Archive for the ‘Uncategorized’ Category

Immunoassay May Help Identify Pediatric Lyme Arthritis

https://www.medscape.com/viewarticle/922645?src=rss

Immunoassay May Help Identify Pediatric Lyme Arthritis

By Marilynn Larkin

December 18, 2019

NEW YORK (Reuters Health) – In Lyme disease-endemic areas, a C6 peptide enzyme immunoassay (EIA) test may help guide initial management of children with acute arthritis, an observational study suggests.

“Children with Lyme disease frequently present to the emergency department with an inflamed joint,” Dr. Lise Nigrovic of Boston Children’s Hospital told Reuters Health by email. “Although Lyme arthritis is initially treated with oral antibiotics, many children will undergo an invasive procedure such as a joint tap or even wash-out as part of the initial evaluation.”

“We demonstrated that the C6 EIA test, a previously approved first-tier test for Lyme disease, with results available within a few hours, could be used to safely guide initial management for children with inflamed joints to avoid unnecessary invasive procedures for children with Lyme arthritis,” she said.

The authors performed C6 EIA tests on 911 children presenting to a Pedi Lyme Net emergency department from 2015-2019. Lyme arthritis was defined as a positive or equivocal C6 EIA test followed by a positive supplemental immunoblot result; septic arthritis was defined as a positive synovial fluid culture result or a positive blood culture result with synovial fluid pleocytosis. Other cases were considered inflammatory arthritis.

As reported in Pediatrics, C6 EIA test results indicated that 211 children (23.2%) had Lyme arthritis, 11 (1.2%) had septic arthritis, and 689 (75.6%) had other inflammatory arthritis.

A positive or equivocal C6 EIA result had a sensitivity of 100% and specificity of 94.2% for Lyme arthritis. None of the 250 children with a positive or equivocal C6 EIA result had septic arthritis. However, of those with a positive first-tier Lyme disease test result, 75 underwent arthrocentesis (30%) and 27 had an operative joint washout performed (10.8%).

Dr. Eugene Shapiro of Yale School of Medicine in New Haven, Connecticut, coauthor of a related editorial, commented by email to Reuters Health, “In an area in which Lyme disease is endemic, although a positive C6 ELISA result in a child with arthritis of the knee is suggestive of Lyme disease, it does not rule out the possibility that it is due a different bacterium such as Staphylococcus aureus. Clinical judgement is still critical in deciding how to manage such patients.”

Lyme disease specialist Dr. Tania Dempsey, founder of Armonk Integrative Medicine in New York, commented, “The C6 EIA test has shown promise over the older ELISA test that is part of the two-tier Lyme testing recommended by the U.S. Centers for Disease Control and Prevention, dating back to 1995. There are serious limitations to the two-tier test, including a nearly 50% false-negative rate.”

“While this study shows promise . . . to accurately identify Lyme arthritis with the use of the C6 EIA test, it is not clear what the false negative rate was,” she told Reuters Health by email. “Their numbers show that they were able to diagnose 23.2% of children with Lyme arthritis and 1.2% with septic arthritis. But 75.6% were identified as having inflammatory arthritis, which means that the diagnosis is unclear. Based on the published false negative rate of this test, we can assume that a fair percentage of those with inflammatory arthritis probably had Lyme arthritis.”

“One key point is that the study design included a confirmatory immunoblot test for C6 EAI positive or equivocal results. This would be equivalent to a two-tier test,” she noted. However, “no immunoblot testing was done on any of the C6 EAI- negative results. Since we we know a large number of patients will be missed by this (test), it is discouraging to think of all those patients who might still be suffering with Lyme disease that was undetected with the screening C6 EAI test.

There is no question that we need better testing for Lyme disease,” she said. “The C6 EIA has some benefits but is clearly not sufficient.

SOURCE: http://bit.ly/34fODsR and http://bit.ly/2EgdP8g Pediatrics, online December 13, 2019.

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**Comment**

While this article desires to make you believe this test is accurate, Dr. Demsey clearly points out it has many problems including not knowing what the false negative rate was, as well as the fact 75.6% were identified as having inflammatory arthritis –  meaning that the diagnosis is unclear. And lastly, based on the published false negative’s, a fair percentage of those with inflammatory arthritis probably had Lyme arthritis.

Take away:  The test still sucks.

For more:  https://madisonarealymesupportgroup.com/2019/03/07/yet-another-worthless-study-showing-2-tiered-lyme-testing-can-not-rule-infection-out/

https://madisonarealymesupportgroup.com/2019/12/01/c6-peptide-test-for-lyme-disease-may-indicate-borrelia-miyamotoi-infection/

https://madisonarealymesupportgroup.com/2019/08/15/borrelia-miyamotoi-infection-leads-to-cross-reactive-antibodies-to-the-c6-peptide-in-mice-men/

https://madisonarealymesupportgroup.com/2018/09/12/lyme-testing-problems-solutions/

 

5 Tips to Calm a Restless Mind Before Going to Sleep

https://www.psychologytoday.com/us/blog/the-savvy-psychologist/201912/5-tips-calm-restless-mind-going-sleep?

5 Tips to Calm a Restless Mind Before Going to Sleep

If your mind won’t turn off at bedtime, use these tips to work with your brain.

Posted Dec 03, 2019

How did you sleep last night? We seem to ask ourselves this question daily, and when we do, it’s almost as if we’re taking note of our overall state of mind: How do I feel? Am I all there today?

And no wonder! It can be discouraging and frazzling when all we want is the soothing balm of sleep to heal the stress from our day, but infuriatingly, when we lie down to sleep, our brains just won’t shut off. Paradoxically, sometimes the more stressful our days are, the harder it is to quiet the brain for sleep at night…. (See link for full article)

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For more:  https://madisonarealymesupportgroup.com/2018/08/23/sleep-sweet-sleep/

https://madisonarealymesupportgroup.com/2018/04/02/cant-sleep-18-plants-herbs-can-help/

https://madisonarealymesupportgroup.com/2019/05/05/ambien-other-sleep-aids-get-fdas-blackbox-label-its-strongest-warning/

 

 

 

 

Multifocal Hepatic Abscess in Immunocompetent Patient Due to Bartonella Henselae: Case Report With Review of Literature

https://www.ncbi.nlm.nih.gov/pubmed/31745036

2019 Apr-Jun;37(2):292-295. doi: 10.4103/ijmm.IJMM_19_4.

Multifocal hepatic abscesses in immunocompetent patient due to Bartonella henselae: Case report with review of literature.

Abstract

To the best of our knowledge, this is the first case of multifocal hepatic abscesses in a young immunocompetent adult from India, which was successfully treated with hepatectomy and short course of oral antibiotic regimen. Publishing further such case reports will provide more clarity regarding the clinical significance of the disease, including associated risk factors and appropriate treatment.

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**Comment**

Hepatic abscesses, like abscesses elsewhere, are localized collections of necrotic inflammatory tissue caused by bacterial, parasitic or fungal agents. In this case, Bartonella.  Multifocal just means the abscesses are in more than one location.

For more:  https://madisonarealymesupportgroup.com/2019/11/27/development-spontaneous-resolution-of-a-full-thickness-macular-hole-in-bartonella-neuroretinitis/

 

 

 

January 2020 Support Group Meeting

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January support group meeting
  • January 4, 2020
  • 2:30-4:40pm
  • East Madison Police Station, 809 S Thompson Dr. Madison, WI  53718

French and Australian Connections on Lyme, Inflammation and Cancer: Medicine Week 2019, Baden-Baden

https://www.linkedin.com/pulse/french-australian-connections-lyme-inflammation-cancer-yu-md/

French and Australian Connections on Lyme, Inflammation and Cancer: Medicine Week 2019, Baden-Baden

By Dr. Simon Yu, MD

Medical Director at Prevention and Healing,Inc.
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Medicine Week in Germany is considered one of the biggest cutting-edge complementary medical conferences in the world and there are multiple lectures simultaneously held at the huge congress hall. I gave a lecture on Parasites, Inflammation and Immune Dysregulation in the section on “Causal Therapies for Chronic Inflammation and Chronic Infection,” sponsored by Dr. med. Rainer Mutschler from Germany.

Many of the international speakers covered cutting edge topics of Lyme, parasites, mold, inflammation and chronic infections, and different treatment modalities. Bacteriophage therapy and hemoadsorption therapy were new concepts for me take home to investigate further.

The first speaker, Louis Charles Teulieres, MD from France and England, spoke on bacteriophages in Lyme disease and diagnostics. Bacteriophages are a hot topic in the Lyme community as a means to detect and treat Lyme disease instead of heavily relying on antibiotics. Bacteriophages, a dominant viral life form existing as naked DNA with a protein coat, infect bacteria and “devour” them. They are everywhere: 50 million bacteriophage viruses are found in one milliliter of seawater.

Dr. Teulieres’ main focus: Is there a place for bacteriophages in diagnosis and treatment of Lyme disease? Can this provide an alternative treatment to antibiotics for Lyme disease, and thereby avoid post-antibiotic resistance? His lecture was highly technical, and it is still theoretical to use bacteriophages as a diagnostic tool, or to kill Borrelia Lyme bacteria with a Borrelia-specific virus. Phage Therapy is a novel idea to be tested soon. I have some skepticism about this approach which overlooks hidden dental spirochete and parasite infections, but stay tuned for more research.

Other topics included molds and fungus in chronic inflammation by Dr. Damien Downing of London, a lecture on biofilm by a doctor from Scandinavia, Lyme and co-infections by Prof. Dr. Kenny de Meirleir of Belgium, immune monitoring of hemoadsorption approaches as a new treatment option in antibiotic resistant chronic Lyme infection by Prof. Dr. Marion Schneider of Germany, and patient cases treated with hemoadsorption and extracorporeal hyperthermia by Dr. med. Rainer Mutschler of Germany.

Bacteriophage testing for Lyme disease claims it could detect direct evidence of Borrelia presence, is highly sensitive and specific, could distinguish Lyme from relapsing fever Borrelia strains, could distinguish active and non-active Borrelia presence, and could be developed to have the ability to distinguish different Borrelia sub-types.

On my last day at the Medicine Week, I met Australian researcher Jennie Burke, MSc from Sydney who gave a lecture on, Cancer and Infection. I did not attend her lecture but at the night meeting at the restaurant, she gave me her lecture slides to review.

To my delight, she presented on viral, bacterial and parasite infections as possible causative agents for the development of tumors or opportunistic inhabitants. Her slides covered controversial topics from Virginia Livingston Wheeler, Royal Rife and Dr. Milbank Johnson on BX virus and Rife frequency therapy, Dr. Laszlo K. Csatary on Newcastle virus, and included a list of bacteria and viruses associated with inducing cancer. Her list of cancer types and infections include Gallbladder carcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, and Ovarian, Colorectal, Lung, Pancreatic, Breast, Prostate, Anal and Oral cancer. She listed the names of the bacterial and viral infections and development of specific cancer types.

Her last slide was: Parasites in Cancer? The antiparasitic mebendazole shows survival benefit in preclinical models of glioblastoma multiforme (brain cancer). Supporting articles include: Mebendazole Monotherapy and Long Term Disease Control in Metastatic Adrenocortical Carcinoma, Mebendazole Inhibits Growth of Human Adrenocortical Carcinoma Cell Lines Implanted in Nude Mice, and Mebendazole Elicits a Potent Antitumor Effect on Human Cancer Cell Lines Both in Vitro and in Vivo.

The development of cancer, infections and environmental toxins are not a new concept, but have been largely sidelined (seduced) by the genetic mutation theory of cancer. It is time to renew infections and environmental toxins, including EMF, as the driving forces of inflammation and immune dysregulation. The end results are the imbalance of Th1, Th2, Th17 and regulatory T immune cells that can trigger autoimmune reactions or development of cancer.

I have written many articles on parasites, fungal infections and cancer connections, presenting cancer as an infectious disease as if cancer is a metabolic parasite. Dr. Tim Guilford and I published, Antiparasitic and Antifungal Medications for Targeting Cancer Cells Literature Review and Case Studies, in PubMed with extensive references. If you are suffering from cancer, get a copy and share with your oncologist. He or she may embrace and try parasite and fungal medications or scorn you and laugh at you. You have nothing to lose by trying.

Listening to French, Australian and other international speakers at Medicine Week was worthwhile, and I learn from going to Baden-Baden every year. Meeting good friends and enjoying good wine, beer, food and Roman Baths give even more incentives to attend, and expand my horizons.

Dr. Simon Yu, M.D. is a Board Certified Internist. He practices Internal Medicine with an emphasis on Integrative Medicine to use the best each has to offer. For more articles and information about integrative medicine, patient success stories, and Dr. Yu’s new book, AcciDental Blow Up in Medicine: Battle Plan for Your Life, visit his website at www.preventionandhealing.com or call Prevention and Healing, Inc., 314-432-7802. You can also attend a free monthly presentation and discussion by on Integrative Medicine at his office on the second Tuesday each month at 6:30 pm. Call to verify the date. Seating is limited, arrive early.