http://commonhealth.wbur.org/2015/06/lyme-disease-bacteria-persister-pulse

After being invited to a Lyme conference and meeting suffering patients, Professor Kim Lewis, chief of the Antimicrobial Discovery Center at Northeastern University, thought, “We should really get into this, and maybe try to do something.” From this thought came research and a subsequent report on how to get rid of persisting Lyme cells by timing the dosage of antibiotics. aac.asm.org/content/early/2015/05/20/AAC.00864-15

His team started by killing Borrelia (the causative agent of Lyme Disease) with antibiotics and waiting three weeks.  He expected and found that persisters remained.  He found this promising as it helps explain why many continue to have symptoms.

He tried numerous things against the persisters – all of which failed, until they focused on Borrelia’s weakness:  it doesn’t develop antibiotic resistant “superbugs.”  From this conclusion they decided to manipulate dosing by killing the Borrelia, waiting, and then going back and hitting them again.  After doing this four times, the researchers discovered no bacteria in the petri dishes.

Lewis is the first to admit that this was only in a test tube, but they are planning to work on studies with animals and humans.

Dr. Harriet Kotsoris, chief scientific officer of Global Lyme Alliance, which funded the research, feels all of this to be very promising.  Many Lyme literate doctors (LLMD’s) have used a pulse antibiotic regimen; however, she states the “off” period may have been too long in humans.

The good news, Lewis feels, is that the results of this research should help formulate better drug regimens within a couple years due to the fact it doesn’t require clinical studies in humans that mandate drug approvals.