Archive for the ‘Treatment’ Category

Study Shows DSM Works for Lyme – Reduces Inflammatory Markers & Antibody Titers

https://www.mdpi.com/2079-6382/9/9/633

Repurposing Disulfiram (Tetraethylthiuram Disulfide) as a Potential Drug Candidate against Borrelia burgdorferi In Vitro and In Vivo

 
*Author to whom correspondence should be addressed.
Antibiotics 2020, 9(9), 633; https://doi.org/10.3390/antibiotics9090633
Received: 10 July 2020 / Revised: 17 September 2020 / Accepted: 21 September 2020 / Published: 22 September 2020
(This article belongs to the Special Issue Drugs Repurposing for the Treatment of Bacterial Infections)

Abstract

Lyme disease caused by the Borrelia burgdorferi (Bb or B. burgdorferi) is the most common vector-borne, multi-systemic disease in the USA. Although most Lyme disease patients can be cured with a course of the first line of antibiotic treatment, some patients are intolerant to currently available antibiotics, necessitating the development of more effective therapeutics. We previously found several drugs, including disulfiram, that exhibited effective activity against B. burgdorferi. In the current study, we evaluated the potential of repurposing the FDA-approved drug, disulfiram for its borreliacidal activity.
 
  • Our results indicate disulfiram has excellent borreliacidal activity against both the log and stationary phase B. burgdorferi sensu stricto B31 MI. Treatment of mice with disulfiram eliminated the B. burgdorferi sensu stricto B31 MI completely from the hearts and urinary bladder by day 28 post infection.
  • Moreover, disulfiram-treated mice showed reduced expressions of inflammatory markers, and thus they were protected from histopathology and cardiac organ damage.
  • Furthermore, disulfiram-treated mice showed significantly lower amounts of total antibody titers (IgM and IgG) at day 21 and total IgG2b at day 28 post infection.
  • FACS analysis of lymph nodes revealed a decrease in the percentage of CD19+ B cells and an increase in total percentage of CD3+ T cells, CD3+ CD4+ T helpers, and naive and effector memory cells in disulfiram-treated mice.

Together, our findings suggest that disulfiram has the potential to be repurposed as an effective antibiotic for treating Lyme disease. View Full-Text

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For more:  https://madisonarealymesupportgroup.com/2019/10/15/disulfiram-psychosis-update/

https://madisonarealymesupportgroup.com/2020/05/26/potential-patient-reported-toxicities-with-disulfiram-treatment-in-late-disseminated-lyme-disease/

https://madisonarealymesupportgroup.com/2020/06/07/disulfiram-for-lyme-disease-profiles-of-two-patients-reporting-good-outcomes/

https://madisonarealymesupportgroup.com/2019/11/19/if-disulfiram-is-the-cure-for-lyme-disease-should-it-be-prescribed-to-all-lyme-disease-patients/

https://madisonarealymesupportgroup.com/2019/06/03/disulfiram-in-the-treatment-of-lyme-babesiosis-3-case-reports/

https://madisonarealymesupportgroup.com/2019/07/14/disulfiram-breakthrough-drug-for-lyme-other-tick-borne-diseases/

 

 

New Dapsone Study: Breaking Biofilm

https://lymediseaseassociation.org/about-lyme/science-a-professional-articles/new-dapsone-study-breaking-biofilm/

New Dapsone Study: Breaking Biofilm

Dr. Richard Horrowitz co-author of the published case study on Lyme disease and COVID-19
Dr. Richard Horowitz, lead-author: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

New in vitro study on dapsone (diaminodiphenyl sulfone), and dapsone combination therapy (DDS CT) was just published by Dr. Richard Horowitz et al. and provides hope of effective treatment for patients with persistent Lyme disease.

The study is suggestive that dapsone combination therapy may well characterize both a novel and successful option to treat Borrelia burgdorferi persister cells in the form of biofilm.  There are several hypotheses causing great controversy regarding the persistent symptoms that greater than 10-20% of patients are experiencing after infection with B. burgdorferi. The study evaluated the effectiveness of dapsone against B. burdorferi biofilm forms of the bacteria by testing in individual as well as in combination therapy with several drugs including cefuroxime, doxycycline, rifampin, and azithromycin in vitro.

The results were robust, showing that using dapsone alone or in various combinations with the above stated drugs significantly reduced the mass and protective glycosaminoglycan layer affecting the capability of the biofilm form of B. burdorferi. DDS CT efficacy on the B. burgdorferi biofilms was also determined by ascertaining the biofilm polysaccharide matrix content, glycosaminoglycans (GAG).

Study results showed the most efficient single use antibiotic at reducing biofilm was dapsone at both 10 µM and 50 µM concentrations,  showing 69% and 58% residual viability respectively. Used individually, other antibiotic treatments (doxycycline, cefuroxime, and azithromycin) proved to be less efficient and, in some cases, even caused an increase biofilm mass. In contrast, triple and quadruple combination antibiotic therapies showed greater efficacy.

  • The most significant finding was that dapsone used individually or in combination therapy with rifampin, and a tetracycline and/or a macrolide and/or a cephalosporin showed great promise in the treatment of persistent Lyme patients, with prior clinical studies demonstrating improvement in many of the debilitating symptoms that patients suffer including fatigue, pain, neuropathy, sleep disturbances, cognitive dysfunction, sweats and flushing.
It is urgent that randomized trials are launched to evaluate the clinical effectiveness of DDS CT as the spread of Lyme disease continues to increase on a global scale.

Read the full journal article: Effect of dapsone alone and in combination with intracellular antibiotics against the biofilm form of B. burgdorferi

Read the 2016 article: The Use of Dapsone as a Novel “Persister” Drug in the Treatment of ChronicLyme Disease/Post Treatment Lyme Disease Syndrome

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**Comment**

This is great news.  If you suffer from chronic symptoms you may want to discuss this with your doctor and consider it in your treatment arsenal.  I have heard the side-effects from Dapsone are substantial so make sure you and your doctor read up on those and ways to mitigate them.  I know Dr. Horowitz utilizes many supplements for this purpose when using Dapsone.

For more:  https://madisonarealymesupportgroup.com/2020/06/26/new-treatments-for-lyme-disease-on-the-horizon/

https://madisonarealymesupportgroup.com/2016/05/09/leprosy-drug-for-lyme/

https://madisonarealymesupportgroup.com/2016/10/09/mycobacterium-drugs-for-ld/

Sadly, those RCTs are far down the research pipeline. Unfortunately the ‘sexy’ topic of climate change trumps effective treatments that would make life bearable for patients.  

Gilead, Big Pharma and the WHO: An Unholy Trifecta of Corruption and Bioterrorism

https://www.naturalnews.com/2020-09-30-gilead-big-pharma-who-unholy-trifecta-corruption-evil.

Gilead, Big Pharma and the WHO: An unholy trifecta of corruption and bioterrorism

Image: Gilead, Big Pharma and the WHO: An unholy trifecta of corruption and bioterrorism

(Natural News) Back in 2009, the World Health Organization (WHO) hoodwinked the world with a so-called “swine flu” pandemic that resulted in the U.S. government needlessly stockpiling deadly vaccines along with $1.5 billion worth of Tamiflu, an influenza drug that just so happened to enrich the estates of Donald Rumsfeld and other key deep state actors. Now in 2020, we are watching the same thing happen all over again with the Wuhan coronavirus (covid-19) pandemic, a manufactured crisis that once again exposes global “public health” initiatives as nothing more than corporate-government fraud.

From the very start of this latest worldwide scare, the WHO has contended that there is nothing anyone can do about the Wuhan coronavirus (covid-19) other than to take Remdesivir, an antiviral drug manufactured by Gilead Pharmaceuticals, and simply wait for a future vaccine – in self-isolation with your mask on, of course. The WHO has further denigrated hydroxychloroquine (HCQ) as dangerous and useless, citing a bogus study that was authored by a porn star and sci-fi writer under the direction of a questionable U.S. healthcare analytics company.

Also in on the ruse are other key deep state players such as the infamous Anthony Fauci, who 15 years after publicly stating that HCQ is effective against coronaviruses is suddenly now opposed to the drug’s use. As it turns out, Fauci has financial ties to new drugs that are being pushed through the pipeline as alleged remedies for the Wuhan coronavirus (covid-19), which explains his anomalous opposition to HCQ, which he once promoted.

Every doctor and medical professional who has bravely come forward in support of HCQ during the current pandemic, by the way, despite the deep state’s opposition to it, has faced ridicule and persecution. Dr. Didier Raoult of France says he has actually received death threats simply for announcing that HCQ combined with the antibiotic drug azithromycin successfully cured 80 of his own patients.

“By administering hydroxychloroquine combined with azithromycin, we were able to observe an improvement in all cases, except in one patient who arrived with an advanced form, who was over the age of 86,” Dr. Raoult is quoted as saying, noting that HCQ-plus-azithromycin had a 91 percent success rate with zero side effects when used in more than 1,000 patients.

Dr. Raoult published these and other findings in an online journal, only to be threatened with death for daring to spill the beans. And according to Great Game India, this death threat came from a top financial recipient of none other than Gilead Pharmaceuticals, which apparently wants to maintain a corner on the available oral drug options for the Wuhan coronavirus (covid-19).

“Professor Raoult testified that, shortly after he started to talk about HCQ as a treatment, in March, he received anonymous death threats,” reports indicate. “He filed a complaint with the police, and an enquiry was opened by the French judiciary.”

“The medical doctor behind the threats was found and happens to be from a Nantes university hospital. It happened to be the person who received the most money from Gilead over the past 6 years.”

Dr. Raoult’s full testimony before the French Parliament, which took place on June 24, is available for viewing at this link.

Gilead Science has “dark history” of “bioterrorism,” claims Great Game India

With the help of the WHO, which at the current time is colluding with both deep state government entities and corrupt pharmaceutical interests to keep the Wuhan coronavirus (covid-19) plandemic going, Gilead was able to strongarm the federal government back in 2009 into buying up stocks of Tamiflu, enriching the pocketbooks of not just Rumsfeld but also George Schultz, a former U.S. secretary of state. Rumsfeld chaired Gilead while Schultz sat on the company’s board.

“The interesting part is, Gilead was part of the vaccine lobby at whose behest the WHO faked the H1N1 pandemic in 2009, and kept it a secret from people until committees were setup (sic) which exposed the entire racket,” reports Great Game India.

As a background, Gilead appears to be a creation of the military-industrial complex with a dark history of bioterrorism, according to Great Game India.

Despite its benign image as a mere pharmaceutical manufacturer, Gilead has been accused of engaging in illegal bioweapons research programs in the country of Georgia, where 73 people are said to have died at the hands of Gilead researchers who were testing deadly chemicals on them.

Igor Giorgadze, a former minister for state security in Georgia, is on record as claiming that the illegal tests were conducted by The Richard Lugar Center for Public Health Research near the nation’s capital of Tbilisi. More than 100,000 pages of classified information shows that Gilead was involved in conducting military research, biological weapons research, and other clinical experiments there that resulted in the deaths of Georgian citizens.

Equally disturbing are Gilead’s ties to the Pentagon, as the company has been accused of bombing a competitor’s manufacturing facility with the deep state entity’s approval, all under the guise of “fighting Al-Qaeda.”

As for Remdesivir, which currently maintains “orphan drug” status, it remains to be seen where the drug ends up in the world and at what cost – or as Great Game India puts it, we will have to see “what countries does Gilead choose to donate to and beyond the donations, whether Gilead prices Remdesivir reasonably, particularly in developed countries.”

More stories about the Wuhan coronavirus (covid-19) plandemic and the corporate-government corruption that is keeping it going can be found at Pandemic.news.

Sources for this article include:

NaturalNews.com

GreatGameIndia.com

NaturalNews.com

NaturalNews.com

Videos.Assemblee-Nationale.fr

GreatGameIndia.com

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**Comment**

Please keep this all in mind when you read science journals and/or listen to the news.  These conflicts of interest run deep and are prolific, and don’t kid yourself – affect what tests & drugs are chosen and what drugs aren’t chosen to treat people.  

Lyme/MSIDS patients often have to learn the hard way that tests and treatments are dictated by a ‘higher power’ that has a strangle-hold on most doctors. These ‘authorities’ entrusted with public health vilify any tests or treatments that they don’t have patents on and then bully doctors into submission by a constant threat of being persecuted by state medical boards for not obeying their directives.  Just know that this same thing is playing out for other diseases – and right now in front of our eyes with COVID.

It’s unfathomable that even one human would choose profit over patients, but that in fact is what is happening at every level of medicine and research.
No one cares about your health more than you do. If you can’t get help in one place, go to another until you get help.  Be persistent, be tenacious in finding that help.  You are worth it.

Hidden Immune Weakness Found in 14% of Gravely Ill COVID-19 Patients

https://www.sciencemag.org/news/2020/09/hidden-immune-weakness-found-14-gravely-ill-covid-19-patients

A new study may help explain why men, like this patient in an Italian intensive care unit, are more likely than women to develop life-threatening COVID-19.  FLAVIO LO SCALZO/REUTERS/NEWSCOM

Hidden immune weakness found in 14% of gravely ill COVID-19 patients

Sciences COVID-19 reporting is supported by the Pulitzer Center and the Heising-Simons Foundation.

doi:10.1126/science.abe9395

Denmark Success With COVID With No Lockdown Or Masks. Tells Citizens the Truth About HCQ

https://principia-scientific.com/denmark-government-tells-citizens-the-truth-about-hcq/

Denmark: Government Tells Citizens The Truth About HCQ

Written by John O’Sullivan

We reported yesterday on the astonishing success of the no lockdown, no mask policy in Denmark, a nation which has not suffered the rampant number of deaths from COVID19 seen in politically-biased US cities such as New York. Below is the official statement from the Danish Government revealing the truth about hydroxychloroquine, regarded by many thousands of doctors worldwide as a “game changer” in defeating the pandemic.

The Danish Medicines Agency writes as follows:

COVID-19: Facts About Chloroquine And Hydroxychloroquine

07 April 2020

There are many rumours that hydroxychloroquine or chloroquine has a documented effect on COVID-19 and that other countries have approved it for COVID-19. Read the facts here.

Hydroxychloroquine is a medicine in tablet form authorised in the EU for the treatment of arthritis and skin diseases and for the prevention of malaria. The fact that the medicine is authorised means, in this context, that the authorities have granted a marketing authorisation to the company which manufactures the medicine. The marketing authorisation allows the company to sell the medicine for the treatment of precisely these diseases. The marketing authorisation has been granted based on documentation from the company that hydroxychloroquine is effective on these diseases and is safe to use. There is a medicine called chloroquine, and there is a medicine called hydroxychloroquine. Only hydroxychloroquine is sold in Denmark.

Since 23 March 2020, hydroxychloroquine in Denmark can only be prescribed by hospital doctors and specialist doctors for rheumatic disorders, skin diseases and childhood diseases as well as only be used in clinical trials. This means that Danish hospital doctors, for example in connection with research projects, have the possibility of testing if hydroxychloroquine has an effect in COVID-19 patients.

In principle, Danish hospital doctors are also allowed to use hydroxychloroquine to treat COVID-19 patients even if they are not enrolled in research projects. This is because doctors have the right to prescribe the medicine of their choice according to their assessment and under their own responsibility. [emphasis added to this key paragraph]

The Danish Medicines Agency cannot authorise hydroxychloroquine for COVID-19 if the company manufacturing the medicine does not apply for an authorisation. Marketing authorisations are granted based on the initiative of the company. In addition, marketing authorisations are based on documentation of efficacy and side effects, and more. Right now, only very few studies have been conducted to investigate the effect of chloroquine and hydroxychloroquine on COVID-19, and their total evidence base is not solid enough to assess if chloroquine or hydroxychloroquine has a real effect on COVID-19. Likewise, it has not been established what side effects the medicines could cause when used to treat COVID-19.

Other Countries’ Reports On Chloroquine And Hydroxychloroquine

Right now, there are many reports in the press and social media claiming that drug regulatory authorities in other countries have authorised chloroquine or hydroxychloroquine for the treatment of COVID-19. It is important to note that the authorities in other countries have not issued marketing authorisations that allow chloroquine or hydroxychloroquine to be marketed as a treatment for COVID-19. The case here is that doctors in other countries have been given possibilities to use the medicines to treat COVID-19 patients. Possibilities that are similar to those given to Danish hospital doctors.

USA’s Reports On Chloroquine And Hydroxychloroquine

The FDA has granted a special permission to use chloroquine and hydroxychloroquine in clinical trials and in emergency situations. This is not a genuine authorisation, but a possibility given to American doctors to use chloroquine in COVID-19 clinical trials and in the treatment of COVID-19 if the doctor has no other options.
See the FDA’s announcement here.

European Medicines Agency (EMA)

The EMA has announced that chloroquine and hydroxychloroquine should only be used for the treatment of COVID-19 in connection with clinical trials or in national emergency use programmes for the treatment of critically ill COVID-19 patients. Denmark is thus in line with the recommendations from the European Medicines Agency, offering the same possibilities to use hydroxychloroquine in clinical trials and allowing hospital doctors to prescribe it. See the EMA’s announcement here.

The Authorisation In Poland

Poland is the only country to have actually authorised a chloroquine-containing product for supportive treatment of COVID-19. The product concerned is produced locally and called Arachin. It is manufactured by the Polish company Adamed Pharma. The Danish Medicines Agency has not seen the Polish company’s authorisation basis, and the drug regulatory authorities in Poland have informed us that use of the product is only permitted in hospitals in Poland. Denmark can neither assess nor issue a marketing authorisation for a Polish product if the Polish company has not submitted an application to the Danish Medicines Agency with the intent of putting it on the Danish market. See Poland’s announcement here.

The Danish Medicines Agency has also investigated how several other European countries like the UKSpain and Belgium have approached the question of hydroxychloroquine and COVID-19. Several other European countries have also emphasised that hydroxychloroquine is not authorised for COVID-19, and that there is presently no evidence of the treatment. Several countries have announced that they indeed prefer the treatment to be conducted as part of clinical trials.

The Danish Medicines Agency is following international research closely. At present, there are not enough scientific studies to draw any conclusions on the effect of chloroquine and hydroxychloroquine on COVID-19.

Danish Medicines Agency

Axel Heides Gade 1

2300 København S

Email: dkma@dkma.dk

Read more at laegemiddelstyrelsen.dk

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About the author: John O’Sullivan John is CEO and co-founder (with Dr Tim Ball) of Principia Scientific International (PSI).  John is a seasoned science writer and legal analyst who assisted Dr Ball in defeating world leading climate expert, Michael ‘hockey stick’ Mann in the ‘science trial of the century‘. O’Sullivan is credited as the visionary who formed the original ‘Slayers’ group of scientists in 2010 who then collaborated in creating the world’s first full-volume debunk of the greenhouse gas theory plus their new follow-up book.

PRINCIPIA SCIENTIFIC INTERNATIONAL, legally registered in the UK as a company 
incorporated for charitable purposes. Head Office: 27 Old Gloucester Street, London WC1N 3AX. 

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**Comment**

There is much evidence that HCQ works on certain COVID patients, particularly early on with the addition of zinc and azithromycin.  There have been numerous attempts to discredit it, which has resulted in doctors speaking out worldwide on how these studies had HUGE design flaws which rigged a poor outcome:  https://madisonarealymesupportgroup.com/2020/06/30/dr-meryl-nass-discovers-hydroxychloroquine-experiments-were-designed-to-kill-covid-patients-how-many-were-murdered/

BTW: the mainstream media is complicit in all of this because they’ve been bought and paid for by Bill Gates:  https://madisonarealymesupportgroup.com/2020/08/29/every-breath-you-take-every-move-you-make-the-who-is-watching-you-the-media-is-bought-out-by-gates/  Why support an effective, cheap drug when you can make billions off of an experimental vaccine and the expensive anti-viral Remdesivir ‘authorities’ serve to profit from (even though it’s not backed by results)? https://madisonarealymesupportgroup.com/2020/07/02/remdesivir-for-covid-19-not-backed-by-results/

For more:  https://madisonarealymesupportgroup.com/2020/07/20/how-a-false-hydroxychloroquine-narrative-was-created/

https://madisonarealymesupportgroup.com/2020/08/11/yale-epidemiologist-dr-fauci-running-misinformation-campaign-against-hydroxychloroquine-aap-says-fda-caused-20000-deaths/

https://madisonarealymesupportgroup.com/2020/06/16/aaps-sues-fda-for-irrational-interference-of-access-to-life-saving-hydroxychloroquine/

https://madisonarealymesupportgroup.com/2020/08/08/new-report-turkeys-use-of-hcq-early-saves-lives-fauci-should-be-in-jail/

https://madisonarealymesupportgroup.com/2020/08/12/more-doctors-speak-out-on-censorship-and-mass-murderer-anthony-faucis-false-information-regarding-hydroxychloroquine/