SOT was created for those with previously untreatable genetic conditions. In my opinion, Lyme disease is not a genetic condition, it’s an infection(s) and depending upon your exact case, is only one of many potential infections that can be bacterial, fungal, viral, and/or parasitic. This is my main problem with SOT besides the fact it is a gene-silencing technique that raises questions about long-term effects as well as the fact Bb changes its outer surface protein, is stealthy, and very probably a bioweaponized pathogen(s) created in a lab to be more persistent and transmissible, and to evade the immune system and treatment.
https://www.treatlyme.net/guide/sot-lyme-treatment
Supportive Oligonucleotide Therapy (SOT) Background
Supportive Oligonucelotide Therapy (SOT) is a new treatment for Lyme disease. SOT is also called Antisense Oligonucelotide Therapy (ASOT) which is the term used in medical research papers. SOT uses laboratory derived nucleic acids (genetic code) that blocks production of disease causing proteins or even gene expression. These pieces of genetic code are called oligonucleotides. You can think of oligonucleotides as a genetic message.
For example, in Duchenne Muscular Dystrophy (DMD), SOT provides oligonucleotides that direct the correct production of a protein called dystrophin. People with muscular dystrophy are born with DNA that provides the wrong genetic message for dystrophin. SOT correction to the DNA message leads to production of dystrophin. This prevents the muscle damage seen in DMD.
In Lyme disease, a currently available type of SOT produced by RGCC in Greece uses oligonucleotides intended to stop germ growth and replication. Unlike the SOT therapy for Duchenne muscular dystrophy, the Lyme SOT is not a US Food and Drug Administration (FDA) approved drug. To be approved by the FDA, a therapy must have scientific evidence of safety and effectiveness. (See link for article)
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**Comment**
Dr. Ross is unsure if SOT for Lyme/MSIDS works, and some of his patients using it before seeing him experienced little to no effects, but some of his colleagues state some patients have experienced improvement. He also reminds readers that there is a placebo effect of 35% on average in clinical trials for drugs.
Also, please read this article on SOT Therapy side effects.
Common side effects: injection site reactions, flu-like symptoms, headaches and fatigue, changes in liver function.
Serious but supposedly rare side effects: thrombocytopenia, changes in kidney function, allergic reactions, neurological effects, potential impact on fertility and pregnancy.
For more on SOT:
- https://madisonarealymesupportgroup.com/2023/09/21/is-sot-for-lyme-tick-borne-infections-a-scam/ Update from Dr. Ross
- https://madisonarealymesupportgroup.com/2025/10/07/sot-for-lyme-experimental-expensive-but-full-of-potential/
- https://madisonarealymesupportgroup.com/2025/10/22/sot-part-2/
- https://madisonarealymesupportgroup.com/2023/04/27/study-sot-potential-treatment-for-viruses-lyme-disease/
- https://madisonarealymesupportgroup.com/2022/09/23/overcome-bacterial-viral-infections-with-sot-and-rgcc-test/
- www.ledamedical.com/_files/ugd/64c59b_84735a6d414e4d0eb15844a2df862877.pdf SOT Guide
- ttps://www.ledamedical.com/sot? SOT works simply by shutting down the gene replication sequences of our target causing apoptosis (cell death) therefore eliminating the next life-cycle.
What is the process?
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Patients will have a blood draw done, in which their blood sample is collected and will be shipped to RGCC labs in Greece. It takes about 4 weeks to create an SOT. When created it will be shipped back to our office for patient administration. Patients will come in the office for an iv infusion which typically takes up to one hour.
- In short, SOT, a form of antisense technology, uses laboratory-derived synthetic strands of nucleic acids to target and silence specific genes in pathogens. It aims to disrupt the replication and function of the pathogens by blocking production of essential proteins.
For more on the RGCC test:
- https://madisonarealymesupportgroup.com/2016/02/13/lyme-disease-treatment/
- https://madisonarealymesupportgroup.com/2020/06/26/new-treatments-for-lyme-disease-on-the-horizon/
- https://madisonarealymesupportgroup.com/2020/11/03/success-of-prescription-alternative-medicine-lyme-treatments/
- https://madisonarealymesupportgroup.com/2020/10/14/peer-reviewed-study-confirms-what-we-knew-all-along-longer-antibiotic-treatment-duration-is-associated-with-better-treatment-response-for-lyme-disease/
Madison Area Lyme Support Group 