Lyme: Rapid bacterial transmission following a tick bite shown in European study
Lyme borreliosis is a disease caused by bacteria of the genus Borrelia that are transmitted by a bite from a tick of the genus Ixodes. Scientists from the Institut Pasteur used mice to study the transmission of bacteria by ticks infected with various European and North American species of Borrelia. They found evidence of rapid bacterial transmission following a bite, with infection occurring within 24 hours of an adult tick bite and sometimes even sooner for nymph bites. This is a timely reminder of the importance of removing ticks as soon as possible after being bitten to prevent infection. Study found here: https://www.frontiersin.org/articles/10.3389/fmicb.2018.01722/full
Public domain image/WHO via CDC
Lyme borreliosis is the most common vector-borne disease in Europe. It is caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. This complex includes several species that are pathogenic for humans: Borrelia burgdorferi sensu stricto, B. afzelii, B. garinii, B. bavariensis, B. spielmanii, B. valaisiana and B. lusitaniae. The bacteria are transmitted through a bite from a hard tick of the genus Ixodes – in Europe, primarily Ixodes ricinus. Ticks can infect a wide variety of hosts. Humans are considered to be an accidental host; transmission can occur if they come into contact with an environment favorable to ticks.
Ticks have three lifecycle stages that can bite humans – larva, nymph and adult -, but bacteria are usually transmitted through bites from nymphs, which are higher in density and often go unnoticed because of their small size.
The amount of time a tick must remain attached to transmit bacteria to the vertebrate host is an essential parameter in assessing the risk of transmission and identifying measures to prevent infection. It is generally accepted that the longer a tick remains attached, the higher the risk of transmission. In Europe, it is regularly stated that there is a real risk of transmission only after 24 hours of attachment.
In this study, we used a mouse model to determine the kinetics of infection by Ixodes ricinus ticks (nymphs and adult females) infected with various European and North American strains or species of Borrelia. We also compared the dissemination of various strains and species of Borrelia by different modes of inoculation (via infected ticks or by injection of bacteria).
Unlike the American strains, all the European species of B. burgdorferi that we studied were detected in the salivary glands of adult ticks before a blood meal, suggesting the possibility of rapid transmission of the bacteria following a bite.
The results were consistent with this theory: infection occurred within 24 hours of a bite from an adult tick. Moreover, our analysis shows that nymphs infected by European species of B. burgdorferi are capable of transmitting these pathogens within 12 hours of attachment.
Our study proves that B. burgdorferi can be transmitted more quickly than stated in the literature.
It is therefore vital to remove ticks as soon as possible after being bitten to prevent infection.
Furthermore, the study shows that the tropism of Borrelia varies depending on the strain and species studied, which explains the variety of clinical manifestations of Lyme borreliosis. We also demonstrate a difference in the tropism of Borrelia following a tick bite, confirming the role of tick saliva in the efficacy of infection and dissemination in vertebrate hosts.
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**Comment**
It’s finally here. The long awaited for information that we ALL know out here in Lyme-land.
People are getting infected way before the oft repeated 24-72 hours of tick bite.
First, it’s important to remember that ALL transmission studies are on mice in a lab, therefore, it doesn’t necessarily mean the information translates to humans.
Second, it’s important to remember that the oft repeated 24-72 hour transmission mantra essentially comes from ONE mouse study that has an inch of dust on it: https://madisonarealymesupportgroup.com/2017/04/14/transmission-time-for-lymemsids-infection/ Even it says animal studies have proven that transmission can occur in under 16 hours and it occurs frequently in under 24 hours. No human studies have been done and no studies have determined the minimum time it takes for transmission.
So instead of asking “how little” time it takes, researchers have always asked“how long” it takes. Big difference.
In this instance, a little girl within 4-6 hours couldn’t walk or talk after a tick bite: https://madisonarealymesupportgroup.wordpress.com/2016/12/07/igenex-presentation/? If she wasn’t taken directly to Dr. Jones over the weekend, things could have turned out horribly. Mainstream medicine wanted her to wait until Monday for a NEURO – CONSULT despite her rapid decline. These people STILL do not get it.
Third, this study points out differences in strains of borrelia (there are 300 and counting in the world and 100 and counting in the U.S.). In the past, doctors have smugly looked at maps delineating where specific ticks are, and assuming only specific geographical borrelia strains will be present; however, birds are migrating everywhere and bringing ticks with them: https://madisonarealymesupportgroup.com/2018/08/13/study-shows-lyme-not-propelled-by-climate-change/
https://madisonarealymesupportgroup.com/2017/08/17/of-birds-and-ticks/
https://madisonarealymesupportgroup.com/2016/10/02/the-role-of-birds-in-tickborne-illness/
And fourth and lastly, this study points out a real and present danger – borrelia in the salivary glands of ticks. This is spoken about in quiet corners but most “experts” want to tout a “grace period,” regarding tick transmission and use all sorts of long words to buttress their case. If it wasn’t so serious it would be funny.
If there’s one thing I know it’s that ticks do not know the meaning of grace.
Madison Area Lyme Support Group 