Rare Lyme Disease-Causing Bacteria Spotted on Routine Blood Films
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The bacterium was revealed through Mayo Clinic Laboratories’ polymerase chain reaction (PCR) blood test for Lyme disease (Test ID: PBORR). That PCR testing is the preferred method for differentiating between the two bacteria. People who have B. mayonii infection also may test positive with the Lyme disease serology test (Test ID: LYME), but the test will not distinguish a B. mayonii infection from a B. burgdorferi infection.
It’s long been known that Lyme disease is caused by bacteria transmitted through the bite of an infected black-legged tick (otherwise known as the deer tick). The understanding for many years was that one species of bacteria was the main culprit behind Lyme disease in the United States: Borrelia burgdorferi.
But in 2016, researchers at Mayo Clinic discovered a new species of bacteria that causes Lyme disease. They named it Borrelia mayonii, after Mayo Clinic’s founders, Drs. William and Charles Mayo.
A key difference that has been noted between B. mayonii and B. burgdorferi is that B. mayonii spirochetes are found at high levels in peripheral blood, whereas B. burgdorferi spirochetes are not. Researchers surmised that meant the B. mayonii spirochetes potentially could be found on routine peripheral blood smears.
Borrelia mayonii, Aug. 18, 2021
“IT IS IMPORTANT FOR PATHOLOGISTS AND LABORATORIANS TO KNOW THAT SPIROCHETES OF BORRELIA MAYONII CAN OCCASIONALLY BE SEEN ON ROUTINE PERIPHERAL BLOOD SMEARS,” SAYS BOBBI PRITT, M.D., CHAIR OF MAYO’S DIVISION OF CLINICAL MICROBIOLOGY AND THE PAPER’S LEAD AUTHOR. “OTHERWISE, THEY WOULD PROBABLY ASSUME THAT THE SPIROCHETES WERE FROM THE BORRELIA SPECIES THAT CAUSE RELAPSING FEVER, WHICH IS VERY DIFFERENT FROM LYME DISEASE.”
Because B. mayonii has only been found in the Upper Midwest of the United States, it remains a rare cause of Lyme disease and may frequently go undetected. Understanding that its spirochetes can occasionally be visualized in routine blood films may raise awareness and recognition of the uncommon bacterium, and it could point the way to more consistent and accurate diagnosis of this cause of Lyme disease.
That proved to be true earlier this year when staff in Mayo Clinic’s Division of Clinical Microbiology observed several spirochaetes on thin blood films from a specimen that had tested PCR positive for B. mayonii. The bacteria were confirmed to be B. mayonii through genome sequencing. The findings were published in July in the journal Clinical Microbiology and Infection.
Since Borrelia miyamotoi is not a reportable illness to the CDC, no one has any clue about prevalence, and despite authorities continually stating it’s “rare,” reports are coming in continually that it’s highly likely to be a much bigger problem than ‘authorities’ believe. Also, despite their statement that Bm has only been found in the upper midwest in the U.S., California ticks have carried Bm for a long time, and there are reports of it worldwide.
It was recently discovered that:
- Among positive ticks, 60% had B. miyamotoi
- Testing on over 2,000 humans (mainly late stage/chronic patients) showed 30% negative results and 70% positive, among which over 60% indicated the presence of specific Borrelia miyamotoi phages: https://madisonarealymesupportgroup.com/2020/11/30/neglected-infections-gastrointestinal-issues-in-patients-with-late-vector-borne-infections/