Archive for the ‘Uncategorized’ Category

Lyme and Tick-borne Diseases: Holly Ahern

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LGLC Living Lands Series 2020

The third presentation in the Lake George Land Conservancy’s Living Lands Series of 2020 features Dr. Holly Ahern, Associate Professor of Microbiology at SUNY Adirondack and Vice President of the Lyme Action Network. She has extensive teaching and research experience in bacteriology and molecular biology. As an expert on the scientific literature pertaining to Lyme disease and other tick-borne infections, Ahern has served on the NYS Senate Tick-borne Disease Task Force and on the Testing and Diagnostics subcommittee of the HHS Tick-borne Disease Working Group in 2018. Her talk informs on the state of the science surrounding ticks and tick-borne diseases like Lyme disease.

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**Comment**

Ahern states that Borrelia Miyamotoi is NOT associated with a rash.  Not so fast:

For decades misinformation has abounded with Lyme disease rashes:
  1. The guidelines state that 60-80% of Lyme patients will get a rash, NOT TRUE.  It’s highly variable.
  2. Rashes must expand to 5 cm and beyond to be from Lyme.  NOT TRUE.
  3. Typically Lyme rashes will take the form of a bull’s eye or target.  NOT TRUE.

So we must be extremely careful in what we state about Borrelia Miyamotoi:

Ahern most probably obtained the “no rash” information from a Shapiro and Wormser study that states, “B. miyamotoi in the United States typically do not have a rash.” Study explained here:

https://danielcameronmd.com/doctors-face-challenges-in-diagnosing-borrelia-miyamotoi/

“Typically” is such a small word but can mean so much.  One word can keep patients from being diagnosed and treated, causing a life-time of suffering.

I would say we must tread carefully when stating supposed facts as this is a relatively newly studied organism. Having a rash is diagnostic for illness, but NOT having one does NOT mean you aren’t infected – just like with Lyme. Mainstream medicine is woefully uneducated about ALL tick-borne illness and we must make sure so-called facts are not limiting patients from diagnosis and treatment.

The rash issue has hurt patients for decades. Let’s make sure it doesn’t hurt patients with Bm.  Testing is already missing most patients.

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Merry Christmas!

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Local Veterinarians Seeing an Increase in Tick-Borne Illnesses Among Dogs

https://www.wymt.com/2020/12/04/local-veterinarians-seeing-an-increase-in-tick-borne-illnesses-among-dogs/  News Video Here

Local veterinarians seeing an increase in tick-borne illnesses among dogs

Published: Dec. 4, 2020

HAZARD, Ky. (WYMT) – If you have a pet at home, you might want to keep reading, as local veterinarians are seeing an increase in tick-borne disease in our four-legged friends.

Doctor Gene Smith at Appalachian Animal Hospital says during the last three years numbers have increased dramatically with three specific diseases.

“Well, what we have seen is a dramatic increase of dogs that we have that are testing positive for Lyme disease and ehrlichiosis as well as anaplasmosis,” said Smith. “We are getting natural tick reproduction plus we are getting some tick eggs imported black-legged ticks, brown dog ticks, Lonestar ticks.”              (See link for article and video)

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**Comment**

Great reminder that pets are often a gateway to human illness:  

Talk to your veterinarian for the latest tick/flea prevention products.

For more:  https://madisonarealymesupportgroup.com/2019/04/12/tick-prevention-2019/

Neglected Infections & Gastrointestinal Issues in Patients With Late Vector-Borne Infections

Neglected-Infections-and-Gastrointestinal-Issues-in-Patients-with-Late-Persistent-Chronic-Vector-Borne-Infections-T-Mijatovic

Crypto-infections Conference

September 26-27, 2020

NEGLECTED INFECTIONS AND GASTROINTESTINAL ISSUES IN PATIENTS WITH LATE / PERSISTENT / CHRONIC VECTOR-BORNE INFECTIONS

Tatjana Mijatovic, PhD

R.E.D. Labs CSO & Lab Managertmijatovic@redlabs.be * http://www.redlabs.com

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**Comment**

Excellent slide-show.  (Please click on top link)

The slides go through numerous topics including a unique kind of testing, which I’ve highlighted below:

Novel Testing Approaches – Phelix Phage-based Test

  • Bacteriophages could become a diagnostic tool (Patent WO2018083491A1) based on the principle that if there are phages it is because there are living bacteria; hence a phage- based test is a direct proof of an active infection.

  • Phelix Charity together with Leicester University microbiology department have recently developed a Borrelia Phage-based PCR test searching for 3 major Borrelia groups:

    Borrelia burgdorferi sl (including B. burgdorferi ss, B. afzelii, B. garinii, B. spielmanii, etc)

    Borrelia miyamotoi and

    Relapsing fever group (B. recurrentis, B. hermsii, etc).

  • This method is efficiently used to assess both human samples and ticks.

  • Highly sensitive and specific.

  • Do not generate positive signal against other bacterial strains.

  • False positive are ruled out by sequencing.

They found:

  • Among positive ticks, 60% were for B. miyamotoi.
  • Testing on over 2,000 humans (mainly late stage/chronic patients) showed 30% negative results and 70% positive, among which over 60% indicated the presence of specific Borrelia miyamotoi phages.

The authors state:

With respect to the obtained results, a question raised: are we searching for the wrong culprit with Lyme-disease testing?

The slides also go through Tularemia and Yersinia. (Please see link for results). The authors state it’s important to test for these pathogens as they contribute to the overall burden on the immune system.

Then there’s a large section devoted to gastrointestinal issues with a chart showing various symptoms caused by 8 different tick-borne diseases.

Important takeaway:

The number of patients presenting with such symptoms is probably reaching epidemic proportions. Testing for gastrointestinal problems need to be included.

Tests are listed followed by a section on Leaky Gut. The important finding regarding 3 years of testing Leaky Gut was – 63.87% patients had increased levels.

The two greatest findings:

  • Searching for actual bacterial presence using phage-based testing might pacify the debate and controversies on testing choices and late/chronic stage patients. Current Lyme testing will not pick up Borrelia miyamotoi, which may explain why many patients are not being diagnosed.
  • The overall high failure rate of therapies for vector-borne infections, especially in late/persistent/chronic patients, underscores the necessity to fully investigate different concurrent infections (including opportunistic infections) along with resulting gastrointestinal and immune dysregulations.

Happy Thanksgiving!

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And for your listening enjoyment:

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Garth & Kat Sing Thanksgiving Songs