Archive for the ‘research’ Category

Response to the Proposed Monoclonal Antibody Injection to Prevent Lyme Disease

https://www.change.org/p/the-us-senate-calling-for-a-congressional-investigation-of-the-cdc-idsa-and-aldf/u/13944776?tk=-q6Qjp9U5xBsfKfijcGzoHsOghM6B0xXtori7lxgItI&utm_source=petition_update&utm_medium=email

Carl Tuttle, a Lyme activist from New Hampshire, has written a letter to Dr. Klempner regarding the safety of the monoclonal antibody injection proposed to prevent Lyme Disease.

  1. There is no safety window to protect against infection. According to Dr. Burgdorfer who stated in 1999 that about 5-10% of ticks that are carrying Lyme have a systemic infection and have the disease already in their salivary glands and can transmit infection immediately.
  2.  There is no protection from blood transmission due to blood transfusion.
  3. It can not protect against transmission by feces, urine, or tick-excretes.
  4. It will not protect sexual transmission.
  5. It will not protect from congenital transmission. 28 Peer-Reviewed Studies http://home.comcast.net/~runagain/Congenital%20Transmission%20of%20Lyme.doc

Another Unknown Illness Spread by Ticks

http://www.telegraph.co.uk/news/health/news/11953087/New-illness-spread-by-ticks-found-similar-to-Lyme-disease.html

A nymph stage blacklegged tick on a leaf Infected nymphs transmit most cases of Lyme disease...AKPYYC A nymph stage blacklegged tick on a leaf Infected nymphs transmit most cases of Lyme disease

A nymph stage blacklegged tick

Scientists have found an illness similar to Lyme which is resistant to many antibiotics. The unnamed disease is carried by the bacteria Borrelia miyamotoi which has been found to be present in 3 out of 954 ticks in southern England. While there are no reports of illness in the UK, there have been 18 diagnoses in the United States in 2013.

There is concern that this unnamed illness could be mistaken for the flu or viruses as it causes relapsing fevers. If people do not receive prompt treatment symptoms become far more serious and pervasive.

Borrelia miyamotoi was identified 20 years ago in Japan but was not known to cause disease until 2011 when Durland Fish, Emeritus Professor at Yale School of Public Health said, “We stumbled across it at our laboratory in our colony of ticks. We reported it, but we could not get any funding. I happened to be at a conference in Cyprus where there were posters about an infection in Russia. I met the guy who was dealing with it and we exchanged notes.” He is hopeful a new antibiotic will be found for the disease.

Doctors have successfully treated the Borrelia miyamotoi illness with stronger varieties of antibiotics.

New Research to Prevent Lyme Disease

http://www.nbcnews.com/health/health-news/lyme-disease-treatment-would-prevent-infection-researchers-say-n441946

Dr. Mark Klempner of the University of Masachusetts’ nonprofit vaccine development arm, MassBiologics, states that they are working on a monoclonal antibody that specifically targets Lyme-causing bacteria that purports the highest level of immunity.

Using genetically engineered mice with human immune system genes, they immunized the mice using Borrelia bacteria and then collected the antibodies the mice produced. They identified four to be potent against multiple strains of Borrelia, the Lyme disease causing bacteria.

When testing the antibodies produced, a single injection protected them from a large dose of Borrelia even after several infected ticks bit the mice.

And while U.S. Biologic is working on a vaccine for mice, produced in pellets resembling kibble, Klemner states emphatically that their monoclonal antibody is not a vaccine, instead it stimulates the immune system to ward off infection.

Monoclonal antibody drugs have been used for various diseases including cancer. It is similar in approach to gamma globulin shots that were used to try and prevent tuberculosis and hepatitis.

The company is hopeful to start testing in humans next year.

Proof of Borrelia Persistence

The following work by microbiologist Thomas Grier and pathologist Alan MacDonald should prove to the CDC that Borrelia can undoubtably persist inside the human body.

http://whatislyme.com/lyme-a-beautiful-killer-by-thomas-grier/

“For years pathologists stained for amyloid to make the diagnosis, but when the same plaques in a serial sectioning were stained for B burgdorferi or B miyamotoi, individual classical spirochetes could be seen, but more commonly a biofilm of Borrelia could be seen in the same plaques. Borrelia is a brain-pathogen.”

grier

Above:  “Borrelia miyamotoi using Alan MacDonald’s FISH stain. This is the first documented case of Bm in Minnesota.”

tom2

Above and below:  “Since Fluorescence FISH stain target species specific nucleotide sequences, it is species specific. Spirochetes are excellent subjects because the Borrelia DNA is associated with the cell wall and membrane. Another probe can isolate cytoplasmic DNA thus giving a 3-D look to it. What a beautiful killer.”

spiro

Below:  “This patient was told for 22 years that she had MS, our work on MS allowed us to determine that this brain MRI was probably a result of Lyme. Do you see the markers? This Philadelphia woman made a very good recovery from her disability and went back to work.”

Below:  “This is Borrelia burgdorferi in the brain of a man sick for two decades. The others in red were Borrelia miyamotoi. Another finding was even after treatment he had neutrophils in the brain, and indication of a breakdown of the BBB and inflammation. He was sicker than doctors realized!”

ms-lyme

“The last photo taken of Grier’s friend Scott from Twig MN.  His deathbed video is all about helping other Lyme victims.”  Scotty was a 57 year old Lumberman who lived his whole life in the forest.  Scotty was seronegative for Lyme but was bedridden with pain and neurolyme and was treated for 7+ years with aggressive antibiotics.  His brain autopsy revealed several surprises and live active Borrelia burgdorferi.”  

scott

Contact Thomas Grier M.S. at donatebrain@gmail.com to ask him about helping fund his research.

For more:  https://madisonarealymesupportgroup.com/2018/04/17/persistent-borrelia-infection-in-patients-with-ongoing-symptoms-of-lyme-disease/  Conclusions: Using multiple corroborative detection methods, we showed that patients with persistent Lyme disease symptoms may have ongoing spirochetal infection despite antibiotic treatment, similar to findings in non-human primates. The optimal treatment for persistent Borrelia infection remains to be determined.

https://madisonarealymesupportgroup.com/2019/01/16/study-shows-diminished-pathogen-specific-antibody-production-in-coinfected-mice-contributing-to-persistent-infection/

https://madisonarealymesupportgroup.com/2018/10/30/study-shows-lyme-msids-patients-infected-with-many-pathogens-and-explains-why-we-are-so-sick/  For the first time, Garg et al. show a 85% probability for multiple infectionsincluding not only tick-borne pathogens but also opportunistic microbes such as EBV and other viruses….In addition to tick-borne co-infections and non-tick-borne opportunistic infections, pleomorphic Borrelia persistent forms may induce distinct immune responses in patients by having different antigenic properties compared to typical spirochetes32,33,34,35. Nonetheless, current LD diagnostic tools do not include Borrelia persistent forms, tick-borne co-infections, and non-tick-borne opportunistic infections.

http://norvect.no/230-peer-reviewed-studies-show-evidence-of-persistent-lyme-disease/

http://lymerick.net/persistent-borreliosis.htm  Microscopy, Culture or PCR-verified cases of persistent [seronegative] Lyme Borreliosis

https://madisonarealymesupportgroup.com/2018/04/13/chronic-lyme-post-mortem-study-needed-to-end-the-lyme-wars/

https://madisonarealymesupportgroup.com/2018/07/23/exploring-the-controversial-concept-of-chronic-lyme-disease/