Volume 27, Number 2—February 2021

Human Tacheng Tick Virus 2 Infection, China, 2019

Zhihui Dong1, Meihua Yang1, Zedong Wang1, Shuo Zhao, Songsong Xie, Yicheng Yang, Gang Liu, Shanshan Zhao, Jing Xie, Quan LiuComments to Author , and Yuanzhi WangComments to Author 
Author affiliations: Shihezi University, Shihezi, China (Z. Dong, M. Yang, Shuo Zhao, Y. Yang, G. Liu, Shanshan Zhao, Y. Wang); Foshan University, Foshan, China (Z. Wang, Q. Liu); First Affiliated Hospital of Shihezi University, Shihezi (S. Xie, J. Xie); Shihezi People’s Hospital, Shihezi (Y. Yang)


We used metagenomic analysis to identify Tacheng tick virus 2 infection in a patient with a history of tick bite in northwestern China. We confirmed the virus with reverse transcription-PCR, virus isolation, and genomic analysis. We detected viral RNA in 9.6% of ticks collected from the same region.

Important excerpt:

Emerging pathogenic tickborne viruses have attracted much attention because of the increasing incidence of tickborne viral diseases and their effects on human health (14). In 2015, high-throughput sequencing of samples from ticks in China revealed several novel phleboviruses, including

  • Tacheng tick virus 2 (TcTV-2)
  • Changping tick virus 1
  • Bole tick virus 1 (BlTV-1)
  • Lihan tick virus
  • Yongjia tick virus 1
  • Dabieshan tick virus (5)

However, the risk for human infection from these viruses is not yet known.

The 38-year old Chinese man who had frequent contact with horses and sheep removed a tick from his arm and had the following symptoms: chills, severe fatigue, headache, anorexia, nausea, vomiting, fever, erythema at the bite site and neck stiffness. 

The researchers further gathered nearly 350 ticks from the patient’s geographical area and found nearly 10% carried the virus.  The sequences from the ticks closely related the isolate in the patient.



Despite the fact the authors stated this particular virus didn’t show growth in numerous media, a human contracted the virus.  This is important to remember.  All the statistics in the world don’t matter a tittle when you are the sorry sucker who becomes ill, despite everyone around you saying it’s ‘rare’! 

Phleboviruses can cause severe fever with thrombocytopenia syndrome, and multiple organ damage, including to the liver and kidneys.

For more:  SFTS explained within – of which the Asian Longhorned tick is often the culprit, which is spreading through the U.S right now.

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