Archive for the ‘Treatment’ Category

Successful Treatment for Lyme Arthritis After Knee Surgery

https://danielcameronmd.com/treatment-for-lyme-arthritis/

SUCCESSFUL TREATMENT FOR LYME ARTHRITIS AFTER KNEE SURGERY

bandaged knee for treatment for lyme arthritis

This published case report by Wright and colleagues features what the authors believe is the “first patient with late Borrelia burgdorferi sensu stricto arthritis-related prosthetic joint infection. They suggest “the case highlights how early, prompt diagnosis and adequate antimicrobial therapy may obviate the need for additional aggressive orthopedic surgical intervention.”

By

Doctors described a 67-year-old avid outdoorsman who received treatment for Lyme arthritis after having had knee surgery. Ten months earlier, the man had received a partial knee replacement for his left knee due to advanced single compartment degenerative arthritis.

Over a 3-month-period, the man developed progressive left knee pain and swelling.  He later presented with a moderate joint effusion but did not have an erythema migrans rash, warmth, instability, or significant pain with range of motion.

There was no history of a tick bite or trauma to the knee nor was there evidence of joint effusion, infection, or Baker’s cyst.

Aspiration of his knee revealed turbid purulent pleocytosis with 91.8% neutrophils, elevated C-reactive protein, and a positive Borrelia burgdorferi polymerase chain reaction (PCR).

Serologic tests were positive for an elevated erythrocyte sedimentation rate (ESR), C-reactive 0.7, and a positive B. burgdorferi antibody enzyme immunoassay (EIA) test and 10 of 10 immunoglobulin G (IgG) Western blot bands were reactive.

Lyme arthritis diagnosis

Based on the detection of B. burgdorferi sensu stricto DNA by PCR, clinicians diagnosed the man Lyme arthritis, a particular type of periprosthetic joint infection (PJI).

The diagnosis was based on criteria established by the Musculoskeletal Infection Society and the Infectious Disease Society of America (IDSA).

“Although there was no communicating sinus tract or direct result from traditional microbiological culture, our patient met these criterion for PJI based upon elevated synovial fluid leukocyte count (>3000 cell/µL), elevated synovial neutrophil count (>65%), purulence, and evidence of a microorganism with identification to the level of genus and species,” according to Wright and colleagues from the Division of Infectious Disease, Department of Medicine, Memorial Medical Center in York, Pennsylvania.

The authors summarized their concern over the seriousness of a PJI. “Periprosthetic joint infection is a devastating complication following joint arthroplasty that causes significant morbidity with an estimated cumulative incidence of 1% – 2% for both hips and knees,” the authors write.

IDSA treatment guidelines not applicable

Wright and colleagues concluded that the IDSA recommendations were not applicable to this patient. They cited two guidelines that would have limited the types of treatment to oral antibiotics and duration to no more than four weeks. These included:
  1. “Late Lyme arthritis can usually be treated successfully with antimicrobial agents administered orally (e.g., doxycycline, amoxicillin, or cefuroxime) for 28 days in adult patients without evidence of neurologic disease.”
  2. “Previous studies have also been published demonstrating the efficacy of once-daily ceftriaxone (2 gram dose) for 14 or 28 days in the treatment of late Lyme disease.”

Successful treatment with antibiotics

The 67-year-old man received treatment for Lyme arthritis which included antibiotics rather than undergoing surgical incision and drainage or excision arthroplasty. Twice daily, 100 mg of oral doxycycline was initiated empirically for a week until testing confirmed the diagnosis. The treatment was converted to a six-week course of daily intravenous 2 grams of ceftriaxone.

The antibiotic treatment for Lyme arthritis was successful.

“Clinically, the patient had cessation of his knee pain, resolution of joint effusion, normalization of synovial infection and inflammatory parameters, and negative end-of-therapy detection of B. burgdorferi DNA by PCR,” according to Wright.

However, the authors cautioned that their strategy of prolonged intravenous antibiotics might not be effective in other types of joint arthroplasties.

“Although this patient’s clinical outcome was achieved without the need for surgical incision and drainage or staged excision arthroplasty procedure, it is unclear whether this same strategy would produce similar results in patients with other types of joint arthroplasties,”

Are there any other cases of arthroplasties that might be prevented by antibiotic therapy? More than 82,660 patients underwent total knee arthroplasty (TKA) across the Medicare and United Health Care populations from 2009 to 2011 at a cost exceeding $10 billion per year. [2]

Authors’ Conclusion

“This case highlights how early prompt diagnosis and adequate antimicrobial therapy may obviate the need for additional aggressive orthopedic surgical intervention,” stressed Wright.

“This case also highlights the value of an aggressive need to further investigate and interpret unexpected findings in clinical practice.”

Related Articles:

5 cases of Lyme arthritis following an operation

Will steroid injections help children with Lyme arthritis of the knee?

Preventing unnecessary surgery for children with Lyme arthritis

References:
  1. Wright WF, Oliverio JA. First Case of Lyme Arthritis Involving a Prosthetic Knee Joint. Open Forum Infect Dis, 3(2), ofw096 (2016).
  2. Cohen JR, Bradley AT, Lieberman JR. Preoperative Interventions and Charges Before Total Knee Arthroplasty. J Arthroplasty, (2016).
  3. Fallon BA, Keilp JG, Corbera KM et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology, 70(13), 992-1003 (2008).
  4. Cameron DJ. Consequences of treatment delay in Lyme disease. J Eval Clin Pract, 13(3), 470-472 (2007)

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**Comment**

I wish there were more doctors questioning and overriding the extremely limited CDC Lyme “Guidelines” as they are inadequate for nearly everyone – unless it’s an acute case.

Speaking of IV ceftriaxone, IDSA founder Dr. Waisbren successfully used high doses (6-8gms) in his patients, despite the smear campaign against it:  https://madisonarealymesupportgroup.com/2017/07/09/idsa-founder-used-potent-iv-antibiotics-for-chronic-lyme/

https://madisonarealymesupportgroup.com/2017/06/23/no-bias-in-mmwr-for-any-other-infectious-disease-requiring-iv-antibiotics-except-for-lyme/

For more:  https://madisonarealymesupportgroup.com/2019/04/11/latent-lyme-disease-resulting-in-chronic-arthritis-early-career-termination-in-a-u-s-army-officer/

https://madisonarealymesupportgroup.com/2020/02/08/a-joint-effort-the-interplay-between-the-innate-and-the-adaptive-immune-system-in-lyme-arthritis/

 

Category:

Lyme, research, Testing, Treatment

Questions for Dr. Fauci

https://spectator.org/questions-for-dr-fauci/

Questions for Dr. Fauci

By George Parry

Aug. 17, 2020

As you may be aware, health-care providers across the country and around the world have reported great success in using Hydroxychloroquine + Zinc + Azithromycin (the “HCQ cocktail”) to treat COVID-19. According to these physicians and researchers, the key to success is to use the HCQ cocktail within the first seven days after onset of COVID-19 symptoms.

Nevertheless, ever since President Trump endorsed Hydroxychloroquine (HCQ), its use has become a highly politicized and controversial matter. The opposition to HCQ started with Dr. Anthony Fauci…

Three practicing physicians have published the following “Open letter to Dr. Anthony Fauci regarding the use of Hydroxychloroquine for treating COVID-19.” It is a devastating written cross-examination of Dr. Fauci that contains much valuable life-saving information and squarely addresses the needless deaths that have occurred due to the opposition to the HCQ cocktail.  (See link for article & letter)
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**Comment**
Seems many people have questions for mafia-overlord, Dr. Fauci:
Also, I found this short video enlightening.
“9 Minutes Explaining the Connections between Gates, Fauci, Google, and Epstein:

http://

June 23, 2020

Patrick Howley exposes how COVID-19 is being used to exert control over American citizens.

Politics aside, just listen to the facts and “follow the money.”

Category:

Activism, Treatment, Viruses

Hydroxychloroquine: A Morality Tale

https://wwwtabletmagcom.cdn.ampproject.org/c/s/www.tabletmag.com/amp/sections/science/articles/hydroxychloroquine-morality-tale


 By Norman Doidge, a contributing writer for Tablet, is a psychiatrist, psychoanalyst, and author of The Brain That Changes Itself and The Brain’s Way of Healing.

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**Comment**

Please read article in full within link above.  Below are excerpts:

Early in the coronavirus pandemic, a survey of the world’s frontline physicians showed hydroxychloroquine to be the drug they considered the most effective at treating COVID-19 patients…..Next we were told hydroxychloroquine was likely ineffective, and also dangerous…Not only are lay people confused; professionals are. All that seems certain is that there is something disturbing going on in our science, and that if and when the “perfect study” were to ever come along, many won’t know what to believe.

I was interested to learn how Chinese physicians initially got the idea of using HCQ. None of their COVID patients had Lupus.  They pondered that perhaps these patients were taking HCQ for Lupus and it protected them from COVID.

Dodge goes through study after study, showing the weaknesses in them all but also the fact that HCQ appears to:

  • be a promising antiviral against SARS-CoV-2
  • be an anti-inflammatory
  • help prevent clots which leads to strokes – a symptom seen in some cases

Important quote:

So here then is a lesson: When scientific competitors, politicians, and the media, dump on a study for not showing X, make sure you know whether that study was even designed with the primary purpose of showing X to begin with.

Dodge points out numerous important issues such as true Science is incremental and will not skip steps. Those that skip steps are skipping Science. He calls out the media and public officials for being hypocritical in that they are quite happy to insist there weren’t any randomized controlled trials (RCTs) on HCQ but turn a complete blind eye to the fact there were no RCTs on ventilators, yet they were used standardly and prolifically and that 80% of those put on them DIED.

I also learned much about the weaknesses of RCTs – namely, in that they exclude patients typical of those in the population.  This is a fantastic parallel to Lyme/MSIDS and why RCTs will never be the answer for us either, due to the wide variety of symptoms people experience and the fact other issues are often involved (other pathogens, environmental issues, immune system deficiencies, and much more).

Important quote:

The RCT evangelist focuses only on the RCT strengths, and forgets their weaknesses. A typical RCT describes several data points about hundreds of patients. It can be helpful in determining what treatment might work for most people in a large population. 

Important to note: Dr. Fauci is one of these RCT evangelists – along with most IDSA members.  Lyme literate doctors are more like Dr. Raoult, the French maverick who out of necessity goes against the flow searching for answers.  Lyme doctors have long learned that “standard” thinking is not going to help their patients – we just don’t fit into a nice box with a bow on top.

Lastly, I couldn’t agree more with the following observation:

We should be giving individual clinicians on the front lines the usual latitude to take account of their individual patient’s condition, and preferences, and encourage these physicians to bring to bear everything they have learned and read (they have been trained to read studies), and continue to read, but also what they have seen with their own eyes.  Unlike medical bureaucrats or others who issue decrees from remote places physicians are literally on our front lines—actually observing the patients in question, and a Hippocratic Oath to serve them—and not the Lancet or WHO or CNN.

I’ve written before on how the CDC has pigeon-holed Lyme/MSIDS into the acute phase – ignoring those with chronic symptoms. They have bullied doctors into following their unscientific and antiquated “Lyme Guidelines” which consists of essentially 21 days of doxycycline when many patients are infected with far more than just Lyme – as well as the fact nearly every single research study done to date on their “standard treatment” has failed. This has gone on, unabated for over 40 years:  https://madisonarealymesupportgroup.com/2020/04/26/cdc-playbook-learning-from-lyme/

Lastly, regarding HCQ, Dodge points out another glaring hypocrisy:

  • HCQ is given to a few, sick patients with nothing to lose and everything to gain. The drug enters and exits the body relatively quickly – as has been shown for decades of use.
  • Experimental COVID vaccines, endorsed by public health officials, being considered to be mandatory for ALL – even those who are ill, are being rushed, bypassing the normal 5-19 year observation period, thereby ignoring normal safety tests and regulations.  Manufacturers know this which is why they insist upon and have been granted indemnification by public health officials.  Isn’t that convenient?  Regarding this experimental vaccine, I recently posted a video about a GSK whistleblower who states it can cause infertility:  https://madisonarealymesupportgroup.com/2020/08/24/gsk-whistleblower-covid-vaccine-caused-sterility-in-97-of-women/  This is HUGE and demands investigating.

But suddenly HCQ is extremely dangerous after being used over-the counter for years by by travelers and by billions of patients with long-term chronic conditions like Lupus and other autoimmune conditions. It’s on the World Health Organization’s Model List of Essential Medicines, the safest and most effective drugs needed in a health system, all of a sudden is held in a dim, shadowy light while Remdesivir, a far more expensive drug which failed for Ebola and is questionable for COVID-19, is always held in a positive light.  Please remember that half of the members on the COVID-19 treatment panel have financial interests in Gilead Sciences:  https://www.covid19treatmentguidelines.nih.gov/panel-financial-disclosure/

The smell of a rat is overpowering, and I smell it clearly.

Dodge prophetically warns us that unless these glaring double-standards are addressed -the HCQ debacle, potentially allowing the unnecessary deaths of tens of thousands, will be only one of many in a chain of disasters.

Spot on.

 

 

 

 

Category:

Activism, Treatment, Viruses

“We Know it’s Curable; It’s Easier Than Treating the Flu” – Professor Thomas Borody & His Triple Therapy Protocol

**UPDATE**

Professor Borody gives a brief interview on the “Night Shift,” on his successful COVID treatments which are being mercilessly censored and maligned by corrupt public health authorities.

http://covexit.com/we-know-its-curable-its-easier-than-treating-the-flu-professor-thomas-borody/

“We Know it’s Curable; It’s Easier than Treating the Flu” — Professor Thomas Borody

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Australian radio host Luke Bona interviewed this August 12 Professor Thomas Borody, from the Centre for Digestive Diseases in Sydney, Australia, about Ivermectin-based therapies for COVID-19. 

The interview is short and to the point, and should be of interest to everyone in the world.

See French version of the article at this link.

Based on existing research and his analysis of therapeutic results using Ivermectin in combination with 2 other widely available generic drugs – Doxycycline and Zinc -, he asserts that COVID-19 is now curable and even easier to treat than the flu.

Here are some excerpts.

“We came up with a treatment that is simple, safe, and can get rid of the coronavirus in almost all patients treated within 6 to 10 days.”

“It can treat and get rid, within 6 to 10 days, of the coronavirus”

“It is an easy, very easy virus to cure, when you combine the dosage we have described, because it inhibits the growth of the bug. It just goes away, and you no longer can find it in an infected person.”

Q: “Why aren’t we treating every elderly person in every health care facility, in every aged care facility with this?”

“There is no drug company behind it. There are no people who are lobbying government and giving donations for reelections and so forth. I don’t know the answer.”

“It also happened when I developed the tritherapy (for H. Pilory infection), because there was no company behind that. It took 26 years… Those people who otherwise would now be dying from bleeding ulcers stopped bleeding, stopped dying…”

“This is the same sort of situation I think. It’s hard to get traction when there is  no big payback, no payout to a large company.”

Q: “I understand there are clinical trials of this ivermectin therapy going on in 32 countries”

“The important ones have already been done. The drugs that we use are all approved by the TGA and the FDA. So tomorrow you can write a script for it, because they are approved for other reasons.” (note: TGA stands for Therapeutic Goods Administration)

“The trials that I know of … have been done in places where there are a lot of coronavirus patients…”

“In Bangladesh, 60 out of 60 were cured.“

“That’s not easy to believe, because it’s just too good too be true.”

“In China, they compared coronavirus treatment with either ivermectin mixed, or hydroxychloroquine mixed.”

“Hydroxychloroquine is not a bad drug when you combine it with azithromycin. They got 96.3% cure”

“But with ivermectin, it was 100%.”

Q: “Have you spoken directly to Greg Hunt?” (Australia’s health minister)

“No I haven’t been able to get through.”

“I don’t blame him at all. Things go to his advisers…. The advisers are not experts in this field… They don’t read the journals, the articles….

.As Boorstin said, ‘One of the great obstacles to discovery, it’s not ignorance,  it’s the illusion of knowledge.,.

“They have the illusion of knowledge. They think they know. They say you have to go to animal studies first, pre-clinical, not knowing you don’t need to do trials on approved drugs.”

Q: “Professor, where do we go from here, how do we get this happening?”

“I would very much like to see … teams set up that would quickly treat all the infected Victorians…”

“We need to treat Victorians today, because we have a therapy which will give people hope.”

“In the future, we will not need to worry if we get positivity.”

“You get treated immediately, you don’t need to go to the hospital.”

“It’s easier than treating the flu now.”

“You can actually eradicate it.”

“You can’t eradicate Hepatitis C that easily. HIV we cannot. Here we use a bunch of drugs, and the bug disappears…”

“We know it’s curable.”

Professor Borody is most famous for his ground-breaking work developing the triple therapy cure for peptic ulcers in 1987, which has saved hundreds of thousands of lives, and the Australian health system more than $10 billion in medical care and operations.

Professor Borody founded the Centre for Digestive Diseases (CDD) in 1984 after a distinguished career with leading hospitals including St Vincent’s in Sydney and the Mayo Clinic in the USA.

He is a world-renowned leader in the clinical microbiota dating back to 1988 when he started performing what is now called Fecal Microbiota Transplantation (FMT).

Professor Borody holds over 150 patents in areas such as; treatment of Helicobacter pylori, Crohn’s disease, bowel lavage, IBS and FMT.

Professor Thomas Borody

See his publications at: https://www.researchgate.net/profile/Thomas_Borody2

Listen to the interview:  https://omny.fm/shows/triple-m-night-shift/a-proven-covid-prevention-and-cure-dr-professor-th

See our previous coverage, with an overview of the (brief) history of Ivermectin-based therapies and an account of Professor Borody’s declarations to Sky News Australia.

Ivermectin & COVID-19: an Overview

COVID-19 Therapies: Sky News Australia Departs from Mainstream Media, Highlights Ivermectin-Based Treatment

Australian GPs Can Legally Prescribe Ivermectin Triple Therapy Protocol — Professor Thomas Borody

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The Centre for Digestive Diseases issued today a press release titled “Ivermectin Triple Therapy Protocol for COVID-19 Released to Australian GPs for Infected Elderly and Frontline Workers.”

As we previously covered, this early treatment protocol combines ivermectin with doxycycline and zinc.

“Triple therapy specialist Professor Thomas Borody, famous for curing peptic ulcers using a triple antibiotic therapy saving millions of lives, today released the COVID-19 treatment protocol to Australian GPs, who can legally prescribe it to their COVID-19 positive patients. They can also prescribe it as a preventative medication. Borody says this could be the fastest and safest way to end the pandemic in Australia within 6-8 weeks.”

“The three medications are now on chemist shelves right now. GPs can email GP@CDD.com.au to obtain the dosing protocol and COVID-19 treatment information for their patients.”

“GPs can legally prescribe the therapy today as an “off label” treatment according to Australian Guidelines – a standard practice in medicine.”

“In fact more than 60% of prescriptions in Australia are “off-label”. It’s not a new concept. It’s happening every day to manage diseases and save lives.”

(See link for article)

But ‘authorities’ don’t care.  They are still waiting for the lucrative, magic-bullet vaccine.

Category:

Treatment, Viruses

40+ Practitioners Failed to Recognize Lyme Disease As Root of My Ailments

https://www.lymedisease.org/gabriela-40-practitioners-lyme/

40+ practitioners failed to recognize Lyme disease as root of my ailments

Gabriela Wijegunawardena

By Gabriela Wijegunawardena

Over the past seven years I’ve seen: five primary care doctors, two neurologists, five OB-GYNs, one gastroenterologist, two urologists, one allergist, five dermatologists, five ER doctors, three functional medicine doctors, one ophthalmologist, one naturopath, four physical therapists, seven acupuncturists, and two craniosacral therapists—on a quest to find answers about my health.

I’m not a layperson. I wasn’t lost in the healthcare system. I know healthcare from the inside out. I have been a nurse for 17 years. I researched every doctor before scheduling an appointment. I prepared a list of questions and concerns for each doctor’s visit. Yet my outcome was misdiagnosis and dozens of prescription medications being thrown at symptoms.

Missing the root cause

If I’d been correctly diagnosed from the start, I could have avoided the following: Botox injections to my scalp and occipital nerve blocks to alleviate debilitating migraine pain and occipital neuralgia; an endoscopy; CT scans; MRIs; numerous ultrasounds; and countless lab tests. Not one doctor was able to determine the cause of my health problems. For starters, most weren’t looking for Lyme disease. Medications served as band-aids, and I was faced with the stark reality that the medical establishment I’d served for so long had failed me.

I hiked regularly in the Bay Area and had a dog when odd symptoms began to appear in 2013. Over the years, I would address one symptom, only to have another emerge months later. Sometimes I’d feel relatively okay for months at a time. My health improved somewhat after being treated for gut dysbiosis, worsening migraines, and interstitial cystitis. However, no one could pinpoint the root cause of my growing list of ailments. And I never felt fully well, like my old self.

In 2016, I saw a naturopath who tested me for Lyme disease as part of my new patient workup, using the standard serological ELISA and Western Blot lab tests. I read my results over and over. Negative. Negative. Negative. At the time, I didn’t know about the unreliability of the CDC’s two-tier testing protocol for Lyme disease. I was just told that Lyme had been ruled out. I’d tested negative, had never seen a tick, felt a bite, or had a bull’s-eye rash.

A Diagnosis

My health was in a downward spiral by the start of 2020. I still didn’t know what was causing my decline, I just knew I needed answers. A friend referred me to an integrative doctor who specializes in treating complex cases. It turns out, he’s a member of ILADS and has a lot of experience in recognizing and treating tick-borne illness.

As he looked over my lab results and read my list of chief complaints, he raised the possibility that Lyme disease could be at the root of my health problems. I couldn’t believe it! Had it been Lyme all along? My body was fighting something and perceived everything as a threat. Overactive mast cells translated into a myriad of symptoms ranging from histamine intolerance to anxiety and insomnia. He diagnosed me with mast cell activation syndrome, prescribed medications to stabilize my mast cells, and we agreed to test for Lyme disease via a specialized lab. My physical symptoms were beginning to make sense. I finally felt like I was headed in the right direction.

Health Inequity, Racial Disparities, & Implicit Bias

Once I was officially diagnosed with tick-borne disease, I joined a number of Lyme support groups. I was determined to find answers and connect with others battling the disease. As I explored each group, I noticed most members were white. I yearned to see representation in these groups. Why were so few people of color diagnosed with Lyme and other tick-borne infections?

As I’ve come to learn, there are many layers to that answer. A textbook bull’s-eye rash indicative of Lyme will present differently in people with dark skin. If the assessing doctor isn’t Lyme-knowledgeable, this cardinal sign may be missed. Latinos are at high risk for contracting tick-borne infections due to occupational exposure. They comprise 44% of ground maintenance workers and 43% of farm workers. Because of health inequity, Black and Brown communities often lack access to healthcare.

Furthermore, access to Lyme-literate medical doctors (LLMDs) is problematic, as most are not in-network with health insurance plans. Thus, the cost of treatment falls squarely on the patient’s shoulders. Language barriers, fear of deportation, work schedules, and seasonal labor are roadblocks to seeking care early on as well. Lastly, a doctor’s bias, implicit or not, will directly impact if and when a diagnosis is made and how a patient’s complaints are treated. One study showed that doctors who harbor pro-white implicit biases aree more likely to prescribe pain medications to white patients than to Black patients.

CDC

Another barrier to diagnosis is the CDC’s rigid definition of Lyme disease. California, where I live, is considered “low-incidence” by the CDC. This means a patient in my state must meet a higher standard to be considered positive for Lyme, as compared to people in “high incidence” states.

The CDC also adheres to the Lyme treatment guidelines of the Infectious Diseases Society of America. According the IDSA, clearing Lyme disease only takes a few weeks of antibiotics. If symptoms persist beyond that, they call it “Post Treatment Lyme Disease Syndrome,” and advise against any further treatment. This also makes it easier for insurance companies to refuse to pay for Lyme medical care beyond the short course recommended by the IDSA.

Now four months into treatment with intravenous and oral antibiotics, I am beginning to see more and more glimpses of “the old me.” I hope to finish up sometime this year. I feel fortunate to have found a treating doctor to help me solve my health puzzle, along with caring and skillful nurses that never miss with IV placement.

I’m also grateful to have found an acupuncturist who has successfully treated Lyme patients for decades. She has helped my body detoxify and feel calmer, month after month. Everyone deserves to have holistic care, with integrative doctors and acupuncturists working collaboratively with a patient-centered approach. Sadly, this is not the case in our broken healthcare system.

Gabriela Wijegunawardena lives in the San Francisco Bay Area. This guest post is adapted from her blog Raising the Revolution.

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**Comment**

And so it goes – patient, after patient, after patient, yet the 40+ year old dogma continues unabated.

 

Category:

Activism, Lyme, Treatment