IPAK Model of Autism Spectrum Causality

January 10, 2019

http://ipaknowledge.org/ASD-Causality-Model.php

“Personal Communication, Dr. J. Lyons-Weiler, The Institute for Pure and Applied Knowledge”

The IPAK Model of ASD Causality (aka “The IPAK Model”)

After reviewing thousands of studies over two years, a more complete picture of the causality of ASD has now emerged.

We are working on an interactive web resource to allow the public and researchers to access the scientific literature in support of each component of this ASD causality model.

Note that this model includes an important component of genetic susceptibility, never addressed in whole-population ecological correlational association studies.

Again, the hypothesis of genetic susceptibility has not been addressed.

USAGE: Please use with citation and reference

Also available for download as .tiff, .ppt

Vaccine Metals and ER Stress

Aremu DA, Ezomo OF, Meshitsuka S. Gene expression in primary cultured astrocytes affected by aluminum: alteration of chaperons involved in protein folding. Environ Health Prev Med. 2011;16:16-24.

Franchi L, Núñez G. The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1beta secretion but dispensable for adjuvant activity. Eur J Immunol. 38(8):2085-9.

Rizvi SH, Parveen A, Ahmad I, Ahmad I, Verma AK, Arshad M, Mahdi AA. Aluminum Activates PERK-EIF2α Signaling and Inflammatory Proteins in Human Neuroblastoma SH-SY5Y Cells. Biol Trace Elem Res. 2016;172(1):108-19.

Rizvi MSH, Parveen A, Verma AK, Ahmad I, Arshad M, Mahdi AA. Aluminium induced endoplasmic reticulum stress mediated cell death in SH-SY5Y neuroblastoma cell line is independent of p53. PLoS One. 2014;30;9(5):e98409.

Stamogiannos A, Papakyriakou A, Mauvais FX, van Endert P, Stratikos E. Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1. ACS Med Chem Lett. 2016;7:681-5.

Direct Mitotoxicity

Kahrizi F 2016. Repeated Administration of Mercury Intensifies Brain Damage in Multiple Sclerosis through Mitochondrial Dysfunction. Iran J Pharm Res. 15:834-841.

Lemire et al., 2009. Aluminum-induced defective mitochondrial metabolism perturbs cytoskeletal dynamics in human astrocytoma cells. J. Neurosci Res 87:1474-83

Sharpe, MA et al., 2012. Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA Journal of Toxicology Volume 2012 Article ID 373678, 12 pages.

Vaccine ER Stress + Unfolded Protein ER Stress = ER Hyperstress

Lyons-Weiler, J. 2018. Autism is an Acquired Cellular Detoxification Deficiency Syndrome with Hetergeneous Genetic Predisposition. Autism Open Access, (Publisher’s “editing version” online: https://www.omicsonline.org/open-access/autism-is-an-acquired-cellular-detoxification-deficiency-syndrome-with-heterogeneous-genetic-predisposition-2165-7890-1000224.pdf

ER Hyperstress -> Impaired Cellular Detoxification

ER/Mito/Golgi Citations in: Lyons-Weiler, J. 2018. Autism is an Acquired Cellular Detoxification Deficiency Syndrome with Hetergeneous Genetic Predisposition. Autism Open Access, (Publisher’s “editing version” online: https://www.omicsonline.org/open-access/autism-is-an-acquired-cellular-detoxification-deficiency-syndrome-with-heterogeneous-genetic-predisposition-2165-7890-1000224.pdf

Leaky Gut -> Absorption of Toxins

De Chambrun G.P., Body-Malapel M., Frey-Wagner I., Djouina M., Deknuydt F., Atrott K., Vignal C. Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice. Mucosal Immunol. 2014;7:589–601.

Kirschbaum, BB and C Schoolwerth. 1989. Acute Aluminum Toxicity Associated with Oral Citrate and Aluminum-Containing Antacids. The American Journal of the Medical Science 297:9-11.

Tian F. 2017. The therapeutic protection of a living and dead Lactobacillus strain against aluminum-induced brain and liver injuries in C57BL/6 mice. PLoS One. 12:e0175398. doi: 10.1371/journal.pone.0175398

Yu L 2016. Potential of Lactobacillus plantarum CCFM639 in Protecting against Aluminum Toxicity Mediated by Intestinal Barrier Function and Oxidative Stress. Nutrients. 8:pii: E783.

Yu, L 2017. Lactobacillus plantarum CCFM639 can prevent aluminium-induced neural injuries and abnormal behaviour in mice. Journal of Functional Foods 30:142-150.

Yu, L. 2017. Dietary Lactobacillus plantarum supplementation enhances growth performance and alleviates aluminum toxicity in tilapia Ecotoxicology and Environmental Safety 143:307-314.

Chronic Microglial Activation -> Leaky Gut

Grubišić V and Parpura V. 2015. The second brain in autism spectrum disorder: could connexin 43 expressed in enteric glial cells play a role? Front Cell Neurosci. 9:242. doi: 10.3389/fncel.2015.00242.

Kirchgessner AL et al., 1997. Excitotoxicity in the enteric nervous system. J Neurosci. 17(22):8804-16.

Unfolded Proteins -> Autoimmunity

Garaud JC, Schickel JN, Blaison G et al. B cell signature during inactive systemic lupus is heterogeneous: toward a biological dissection of lupus. PLoS One 2011;6:e23900.

Clavarino G, Adriouach S, Quesada JL, Clay M et al. Unfolded protein response gene GADD34 is overexpressed in rheumatoid arthritis and related to the presence of circulating anti-citrullinated protein antibodies. 2016;49(3):172-8.

Immunoneuroexcitotoxicity -> Aberrant Pruning

Cunningham CL et al., 2013. Microglia regulate the number of neural precursor cells in the developing cerebral cortex. J Neurosci. 33(10):4216-33. doi: 10.1523/JNEUROSCI.3441-12.2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711552/

Fiorentino et al., 2016. Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders. Molecular Autism 4:49

Strunecka A., et al. 2018. Immunoexcitotoxicity as the central mechanism of etiopathology and treatment of autism spectrum disorders: A possible role of fluoride and aluminum. Surg Neurol Int. 2018; 9:74.

Aberrant Pruning -> Altered Development

Thomas MS. The over-pruning hypothesis of autism. Dev Sci. 2016 19(2):284-305.

Kim HJ et al. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol Psychiatry. 2017 22(11):1576-1584.

Vaccine Metals Release -> Autoimmunity

Tomljenovic L, Shaw CA Mechanisms of aluminum adjuvant toxicity and autoimmunity in pediatric populations. Lupus. 2012 21(2):223-30.

Autoimmunity -> Altered Development

Braunschweig D et al., 2008. Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology. 29(2):226-31.

Cabanlit M et al., 2007. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci. 1107:92-103.

Malkki H. Neurodevelopmental disorders: Maternal antibodies induce autism-like phenotype in mice. Nat Rev Neurol. 2016 12:678-679. doi: 10.1038/nrneurol.2016.165.

 

Category:

Activism, Autism, research, vaccines

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Fatigue, Joint Pain and Low Testosterone – Had Lyme Podcast

https://livingwithlyme.us/episode-52-restoring-health-through-a-multi-therapeutic-approach/

Episode 52: Restoring Health Through a Multi-Therapeutic Approach

January 9, 2019

Cindy Kennedy, FNP, is joined by Dr. Jaban Moore, whose passion for restoring health through a multi-therapeutic approach came from watching his mother deal with health issues. His own Lyme struggle put him on a learning path to conquer this illness and now he treats and advocates for other Lyme sufferers.

Dr. Moore’s mother was diagnosed with diabetes after a three-year struggle trying to figure out what was causing her health to decline. She was diagnosed only because she was in a car accident and in the emergency room she was told that she was diabetic. Her doctors noted that the diagnosis was possibly missed for years. By this point she had gained 100 pounds, her cholesterol was out of control, she had ulcers in her stomach, depression, high blood pressure and chronic fatigue.

Growing up Dr. Moore watched his mother’s condition progress, adding new medications but never curing or making her feel better for long – just stabilizing one symptom until the next started. This eventually lead to thyroid cancer and two surgeries. Through this experience, Dr. Moore found his mission to discover the root cause of a condition so that the progression can be stopped so the next person doesn’t have to go through a story like hers.

During chiropractic school, when his own health journey began, he started to decline physically rapidly with no known cause at the age of 25. Over the next year, he searched for answers with many different doctors. He was experiencing fatigue, joint pain and low testosterone. After not finding many answers from several doctors he was at a conference of functional medicine doctors. It was there he met one who suggested the possibility of Lyme disease. After some testing and further investigation, Dr. Moore was found to be positive for Lyme. This began his journey of learning how to treat it. After consulting several doctors and trying many treatments Dr. Moore found relief and has been symptom-free for over five years now.

Dr. Moore’s professional and postdoctoral training includes True Cellular Healing, Chiropractic Plus Kinesiology, Applied Kinesiology, Clinical Kinesiology, Acupuncture, Bio-Resonance Therapy, Sacro-Occipital Technique (SOT), Nutrition, Rehabilitation, Functional Medicine, Blood Laboratory Analysis and Live Cell Microscopy.

He has taken courses on Mastering Functional Blood Chemistry, Mastering Thyroid, Mastering Brain Chemistry, and has trained with several Lyme disease and parasitology experts.

 

 

 

 

 

Category:

Activism, Lyme, Treatment

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Relapsing Fever Found at Popular Recreation Site in CA Ticks

https://www.ncbi.nlm.nih.gov/pubmed/30517684

2018 Dec 4. doi: 10.1093/jme/tjy213. [Epub ahead of print]

Borrelia parkeri in Ornithodoros parkeri (Ixodida: Argasidae) Collected Using Compact Dry Ice Traps in Madera County, California.

Osborne CJ1, Crosbie PR1, Van Laar TA1.

Abstract

Tick-borne relapsing fever (TBRF) is a potentially serious vector-borne disease endemic to the western United States. Vector surveillance is compromised by the nidicolous life history of the three Ornithodoros species that transmit TBRF to people in this region. Large-scale stationary trapping methods were developed to survey a wide geographical range of Ornithodoros spp. which are known to vector relapsing fever Borrelia spp. in California. Ninety-six Ornithodoros parkeri were collected from four locations in the foothills of Fresno and Madera Counties. Two of these O. parkeri nymphs were PCR positive for Borrelia parkeri, and their collection at a popular recreation site increases the public health concern.

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More on Relapsing Fever:  https://igenex.com/ticktalk/2018/01/11/borreliosis-relapsing-fever-disease/

Category:

Borrelia Miyamotoi (Relapsing Fever Group), research, Ticks

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Transverse Myelitis & Guillain-Barre Associated with Bartonella

January 9, 2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106413/

Transverse Myelitis and Guillain-Barré Syndrome Associated with Cat-Scratch Disease, Texas, USA, 2011

Emerg Infect Dis. 2018 Sep; 24(9): 1754–1755.

Ramia Zakhour,corresponding author Pedro Mancias, Gloria Heresi, and Norma Pérez

Abstract

We describe a case of coexisting transverse myelitis and Guillain-Barré syndrome (GBS) related to infection with Bartonella henselae proteobacterium and review similar serology-proven cases. B. henselae infection might be emerging as a cause of myelitis and Guillain-Barré syndrome and should be considered as an etiologic factor in patients with such clinical presentations.

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**Comment**

This case study is of a previously healthy 10 year old girl who presented with lower extremity weakness, abdominal pain, vomiting, urinary retention, lymphadenopathy, headache, neck pain, lower back pain, burning in wrists, knees, ankles, and feet, and increases sensitivity to pain in her legs.

She had evidence of myelitis, brain lesions, and peripheral nerve involvement.

They administered rifampin and doxycycline for a possible CSD (Cat Scratch Disease) diagnosis but had to discontinue rifampin due to rising liver enzyme levels.  She was then given IV immunoglobulin for possible GBS (Guillain Barre Syndrome) and showed tremendous improvement with resolution of urinary retention and decrease in pain & weakness.  Four months later she had only residual sensory deficits.

According to the study, by 1971, 40 cases of Bartonella with neurological complications occurred with 90% involving encephalitis with a few myelopathy.  Other CSD associated myelitis cases and other GBS-associated Bartonella cases have been reported.

Key quote:

Studies of the efficacy of treatments for CSD-associated neurologic manifestations are lacking, and thus, the optimal regimen and duration of therapy are unknown. However, we suggest that clinicians consider CSD early in disease courses involving neurologic complications; the possibility of GBS, myelitis, or both in the setting of possible CSD should prompt clinicians to initiate antimicrobial treatment early and consider steroid or intravenous immunoglobulin therapy to prevent progression of disease.

For Lyme/MSIDS patients with these presentations, steroids would be counter-indicated due to the immune suppression which would enhance pathogen involvement:  http://www.lymenet.de/literatur/steroids.htm

“It is interesting to note that in dogs who had Lyme disease, injections of dexamethasone, a corticosteroid, enabled Borrelia burgdorferi to be cultured from blood drawn on the following day.”

This was done by Dr. Elizabeth Burgess at the University of Wisconsin. This suggests that the steroid suppresses a mechanism for keeping the bacteria out of the circulatory system, since ordinarily it is difficult to grow the Lyme organism from the blood. Entrance of the bacteria into the bloodstream can allow seeding of other organs.

“In conclusion, the decision to use the steroids in a Lyme patient must be given considerable thought and the possible benefits must be weighed against the risks. I would not use steroids unless the patient was also on antibiotics.“

Please keep in mind the difference between catabolic (break down) steroids and anabolic (build up) steroids.

 

 

 

 

Category:

Bartonella, research, Viruses

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Doctors, Money & Conflicts of Interest

 Approx. 6 Min.

Doctors, Money, and Conflicts of Interest

Physician Payments Sunshine Act (PPSA), also known as section 6002 of the Affordable Care Act (ACA) of 2010 requires medical product manufacturers to disclose to the Centers for Medicare and Medicaid Services (CMS) any payments or other transfers of value made to physicians or teaching hospitals.  https://www.healthaffairs.org/do/10.1377/hpb20141002.272302/full/

The data will be published annually in a publicly searchable database. The first data collection period began in August 2013, and the deadline for submission to CMS was in March 2014. These data will be aggregated and made available to physicians and manufacturers for review and correction, and will then be published on a public website:  https://openpaymentsdata.cms.gov  You can look up doctors and teaching hospitals in link.

Best quote,

“Sometimes we have to poke doctors with a stick. That’s how we show our love.”

 

Category:

Activism

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