Archive for the ‘research’ Category

TMJ Arthritis Triggered By Lyme Disease

https://danielcameronmd.com/tmj-arthritis-triggered-by-lyme-disease/

TMJ ARTHRITIS TRIGGERED BY LYME DISEASE

woman with TMJ from Lyme disease holding her jaw

A case report by Weise and colleagues demonstrates that Lyme disease can induce temporomandibular joint (TMJ) pain and may be misdiagnosed as a common temporomandibular disorder (TMD).

By 

In the article, “Acute arthritis of the right temporomandibular joint due to Lyme disease: a case report and literature review,” the authors describe a 25-year-old patient who presented to a medical center with acute pain in the right temporomandibular joint and mouth opening disorders.¹

Over a 5-year period, the woman’s distal bite was treated with removable and fixed orthodontic appliances. Three months after the first symptoms, “the patient developed increasing pain in the right TMJ, increasing active mouth opening restriction to 20 mm and a habitual deviation of the lower jaw to the left.”

The patient was initially diagnosed with a total ventral deviation of the discus on the right side without reduction. Treatment with anti-inflammatory medications, a bite splint and a corticosteroid injection, however, were not effective and the woman’s symptoms continued.

Although the patient did not recall a tick bite or EM rash, testing for Lyme disease was positive and she was diagnosed with Lyme arthritis affecting the right temporomandibular joint.

“Early interdisciplinary diagnosis of Lyme disease and early antibiotic therapy are essential to avoid misdiagnosis and unnecessary, sometimes invasive, therapies.”

The patient was prescribed a 3-week course of Cefuroxime. After one week of antibiotic treatment, her symptoms improved.

“It can be assumed that there must have been an infection with Borrelia in the right temporomandibular joint for a longer period of time before the symptoms occurred.”

Lyme disease presenting with TMJ “very often is misinterpreted as a temporomandibular disorder,” the authors state.

“In the case of unclear TMJ problems and when the TMD treatment is not successful,” the authors stress, “the possibility of a [Lyme disease] infection should definitely be considered as a differential diagnosis.”

References:
  1. Weise, C., Schulz, M.C., Frank, K. et al. Acute arthritis of the right temporomandibular joint due to Lyme disease: a case report and literature review. BMC Oral Health 21, 400 (2021). https://doi.org/10.1186/s12903-021-01744-4

_______________

**Comment**

Been there, done that.

Sadly, what isn’t mentioned is the fact most people don’t test positive – sometimes ever.

What happens to these sorry-sacks?  Well, they simply go on to suffer and are gaslit by mainstream medicine who will then tell them it’s all in their head.

One other little factoid is that this person could very well relapse in the future.  What happens then?  Well, it’s quite simple.  If she stays in the mainstream medical paradigm, and doesn’t get to an independent doctor, she will simply suffer because this paradigm doesn’t recognize chronic/persistent Lyme/MSIDS.

Category:

Lyme, research

Flubendazole With Herxheimer Reactions Followed by a Cure in a Patient With Symptoms Suggestive of Chronic Lyme

https://www.fortunejournals.com/articles/effect-of-flubendazole-with-jarishherxheimer-reactions-followed-by-cure-in-a-patient-with-a-polymorphic-persistent-syndrome-sugges.

Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease?

Article Information

Alexis Lacout1, Christian Perronne2

1Centre de diagnostic ELSAN, Centre médico-chirurgical 83 avenue Charles de Gaulle 15000 Aurillac, France

2Infectious Diseases, Paris

*Corresponding author: Alexis Lacout. Centre de diagnostic ELSAN, Centre médico-chirurgical 83 avenue Charles de Gaulle 15000 Aurillac, France

Received: 02 February 2023; Accepted: 09 February 2023; Published: 13 March 2024

Citation: Alexis Lacout, Christian Perronne. Effect of Flubendazole, with Jarish-Herxheimer Reactions Followed by Cure, in A Patient with A Polymorphic Persistent Syndrome Suggestive of Chronic Lyme Disease: A Sign of Parasitic Disease. Archives of Microbiology and Immunology. 8 (2024): 96-100.

View / Download PdfShare at Facebook

Abstract

This paper discusses the case of a 40-year-old male patient presenting with a “polymorphic persistent syndrome after a possible tick bite” (SPPT), a syndrome officially recognized by the French High Authority for Health (HAS). Anti-infection protocols were implemented, gradually improving the patient’s clinical condition until complete remission was achieved. Each time flubendazole was taken, it was accompanied by severe symptoms – not suggestive of adverse reactions but of a Jarisch-Herxheimer reaction. Each administration of flubendazole was followed by a period of remission of symptoms.  ________________

**Comment**

Please note study author Dr. Christian Perronne, a long outspoken critic of how Lyme has been handled as well as COVID.  He’s yet another doctor who has been persecuted for this departure from ‘consensus’ based medicine where doctors are expected to check their brains at the door and simply follow illogical and unscientific government dictates.

Flubendazole is a antiparasitic (anthelmintic) agent and a fluorine analogue of mebendazole which is better absorbed when taken with or after a meal.  Used as a dewormer in humans and animals for 40 years, recent studies suggest its potential use as an anticancer agent.  The same can be said of Fenbendazole (Fedben).

I highly recommend viewing Dr. Lee Merrit’s 50 Min video: The Parasite Paradigm.  Parasite egg sacks and cancer look identical under a microscope and German scientists have been saying for decades that cancer is caused by parasites.  Her protocols are found here.

Flubendazole is also available in a slow-release parenteral preparation given subcutaneously or intramuscularly, which allows sustained release over 5 days. The usual dosage is 750 mg/wk for onchocerciasis. It is used to treat hookworm, T. trichiura, and A. lumbricoides. Side effects are vague and mostly abdominal, such as nausea, abdominal pain and rumbling, soft/loose stools, and dyspepsia.  Breathlessness and fatigue have also been reported.

For more on Perronne’s work:

Category:

Activism, Cancer, Lyme, Parasites, research, Treatment

Biologists Map DNA of 47 Strains of Lyme Disease

https://www.lymedisease.org/map-dna-lyme-disease-bacteria/

Biologists map the DNA of 47 strains of Lyme disease

By City University of New York

August 15, 2024

A team led by CUNY Graduate Center biologists has produced a genetic analysis of Lyme disease bacteria that may pave the way for improved diagnosis, treatment, and prevention of the tick-borne ailment.

Weigang Qiu, a professor of biology at the CUNY Graduate Center and Hunter College, and an international team mapped the complete genetic makeup of 47 strains of Lyme disease-related bacteria from around the world. This created a powerful tool for identifying the bacterial strains that infect patients.

More accurate tests and treatments?

Researchers said this could enable more accurate diagnostic tests and treatments tailored to the bacteria causing each patient’s illness.

“By understanding how these bacteria evolve and exchange genetic material, we’re better equipped to monitor their spread and respond to their ability to cause disease in humans,” said Qiu, the corresponding author of the study.

The study was published in mBio, the flagship journal of the American Society for Microbiology.

Researchers said the genetic information uncovered in the study may help scientists develop more effective vaccines against Lyme disease.

Lyme disease is the most common tick-borne illness in North America and Europe, affecting hundreds of thousands of people a year. The disease arises from bacteria belonging to the Borrelia burgdorferi sensu lato group, which infect people through the bite of infected ticks. Symptoms can include fever, headache, fatigue, and a characteristic skin rash. If left untreated, the infection can spread to joints, the heart, and the nervous system, causing more severe complications.

Case numbers are increasing steadily, with 476,000 new cases each year in the United States, and may grow faster with climate change, the authors of the study said.

The research team sequenced the complete genomes of Lyme disease bacteria representing all 23 known species in the group. Most hadn’t been sequenced before the effort. The National Institutes of Health-funded project included many bacteria strains most associated with human infections and species not known to cause disease in humans.

Evolutionary history of Lyme bacteria

By comparing these genomes, the researchers reconstructed the evolutionary history of Lyme disease bacteria, tracing the origins back millions of years. They discovered the bacteria likely originated before the breakup of the ancient supercontinent Pangea, explaining the current worldwide distribution.

The study also disclosed how these bacteria exchange genetic material in and between species. This process, known as recombination, allows the bacteria to rapidly evolve and adapt to new environments. The researchers identified specific hot spots in the bacterial genomes where this genetic exchange occurs most frequently, often involving genes that help the bacteria interact with their tick vectors and animal hosts.

To facilitate ongoing research, the team has developed web-based software tools (BorreliaBase.org) that allow scientists to compare Borrelia genomes and identify determinants of human pathogenicity.

Looking ahead, the researchers said they plan to expand their analysis to include more strains of Lyme disease bacteria, especially from understudied regions. They also aim to investigate the functions of genes unique to disease-causing strains, which could uncover new targets for therapeutic interventions.

As Lyme disease expands its geographic range because of climate change, the research provides valuable tools and insights for combating this rising public health threat.

The study is supported by grants from NIH and an award from the Steven and Alexandra Cohen Foundation.

Click here to read the study.

SOURCE:  CUNY Office of Communications and Marketing

________________

**Comment**

Predictably, the study throws in the globalist talking points of vaccines and climate change, despite there being major disagreements within the scientific community on both issues.

While mapping the strains of borrelia should be good news, nothing will come of this but more lucrative vaccines that will maim and kill many people.  No good tests and no effective treatments will be created.

How do I know?

University research has been hijacked.  NIH, HHS, CDC, and FDA are bought out agencies.  We will get nothing helpful from them.  COVID exposed to all with eyes to see and ears to hear that ‘public health’ isn’t about health at all but  is about power and money.

Patients mean absolutely nothing to these players.

______________

For more:

Category:

Lyme, research, Uncategorized

New Compound Kills Drug-Resistant Bacteria

https://www.theepochtimes.com/health/scientists-develop-new-compound-that-kills-flesh-eating-bacteria-and-other-drug-resistant-bacteria

Scientists Develop New Compound That Kills Flesh-Eating and Other Drug-Resistant Bacteria

The new compound, PS757, may form a new type of antibiotic drug class, researchers hope.

Twenty years ago, professor Fredrik Almqvist, an organic chemistry professor at Umeå University in Sweden, was asked by his collaborating researchers at Washington University in St. Louis (WashU) to design a compound that would prevent urinary tract infections, which are often caused by Gram-negative bacterial infections.

Almqvist’s team created various compounds that were then screened for their effects.

Rather than controlling Gram-negative bacteria adherence, they found some of the compounds were highly effective at killing various Gram-positive bacteria. These included multidrug-resistant strains classified as concerning threats by the U.S. Centers for Disease Control and Prevention (CDC).

The researchers singled out one compound, which they named PS757. Lab testing has shown PS757 to be effective against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), multidrug-resistant Streptococcus pneumoniae, and erythromycin-resistant Streptococcus pyogenes (S. pyogenes), among others.

They further studied the effect of PS757 on S. pyogenes, a potentially flesh-eating bacteria, in animals.  (See link for article)
________________
**Highlights**
  • an animal study shows it may help control the spread of flesh-eating bacteria in rats and aid in recovery.  The study also showed it to be effective against other Gram-positive bacteria.
  • The U.S., China, and the UK has seen resistance to clindamycin.  Linezolid has been a useful alternative.  (I’ve had reports that it’s helped with Lyme/MSIDS)
  • There haven’t been any toxicity studies on PS757 yet.
  • The compound was designed by mimicking a bacterial peptide.
  • The bactericidal effect on wild-type bacteria is only seen with Gram-positives but the scientists are confident they can develop the compound further to affect Gram-negative bacteria.
  • The properties in PS757 make it effective against persister cells, living bacteria that have stopped growing – a particular problem with borrelia, the organism that causes Lyme disease.
  • Without increasing dosage, it can also kill bacteria in biofilms, a protective bacterial community also seen in Lyme/MSIDS patients.
  • So far researchers have not been able to find bacteria resistant to PS757.
  • The compound is now patented and licensed to a company in the hopes of clinical trials and drugs.

Category:

Activism, research, Treatment

Tick Bite Leads to Murder-Suicide

https://www.trialsitenews.com/a/true-crime-as-true-lyme-tick-bite-leads-to-murder-suicide

True Crime as True Lyme: Tick Bite Leads to Murder-Suicide

Investigative Journalist at Trial Site News | In this to change this.
Jul. 24, 2024, 4:30 p.m.

Tortured by Lyme disease, a young man killed his friend and himself. He is not alone.

MARY BETH PFEIFFER

For decades, Lyme disease physicians have seen a small share of late-stage patients with symptoms far beyond the physical ravages of a tick bite. These patients, estimated to be 1 percent of chronic Lyme psychiatric cases, manifest brain disorders so intractable that they become violent, even homicidal.    

Now, a new article in the science journal Heliyon validates these observations and reveals possible mechanisms driving them. It tells the horrific story of a 32-year-old man whose tickborne infection at age 14—one of several—went unrecognized until it was unresponsive to treatment. Failed by short-course antibiotics that mainstream medical guidance swears by, he descended into substance abuse, as many chronic Lyme patients do, to ease his anxiety, depression, and physical pain.

Finally, in the delusional throes of PCP withdrawal, he walked next door, impulsively killed his best friend, stabbed the friend’s father and brother, and turned the knife on himself. He died on a bathroom floor, his mother having tried in vain to stanch two neck wounds.

All of this is a likely outcome of poorly treated Lyme disease under medical protocols that leave even early-treated patients sick—36 percent at six months and 5 percent at fifteen years. While animal studies and a handful of post-mortem reports have illustrated the failure of recommended treatments to quell Lyme disease—using antibiotics in insufficient strength or duration—this study goes further.

For the first time, based on analysis of autopsy samples, it shows both how persisting infection combined with chemical brain changes from substance abuse may have contributed to a disastrous outcome.  (See link for article and study)

________________

**Comment**

It’s stories like these that also make me highly critical of any federal attempt at rectification.

This story is a perfect example of how many go undiagnosed for so long they become recalcitrant.  The picture becomes muddier yet as they seek out ways to simply cope – and in this case turn to harmful drugs which adds a whole other dimension to an already complex picture.

The study thankfully was led by none other than Dr. Robert Bransfield, a literal icon in the world of Lyme and psychiatry.  He’s single-handedly written pretty much all that is known about how Lyme/MSIDS affects the brain.  Even though since 2015 the APA has recommended that evals for mental illness include assessments of ‘locally endemic infectious diseases such as Lyme disease,’ be done, they typically aren’t done.

The study showed that the patient had attached ticks on him at least fifteen times.  At 14 he developed the hallmark summer flu-like illness Lyme is known to cause that his pediatrician considered to be caused by a virus despite an attached tick!  His brain was found to have major inflammation and quinolinic acid – both of which are common in late Lyme disease.  PCP, the illegal drug he took reduces quinolinic acid.

The patient sought but was denied a bed in a substance abuse rehabilitation facility.  PCP withdrawal is known to cause fear, agitation, anxiety, irritability, hallucinations and flashbacks.

For more:

Category:

Activism, Psychological Aspects, research, Ticks