NEWVEC research at UMass Amherst may lead to strategies to reduce the incidence of tick-borne illness

As tick season kicks in across the country, the executive director of the University of Massachusetts Amherst-based New England Center of Excellence in Vector-Borne Diseases (NEWVEC) and his team have completed research that offers a promising lead in the fight against Lyme disease.

The study, published recently in the journal Vector-borne and Zoonotic Diseases, demonstrates that the blood of the white-tailed deer kills the corkscrew-shaped bacterium that causes Lyme disease, a potentially debilitating illness. The Centers for Disease Control and Prevention (CDC) estimates that each year some 476,000 people are diagnosed with and treated for Lyme, the most common vector-borne disease in the U.S.

“Deer are vitally important to the survival of deer ticks, but they are not involved with transmitting the Lyme bacteria, Borrelia burgdorferi,” explains senior author Stephen Rich, professor of microbiology. “We’ve known for some time that ticks taken from white-tailed deer are not infected, and we speculated that something about the deer prevented those ticks from becoming infected. But until publication of our paper, no one had done the experiment to show that deer blood – specifically the serum component of white-tailed deer blood – kills Lyme.”

A tick biting a person with the bullseye rash indicative of Lyme disease. Credit: Getty Images
Some people infected with Lyme get a tell-tale target rash around their tick bite. Credit: Getty Images

The results of the study may one day lead to new strategies and approaches for Lyme disease prevention and treatment, says lead author Patrick Pearson, a Ph.D. student in NEWVEC, whose upcoming doctoral examination focuses in part on this research.

“In these experiments we determined that white-tailed deer serum kills the Lyme bacterium. The next important question will be to understand exactly how deer blood kills Lyme bacteria,” Pearson says.

The research is one project of NEWVEC, which was funded by the CDC last year with a $10 million award to prevent and reduce tick- and mosquito-borne diseases in New England. NEWVEC aims to bring together academic communities, public health practitioners, residents and visitors across the Northeast, where Lyme infections are concentrated.

The Lyme disease bacterium is passed to juvenile blacklegged (Ixodes scapularis) deer ticks from mice the arthropods feed on. The infected ticks then pass the bacterium on to humans when they feed on people.

“We are the accidental host,” Rich says. “The ticks that bite us are actually looking for a deer because that’s where they breed. Without the deer, you don’t have ticks. But if you had only deer, you wouldn’t have any Lyme.”

To carry out their experiment, the researchers obtained blood serum from a semi-captive white-tailed deer herd at Auburn University in Alabama. The deer were believed to have no exposure to ticks and the bacteria that causes Lyme disease.

The researchers then grew the Lyme disease germ in test tubes and added the deer serum. “And lo and behold, it killed the bacteria,” Rich says. “Whatever it is in the deer that’s killing the germ is part of the innate immune system, a part of the immune system that precedes antibodies.”

Pearson adds, “The Lyme bacterium has proteins on its surface that protect it from the human innate immune system. Deer blood is somehow different such that Lyme bacteria are apparently unable to protect themselves from the innate immune system of white-tailed deer.”

The next research step is to determine the precise mechanisms in deer blood that kill the bacteria.

“We’d like to determine if it’s something we can induce in humans,” Rich says. “Or maybe we could use this somehow to our advantage to reduce the incidence of Lyme disease in the wild.”



Go here for more on tick prevention.

While the age-old repellents permethrin, Deet, and Picaridin are all mentioned in the article, a few new things are in the pipeline:

  • GearJump Technologies received DoD funding to design a controlled-release device utilizing synthetic pyrethroids (not to be put on skin) transfluthrin and metofluthrin that can attach to the boot of soldiers has shown affected ticks became slower moving, less mobile and appeared to be in a “drunken-like state.”
  • Nootkatone, derived from Alaska yellow cedar trees and citrus fruit, had statistically significant knockdown effects when compared to water-only controls.  It also displayed significant residual tick-killing activity after weathering naturally in the landscape for 2 weeks prior to tick application/testing.
    • While this article states products could be available by 2022, they are obviously not forthcoming. This NY Times article explains it’s considered safe and is used in food and perfume, but the EPA registration only applies only to Nootkatone – not forthcoming products which will each need to be tested and registered.
    • The CDC has licensed patents to its partners Evolva and Allylix. The substance is available to be used to develop new insect repellents and insecticides.  And this is exactly what is wrong with the CDC.  I heard about Nootkatone years and years ago and it’s languished on the sidelines like so many things due to CDC patents/influence.
    • The chemical repels mosquitoes, ticks, bedbugs, fleas and may be effective against lice, sandflies, midges, and other pests. An ISU insect toxicologist found it to be an “impressive repellent but a weak insecticide.” It can kill insects but takes a vast amount of product making it impractical.  Nootkatone repels ticks better than synthetics and is their equal at repelling mosquitoes.  Unlike other natural products, it does not lose its potency after an hour but lasts as long as synthetics.

Knowing that Lyme/MSIDS is a modern-day plague, it’s disheartening that good, safe, affordable products are not being developed more quickly.  This shouldn’t shock anyone; however, as it’s become perfectly clear that public health is not about public health but patents, secret royalties, collusion, fraud, and control.

Many other animals are involved and utilized by ticks besides mice:

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