Archive for the ‘Viruses’ Category

Clinical Trial in the Works Using IV Vitamin C Against the 2019-nCoV Virus

https://clinicaltrials.gov/ct2/show/NCT04264533

Brief Summary:

2019 new coronavirus (2019-nCoV) infected pneumonia, namely severe acute respiratory infection (SARI) has caused global concern and emergency. There is a lack of effective targeted antiviral drugs, and symptomatic supportive treatment is still the current main treatment for SARI.

Vitamin C is significant to human body and plays a role in reducing inflammatory response and preventing common cold. In addtion, a few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections.

We hypothize that Vitamin C infusion can help improve the prognosis of patients with SARI. Therefore, it is necessary to study the clinical efficacy and safety of vitamin C for the clinical management of SARI through randomized controlled trials during the current epidemic of SARI.

Condition or disease Intervention/treatment Phase
Vitamin CPneumonia, ViralPneumonia, Ventilator-Associated Drug: Vit CDrug: Water for infusion Phase 2

Detailed Description:

At the end of 2019, patients with unexplained pneumonia appeared in Wuhan, China. At 21:00 on January 7, 2020, a new coronavirus was detected in the laboratory, and the detection of pathogenic nucleic acids was completed at 20:00 on January 10. Subsequently, the World Health Organization officially named the new coronavirus that caused the pneumonia epidemic in Wuhan as 2019 new coronavirus (2019-nCoV), and the pneumonia was named severe acute respiratory infection (SARI). Up to February 4, 2020, over 20000 cases have been diagnosed in China, 406 of which have died, and 154 cases have been discovered in other countries around the world. Most of the deaths were elderly patients or patients with severe underlying diseases. SARI has caused global concern and emergency.

Statistics of the 41 patients with SARI published in JAMA initially showed that 13 patients were transferred into the ICU, of which 11 (85%) had ARDS and 3 (23%) had shock. Of these, 10 (77%) required mechanical ventilation support, and 2 (15%) required ECMO support. Of the above 13 patients, 5 (38%) eventually died and 7 (38%) were transferred out of the ICU. Viral pneumonia is a dangerous condition with a poor clinical prognosis. For most viral infections, there is a lack of effective targeted antiviral drugs, and symptomatic supportive treatment is still the current main treatment.

Vitamin C, also known as ascorbic acid, has antioxidant properties. When sepsis happens, the cytokine surge caused by sepsis is activated, and neutrophils in the lungs accumulate in the lungs, destroying alveolar capillaries. Early clinical studies have shown that vitamin C can effectively prevent this process. In addition, vitamin C can help to eliminate alveolar fluid by preventing the activation and accumulation of neutrophils, and reducing alveolar epithelial water channel damage. At the same time, vitamin C can prevent the formation of neutrophil extracellular traps, which is a biological event of vascular injury caused by neutrophil activation. Vitamins can effectively shorten the duration of the common cold. In extreme conditions (athletes, skiers, art workers, military exercises), it can effectively prevent the common cold. And whether vitamin C also has a certain protective effect on influenza patients, only few studies have shown that vitamin C deficiency is related to the increased risk and severity of influenza infections. In a controlled but non-randomized trial, 85% of the 252 students treated experienced a reduction in symptoms in the high-dose vitamin C group (1g / h at the beginning of symptoms for 6h, followed by 3 * 1g / day). Among patients with sepsis and ARDS, patients in the high-dose vitamin group did not show a better prognosis and other clinical outcomes. There are still some confounding factors in the existing research, and the conclusions are different.

Therefore, during the current epidemic of SARI, it is necessary to study the clinical efficacy and safety of vitamin C for viral pneumonia through randomized controlled trials.

Study Design
Go to  sections
Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 140 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia: a Prospective Randomized Clinical Trial
Estimated Study Start Date : February 10, 2020
Estimated Primary Completion Date : September 30, 2020
Estimated Study Completion Date : September 30, 2020
Arms and Interventions
Go to  sections
Arm Intervention/treatment
Experimental: Vit C

24g Vitamin C+water for injection, total volume 50ml. 7ml/h; infusion pump.
 Drug: Vit C

24g Vitamin C will be infused in the experimental group per day for 7 days by the infusion pump with a speed of 7ml/h.
Other Name: Vitamin C
Placebo Comparator: Water for injection

50ml water for injection. 7ml/h; infusion pump.
 Drug: Water for infusion

50ml water for infusion will be infused in the placebo comparator group per day for 7 days by the infusion pump with a speed of 7ml/h.
Outcome Measures
Primary Outcome Measures :

  1. Ventilation-free days [ Time Frame: on the day 28 after enrollment ]
    days without ventilation support during 28 days after patients’ enrollment
Secondary Outcome Measures :

  1. 28-days mortality [ Time Frame: on the day 28 after enrollment ]
    wether the patient survives
  2. ICU length of stay [ Time Frame: on the day 28 after enrollment ]
    days of the patients staying in the ICU
  3. Demand for first aid measuments [ Time Frame: on the day 28 after enrollment ]
    t t the rate of CPR
  4. Vasopressor days [ Time Frame: on the day 28 after enrollment ]
    days of using vasopressors
  5. Respiratory indexes [ Time Frame: on the day 10 and 28 after enrollment ]
    P O2/Fi O2 which reflects patients’ respiratory function
  6. Ventilator parameters [ Time Frame: on the day 10 and 28 after enrollment ]
    Ecmo or ventilator
  7. APACHE II scores [ Time Frame: on the day 10 after enrollment ]
    Acute Physiology and Chronic Health Evaluation
  8. SOFA scores [ Time Frame: on the day 10 after enrollment ]
    Sepsis-related Organ Failure Assessment

 

Category:

research, Supplements, Treatment, Viruses

How to Protect Yourself & Your Family From Infections

How to Protect Yourself and Your Family From Infections

  1. Stay home when possible, avoid planes, buses, trains, queues, busy areas.
  2. No visitors, avoid close contact with symptomatic people or potential carriers, don’t share cups.
  3. No handshakes, kisses, hugs. Don’t kiss babies. All outside surfaces, money.
  4. Gloves and meticulous hand hygiene, don’t touch eyes, nose mouth.
  5. Wash hands, warm water and soap or hand sanitizers.
  6. Catch it – bin it – kill it.
  7. Coughs and sneezes spread diseases.
  8. Faecal contamination, meticulous hand and surface hygiene.
  9. Wear a quality medical mask or n95.
  10. Wrap around glasses.
  11. Avoid hospitals, limited visiting.
  12. Good nutrition, vitamin D.
  13. Keep warm, sleep, family life.
  14. Thoroughly cook meat and eggs.
  15. Avoid public spaces and wear a mask at home if you start to feel ill with fever.

___________________

**Comment**

Great simple, logical, and straightforward suggestions.  I’d ditch the hand sanitizer, however:  https://www.ncbi.nlm.nih.gov/pubmed/29182464

Excerpt:

The burgeoning literature on human health effects associated with TCS (triclosan) exposure, such as reproductive problems, was also summarized.

https://www.pnas.org/content/early/2014/11/12/1419119111

Excerpt:

These findings strongly suggest there are adverse health effects in mice with long-term TCS exposure, especially on enhancing liver fibrogenesis and tumorigenesis, and the relevance of TCS liver toxicity to humans should be evaluated.

Also, hand sanitizers are 60% alcohol – which not only is very drying but is also a no-no for anyone on disulfiram. I found this out the hard way in the hospital:  https://madisonarealymesupportgroup.com/2019/10/27/disulfiram-psychosis-update-2/

 

 

 

 

 

Category:

Transmission, Viruses

2019-nCov Vaccine Recommended Readings

https://jameslyonsweiler.com/2020/02/07/2019-ncov-vaccine-recommended-readings/

By James Lyons Weiler

2019-nCov Vaccine Recommended Readings

UPDATE – 2/9/2020 – IPAK HAS CONDUCTED FURTHER, IN-DEPTH STUDIES OF THE GENOMIC AN PROTEIN SEQUENCES OF THE 2019-nCoV CORONAVIRUSES AND THEIR RELATIVES AND HAVE COMPELLING RESULTS OF A KEY SIGNATURE USEFUL FOR IDENTIFYING A PARTICULARLY PATHOGENIC CORONAVIRUSES LINEAGE. GIVEN THAT WE HAVE FOUND THIS SIGNATURE, A FUNCTIONAL MOTIF FINGERPRINT, PRESENT IN THE HK-3 CoV FROM 2005, WE BELIEVE THIS EXONERATES RECOMBINATION IN THE LAB AS A SOURCE OF THE VIRUS. THIS DOES NOT EXONERATE ACCIDENTAL RELEASE, HOWEVER. WE ARE WORKING TO PUBLISH OUR FINDINGS.

IN THE INTEREST OF TRANSPARITY, WE ARE KEEPING THE ARTICLE BELOW AS ORIGINALLY PUBLISHED FOR POSTERITY AND PROVENANCE. – JLW

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus. “Lung mononuclear infiltrates occurred in all groups after virus challenge but with increased infiltrates that contained eosinophils and increases in the eosinophil promoting IL-5 and IL-13 cytokines only in the vaccine groups. Inactivated MERS-CoV vaccine appears to carry a hypersensitive-type lung pathology risk from MERS-CoV infection that is similar to that found with inactivated SARS-CoV vaccines from SARS-CoV infection.” https://www.ncbi.nlm.nih.gov/pubmed/27269431

Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants.“VRP-N vaccines not only failed to protect from homologous or heterologous challenge, but resulted in enhanced immunopathology with eosinophilic infiltrates within the lungs of SARS-CoV-challenged mice. VRP-N-induced pathology presented at day 4, peaked around day 7, and persisted through day 14, and was likely mediated by cellular immune responses.”https://www.ncbi.nlm.nih.gov/pubmed/17194199

Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets “Immunized ferrets developed a more rapid and vigorous neutralizing antibody response than control animals after challenge with SARS-CoV; however, they also exhibited strong inflammatory responses in liver tissue.”

https://jvi.asm.org/content/78/22/12672.abstract

https://science.sciencemag.org/content/303/5660/944.full

Lab-Made Coronavirus Triggers Debate  “…a study on his team’s efforts to engineer a virus with the surface protein of the SHC014 coronavirus, found in horseshoe bats in China, and the backbone of one that causes human-like severe acute respiratory syndrome (SARS) in mice. The hybrid virus could infect human airway cells and caused disease in mice…”

https://www.the-scientist.com/news-opinion/lab-made-coronavirus-triggers-debate-34502

Certainly additional advances have been made in attempts to make Spike-protein related vaccines safer.

________________

For more:  https://madisonarealymesupportgroup.com/2020/02/01/on-the-origins-of-the-2019-ncov-virus-wuhan-china-experimental-vaccine-type/

Category:

Activism, vaccines, Viruses

Washington Doctors Successfully Treat Coronavirus

Washington Doctors Successfully Treat Coronavirus Patient – Results Seen in hours, Patient Sent Home

https://www.theverge.com/2020/2/4/21122327/coronavirus-experimental-medication-treatment-wuhan-china-gilead-hiv

Excerpt: 

It’s not clear if the medication, called remdesivir, actually helped the patient, or if his improvement was a coincidence. But it’s one of a few drugs, including a combination of anti-HIV drugs, that doctors think might help patients with the new coronavirus.

Ironically, the antivirus was created by the pharmaceutical company Gilead as a treatment for Ebola.

The article states the drug didn’t do much for Ebola but a larger clinical trial on coronavirus patients is underway:  https://www.bioworld.com/articles/432804-gileads-remdesivir-enters-china-phase-iii-trial-to-fight-coronavirus

Excerpt:

The study, expected to be completed on April 27, is a phase III randomized, double-blind, placebo-controlled multicenter study to evaluate the efficacy and safety of remdesivir in hospitalized adult patients with mild and moderate 2019-nCoV infections. It will enroll 270 patients and be carried out in the China-Japan Friendship Hospital in Beijing.

Remdesivir is not approved by the Food and Drug Administration but has gone through safety testing during the Ebola outbreak and why Gilead is able to test it in sick patients.

_________________

For more:  https://www.pnas.org/content/early/2020/02/12/1922083117

Excerpt:

We tested the efficacy of the broad-acting antiviral remdesivir in the rhesus macaque model of MERS-CoV (Middle East Respiratory Syndrome) infection. Remdesivir reduced the severity of disease, virus replication, and damage to the lungs when administered either before or after animals were infected with MERS-CoV. Our data show that remdesivir is a promising antiviral treatment against MERS that could be considered for implementation in clinical trials. It may also have utility for related coronaviruses such as the novel coronavirus 2019-nCoV emerging from Wuhan, China.

 

 

 

 

 

Category:

Treatment, Viruses

Circovirus: Why This Fatal Dog Virus Should Be Taken Seriously

https://www.dogsnaturallymagazine.com/circovirus-dog-virus-fatal/? Article Here

Circofirus: Why This Fatal Dog Virus Should Be Taken Seriously

By:

Circovirus-Why-This-Fatal-Dog-Virus-Should-Be-Taken-SeriouslyThe article found in the link above is about far more than a virus.  The article states it was likely caused by vaccination itself.
________________________

Circovirus, a virus normally found in pigs, is from a family of viruses that has not been known to cause disease in dogs prior to this year. It causes a skin condition called vasculitis and often appears as a coinfection along with other pathogens.  The article warns that scientists have discovered around 30 new human diseases, at a rate of one to two every year.

The really important take away is this excerpt from the article:

There’s no doubt that scientists will soon be racing to formulate a vaccine to prevent canine circovirus. But the interesting twist is, like many other emerging and novel diseases, canine circovirus was likely caused by vaccination itself.

The human rotavirus vaccine, Rotarix, was suspended in the US. The cause? The vaccine was found to be contaminated with porcine circovirus, the very same virus they are now finding in dogs.

The discovery that Rotarix was contaminated was made by a team of scientists at an independent research lab in San Francisco, where they used new technology to detect small amounts of viral material in vaccines using genetic sequencing.

The article then goes on to state that contamination of vaccines has a long and sordid history which should force manufacturers to question the use of animal cells and vaccines. The microbes often go undetected by testing and end up in the finished product. The article mentions the polio vaccine contaminated with simian virus 40 (SV40), which was found to cause cancer in animals and is associated with human brain, bone and lung cancers, which the government completely denies.

The frightening aspect is that labs are still finding SV40 in biopsies of human cancers. Evidently Congress ordered Merck to remove the contamination but they can’t.

I’ve written about vaccine contamination before:  https://madisonarealymesupportgroup.com/2017/10/15/vaccines-and-retroviruses-a-whistleblower-reveals-what-the-government-is-hiding/   This is so big that the author of an article within this link states that 20 million Americans are likely infected with a retroviruses that in turn can lead to acquired immune deficiency.

https://madisonarealymesupportgroup.com/2018/04/28/italian-lab-shut-down-about-to-testify-about-vaccine-contamination-damage/

Could this lead some to become more susceptible to acquiring Lyme/MSIDS?

It appears this has great potential:  https://madisonarealymesupportgroup.com/2018/12/09/vaccines-likely-infected-with-retroviruses-linked-to-chronic-disease/

Excerpt:

  • A retrovirus family known as xenotropic murine leukemia virus-related viruses (XMRV) may play a causal role in chronic fatigue syndrome, chronic myalgic encephalopathy (ME) and other diseases, including autism
  • Some retroviruses, including XMRV (but not HIV as far as we know), infect your germ cells, which means they are transmitted to your offspring

And, recently, I posted this astute article linking the latest Coronavirus to vaccines:  https://madisonarealymesupportgroup.com/2020/02/01/on-the-origins-of-the-2019-ncov-virus-wuhan-china-experimental-vaccine-type/

Excerpt:

“The available evidence most strongly supports that the 2019-NCOV virus is a vaccine strain of coronavirus either accidentally released from a laboratory accident, perhaps a laboratory researcher becoming infected with the virus while conducting animal experiments, or the Chinese were performing clinical studies of a Coronavirus vaccine in humans.”

Also, the article goes on to state that:

“IF THE CHINESE GOVERNMENT HAS BEEN CONDUCTING HUMAN TRIALS AGAINST SARS, MERS, OR OTHER CORONAVIRUSES USING RECOMBINED VIRUSES, THEY MAY HAVE MADE THEIR CITIZENS FAR MORE SUSCEPTIBLE TO ACUTE RESPIRATORY DISTRESS SYNDROME UPON INFECTION WITH 2019-NCOV CORONAVIRUS.”

 

 

 

 

Category:

Activism, vaccines, Viruses