https://journals.asm.org/doi/10.1128/mbio.00712-23

Powassan virus persistence after acute infection

Authors
6/20/23
Survivors of Powassan encephalitis often have persistent neurological disease. A new mouse model replicates some elements of the human disease and demonstrates the presence of viral RNA in the brain as well as myelitis more than 2 mo after the acute infection. The related tick-borne encephalitis and West Nile Neuroinvasive Disease (WNND) also have common neurological sequelae, and models for these better-studied diseases provide evidence for prolonged virus, RNA, and inflammation in some cases, in addition to damage from the acute encephalitic disease. A better understanding of the biological basis for persistent signs and symptoms after Powassan encephalitis, currently a rare disease, could benefit from further studies of the more prevalent flaviviral encephalitides.
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**Comment**
Unfortunately, the acknowledgment of this will be for a future lucrative vaccine – not treatments or things that will actually help patients.

Please note that Wisconsin is a hot-spot for Powassan.  Read this article on how Powassan IS NOT RARE, yet the CDC continues to state it is.

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