Archive for the ‘Babesia’ Category

Babesia and Heart Issues

Normally when Lyme/MSIDS patients have heart issues, Lyme is blamed; however, sometimes it’s not Lyme, but Babesia.

https://www.researchgate.net/publication/7840479_Cardiac_involvement_in_canine_babesiosis

Lobetti, Remo. (2005). Cardiac involvement in canine babesiosis. Journal of the South African Veterinary Association. 76. 4-8. Cardiac dysfunction in canine babesiosis has traditionally been regarded as a rare complication, with the majority of lesions reported as incidental findings at post-mortem examination. Recent studies have, however, demonstrated cardiac lesions in canine babesiosis. Cardiac troponins, especially troponin I, are sensitive markers of myocardial injury in canine babesiosis, and the magnitude of elevation of plasma troponin I concentrations appears to be proportional to the severity of the disease. ECG changes in babesiosis are similar to the pattern described for myocarditis and myocardial ischaemia and together with histopathological findings indicate that the heart suffers from the same pathological processes described in other organs in canine babesiosis, namely inflammation and hypoxia. The clinical application of the ECG appears to be limited and thus cardiovascular assessment should be based on functional monitoring rather than an ECG tracing. On cardiac histopathology from dogs that succumbed to babesiosis, haemorrhage, necrosis, inflammation and fibrin microthrombi in the myocardium were documented, all of which would have resulted in ECG changes and elevations in cardiac troponin. Myocardial damage causes left ventricular failure, which will result in hypotension and an expansion of the plasma volume due to homeostatic mechanisms.

BabesiosisMonsters Inside Me

Great video showing the extreme fatigue a person with both Lyme and Babesia has.

https://www.envita.com/lyme-disease/chronic-lyme-diseases-parasitic-coinfection-babesiosis  An article put out by Envita explains that Babesia is rarely tested for – leaving many undiagnosed.  Like other coinfections, there are numerous infectious strains and symptoms can look like malaria but can also lead to death.  Evidently 41% can develop cardiovascular issues like acute respiratory failure, disseminated intravascular coagulation (thick blood which can lead to clotting), and even congestive heart or renal failure.  

**Complex Babesiosis is associated with severe anemia and high parasitaemia levels.

**Chronic Babesiosis can trigger cardiovascular, kidney, and liver problems.

Personally, I can attest to the importance of the anti-malarial medications my husband and I were both put on.  We both had chest pressure and dizziness but the headaches I had were out of this world.  My heart would also flop like a fish out of water and wake me up from a dead sleep – racing.  Neither of us had night sweats and we presented differently.  My husband developed hyper coagulation and anemia while I did not.  Heparin helped him tremendously.

If you are having heart involvement and antibiotics typically used for Lyme are not touching it, please discuss Babesia with your health care provider.  For us, treating for Babesia made a huge difference.  I’m happy to report ALL of those symptoms are completely gone after a full year hitting it hard with anti-malarials.  The best treatments overlap.  Please see the following link for treatment ideas to discuss with your doctor.

More on Babesia:  https://madisonarealymesupportgroup.com/2016/01/16/babesia-treatment/ (checklist within the link that you can print and fill out)

Good article by Dr. Rawls:  https://rawlsmd.com/health-articles/understanding-babesia

 

Neglected Vector-borne Zoonoses in Europe

https://www.ncbi.nlm.nih.gov/m/pubmed/29426471/

Neglected vector-borne zoonoses in Europe: Into the wild.

Tomassone L1Berriatua E2De Sousa R3Duscher GG4Mihalca AD5Silaghi C6Sprong H7Zintl A8. Vet Parasitol. 2018.

Abstract

Wild vertebrates are involved in the transmission cycles of numerous pathogens. Additionally, they can affect the abundance of arthropod vectors. Urbanization, landscape and climate changes, and the adaptation of vectors and wildlife to human habitats represent complex and evolving scenarios, which affect the interface of vector, wildlife and human populations, frequently with a consequent increase in zoonotic risk. While considerable attention has focused on these interrelations with regard to certain major vector-borne pathogens such as Borrelia burgdorferi s.l. and tick-borne encephalitis virus, information regarding many other zoonotic pathogens is more dispersed. In this review, we discuss the possible role of wildlife in the maintenance and spread of some of these neglected zoonoses in Europe. We present case studies on the role of rodents in the cycles of Bartonella spp., of wild ungulates in the cycle of Babesia spp., and of various wildlife species in the life cycle of Leishmania infantum, Anaplasma phagocytophilum and Rickettsia spp.

These examples highlight the usefulness of surveillance strategies focused on neglected zoonotic agents in wildlife as a source of valuable information for health professionals, nature managers and (local) decision-makers. These benefits could be further enhanced by increased collaboration between researchers and stakeholders across Europe and a more harmonised and coordinated approach for data collection.

______________

**Comment**

They are neglected in the U.S. too, but all play a significant role in patient case complexity.

TBD Serochip Will Identify Six Tick Borne Pathogens

https://www.mailman.columbia.edu/public-health-now/news/first-multiplex-test-tick-borne-diseases

INFECTIOUS DISEASE Feb. 16 2018

First Multiplex Test for Tick-Borne Diseases

PROMISING TO REVOLUTIONIZE DIAGNOSIS, A SINGLE BLOOD TEST CAN NOW ACCURATELY DETECT IF SOMEONE HAS LYME DISEASE AND/OR ONE OF SEVEN OTHER TICK-BORNE DISEASES

A new blood test called the Tick-Borne Disease Serochip (TBD Serochip) promises to revolutionize the diagnosis of tick-borne disease by offering a single test to identify and distinguish between Borrelia burgdorferi, the pathogen responsible for Lyme disease, and seven other tick-borne pathogens. Led by scientists at the Center for Infection and Immunity (CII) at Columbia University’s Mailman School of Public Health, the research team reports details on the new test in the journal Nature Scientific Reports.

The researchers—who also include scientists from the Centers for Disease Control and Prevention, National Institute of Allergy and Infectious Diseases, Roche Sequencing Solutions, Farmingdale State College, and Stony Brook University—sought to improve on existing tests for tick-borne diseases (TBDs), which have limited diagnostic accuracy and cannot test for more than one infection simultaneously. Currently, diagnosis of Lyme disease, the most common TBD, requires two separate tests. This cumbersome approach also relies on subjective criteria for the interpretation of results, and accurately identifies fewer than 40 percent of patients with early disease and results in false positives 28 percent of the time. The accuracy of the method used to diagnose TBDs Babesia, Anaplasma, Ehrlichia, and Rickettsia varies widely among testing laboratories. And for other tick-borne agents, specific blood tests are not yet available, or in the case of the potentially deadly Powassan virus or Heartland virus, are only performed in specialized laboratories.

“The number of Americans diagnosed with tick-borne disease is steadily increasing as tick populations have expanded geographically,” says Rafal Tokarz, PhD. “Each year, approximately 3 million clinical specimens are tested for TBDs in the U.S. Nonetheless, the true incidence of TBDs is likely greatly underestimated, as patients with presumed TBDs are rarely tested for the full range of tick-borne agents, and only a fraction of positive cases are properly reported,” adds Nischay Mishra, PhD. Co-lead authors Tokarz and Mishra are associate research scientists in the Center for Infection and Immunity.

The TBD Serochip can simultaneously test for the presence of antibodies in blood to more than 170,000 individual protein fragments. Version 1.0 can identify exposure to eight tick-borne pathogens present in the U.S., including Anaplasma phagocytophilum (agent of human granulocytic anaplasmosis), Babesia microti (babesiosis), Borrelia burgdorferi (Lyme disease), Borrelia miyamotoi, Ehrlichia chaffeensis (human monocytic ehrlichiosis), Rickettsia rickettsii (Rocky Mountain spotted fever), Heartland virus and Powassan virus. The researchers also included Long Island tick rhabdovirus, a novel virus they recently discovered in Amblyomma americanum ticks. As new tick-borne infectious agents are discovered, the TBD-Serochip will be modified to target them—a process the researchers say can be done in less than four weeks.

The TBD Serochip is also able to identify whether an individual is infected with more than one tick-borne pathogen. Individual ticks are frequently infected with more than one agent; Ixodes scapularis ticks alone can transmit at least five human pathogens. Evidence of exposure to other tick-borne pathogens in patients with Lyme disease has been well documented. In the new paper, the researchers report finding antibodies to another agent in 26 percent of blood specimens from patients with TBD.

In addition to its utility as a diagnostic platform, the TBD Serochip also provides a powerful research tool for studies of TBDs. The technology can be employed to discriminate individual antibody responses in patients with TBD and thus examine the interplay of TBD agents on disease manifestation and progression. It can also be used to assess the impact of genetic diversity of tick-borne pathogens on the host immune response.

“Diagnosing tick-borne illness is a difficult journey for patients, delaying effecting treatment,” says senior author W. Ian Lipkin, MD, director of CII and John Snow Professor of Epidemiology at Columbia University’s Mailman School of Public Health. “The TBD Serochip promises to make diagnosis far easier, offering a single, accurate test for eight different TBDs. Early detection of infection enables rapid and appropriate treatment.”

Co-authors include Thomas Briese, Teresa Tagliafierro, Stephen Sameroff, Adrian Caciula, Lokendrasingh Chauhan, of CII; Jigar Patel and Eric Sullivan of Roche Sequencing Solutions, Madison, WI; Azad Gucwa of Farmingdale State College, Farmingdale, NY; Brian Fallon of Columbia University; Marc Golightly of Stony Brook University; Claudia Molins and Martin Schriefer of Centers for Disease Control and Prevention; and Adriana Marques of National Institute of Allergy and Infectious Diseases.

This study was funded through grants from the Steven & Alexandra Cohen Foundation and the National Institutes of Allergy and Infectious Diseases (AI109761). The content of study does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. CII has filed an invention report and provisional patent application for the technology.

The Persistent Spiral – The Ancient History of Lyme Disease and Tick-Borne Infections

borrelia_burgdorferi

Looking through history with knowledgable eyes, historian M.M. Drymon underscores how tick-borne illness has been with us since the beginning of time, and that many prominent historical figures showed signs of it in her latest book, The Persistent Spiral – The Ancient History of Lyme Disease and Tick-borne Infections.

First, she gives details of Ozti, the ancient man discovered in 1991 who represents the earliest documented case of Lyme Disease. Evidently, Ozti was carrying mushrooms with antibiotic qualities. He walked the forested area now located between Italy and Austria – one of the highest rates of modern LD in Europe. They even know he died in the Spring due to the intact pollen cells in his stomach.

Interestingly, from many standpoints, he had 57 tattoos – many in places that coincide with acupuncture points used to treat Lyme and pain relief – some 2,000 years before their documented use in China.  https://www.huffingtonpost.com/2015/01/26/otzi-iceman-new-tattoo_n_6546884.html

And while all these intimate details of a fellow sufferer are intriguing, the recent discovery of what Drymon calls the pot smoking, dispersed living, individualistic Bronze Age Cowboys, enlightens for sure. The discovery of the Yamnaya helps explain old Chinese books describing people of great height, deep-set blue or green eyes, long noses, full beards,and red or blonde hair. These nomadic horse breeding and cattle and sheep herding people contributed to many ancestries and very well may relate to how modern patients handle Lyme Disease (LD).  For more on the Yamnaya:  https://dna-explained.com/2015/06/15/yamnaya-light-skinned-brown-eyed-ancestors/

Drymon and many others believe genetics to be one reason some become so ill with tick-borne illnesses.

The Yamnaya were grassland inhabiters who eventually migrated into Northern Europe and may be the reason most of us can tolerate lactose, which was rare previously. They also might be a reason we don’t handle tick illness well. Since they lived outside tick infested areas, they most probably had immune systems inexperienced with Tick borne illness (TBI’s) and when exposed suffered with autoimmune illness.

Drymon states the Chinese had more experience treating LD due to historically inhabiting temperate forests which harbor ticks. Traditional Chinese medicine indicates this fact by having treatments for spirochetal diseases and specific herbs for Bell’s palsy, joint pain, inflammation, heart problems, fever and skin diseases, and convulsions – all of which are TBI symptoms.

Fast forward to the Crusades and the fact both King Richard I and Philippe Augustus II became ill and nearly succumbed to Trench Mouth which is caused by Bacillus fasiformis & Borrelia vincenti (a strain of borrelia, and also a spirochete). Richard apparently became ill again later with Autumnal Fever which has a relapsing nature and is proposed to be tick-borne.

Then there’s Catherine of Aragon, lover of the hunt, who after staying at a hunting lodge, survived The Sweat and was periodically ill from that point on. A physician of the time described The Sweat as a pestilence with copious sweating, stinking, redness of face and body, continual thirst, with a great headache.  Symptoms followed a pattern – sudden flu-like symptoms, apprehension, headaches, shivering, with muscle aches, and fatigue. Then came gut pain, vomiting, a hot and sweaty stage followed by headaches and delirium. There were also chest pains and difficulty breathing with great fatigue. (Sound familiar?)  If patients didn’t die, they were repeatedly afflicted. It seemed to be a summer illness found in rural families.  It also made many chronically affected for life.

There is no record of The Sweat until the landing of Henry Tudor’s soldiers in Wales after camping in forest edge environments. After that there were periodic outbreaks and two hundred and fifty years later an identical illness appeared in the exact same region. Another physician noted that black marks were sometimes on the skin.

Drymon lists the symptoms of numerous tick borne infections and how they look precisely like The Sweat. Symptoms of Borrelia miyamotoi cause high relapsing fevers, vomiting, nausea, diarrhea, heart problems, shortness of breath, and a whole slew of neurological symptoms. Babesia is known to cause drenching sweats, anxiety, fatigue, headache, muscle, chest, and hip pain, and the ever lovely shortness of breath.

Poor Catherine struggled through seven pregnancies and her confessor reported that one knee pained her. If the babies weren’t still-born, they all died young except one daughter who became Queen Mary I. After Catherine was put to death by Henry, his next wife, Anne Boleyn battled The Sweat as well, and after marrying Henry also had a series of miscarriages with the only surviving heir being a daughter who became Queen Elizabeth I.  Catherine and Anne had a lot in common, including the same husband, and while Drymon didn’t go over the probability of sexual transmission, there is evidence:  https://madisonarealymesupportgroup.com/2017/02/24/pcos-lyme-my-story/ and https://madisonarealymesupportgroup.com/2018/02/06/lyme-in-the-southern-hemisphere-sexual-transmission/

Regarding pregnancy and TBI’s, fertility problems, miscarriages, birth defects and still births, are all possibilities.  https://madisonarealymesupportgroup.com/2017/10/15/pregnancy-in-lyme-dr-ann-corson/  Autopsy’s have revealed borrelia in the placenta, spleen, fetal myocardium, kidneys, liver, arachnoid space of fetal mid brain, and bone marrow.  https://durayresearch.wordpress.com/about-2/seven-provocative-p2/

After Anne was put to death by Henry, and all likenesses of her were ordered to be destroyed, one of the few surviving pictures show a protruding lymph node below her jaw – another common TBI symptom.

Drymon goes through the various theories of what caused The Sweat, and logically refutes them all except for tick-borne illness. One telling quote by John Josselyn in the early seventeenth century states,

“there be infinite numbers of tikes hanging upon the bushes in summer time that will cleave to a man’s garments and creep into his breeches eating themselves in a short time into the very flesh of a man. I have seen the stockins of those that have gone through the woods covered with them.”

Evidently ticks were a problem then too.

Dr. John Caius who treated patients with The Sweat recommended regular burnings of fields and forest understory, as well as insect repellents and herbal treatments such as enula root and wormwood, herbs that are known even today to have action against borrelia and Babesia.

Drymon also discusses burnings in her other book, Disguised as the Devil,
https://madisonarealymesupportgroup.com/2016/10/08/did-lyme-create-witches/, another fascinating read about TBI’s and the witchcraft hysteria. She draws a connection between the fact that burnings were often abandoned in times of war due to upheaval and the absence of men to do the job. This in turn allowed ticks to propagate which in turn probably meant more people got infected – particularly women of that era who wore long dresses that essentially became tick drags.

Unfortunately, this effective method of reducing the tick population is frowned upon today due to the fear of pollution. Drymon states the ramifications of burning should quantified to determine its seriousness and if accommodations could be made.

While the entire book is fascinating, and frankly a lot of fun to read, one of the most important take-aways for me is the ever present issue of reducing ticks safely, effectively, and economically.

Burning is such a simple yet brilliant method that it begs to be used.

Being a Lyme patient and advocate, I’ve read about burning before. In fact, when I asked an older Wisconsin Representative who has lived here his whole life why this practice was abandoned, he repeated precisely what Drymon said about folks being concerned about pollution. He also said burnings worked and he wished they were still being done.

When I asked well known and respected entomologists in Integrated Pest Management, they assured me that burnings weren’t successful and gave me a 1998 study conducted in Connecticut using a single controlled burn on two different days with varying burn intensities. The results state that in both burns ticks were reduced substantially (74% and 97%). What the authors felt made it unsuccessful was an abundance of ticks in the fall – meaning, they felt it was temporary.  

I detect much more excitement from those in the field when you mention releasing GMO mice, lacing pellets with pesticides for rodents to eat, and high powered acaricides.  All things that cost a lot of money and have significant blow-back to the environment and humans.  https://madisonarealymesupportgroup.com/2016/06/21/first-frankenbugs-now-frankinmice/ and https://madisonarealymesupportgroup.com/2017/07/10/wolbachia-the-next-frankenstein/

I was thankful for Drymon’s usage of a 2014 burn study performed in Georgia and Florida over a two year time period that indicates regular prescribed burning is an effective tool for reducing ticks and probably reduces disease as well.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112174

I think we need to seriously revisit burning.

Drymon’s book reminds us that tick borne illness is as old as time and if we are going to get well it would behoove us to learn from the past.  

 

 

 

 

 

 

 

 

 

Forget Ebola, Sars and Zika: Ticks are the Next Global Health Threat

https://www.theguardian.com/science/blog/2018/jan/25/forget-ebola-sars-and-zika-ticks-are-the-next-global-health-threat

Forget Ebola, Sars and Zika: ticks are the next global health threat

Ticks carry a wide array of pathogens – and environmental changes mean they are spreading

A blacklegged tick - also known as a deer tick.

Since the beginning of our species we have been at war. It’s a continuous, neverending fight against the smallest of adversaries: armies of pathogens and parasites. As we have developed new ways to survive and stop them, they have evolved ever more complex and ingenious methods to thwart our efforts.

Humans have faced numerous attempts to challenge our dominance on planet Earth and from the Black Death to the Spanish flu, we have weathered them all. However, since the start of the 21st century, with its trend towards global interconnectedness, these onslaughts are ever-increasing. In the past 17 years we have battled Sars, the Ebola virusMers, and more recently the mysterious mosquito-borne Zika virus. These diseases seeming to appear from nowhere and rapidly ravage our populations. One commonality is that they almost always originate in animals before jumping across to people, and few parasites are as good at jumping between animals and people as the tick.

Ticks could be best described as the used syringes of the natural world due to their promiscuous feeding habits. Most ticks go through three stages in their lives and feed on a different host at each stage, whilst simultaneously collecting hitchhiking microbes in their blood meals. Ticks also have one of the widest distributions of any vector on Earth – they can be found on every continent, including frigid Antarctica. This combination of ubiquity and a bad habit for accumulating pathogenic microbes make ticks some of the most dangerous vectors on the planet.

So why ticks? And why now?

Partly, it’s because ticks have been understudied for so long that only recently have we begun to realise just how much they affect our health. It took until 1975 for the infamous Lyme disease even to be formally described, and today the list of microbes found within ticks grows ever larger every year as numerous new species are discovered.

An engorged tick removed from a host.
An engorged tick removed from a host. Photograph: Astrid860/Getty Images/iStockphoto

Changing ecosystems are also forcing ticks into closer contact with humans. Perhaps the most immediate changes are being driven by land clearing, which is forcing wildlife into closer contact with humans; with wildlife come ticks and the diseases they carry. Climate change has also been implicated: as the climate gets warmer, some ticks are expanding their ranges into places where cool winter temperatures previously limited their distribution. Geographical boundaries are also being eroded as rapid transport links environments which were previously isolated from one another. This presents easy opportunity for ticks to cross borders and spread to new habitats they may not have previously occupied.

In short, our manipulation of the environment has set the stage for a tick-driven health crisis.

Ticks can carry an extremely wide array of human pathogens, including bacteria, viruses, and protozoa. Within the long list of human ailments caused by ticks, several dangerous diseases stand out.

https://interactive.guim.co.uk/uploader/embed/2017/08/ticks_lyme_disease/giv-3902DdVd63hb2z2v/

While the recognition of Lyme disease has led to a greater study of the bacteria which cause it and more frequent testing for patients, it has been a double-edged sword, as its notoriety has overshadowed equally important diseases like tick-borne rickettsiosis (TBR). TBR is caused by a number of different bacteria distributed across the globe. Unfortunately, TBR often presents with signs and symptoms similar to Lyme disease, such as rashes, joint and muscle pain, and fatigue. Although deaths are rare when TBR is treated with antibiotics like doxycycline, when the disease is incorrectly diagnosed or adequate medical infrastructure is lacking, mortalities can still occur.

Babesiosis is an emerging tick-borne disease caused by a protozoan called Babesia, a species related to the microbe which causes malaria. The disease is rarely tested for by doctors and the global levels of human infection are unknown, although some researchers believe that they may be much higher than present rates of diagnosis indicate. Infections can be highly variable, with about a quarter of infected adults showing no signs of the disease, while others will die from the infection. In truth the disease is still poorly understood in humans, which is compounded by the fact that several species of Babesia cause the disease and the signs and symptoms can be wide-ranging and often include fever, fatigue, anaemia, and nausea – all common features of other illnesses.

The distinctive “bullseye” marking caused by a bite from a deer tick.
The distinctive “bullseye” marking caused by a bite from a deer tick. Photograph: anakopa/Getty Images/iStockphoto

Crimean-Congo haemorrhagic fever (CCHF) is perhaps the most terrifying disease spread by ticks, as there are no treatments available, and mortality rates can be as high as 40% in infected humans. To put it into perspective, that mortality rate is similar to untreated cases of Ebola or the bubonic plague. The World Health Organisation views CCHF virus as having a high chance of causing human disease epidemics and has accordingly directed considerable funding towards finding a treatment, although to date none have been developed. The wide distribution of tick vectors capable of spreading the disease coupled with the ability of common domestic animals such as sheep and cattle to maintain the CCHF virus in their blood at high levels means the potential for CCHF to expand into new regions like Europe is highly probable.

While only discovered in 2009, SFTS virus (severe fever with thrombocytopenia syndrome) has sparked widespread fear through much of Asia, especially in Japan where 57 people have died of the disease since 2013. Signs of the disease can range in severity from relatively mild, like fever and diarrhoea, to severe, which can include multiple organ failure. The fact that the epidemiology of the disease is so poorly known makes predicting and controlling its spread difficult. It is also known to be carried by at least two cosmopolitan tick species which are spread throughout the world from the UK, to the US, and even Australia. That might sounds bad enough, but things are even worse: although the disease typically gets to humans via a tick, from there it can spread to other humans or their pets and back again into ticks who feed on infected hosts.

Ticks are ubiquitous, dangerous, and are coming into ever greater contact with us. We must recognise that the next public health crisis may come from our backyards rather than a remote equatorial jungle in Africa or Asia.

_____________

**Comment**

I’m thankful the article points out that other pathogens are involved.  For those with Lyme as well as these other pathogens (which is common), they typically have more severe cases and require longer and more extensive treatment.  

Ticks carry many viruses, and tick bites as well as vaccines can ignite dormant viruses in the body:  https://madisonarealymesupportgroup.com/2017/12/02/scottish-doctor-gives-insight-on-lyme-msids/

https://madisonarealymesupportgroup.com/2017/11/04/24514/  Many Lyme/MSIDS patients have reactivated Epstein Bar Virus (EBV).

https://madisonarealymesupportgroup.com/2018/01/16/a-strange-itch-trouble-breathing-then-anaphylactic-shock/

The Cabal still denies ticks transmit Bart; however, many feel otherwise.  This is why all the research in the world put out by the Cabal will never touch Bart.  It doesn’t fit the narrative.  The fly in the ointment is similar to sexual transmission for Lyme, the organisms have been found but there isn’t conclusive proof of transmission.  Many of these pathogens are fastidious and hard to study in a lab.  All case studies are ignored.

I’m always fascinated that Bartonella and Mycoplasma are rarely mentioned in regards to coinfections by mainstream news – as according to experts Dr. Nicholson and Dr. Breitshwerdt, they are probably the TOP coinfections with Lyme.  

More on Bartonella:  

https://www.northcarolinahealthnews.org/2013/12/05/bartonella-is-everywhere-so-why-dont-we-know-more-about-it/  Bartonella is a bacteria transmitted by fleas, ticks, animals, even spiders, but few people know about it.

https://madisonarealymesupportgroup.com/2016/01/03/bartonella-treatment/

https://madisonarealymesupportgroup.com/2017/11/03/first-report-of-bartonella-quintana-immune-reconstitution-inflammatory-syndrome-complicated-by-jarisch-herxheimer-reaction/

https://madisonarealymesupportgroup.com/2017/10/23/opthalmic-manifestations-of-bartonella-infection/

More on Myco:  https://madisonarealymesupportgroup.com/2016/02/07/mycoplasma-treatment/

https://madisonarealymesupportgroup.com/2015/08/12/connecting-dots-mycoplasma/

https://wwwnc.cdc.gov/eid/article/3/1/97-0103_article  This 1997 article even implicates Myco with Gulf War Syndrome, despite the CDC denying, denying, denying it.

https://madisonarealymesupportgroup.com/2017/08/26/interstitial-cystitis-and-lyme-disease/