The Cocktail Effect

The following article is a reminder that we must be ever diligent about what we put into and onto our bodies and I would add into our minds.  It’s also a reminder that we need to consider everything we are taking and understand the possible synergistic effects of those substances.  It’s common for patients to not be completely honest with their medical professionals about everything they are taking.  They will be open about all the pharmaceutical agents but they often are reticent to mention the so-called “natural” substances as they fear the potential negative reactions; however, this is a mistake from numerous standpoints – 1) trained professionals can only truly help if they know everything the patient is taking 2) “natural” substances have effects as well 3) the combination or synergy of everything we are taking might interact into what Dr. Brogan calls “The Cocktail Effect.”

Be honest with yourself and your practitioners.

Also, remember that people have vested interests and it’s often about sales not you.  Only you truly care about you.  Take the time to learn.  Ask your pharmacist questions.  Learn.  Never quit learning.  It won’t be wasted.

And lastly, if you’ve read anything I’ve ever written, it’s become clear that scientists and researchers have vested interests as well.  And these interests do not concern primarily you.  Their heads have been turned by the bombshells in the corner:  money & power.

https://kellybroganmd.com/the-cocktail-effect/?

The Cocktail Effect

Be skeptical.

Be very skeptical when you are delivered platitudes of reassurance about the safety of chemicals and pharmaceutical products from those who stand to profit from their sales. It can take more than a decade for signals of harm to trickle into consciousness.  We have an even more complex problem at play here: scientists are not doing the right types of studies.

I specialized, in residency and fellowship, in the “safety” of psychiatric medications during pregnancy and breastfeeding. After memorizing every study on the subject, I furrowed my brow and said, “Hold on a minute…these studies aren’t asking the right questions!” They ask – are babies born on time, are they big or small, and are they born with ten fingers and ten toes.

In today’s modern day toxic soup, these questions miss the mark of establishing the risk of chronic disease and neurodevelopmental delay and dysfunction. These studies tend not to control for important variables of biochemical individuality such as inflammatory markers, the gut microbiome, and obesity. And they definitely don’t ask questions about synergy.

What’s Synergy?

It’s the dynamic effects of toxicants in combination. It’s the new toxicology. One that acknowledges that even low doses of chemicals, particularly when combined, can sabotage cellular processes. It also acknowledges the role of hormones in this reaction, from cortisol to estrogen.

A powerful new study published in Nature Communications meets the science head on, exploring the Cocktail Effect. It looks at the effect of a synthetic estrogen in the birth control pill  on the toxicity of a pesticide. The endocrine disrupting potential of the more than 150,000 chemicals in our environment may have the capacity to disrupt our metabolism when combined with pharmaceutical exposures as common as oral contraceptives.

Delfosse et al are the first to identify how this can happen by showing that independent chemical molecules can help each other plug into the same hormonal receptor and activate it in a supercharged way. The amazing fact is that these chemicals have this hormonal effect at doses at which they are inactive when separate. In their non-user-friendly jargon, they state:

Our results suggest that the formation of ‘supramolecular ligands’ within the ligand-binding pocket of nuclear receptors contributes to the synergistic toxic effect of chemical mixtures, which may have broad implications for the fields of endocrine disruption, toxicology and chemical risk assessment.

What this means is that one chemical/toxicant can make you more vulnerable to another, as we have seen with glyphosate, the active ingredient in Roundup, and that multiple chemicals can wreak more havoc than individual chemicals alone.

Here’s one more reason to ditch birth control, go organic, and clean up your products!

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**Comment**

Great, great reminder.  If you haven’t begun this life “clean up” process, take a deep breath and realize it took you decades to develop your habits.  It’s going to take some time to change them.  Please, don’t beat up on yourself now, just start.  Take one thing and then when you are able, take another thing.

I remember feeling so overwhelmed when I first found out both my husband and I were infected with numerous tick borne illnesses.  I knew we were at the precipice of something monumental and my mind went crazy with the implications – from how we were going to pay the monumental out-of-pocket medical bills, to the implications of homeschooling 3 teenagers (something we were already doing but now were ill & broke to boot), to the timing of the plethora of medications, to considering dietary, and other changes that needed to be made.  It seriously made me want to scream in frustration as I was having trouble remembering why I walked into a room!  The insomnia was maddening and I couldn’t handle stress at all.  The pain sent me to the fetal position in bed, and trying to unravel my husband’s hallucinations made me feel as if I stepped into a Sci-Fy novel of the worst kind – the kind where reality and fantasy are inseparable.

So just begin by putting one foot in front of the other.