By Doris Loh, independent researcher
It would appear that the ability of the Lyme spirochete to evade host immune responses, resist antimicrobial treatment, alter systemic metabolic functions and destroy mitochondrial function hinges upon the enhanced activity of hypoxia-inducible transcription factors HIF-1 and HIF-2, where HIF-1 alters metabolic pathways to favor glycolysis, and HIF-2 decreases osteoblast formation, resulting in chronic unresolved inflammation, bone loss and reduced mitochondrial functions.
Hypoxia-inducible transcription factors (HIF) are also heavily implicated in tumorigenesis, where HIF1a is found to be overexpressed in many cancers. Yet HIF is our body’s primary response to fluctuations in cellular oxygen levels. How do our bodies control HIF regulation and why is Vitamin C, ascorbic acid, indispensable in the regulation of HIF? ……… To Be Continued ……..