https://www.science.org/doi/10.1126/sciadv.abi6110
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
Science Advances • 20 Jan 2022 • First Release • DOI: 10.1126/sciadv.abi6110
The spread of SARS-CoV-2 and ongoing COVID-19 pandemic underscores the need for new treatments. Here we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression and reversing many effects of SARS-CoV-2 on host gene transcription. CBD inhibits SARS-CoV-2 replication in part by up-regulating the host IRE1α RNase endoplasmic reticulum (ER) stress response and interferon signaling pathways.
In matched groups of human patients from the National COVID Cohort Collaborative, CBD (100 mg/ml oral solution per medical records) had a significant negative association with positive SARS-CoV-2 tests. This study highlights CBD as a potential preventative agent for early-stage SARS-CoV-2 infection and merits future clinical trials. We caution against use of non-medical formulations including edibles, inhalants or topicals as a preventative or treatment therapy at the present time.
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For more:
- https://madisonarealymesupportgroup.com/2021/04/27/covid-natural-remedies-banned-as-doj-ftc-seek-to-silence-doctors-promoting-vitamin-d-c-zinc-etc/
- https://madisonarealymesupportgroup.com/2020/09/24/studies-show-proper-levels-of-vitamin-d-slashes-risk-of-covid-as-does-gargling-with-iodine-vaccine-not-needed/
- https://madisonarealymesupportgroup.com/2020/06/15/the-functional-medicine-approach-to-covid-19-virus-specific-nutraceutical-botanical-agents/
- https://madisonarealymesupportgroup.com/2020/06/14/potential-interventions-for-novel-coronavirus-in-china-a-systematic-review/
- https://madisonarealymesupportgroup.com/2021/10/27/two-new-studies-test-quercetin-covid-outcomes/
- https://madisonarealymesupportgroup.com/2021/09/07/the-story-of-ivermectin-covid-19-must-see-video/
- https://madisonarealymesupportgroup.com/2021/11/26/another-patient-saved-another-doctor-suspended-in-the-world-of-ivermectin/
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