Inquiry to the Inspector General for Scientific Integrity (Klempner antibiotic trials)

Carl Tuttle

Hudson, NH, United States

Aug 26, 2022 — 

The open inquiry below has been acknowledged by the National Science Foundation Office of Inspector General and Director of the Office of Research Integrity. Dr. Peggy Fischer has since retired so I am now communicating with her superiors. Updates to follow…

———- Original Message ———-
To: “” <>
Date: 08/22/2022 1:29 PM
Subject: NIH funded study in 2001 Identifier: NCT00000938
Dr. Peggy Fischer
Associate Inspector General for Scientific Integrity
National Science Foundation
4201 Wilson Boulevard, Suite 1135
Arlington, VA 22230

Dear Dr. Fischer,

I would like to call attention to the 2018 letter below addressed to Dr. Mark Klempner Principal Investigator of the so-called “Klempner Antibiotic Trials” for Lyme disease (NIH funded in 2001) which by the way were stopped after only 90 days.

The reason for contacting you is strait forward; I believe (as do countless others in the medical/academic fields) that these studies were fatally flawed and set the stage for unimaginable pain and suffering all across America. The letter to Klempner below describes the issue and the attached document with over 360 references concluding the exact opposite of the Klempner findings, warrants an investigation.

Persistence of The Lyme Disease Bacterium, Borrelia burgdorferi

This “cherry picking” of the Klempner Antibiotic Trials by our Public Health Officials and Infectious Diseases Society of America has got to stop because all other evidence is pointing to an antibiotic resistant/tolerant superbug which would put Lyme in a different class of infection altogether, one requiring an immediate response similar to a Manhattan Project.

Since there is a 6-year time limitation [1] for occurrences of research misconduct to be brought to the attention of an institution or the Department of Health and Human Services, I’m not claiming misconduct here. I’m asking for your assistance as Associate Inspector General for Scientific Integrity as to what can be done to rectify the divergence between what Klempner has reported vs all the other equally important evidence.

A response to this inquiry is requested.

Respectfully submitted,

Carl Tuttle
Hudson, NH


[1] Requirements for Making a Finding of Research Misconduct

2018 letter addressed to Dr. Mark Klempner (There was no response)

From: Carl Tuttle <>
Cc:,,,,,,, Elias, John,
Date: 04/27/2018 7:53 AM
Subject: Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

April 27, 2018

University of Massachusetts Medical School
55 Lake Avenue North
Worcester, Massachusetts 01655
Attn: Mark S. Klempner, MD, Executive Vice Chancellor, MassBiologics

Dr. Klempner,

I would like to call attention to the attached study recently identifying chronic Lyme disease in twelve patients from Canada.

Persistent Borrelia Infection in Patients with Ongoing Symptoms of Lyme Disease

All of these patients were culture positive for infection (genital secretions, skin “Morgellons” and blood) even after multiple years on antibiotics so there was no relief from current antimicrobials. Some of these patients had taken as many as eleven different types of antibiotics.

In contrast, your 2001 antibiotic treatment study found; “no evidence of B. burgdorferi in a total of more than 700 different blood and cerebrospinal fluid samples from the 129 patients in these studies.”

Two Controlled Trials of Antibiotic Treatment in Patients with Persistent Symptoms and a History of Lyme Disease

Not a single positive Dr. Klempner? Doesn’t this statistically prove that your methodology was fatally flawed?

Did you culture skin and genital secretions as the Middelveen paper reports? It would appear that you conveniently stopped looking after your results supported the existing thirty year dogma; chronic Lyme does not exist.

Persistent Lyme disease is not new and has been intentionally/deceitfully suppressed for decades as described in the Vicki Logan case identified in the following letter to past CDC Director Barbara Fitzgerald:

In 1991 B. burgdorferi had been isolated in culture from Vicki Logan’s CSF (CDC’s laboratory in Fort Collins CO.) despite prior treatment with 21 days of IV cefotaxime and 4 months of oral minocycline.

The dishonest science here in the U.S. has denied chronic Lyme which stifled research to find a curative approach. Now the rest of the world is suffering. 

We have lost nearly four decades to this 21st century plague due to the racketeering scheme identified in the RICO lawsuit filed by SHRADER & ASSOCIATES, LLP against the Infectious Disease Society of America, seven IDSA Panelists and eight insurance companies. The U.S. Centers for Disease Control has aligned itself with the seven IDSA Panelists identified in this lawsuit.

Court Document:

Lyme is an incurable disease when not treated immediately which is spreading across North America and deceitfully misclassified as a low-risk and non-urgent health issue. Patient experience is describing a disease that is destroying lives, ending careers, causing death and disability while leaving victims in financial ruin. Current antimicrobials are ineffective for eradicating all forms of the Borrelia spirochete.

Public outcry has been ignored for decades while the Centers for Disease Control sat on evidence that this infection was not easily treated with a one size fits all treatment approach as dictated by the Infectious Diseases Society of America.

Once again your studies were fatally flawed while supporting the controlling dogma leaving hundreds of thousands if not millions worldwide with a persistent infection and absolutely no relief. We have another AIDS on our hands.

Carl Tuttle

Independent Researcher

Lyme Endemic Hudson, NH

Cc: -Michael F. Collins, Chancellor

-The Tick Borne Disease Working Group

-US Department of Justice



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