We are closing in on the 8%, Dr. Horowitz whispered.
At the Beyond Lyme and Other Chronic Illnesses: Reclaiming Your Health and Well-Being, conference, Dr. Horowitz and Ying Zhang from John Hopkins, revealed they are having success with mycobacterium drugs, such as dapsone (pyrazinamide) for their most serious cases – the 8% of folks who do not respond well to treatment. These drugs are used in leprosy and tuberculosis to target the bacteria that have become “persisters,” which do not respond to typical antibiotics.
http://beforeitsnews.com/health/2015/10/lyme-disease-persister-drugs-dr-ying-zhang-2593390.html Interview with Professor Ying Zhang at the NorVect Converence 2015. Zhang’s work with TB helped him see the similarities to Lyme concerning persisters.
Horowtiz, the General MacArthur of MSIDS, has laid out most of his battle plan in the book, Why Can’t I Get Better? Solving the Mystery of Lyme and Chronic Disease. In a nutshell, he combines 2-3 intracellular antibiotics to reach the persister bacteria inside the cells. He calls this the “triple persister” cocktail. Then he pulses with a cellular antibiotic, which is based on work by professor and researcher Kim Lewis of Northeastern University. http://aac.asm.org/content/early/2015/05/20/AAC.00864-15.abstract
“This is the first time, we think, that pulse-dosing has been published as a method for eradicating the population of a pathogen with antibiotics that don’t kill dormant cells,” Lewis said. “The trick to doing this is to allow the dormant cells to wake up.”
Horowitz has found this regimen to be very successful, but the addition of dapsone for the most difficult cases could be the magic key.
At the seminar they discussed why so many are getting MISDS. The reasons given were:
- Sexual Transmission
- Maternal Transmission to fetus
- Blood transfusions (4 out of 1,000 transfusions are now believed to transmit Babesia.
- Constant discovery of new borrelia species and new co-infections
- Horrible diagnostic standards
- Fox population decrease. This increases the mouse population – probably the number one reservoir for ticks.
- The reality of persisters – bacteria that persist despite antibiotic treatment
- Migrating birds – why the Lone Star tick is now in the eastern U.S. This tick can detect body heat and carbon dioxide from 15 feet away and will aggressively move towards the source.
- Infected tick mothers pass infections to their off spring
- Climate change – ticks are emerging 3 weeks early
- Healthcare politics
Overview of different forms of Borrelia:
Overview of antibiotics that attack different forms:
Horowitz is optimistic about the future and already feels things are starting to change in the diagnostics world with work on a new “C6 Elisa Test” that picks up more strains of Borrelia. Also, more are starting to believe that having ONE band is enough for a clinical diagnosis of Lyme, if other diseases have been ruled out. He feels a final hurdle; however, is for the PCR test to address additional strains of Borrelia.
Horowitz will publish this work on his patients in the upcoming year.