https://www.sciencedirect.com/science/article/pii/S0899900720303002

Cohort study to evaluate effect of vitamin D, magnesium, and vitamin B12 in combination on severe outcome progression in older patients with coronavirus (COVID-19)

 

Highlights

  • Use of a combination of vitamin D, magnesium, and vitamin B12 (DMB) in patients with coronavirus disease (COVID-19) was studied.
  • Fewer patients ≥50 y of age with COVID-19 on DMB suffered clinical deterioration.
  • Further studies are warranted to ascertain the full benefit of DMB in patients with COVID-19.

Abstract

Objectives

The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized that fewer patients administered this combination would require oxygen therapy, intensive care support, or a combination of both than those who did not.

Methods

This was a cohort observational study of all consecutive hospitalized patients ≥50 y of age with COVID-19 in a tertiary academic hospital. Before April 6, 2020, no patients received the (DMB) combination. After this date, patients were administered 1000 IU/d oral vitamin D3, 150 mg/d oral magnesium, and 500 mcg/d oral vitamin B12 upon admission if they did not require oxygen therapy. Primary outcome was deterioration leading to any form of oxygen therapy, intensive care support, or both.

Results

Between January 15 and April 15, 2020, we identified 43 consecutive patients ≥50 y of age with COVID-19. Seventeen patients received DMB before onset of primary outcome and 26 patients did not. Baseline demographic characteristics between the two groups were significantly different by age. In univariate analysis, age and hypertension had a significant influence on outcome. After adjusting for age or hypertension separately in a multivariate analysis, the intervention group retained protective significance. Fewer treated patients than controls required initiation of oxygen therapy during hospitalization (17.6 vs 61.5%, P = 0.006). DMB exposure was associated with odds ratios of 0.13 (95% confidence interval [CI], 0.03–0.59) and 0.20 (95% CI, 0.04–0.93) for oxygen therapy, intensive care support, or both on univariate and multivariate analyses, respectively.

Conclusions

A vitamin D / magnesium / vitamin B12 combination in older COVID-19 patients was associated with a significant reduction in the proportion of patients with clinical deterioration requiring oxygen support, intensive care support, or both. This study supports further larger randomized controlled trials to ascertain the full benefit of this combination in ameliorating the severity of COVID-19.

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**Comment**

Once again we see there are numerous things that can be used successfully against COVID-19, but don’t expect to hear about this in main stream media.  They are all about pushing products that our public ‘authorities’ have financial interests in.  One is a dangerous, experimental vaccine:  https://madisonarealymesupportgroup.com/2020/08/29/every-breath-you-take-every-move-you-make-the-who-is-watching-you-the-media-is-bought-out-by-gates/

We’ve been warned about this vaccine:  https://madisonarealymesupportgroup.com/2020/10/20/experts-issue-serious-warnings-about-a-covid-vaccine/

https://madisonarealymesupportgroup.com/2020/10/05/covid-19-vaccine-explained/

And another is the expensive anti-viral Remdesivir which has recently been given EUA status despite lack of results:  https://madisonarealymesupportgroup.com/2020/10/26/remdesivir-gets-fda-approval-but-who-says-drug-ineffective-for-covid/

https://madisonarealymesupportgroup.com/2020/07/02/remdesivir-for-covid-19-not-backed-by-results/

For more successful COVID-19 treatments that doctors have been using successfully: