach. I was my own experiment. I learned a lot about my body; gluten turned out to be a big trigger for joint pain and inflammation – that was the first step. Cutting out sugar was next, and I noticed of the inflammation easing up.

I incorporated more plant-based foods, ancient grains, and fermented foods. These changes naturally led to steps four and five, which I’ll discuss below. By taking these steps, I was strengthening my gut. When it was time for treatment, this turned out to be the most beneficial thing I could have done. In my other blog about Lyme, the gut microbiome and inflammation, I discussed the results of testing I had done on my gut health immediately after I had been on pulsed antibiotics for 1.5 years; I did it right. I unlocked key pieces to this puzzle when I started all of that work with my own diet in 2015. And this is the exact system I am passionate about sharing with others.

Imagine the pyramid below as a game of Jenga. As you begin to remove or weaken a piece (symbolizing a decline in that particular bodily function), the stability of the entire structure becomes compromised, eventually leading to its possible collapse. Gut health has been a buzz word for a number of years now, so first, let’s have a look at why it matters for our overall health.

Pyramid of the gut functions

What does the gut do?

  • Digestion and Nutrient Absorption: The gut is responsible for breaking down food, absorbing nutrients, and eliminating waste products.
  • Immune System Support: A balanced gut microbiota helps regulate the immune response.
  • Mental Health and Brain Function: The gut and brain communicate through the gut-brain axis. Neurotransmitters and other signaling molecules are produced in the gut and they can affect mood, cognition, and behavior. Imbalances in gut bacteria have been linked to undesirable mental health outcomes.
  • Inflammation: An imbalance in gut microbiota can lead to chronic inflammation, which is associated with various diseases, including Lyme disease, inflammatory bowel disease, autoimmune conditions, and metabolic disorders.

Now that you understand how these building blocks stack together, let’s look at five ways you can support your Lyme diagnosis with food and nutrition, giving you actionable steps to strengthen your gut health, manage inflammation, and enhance your journey towards managing and healing from Lyme disease:

1. Remove gluten
When you have Lyme disease, you may have more inflammation in your body, and gluten can trigger an inflammatory response, potentially worsening symptoms such as joint pain, fatigue, and neurological issues associated with Lyme disease.

Gluten can contribute to gut inflammation and hyper-permeability of the intestinal barrier, commonly known as “leaky gut”, allowing large particles into the blood stream that shouldn’t have been able to pass through. This can further heighten inflammation and immune dysregulation, which are already intensified in Lyme disease.

The relationship between gluten and Lyme disease symptoms is unique to everyone, but minimizing or eliminating gluten intake may be beneficial for individuals with Lyme disease, particularly those who experience heightened inflammation, gut issues, or gluten sensitivities.

 2. Remove added sugar

The average daily intake of sugar is reported to be around 68 grams (17 teaspoons), but this figure may underestimate reality. Consider the sugar content in some common food and drink options:

  • A 16oz bottle of Cola contains 44 grams (11 tsp) of sugar.
  • A 12oz bottle of Gatorade contains 21 grams (5.25 tsp).
  • One cup of oat milk contains about 6 grams (1.5 tsp).
  • A tall lavender oat latte from Starbucks has 15 grams (3.75 tsp).
  • Honey Nut Cheerios, a popular gluten-free cereal, contains 9 grams (2.25 tsp) in ¾ cup.
  • Silk Vanilla Non-Dairy yogurt has 11 grams (2.75 tsp) in ¾ cup.
  • One tablespoon of Silk Vanilla Coffee Cream contains 4 grams (1 tsp).

While cola and Gatorade aren’t likely staples, the other items are typical common treats or pantry staples. It’s crucial to recognize how quickly added sugar can accumulate throughout your day, especially since it’s often concealed in packaged foods like condiments, salad dressings, frozen meals, crackers, cereals, and more. But why should you aim to cut back on added sugar?

Eating too much sugar can contribute to inflammation in your body in several ways:

  • First, it can lead to oxidative stress and inflammation in the body by reacting with proteins in a process called glycation, forming advanced glycation end products (AGEs). AGEs contribute to inflammation.
  • Second, it can activate inflammatory signals. High amounts of sugar can turn on inflammation pathways in the body that lead to inflammatory molecules called cytokines, causing your body to produce more substances that make it swell and hurt, and well… stay inflamed.
  • Third, it can contribute to an imbalance in the microbes living in the gut. Too much sugar can tip the balance of good bacteria in your gut, leading to what we call “dysbiosis” and inflammation of the gut which can contribute to “leaky gut” and immune dysregulation, and it can also contribute to inflammation throughout the whole body.
  • Fourth, eating lots of sugar can make your body less sensitive to insulin (aka “insulin resistance”) and that can trigger pro-inflammatory cytokines, contributing to systemic, whole-body inflammation. This can also lead to more metabolic effects that we would rather avoid.

Hopefully, you can now see how there is an overlap between why gluten and sugar can be harmful when you’re trying to eat to support your Lyme diagnosis.

If you would like to learn more about how to identify sugar on food labels and quickly know exactly how many teaspoons are in a serving? Grab my Lyme Friendly Recipe Book and I’ll send you a few emails to help you learn how to do this yourself in the simplest way possible.

3. Aim for 30+ plant foods per week

Our gut has trillions of tiny living microorganisms that make up our own unique internal ecosystem. These microorganisms can affect our health and cause diseases or help prevent it and improve disease states.

Each person’s gut has its own unique mix of these microorganisms, which usually stays pretty consistent over time, but can change from day to day. What we eat can have a big impact on the types of microorganisms living in our gut, this affects the composition of our gut microbiota, and suggests that dietary changes could alter microbial diversity, composition, and stability.

Eating a diverse range of plant-based foods offers numerous benefits for improving gut microbiome health. The greater the variety of plant foods in our diet, the wider array of benefits we can experience:

Fiber: Plant foods contain several types of fiber, which serve as “prebiotics” – these feed the beneficial bacteria in the gut. By fermenting the fiber we eat, gut bacteria produce short-chain fatty acids (SCFAs) such as acetate, propionate, and butyrate. SCFAs play essential roles in gut health, including nourishing colon cells, reducing inflammation, and regulating metabolism.

Polyphenols: These are antioxidants that are found in fruits, vegetables, nuts, seeds, and whole grains and they also have prebiotic effects on the gut microbiota. They can help the growth of beneficial bacteria and inhibit the growth of harmful pathogens, contributing to a healthier gut environment.

Resistant Starch: You’ll find this in foods like legumes, whole grains, and green bananas. These starches escape digestion in the small intestine and reach the colon intact, where they serve as fuel for beneficial gut bacteria. Fermentation of resistant starch produces SCFAs, promoting gut health.

You can actually boost the amount of resistant starch in your diet a technique called “retrogradation” in starchy foods like rice and potatoes. This happens when these foods are cooked, cooled and reheated. The starch undergoes structural changes: they gelatinize, and upon cooling, some of the starches retrograde, forming resistant starches.

The process of cooking, cooling, and reheating foods to increase resistant starch content is particularly beneficial for individuals looking to support gut health and optimize the nutritional benefits of their diet. Including a variety of foods rich in resistant starches, both cooked and cooled, can contribute to a healthier gut microbiome and overall well-being.

Diverse Nutrients: Plant foods provide a wide range of vitamins, minerals, and phytonutrients that support overall health and microbial diversity in the gut. A diverse diet rich in different types of plant foods ensures that the gut microbiota receives a variety of nutrients needed for optimal function.

Overall, consuming a diverse array of plant foods ensures a rich and varied supply of nutrients and compounds that promote the growth of beneficial gut bacteria, enhance SCFA production, and support overall gut microbiome health. Adding in a variety of plant foods doesn’t need to be complicated.

Go for colorful fruits and vegetables, and consider adding nuts and seeds to your meals – sprinkle them onto salads or blend them into smoothies. If you can tolerate grains, they make a great alternative to store-bought bread and pasta (yes, even those gluten-free options). Quinoa, rice, millet, and amaranth are all excellent choices. Don’t forget about herbs and spices! Adding parsley or cilantro to your dishes or salads can boost flavor and nutritional impact. Experiment with seasonings like turmeric, ginger, and cinnamon, they can add a variety of health benefits to your meals too.

If you’re curious for more about this, you can check out this post on my Instagram where I list out 30 different plant foods you can incorporate in a week. It’s not as overwhelming as it sounds, I promise!

4. Incorporate More Anti-Inflammatory Foods

Certain foods possess anti-inflammatory properties due to their rich content of nutrients and compounds that fight inflammation. These foods can hinder inflammatory pathways, regulate the immune system, and scavenge free radicals, neutralizing and removing highly reactive molecules that can cause cellular damage and contribute to oxidative stress.

Choose foods high in antioxidants like vitamins A, C, and E, selenium, anthocyanins, beta-carotene, and flavonoids. Antioxidants play a crucial role in neutralizing free radicals. To add more of these beneficial nutrients into your diet, include foods such as berries, leafy greens, nuts, seeds, colorful vegetables, spices, beans, lentils, and chickpeas.

Prioritize foods rich in omega-3 fatty acids such as salmon, mackerel, sardines, flaxseeds, chia seeds, and walnuts. These foods can reduce the production of pro-inflammatory compounds such as certain prostaglandins and cytokines while promoting the production of anti-inflammatory compounds.

Polyphenols, another class of antioxidant plant compounds, are abundant in foods like berries, green tea, matcha, dark chocolate, and olive oil. They contain flavonoids which can help neutralize harmful free radicals and reduce oxidative stress and inflammation.

As discussed previously, fiber plays a significant role in lowering inflammation by promoting a healthy gut microbiome. By nourishing beneficial gut bacteria, fiber facilitates the production of short-chain fatty acids (SCFAs), which have anti-inflammatory effects in the body.

Additionally, incorporating herbs and spices such as turmeric, ginger, cinnamon, and garlic can be beneficial due to their compounds with anti-inflammatory properties. In summary, including a diverse array of whole, nutrient-rich foods in your diet can fight inflammation and support overall health and well-being throughout your journey with Lyme and beyond.

Considering points three and four, it becomes obvious that many foods overlap between the two categories. The benefits of a diet focused on whole foods that are minimally processed and rich in nutrients can simultaneously improve gut health and reduce inflammation.

If diving into the intricacies of gut health and inflammation isn’t your priority and you prefer a straightforward approach, the next point may resonate with you. Follow this next approach, and you’ll naturally be supporting yourself in a simplified way.

5. Focus on lots of different whole foods

Emphasizing whole foods simplifies the steps mentioned above. By reducing packaged foods (even gluten free ones), you naturally gravitate towards gluten-free options and foods without added sugars. Opting for whole foods, in their natural state, also helps you to achieve your goal of consuming 30 plant-based foods per week. You’ll naturally eat more fiber that will help function as a prebiotic in your body. And lastly, as you incorporate a variety of colorful whole foods into your diet, you’re not only increasing nutrient density but also benefiting from their inherent antioxidant and anti-inflammatory properties.

Lyme is complicated, but nutrition doesn’t have to be.

***

Thank you to RxSugar® for being the Official Sponsor of our Lyme and Nutrition Series. RxSugar® Certified Allulose products are a great natural sugar alternative to refined sugar. Allulose is the only natural sugar with metabolic benefits and supports the body’s production of GLP-1 and GLP-2 (which helps to mitigate the impact of leaky gut). RxSugar®‘s Plant-based Certified Sugar, Syrup and Chocolate Snacks are USDA Organic, Keto Certified, Grain & Gluten-free, FODMAP Friendly Certified, Vegan with zero blood sugar impact. Use discount code GLA20 at checkout at https://rxsugar.com/ 

*GLA Contributor and Author not compensated by brand for this post

GLA Contributor

Sara Brunner, RD

GLA Contributor

Opinions expressed by contributors are their own. Sara Brunner is a Registered Dietitian (RD) hailing from Canada. In 2014, Sara experienced a significant health challenge after being bitten, initially diagnosed as a spider bite. Despite seeking medical advice, she remained untreated and eventually found herself bed-bound within two years. Throughout this period of undiagnosed illness and escalating symptoms, Sara took proactive measures to manage her health, drawing upon her expertise as a Registered Dietitian. In 2016, Sara received a Lyme+ diagnosis, marking the beginning of her journey towards recovery. It wasn’t until 2022 that she began to witness significant improvements. Despite the prolonged and challenging nature of her journey, Sara remained determined. During this time, she focused on developing The Universal Lyme Diet (ULD), a self-paced online course designed to empower individuals with Lyme disease to create personalized nutrition management plans. Scheduled for release in late 2024, the ULD offers a systematic framework tailored to each individual’s needs. In the interim, you can join the waitlist for the ULD by visiting: https://training.sarabrunner.com/uldwaitlist For more insights and practical tips on navigating your Lyme journey, follow Sara on Instagram: @thelymedietitian

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For part 1:  https://www.globallymealliance.org/blog/lyme-disease-the-gut-microbiome-and-inflammation-the-dos-and-donts

Two Plants in Plaintain Family Show Antioxidant and Bb Inhibiting Properties

https://www.mdpi.com/1422-0067/25/13/7112

Plantago major and Plantago lanceolata Exhibit Antioxidant and Borrelia burgdorferi Inhibiting Activities

by Pille-Riin Laanet, Olga Bragina, Piia Jõul and Merike Vahe*
Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
*Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 202425(13), 7112; https://doi.org/10.3390/ijms25137112
Submission received: 18 May 2024 / Revised: 15 June 2024 / Accepted: 20 June 2024 / Published: 28 June 2024

Abstract

Lyme disease, caused by Borrelia burgdorferi sensu lato infection, is the most widespread vector-borne illness in the Northern Hemisphere. Unfortunately, using targeted antibiotic therapy is often an ineffective cure. The antibiotic resistance and recurring symptoms of Lyme disease are associated with the formation of biofilm-like aggregates of B. burgdorferi. Plant extracts could provide an effective alternative solution as many of them exhibit antibacterial or biofilm inhibiting activities. This study demonstrates the therapeutic potential of Plantago major and Plantago lanceolata as B. burgdorferi inhibitors. Hydroalcoholic extracts from three different samples of each plant were first characterised based on their total concentrations of polyphenolics, flavonoids, iridoids, and antioxidant capacity. Both plants contained substantial amounts of named phytochemicals and showed considerable antioxidant properties. The major non-volatile constituents were then quantified using HPLC-DAD-MS analyses, and volatile constituents were quantified using HS-SPME-GC-MS. The most prevalent non-volatiles were found to be plantamajoside and acteoside, and the most prevalent volatiles were β-caryophyllene, D-limonene, and α-caryophyllene. The B. burgdorferi inhibiting activity of the extracts was tested on stationary-phase B. burgdorferi culture and its biofilm fraction. All extracts showed antibacterial activity, with the most effective lowering the residual bacterial viability down to 15%. Moreover, the extracts prepared from the leaves of each plant additionally demonstrated biofilm inhibiting properties, reducing its formation by 30%.
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**Comment**
Both plants are in the plantain family, which is a diverse family of flowering plants and herbs and includes snapdragons, foxglove, particularly the broadleaf or greater plaintain (Plantago major) which is considered an herb, and narrowleaf plantain or ribwort (Plantago lanceolata).  You will find the former to be a common weed that is often found along the edge of the road.  This is handy because if you react to bee/wasp stings you can chew these leaves which are highly anti-inflammatory and them put it directly on the sting until you get home.  I’ve had to do this.  The tea is also excellent for bronchitis.  While narrowleaf plantain is has supposedly been introduced in WI, I don’t believe I’ve ever seen it and I consider myself a plant freak.
For more:

Word of warning: many think herbs are always safe.  I know of patients who messed themselves up pretty badly with herbs.  Herbs are strong medicine.  Never forget that.  For some they make all the difference.  For others, not so much.  Make sure you learn all you can about these powerful plants and as always – use with caution – as with any treatment.  I’m certainly not trying to dissuade you, just remind you to take heed, do your homework, and preferably work with experienced herbalists.  Nothing beats experience.