The following case report is an update from an earlier version. The reason I include it is found in the comment section.
We describe a case of relapsing babesiosis in an immunocompromised patient. A point mutation in the Babesia microti 23S rRNA gene predicted resistance to azithromycin and clindamycin whereas an amino acid change in the parasite cytochrome b predicted resistance to atovaquone. Following initiation of tafenoquine, symptoms and parasitemia resolved.
A wonderful example of how mutations can affect treatment outcome and the importance that a singular drug can make in a person’s life. This person is truly lucky to have this information to help guide their treatment. Most patients simply have to struggle forward, shooting in the dark to find answers.
The topic of mutations is rarely is discussed or researched and is clearly an area begging for more work to be done. How many more patients out there have this problem?
We need treatments, not a supposed magic-cure all injection.
Another topic that is rarely discussed or researched is the very real problem with wide-spread use of antibiotics in healthy animals in live-stock farming.
Study Sounds Alarm Over New Bacteria Increasingly Spreading Among Humans
A strain of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is suspected to have merged among European pigs and other livestock in the past several decades because of frequent antibiotic use in farming.
“Historically high levels of antibiotic use” may have led to the cause of this “highly antibiotic-resistant strain of MRSA on pig farms,” said Dr. Gemma Murrayn, who worked on the study released by the University of Cambridge, in a news release.
“We found that the antibiotic resistance in this livestock-associated MRSA is extremely stable—it has persisted over several decades, and also as the bacteria has spread across different livestock species,” Murrayn added in the news release.
(See link for article)