Yale researchers have found that combining atovaquone and ELQ-334, at low doses, cleared Babesia in mice and prevented recurrence up to 122 days.
ELQ stands for Endochin like quinolone and is a preclinical candidate that targets the liver and blood stages of malarial organisms.
http://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-339 It’s been known since 1948 that Endochin has anti-malarial properties; however, it has proven to be ineffective in vivo against human malaria. Recent advances have suggested revisiting previously abandoned lead molecules to be possible viable anti-malarial drug candidates.
http://www.ncbi.nlm.nih.gov/pubmed/23019377 ELQ-271 and ELQ-316 are effective against acute and latent toxoplasmosis.
When I asked my pharmacist about the ELQ’s, he said he couldn’t find anything about the manufacturing process, and that as far as side effects, there won’t be a much information available until ELQ-334 proceeds further in the approval process. Sometimes side effects don’t show up until well after drugs have been on the market. He also stated that there were only 800 cases of neuropathy from 1998-2013 reported to the FDA for quinolines.
While I could be wrong, Endochin like quinolone could possibly mean it is made with fluoride.
http://articles.mercola.com/sites/articles/archive/2009/07/18/antibiotics-to-avoid–the-plague-due-to-fdas-oversight-failure.aspx Quinolones are made with fluoride, which enables them to penetrate into tissue, including your brain. This ability is what makes them valuable against tick borne infections.
Omniflox, Raxar, Trovan, Zagam, and Tequin have all been banned due to their side effects; however, Cipro, Levaquin, Avelox, and Floxin continue to be prescribed.
In Dr. Cohen’s 2001 study, the following side effects were documented:
*Nervous system symptoms occurred in 91 percent of patients (pain, tingling and numbness, dizziness, malaise, weakness, headaches, anxiety and panic, loss of memory, psychosis)
*Musculoskeletal symptoms in 73 percent of patients (tendon ruptures, tendonitis, weakness, joint swelling)
*Sensory symptoms in 42 percent of patients (tinnitus, altered visual, olfactory, and auditory function)
*Cardiovascular symptoms in 36 percent of patients (tachycardia, shortness of breath, chest pain, palpitations)
*Skin reactions in 29 percent of patients (rashes, hair loss, sweating, intolerance to heat or cold)
*Gastrointestinal symptoms in 18 percent of patients (nausea, vomiting, diarrhea, abdominal pain)
A comprehensive list of reactions can be found at Dr. Cohen’s site Medication Sense.
According to Dr. Mercola, quinolones are too often prescribed for minor problems such as sinus, bladder, and prostate infections. He feels these super-antibiotics should be used as a last line of defense.
Be armed with facts to make an informed decision about these antibiotics with your LLMD (Lyme literate doctor). One of the most experienced LLMD’s in Wisconsin states that he has used quinolones for over 20 years without tendon rupture. It’s important to notify your doctor immediately if you notice symptoms such as tendon pain or anything else that doesn’t seem right.