https://clo2xuewuliu.substack.com/p/a-comprehensive-review-13-medical?
A Comprehensive Review: 13 Medical Applications of Chlorine Dioxide (ClO₂) Therapy

Over the past decade, I have developed and published 13 distinct chlorine dioxide (ClO₂) therapeutic protocols across a wide range of diseases. Each protocol is based on specific delivery routes, unique mechanisms of action, and clinical rationale. Below is a unified review of these therapies, with links to each article and an explanation of their underlying mechanisms based on three core principles:
- Cellular Elimination (via oxidative necrosis)
- Tissue Regeneration (via microbial control + inflammation resolution)
- Immune Modulation (suppressing autoimmunity or stimulating anti-disease responses)
1. Treating Cancer with Chlorine Dioxide (Intra-Tumoral Injection)
Link: https://open.substack.com/pub/clo2xuewuliu/p/16-treating-cancer-with-chlorine?r=48chtc
Mechanism:
- Rapid oxidative destruction of tumor cells
- Collapse of tumor vasculature
- Activation of systemic immune response against metastases
- Promotion of local tissue regeneration
2. Treating Arthritis and Autoimmune Diseases
Link: https://open.substack.com/pub/clo2xuewuliu/p/treating-arthritis-with-chlorine?r=48chtc
Mechanism:
- Local or intra-articular injection reduces cytokine-driven inflammation
- Resets joint immune environment to suppress autoimmunity
- Accelerates cartilage and synovial tissue recovery
3. Treating Hair Loss
Link: https://open.substack.com/pub/clo2xuewuliu/p/treating-hair-loss-with-chlorine?r=48chtc
Mechanism:
- Clears microbial and oxidative damage on scalp
- Activates dormant follicles via immune reset
- Improves blood flow to hair roots through local vasodilation
4. Treating Alopecia Areata
Link: https://open.substack.com/pub/clo2xuewuliu/p/6-treating-alopecia-areata-with-chlorine?r=48chtc
Mechanism:
- Targets autoimmune attack zones
- Reduces scalp inflammation
- Encourages regrowth by rebalancing local immunity
5. Treating Acne
Link: https://open.substack.com/pub/clo2xuewuliu/p/7-treating-acne-with-chlorine-dioxide?r=48chtc
Mechanism:
- Destroys P. acnes bacteria
- Opens clogged follicles and reduces oil overproduction
- Suppresses secondary inflammation and redness
6. Treating Eczema
Link: https://open.substack.com/pub/clo2xuewuliu/p/10-treating-eczema-with-chlorine-6e4?r=48chtc
Mechanism:
- Reduces microbial overgrowth and toxins
- Rebuilds skin barrier through anti-inflammatory effect
- Calms itch through local immune regulation
7. Treating Psoriasis
Link: https://open.substack.com/pub/clo2xuewuliu/p/11-treating-psoriasis-with-chlorine?r=48chtc
Mechanism:
- Suppresses keratinocyte hyperproliferation
- Reduces local autoimmunity
- Supports lesion healing with antimicrobial action
8. Treating Vitiligo
Link: https://open.substack.com/pub/clo2xuewuliu/p/12-treating-vitiligo-with-chlorine?r=48chtc
Mechanism:
- Oxidative modulation to remove inhibitory immune cells
- Supports melanocyte niche recovery
- May enhance pigmentation restart
9. Using ClO₂ for Skin Care (Beyond Cosmetics)
Link: https://open.substack.com/pub/clo2xuewuliu/p/13-using-chlorine-dioxide-for-skin?r=48chtc
Mechanism:
- Deep cleansing of microbial and oxidative buildup
- Improves dermal texture and cellular turnover
- Long-term inflammation prevention
10. Treating Pharyngitis
Link: https://open.substack.com/pub/clo2xuewuliu/p/treating-pharyngitis-with-chlorine?r=48chtc
Mechanism:
- Rapid microbial decontamination
- Relieves throat inflammation
- Speeds mucosal healing and prevents secondary infection
11. Treating Rhinitis
Link: https://open.substack.com/pub/clo2xuewuliu/p/14-treating-rhinitis-with-chlorine?r=48chtc
Mechanism:
- Nasal spray or irrigation kills pathogens
- Reduces allergic and non-allergic nasal swelling
- Prevents sinus complications
12. Treating Dry Eye Syndrome
Link: https://open.substack.com/pub/clo2xuewuliu/p/8-treating-dry-eye-syndrome-with?r=48chtc
Mechanism:
- Restores tear film via ocular surface decontamination
- Calms inflammation in meibomian glands
- Promotes epithelial regeneration
13. Using ClO₂ for Localized Fat Reduction
Link: https://open.substack.com/pub/clo2xuewuliu/p/17-using-chlorine-dioxide-for-localized?r=48chtc
Mechanism:
- Oxidative destruction of subcutaneous adipocytes
- Induces fibrosis-free tissue remodeling
- Safe aesthetic alternative to liposuction
These applications show that chlorine dioxide is not a one-size-fits-all remedy. Its value lies in protocol design, precision dosing, and mechanism-specific logic.
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For more:
- https://madisonarealymesupportgroup.com/2025/05/08/existing-evidence-for-chlorine-dioxide-in-treating-human-disease/
- https://madisonarealymesupportgroup.com/2025/02/14/history-therapeutic-mechanisms-safety-of-chlorine-dioxide/
- https://madisonarealymesupportgroup.com/2025/01/09/chlorine-dioxide-yet-another-safe-cheap-treatment-attacked-by-the-fda/
- https://madisonarealymesupportgroup.com/2024/03/06/chlorine-dioxide-natural-medicine-kerri-rivera/
- https://robertyoho.substack.com/p/280-nasa-said-that-chlorine-dioxide Dr. Yoho has a lot on CDS
- https://dioxipedia.com/index.php?title=Main_Page Dioxipedia is a comprehensive source on CDS treatments.
- https://odysee.com/@Truewholehuman:c/Chlorine-Dioxide-Tutorial-2:2 How to make and take Chlorine Dioxide Solution
- Raw ingredients – Sodium Chlorite and either Citric Acid or Hydrochloric Acid
- A syringe that holds/measures at least 10 milliliters
- Shot glass
- Short, sealable glass container that is just big enough to hold a shot glass
- Dark glass spray bottle (optional)
- Funnel
- Dark glass bottle for CDS storage
- One liter, dark (or covered) glass water bottle for drinking