Archive for the ‘Babesia’ Category

Babesia Found in Patient With Persistent Symptoms Following Lyme Treatment

https://www.ncbi.nlm.nih.gov/m/pubmed/30262525/

Diagnosis of a tick-borne coinfection in a patient with persistent symptoms following treatment for Lyme disease.

Hoversten K, et al. BMJ Case Rep. 2018.

Abstract

A 67-year-old woman presented with 5 days of myalgias and fevers on completion of a 21-day course of amoxicillin for Lyme disease (Borrelia burgdorferi infection). She was found to have profound thrombocytopenia, as well as new anaemia and leucopenia. Workup revealed Babesia microti as the causative agent of her symptoms. The patient quickly improved after appropriate antimicrobial therapy directed against babesiosis was started. This case illustrates the importance of basic microbiology, including epidemiology and common vectors, when creating a differential diagnosis. Because the Ixodes scapularis tick can harbour and transmit multiple parasites simultaneously, the possibility of coinfection should be considered in any patient not responding to appropriate initial medical therapy.

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**Comment**

Expect a lot more articles like this.  

Word is finally getting out that Lyme is just the Rock Star we all know by name but there are a lot of wanna be’s right behind him that haven’t made the news.  Research still hasn’t been done showing the synergistic effects of all of this together on the human body.  

To date, ticks can transmit 18 and counting pathogens – ALL as devastating as Lyme:  https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/

Lyme alone is a formidable foe that shape shifts to avoid treatment and the immune system that persists for many despite treatment.

Throw in Babesia, Bartonella, Mycoplasma, viruses, Nematodes (parasitic worms), and stuff not even named yet and a scary but telling picture begins to emerge.

More on Babesia:  https://madisonarealymesupportgroup.com/2016/01/16/babesia-treatment/

Please note that Dr. Horowitiz, a prominent Lyme literate doctor (LLMD) recommends 9 months to a year of solid treatment for Babesia.  He’s finding it to be particularly tenacious.

https://madisonarealymesupportgroup.com/2018/06/08/two-cases-of-babesia/  (They typically blame “severe” cases on a compromised immune system like a missing spleen but here we see someone as healthy as a horse all of a sudden develop shock and near respiratory failure).  If you have Lyme & Babesia &/or any other coinfection, your immune system is severely compromised.

https://madisonarealymesupportgroup.com/2018/07/02/splenic-rupture-from-babesiosis-an-emerging-concern-a-systematic-review-of-current-literature/

https://madisonarealymesupportgroup.com/2018/02/20/babesia-and-heart-issues/

https://madisonarealymesupportgroup.com/2018/10/06/case-of-recurrent-fever-multiple-splenic-infarcts-why-short-treatment-duration-often-doesnt-work-for-babesia/

https://madisonarealymesupportgroup.com/2018/06/03/heart-problems-tick-borne-disease/

https://madisonarealymesupportgroup.com/2018/05/31/widespread-babesiosis-in-canada/

https://madisonarealymesupportgroup.com/2018/03/22/what-is-air-hunger-anyway/

Transfusion-transmitted Babesiosis: One State’s Experience

https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.14943

BACKGROUND

The risk for tickborne exposure to Babesia microti infection exists statewide in Massachusetts. Broad exposure complicates investigations of transfusion‐transmitted babesiosis (TTB). We summarize 8 years of the epidemiology of TTB and highlight the role of public health in prevention and control.

STUDY DESIGN AND METHODS

Cases of babesiosis are routinely reported to the Massachusetts Department of Public Health. These are investigated to determine whether they meet the surveillance case definition and to identify whether they were potentially transfusion transmitted. Frequencies from 2009 to 2016 are described and incidence rates calculated using population denominators from the US census. Changes over time were analyzed using simple linear regression.

RESULTS

From 2009 to 2016, there were 2578 cases of babesiosis reported; of these, 45 (1.7%) were transfusion transmitted. Of the 45 cases of TTB, 15 (33%) received blood products from two or more suppliers. In 11 TTB cases, the Department of Public Health was notified first, who in turn notified the appropriate blood provider. In 2009, the crude rate of reported babesiosis was 1.2 per 100,000 population and increased significantly through 2016 to 7.8 per 100,000 population (p = 0.006). The number of blood donors reported with laboratory evidence of B. microti infection increased from 19 in 2012 to 78 in 2016; at the same time, the number of TTB cases decreased from six to three.

CONCLUSION

TTB remains a major challenge, and blood donor screening strategies are currently in the process of implementation. While population and environmental changes facilitate increases in babesiosis, donor screening has the potential to eliminate TTB.

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**Comment**

One problem with blood is ……Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-endemic areas are distributed nationally; thus, clinicians in nonendemic states may fail to include babesiosis in the differential diagnosis of a patient who had a recent transfusion history and a fever of unknown origin.  https://madisonarealymesupportgroup.com/2017/08/08/transfusion-transmitted-babesiosis-in-nonendemic-areas/

And Babesia can rock your world:  https://madisonarealymesupportgroup.com/2016/01/16/babesia-treatment/

https://madisonarealymesupportgroup.com/2018/10/06/case-of-recurrent-fever-multiple-splenic-infarcts-why-short-treatment-duration-often-doesnt-work-for-babesia/

https://madisonarealymesupportgroup.com/2018/10/05/variable-clinical-presentations-of-babesiosis/  (Please read my comments after the references as this article misses many important points)

 

Lyme Carditis Presenting With Atrial Fibrillation

https://www.hindawi.com/journals/cric/2018/5265298/

Case Reports in Cardiology

Volume 2018, Article ID 5265298, 5 pages
https://doi.org/10.1155/2018/5265298

A Case of Lyme Carditis Presenting with Atrial Fibrillation

Peter J. Kennel,1 Melvin Parasram,2 Daniel Lu,3 Diane Zisa,1 Samuel Chung,1 Samuel Freedman,1 Katherine Knorr,1 Timothy Donahoe,1 Steven M. Markowitz,3 and Hadi Halazun3

Published 2 September 2018

Academic Editor: Kjell Nikus

Abstract

We report a case of a 20-year-old man who presented to our institution with a new arrhythmia on a routine EKG. Serial EKG tracings revealed various abnormal rhythms such as episodes of atrial fibrillation, profound first degree AV block, and type I second degree AV block. He was found to have positive serologies for Borrelia burgdorferi. After initiation of antibiotic therapy, the atrial arrhythmias and AV block resolved. Here, we present a case of Lyme carditis presenting with atrial fibrillation, a highly unusual presentation of Lyme carditis.

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**Comment**

Sigh….there it is again – “highly unusual presentation of Lyme carditis……”

Nothing about Lyme is rare.  It’s just not reported.  Please remember, most of these patients for the past 40 years have been told they are imagining their symptoms and, “it’s all in their head.”  Autopsies have rarely been done on these people and they have faced denial the entire time.

For more on heart-related symptoms with tick borne infections:  https://madisonarealymesupportgroup.com/2018/09/17/lyme-carditis-heart-block-other-complications-of-ld/

https://madisonarealymesupportgroup.com/2018/08/14/vermont-resident-dies-of-rare-lyme-disease-complication-that-isnt-rare/  Trust me, folks have been dying from this for a long time.  It’s just now beginning to make the radar.  If you have Lyme/MSIDS and heart issues, speak loudly about it.

https://madisonarealymesupportgroup.com/2018/07/09/with-unexpected-death-autopsies-should-look-for-lyme-carditis/

Microbiologist Tom Greer has a fantastic article about how post-mortem work is one of the only ways we are going to get to the bottom of the Lyme Wars: https://madisonarealymesupportgroup.com/2018/04/13/chronic-lyme-post-mortem-study-needed-to-end-the-lyme-wars/
For information on preparing for brain and tissue donations upon death for Lyme research, please see: http://whatislyme.com/guidelines-for-brain-and-tissue-donations-for-lyme-patients/

Lyme, BTW, is NOT the only tick borne illness that can cause heart issues:  https://madisonarealymesupportgroup.com/2018/02/20/babesia-and-heart-issues/

https://madisonarealymesupportgroup.com/2018/06/03/heart-problems-tick-borne-disease/  (cases listed here)

Most common parasites causing carditis:

  • Borrelia burgdorferi
  • Ehrlichia species
  • Babesia species
  • Trypanosoma cruzi (Chagas Disease)
  • Bartonella (My addition due to the following…..)
    (RESEARCH NEEDED. TONS OF PARASITES INVOLVED WITH TBD)

 

Updates and News From Russell Labs – Wisconsin

http://labs.russell.wisc.edu/wisconsin-ticks/

Updates

August, 2018: Nymphal deer ticks are less abundant but still active in Wisconsin right now. About 20-25% of nymphs are infected with the Lyme spirochete. Overall, 2018 has been normal in terms of tick numbers.

Live in Wisconsin and want your tick identified?

 

Take a picture of ticks on your phone and go here:  https://uwmadison.co1.qualtrics.com/jfe/form/SV_3s1wBopYCcW0lzT

Wisconsin ticks:  http://labs.russell.wisc.edu/wisconsin-ticks/

Go to link for pictures and information on each.  There are 4 ticks listed including the Lone Star Tick, which was until recently considered a Southern tick but is here as well.  Wisconsin had its first RMSF death, transmitted by the Lone Star Tick, recently:  https://madisonarealymesupportgroup.com/2018/07/10/first-rmsf-death-in-wisconsin/

There is also a tab titled “Tick-Borne Diseases.”  Go to link to read about them.  They give WI stats as well.  Please remember ALL the numbers are low as many go unreported:

  • Lyme (Bb or Bm)
  • Borrelia miyamotoi (relapsing fever)
  • Anasplasmosis
  • Ehrlichia muris eauclairensis (EML)
  • Babesiosis
  • Powassan virus/deertick virus
  • Ehrlichia chaffeensis
  • Rocky Mountain Spotted Fever

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A few points stick out to me:

  1. Please take pictures of these ticks & send them in so we finally have an accurate record.  They are asking us for help so let’s give it.  It will only help us in the end.  Flood them with ticks!
  2. Baronella didn’t make the list, yet nearly everyone I work with has it.  WHY?  Because while Bart has been found in ticks, it hasn’t been proven conclusively they transmit.  Bart is a nasty, nasty bug and alone can kill you.  Coupled with Lyme it can make you want to die.
  3. For viruses, they only list Powassan when many more are on record including Heartland and Bourbon (unfortunately they aren’t mandatory to report).  They know Heartland is transmitted by the Lone Star tick but I couldn’t even find the tick supposedly responsible for Bourbon, although it’s a killer:  https://madisonarealymesupportgroup.com/2017/07/01/one-tick-bite-could-put-you-at-risk-for-at-least-6-different-diseases/
  4. The lack of data is glaring.  Seriously.  Glaring.  Zika makes front page news here and our mosquitoes can’t even carry it.  https://madisonarealymesupportgroup.com/2018/03/13/wed-nite-the-lab-talk-on-mosquitoes-ticks-disease/  There were only 46 cases of Zika in the U.S. in 2018 – ALL due to travelers returning from affected areas.The CDC “estimates” that there are 300,000 NEW Lyme Disease cases annually in the U.S.  Anyone see a disparity here between Zika and Lyme?  (Other tick-borne diseases aren’t even on the radar yet)

 

 

 

 

 

 

 

 

Increase of Infected Ticks Means Higher Risk of Tick Bites

https://www.lymedisease.org/lymesci-tick-bites/  (Please see comment at end of article)

LYMESCI: Increase of infected ticks means higher risk of tick bites

by Lonnie Marcum

More ticks in more places means more tick bites.
More tick bites resulting in more sick people.

That’s the result the Entomological Society of America (ESA) was trying to avoid, when in 2015, it published a “Position Statement on Tick-Borne Diseases.”

The article describes a multitude of factors that have created a near “perfect storm,” leading to more infected ticks in more places throughout the United States.

Along with other steps, the ESA recommended engaging the help of citizen-scientists. In 2016, the Bay Area Lyme Foundation (BALF) decided to do just that. The results of this groundbreaking nationwide project have recently been published—and the news is NOT GOOD!

Among many disturbing facts, the new study found blacklegged ticks —carriers of 7 of 18 US tick-borne diseases—in 83 counties where they had never previously been recorded.

More tick bites = more sick people

Ticks have undergone a population explosion over the past two decades, with Ixodes ticks, the primary source of Lyme disease, now found in nearly 50% more U.S. counties than in 1996.

“Since the late 1990s, the number of counties in the northeastern United States that are considered high-risk for Lyme disease has increased by more than 320%,” says Rebecca Eisen from the Division of Vector-Borne Diseases at the CDC. “The tick is now established in areas where it was absent 20 years ago,” she adds.

The reasons for the explosion of tick populations involves complex human and environmental factors and varies by geographic region. Experts feel the major contributing factors are:

  • Warming winter temperatures
  • Migratory bird patterns
  • Changes in landscape, land use and fragmented forests
  • Abundance of vertebrate hosts (mice, deer, squirrels, etc)
  • Reduction in natural predators (foxes, bobcats, etc.)
  • Invasive and non-native plant species
  • Accidental transport by humans (pets, livestock)

With the increase in ticks, we’ve seen a sharp rise in tick bites and tick-borne diseases, with reports of Lyme disease now coming from all 50 states, costing upwards of $75 billion per year.

What’s being done?

While the CDC lists Lyme disease as a nationally notifiable disease, the responsibility for reporting falls to each state’s health departments. The fact is, many states do not (or can’t) enforce these reporting requirements.

In addition to Lyme disease, the CDC lists six other tick-borne diseases as reportable—anaplasmosis, babesiosis, ehrlichiosis, spotted fever rickettsiosis (including Rocky Mountain spotted fever), and tularemia. Again, many states don’t put resources in tracking these illnesses.

The lack of accurate disease reporting leads to a reduction in public health awareness and medical education in areas where it’s needed. This then hinders a patient’s access to timely and accurate diagnosis and early treatment—which are absolutely critical to a good prognosis.

Citizen scientists collect ticks

BALF’s recently published tick study invited citizens from all over the US to send ticks to Northern Arizona University (NAU) for free testing, with the goal of mapping ticks and the diseases they carry.

Many Lyme advocacy groups helped spread the word. For instance, there were more than 16,000 website hits on LymeDisease.org’s announcement about the project.

Researchers had expected that maybe 2,400 ticks would be sent in. To their astonishment, they received over 16,000 ticks collected from 49 states and Puerto Rico. No ticks were received from Alaska.

As lead author Nate Nieto, PhD, associate professor in NAU’s Department of Biological Sciences, explains,

“This study offers a unique and valuable perspective because it looks at risk to humans that goes beyond the physician-reported infection rates and involves ticks that were found on or near people.”

This represents the first nationwide tick study with the goal of mapping the prevalence of disease-carrying ticks throughout the United States. During the period from January 2016 through August 2017, people could send ticks to NAU, free of charge, for testing of the most common tick-borne infections:

  • Borrelia burgdorferi, the cause of Lyme disease,
  • Borrelia miyamotoi, which causes tick-borne relapsing fever (TBRF), a Lyme-like illness,
  • Anaplasma phagocytophilum, the cause of granulocytic anaplasmosis, and
  • Babesia microti, the protozoan parasite that causes Babesiosis.
The Findings
  • Over 70% of submissions were the result of human tick bites.
  • Blacklegged ticks were found in 83 counties (in 24 states) where they had not previously been recorded.
  • All four pathogens tested for (Anaplasma, Babesia, Borrelia burgdorferi and Borrelia miyamotoi) were found in all three of the most commonly encountered hard-ticks species collected (deer tick, American dog tick, lone star tick).
  • Some ticks tested positive for up to three pathogens (no ticks contained all four).
  • All life stages of these three hard-tick species, including some larvae, were found to be infected with both Borrelia burgdorferi and Borrelia miyamotoi.
  • On the East Coast, B. burgdorferi, the cause of Lyme disease, was predominantly detected in adult Ixodes scapularis (deer tick).
  • On the West Coast, B. burgdorferi was highest in larval Ixodes pacificus (western blacklegged tick).
  • The highest prevalence of Borrelia miyamotoi (a relapsing fever species Borrelia that causes Lyme-like illness) was found in larval ticks in the western US.
  • Babesia was found in lone star ticks in 26 counties (in 10 states) where public health departments do not require reporting.
  • Several Amblyomma americanum, commonly known as the lone star tick and capable of carrying bacteria that cause disease in humans, were found in Northern California, the first known report of this tick in the state.

tick-bite-map

Tick bite map of US

Limits of the Study

While the study was hugely successful, it did have some limits. For one, the sample of ticks was limited to only those areas where citizens were participating, therefore the maps may not show all areas with ticks.

In addition, the researchers only tested for four of the many pathogens known to cause illness in humans.

Pathogens not tested for include: Multiple species of Borrelia including Mayonii, and Bisettii, which also cause Lyme-like illness; Ehrlichia chaffeensis, the cause of human monocytic erhlichiosis; Francisella tularensis, the cause of tularemia; Rickettsia rickettsii, the bacterial agent of Rocky Mountain spotted fever; multiple species of the protozoan pathogen Babesia, including duncani and divergens; and several viruses known to be transmitted by ticks including Bourbon virus, Colorado tick fever virus, Heartland virus, and Powassan virus.

Lack of funding for more studies

Lack of funding poses the biggest challenge to fully understanding the risks that ticks pose to the US population.

When asked, the CDC’s Ben Beard stated

“We’ve got national maps, but we don’t have detailed local information about where the worst areas for ticks are located.…The reason for that is there has never been public funding to support systematic tick surveillance efforts.”

It’s no secret that within weeks of the first Zika infection in 2016, Congress authorized $1.7 billion in funding, of which $397 million was made immediately available to rapidly develop an accurate test and begin work on a vaccine.

That same year, the federal budget allotted only $28 million for Lyme disease—the most common vector-borne disease in the US. (Note: while the CDC can study and report on diseases, it is not allowed to lobby Congress for funding.)

What did we learn?

The big take-away from the NAU study is that ticks are everywhere, and they are full of dangerous pathogens—not just Lyme disease. This study demonstrates that ticks are spreading in range, and they are carrying more pathogens than ever before.

Until we find better ways for the CDC to report illnesses, these type of risk maps, that are generated from the pathogens the ticks are carrying, will be the best predictor of disease.

Finally, we all need to get out there and tell our representatives the dangers that lurk in our backyards. Call them. Ask to meet with them. Bring them a copy of this report. Let them know we need an dramatic increase in funding for Lyme and tick-borne diseases.

Click here for more information about ticks:  https://www.lymedisease.org/lyme-basics/ticks/about-ticks/

LymeSci is written by Lonnie Marcum, a Licensed Physical Therapist and mother of a daughter with Lyme. Follow her on Twitter: @LonnieRhea Email her at: lmarcum@lymedisease.org .

References:

  1. Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States, PLOSone, July 2018,  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199644
  2. County-Scale Distribution of Ixodes scapularis and Ixodes pacificus (Acari: Ixodidae) in the Continental United States , Journal of Medical Entomology, Volume 53, Issue 2, 1 March 2016, Pages 349–386,  https://academic.oup.com/jme/article/53/2/349/2459744
  3. Entomological Society of America Position Statement on Tick-Borne Diseases Approved on July 29, 2015, Valid through July 29, 2019  http://www.entsoc.org/PDF/2015/ESA-PolicyStatement-TickBorneDiseases.pdf
  4. Report of the Disease Vectors, Surveillance, and Prevention Subcommittee to the Tick-Borne Disease Working Group  https://www.hhs.gov/ash/advisory-committees/tickbornedisease/reports/disease-vectors-2018-5-9/index.html

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**Comment**

Canadian independent tick researcher, John Scott, stands in opposition to the climate change model affecting tick movement:  https://madisonarealymesupportgroup.com/2018/08/13/study-shows-lyme-not-propelled-by-climate-change/  A recent study shows that warm winters are lethal to I. scapularis (black-legged) ticks. In fact, overwinter survival dropped to 33% when the snow melted. This has been substantiated by other researchers as well. Scott & Scott, 2018, ticks and climate change, JVSM

Also, illogically, people on one hand admit that ticks are now “everywhere” but keep pushing the importance of geographical maps.  Why?  These maps are worthless & constantly changing.  Migratory birds are transiting ticks worldwide along with the fox, coyote, lizard, mouse, and 1,000 other carriers including humans traveling everywhere.

Why do we continue to push and believe in maps that have kept people from diagnosis and treatment for decades?

I’ll tell you why – it’s lining pockets with money.

Authorities look at the inaccurate and constantly changing maps and announce,
“You can’t have ______________, it doesn’t exist here.”

More data that actually hurts patients.

This tick border thing is a man-made constructed paradigm that has never been accurate, but it fits the CDC/NIH/IDSA narrative. http://steveclarknd.com/wp-content/uploads/2013/11/The-Confounding-Debate-Over-Lyme-Disease-in-the-South-DiscoverMagazine.com_.pdf (go to page 6 and read about Speilman’s maps which are faulty but have ruled like the Iron Curtain, and have been used to keep folks from being diagnosed and treated)

Dr. Masters fought this tooth and nail for his suffering patients in the South:  https://madisonarealymesupportgroup.com/2017/10/06/remembering-dr-masters-the-rebel-for-lyme-patients-who-took-on-the-cdc-single-handedly/  Even though Fier found borrelia in 2% of sampled lone star ticks and subsequently supported Masters’ Missouri Lyme, the CDC insisted that the EM rash was NOT diagnostic for LD for Missouri patients due to the fact that neither Ixodes dammini nor Ixodes pacificus were found there.  

Maps are continually used against patients and have ALWAYS been faulty:  https://madisonarealymesupportgroup.com/2017/08/24/canine-maps-better-than-the-cdcs-in-predicting-lyme-disease/ (nothing’s changed)

TIME TO PULL THE BLINDERS OFF AND LOOK AT THIS THING AS THE PANDEMIC IT TRULY IS, AND TIME TO FOCUS ON ISSUES THAT ACTUALLY RELIEVE PATIENT SUFFERING.